MOUSE:OTX2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Otx2 (synonyms: Otx-2)
Protein Name(s)	Homeobox protein OTX2 Orthodenticle homolog 2
External Links
UniProt	P80206
EMBL	X68884
CCDS	CCDS49473.1
PIR	S35346
UniGene	Mm.134516 Mm.487292
PDB	2DMS
PDBsum	2DMS
ProteinModelPortal	P80206
SMR	P80206
MINT	MINT-1347226
PhosphoSite	P80206
PRIDE	P80206
MGI	MGI:97451
eggNOG	NOG245767
HOGENOM	HOG000082677
HOVERGEN	HBG004028
InParanoid	P80206
PhylomeDB	P80206
ChiTaRS	Otx2
EvolutionaryTrace	P80206
PRO	PR:P80206
Proteomes	UP000000589
CleanEx	MM_OTX2
Genevestigator	P80206
GO	GO:0005737 GO:0005634 GO:0046982 GO:0043565 GO:0003700 GO:0048856 GO:0009952 GO:0030154 GO:0045165 GO:0001708 GO:0007417 GO:0048852 GO:0009953 GO:0007492 GO:0042706 GO:0030900 GO:0042472 GO:0022037 GO:0030901 GO:0030182 GO:0048663 GO:0048664 GO:0009887 GO:0040019 GO:2000543 GO:0045944 GO:0045893 GO:0090009 GO:0006357 GO:0032525
Gene3D	1.10.10.60
InterPro	IPR017970 IPR001356 IPR009057 IPR003022 IPR003025 IPR013851
Pfam	PF00046 PF03529
PRINTS	PR01257 PR01255
SMART	SM00389
SUPFAM	SSF46689
PROSITE	PS00027 PS50071

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010468	regulation of gene expression	PMID:20463215^[1]	ECO:0000315			P		p6517 blimp1 expression is reduced in otx2 knockouts	complete
involved_in	GO:2000543	positive regulation of gastrulation	PMID:11291865^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090009	primitive streak formation	PMID:11291865^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:11291865^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0040019	positive regulation of embryonic development	PMID:11291865^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990830	cellular response to leukemia inhibitory factor	PMID:20439489^[3]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090009	primitive streak formation	PMID:11291865^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857502	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071542	dopaminergic neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32243	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0065003	protein-containing complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32243	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048856	anatomical structure development	PMID:11412024^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109448	P	results_in_development_of:(EMAPA:16109)\|results_in_development_of:(EMAPA:16112)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048852	diencephalon morphogenesis	PMID:20816794^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97450	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048709	oligodendrocyte differentiation	PMID:26166575^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178753 MGI:MGI:3665330	P	occurs_in:(EMAPA:32665)\|occurs_in:(EMAPA:16913)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048664	neuron fate determination	PMID:19592574^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2446434,MGI:MGI:2661065	P	results_in_determination_of:(CL:0000117)\|occurs_in(EMAPA:16974)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048663	neuron fate commitment	PMID:26166575^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178753 MGI:MGI:3665330	P	occurs_in:(EMAPA:32665)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048663	neuron fate commitment	PMID:16339193^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2446434,MGI:MGI:2661065	P	has_participant:(EMAPA:16974) results_in_commitment_to:(CL:0000700)	Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:15890343^[9]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q91ZK4	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15890343^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2153518	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16539743^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32243	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045165	cell fate commitment	PMID:15105370^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2661065	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042706	eye photoreceptor cell fate commitment	PMID:14625556^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178753	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:10225993^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97450	P	has_participant:(EMAPA:17290)\|has_participant:(EMAPA:17290)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32243	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032525	somite rostral/caudal axis specification	PMID:11291865^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857502	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030901	midbrain development	PMID:20816794^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97450	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030901	midbrain development	PMID:15201224^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97450	P	results_in_development_of:(EMAPA:16974)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030901	midbrain development	PMID:15888661^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176222,MGI:MGI:2661065	P	results_in_development_of:(EMAPA:16472)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030901	midbrain development	PMID:15201223^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857510 MGI:MGI:3046841	P	results_in_development_of:(EMAPA:16974)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:15917450^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95388	P	results_in_development_of:(EMAPA:17769)\|results_in_development_of:(EMAPA:17544)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:15201223^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97450	P	results_in_development_of:(EMAPA:16896)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:15201223^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857510 MGI:MGI:3046841	P	results_in_development_of:(EMAPA:16895)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030900	forebrain development	PMID:14625556^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178753	P		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32243	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:15888661^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176222,MGI:MGI:2661065	P	occurs_in:(EMAPA:16974) results_in_acquisition_of_features_of:(CL:0000700)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030154	cell differentiation	PMID:14625556^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178753	P	occurs_in:(EMAPA:18778) results_in_acquisition_of_features_of:(CL:0000652)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0022037	metencephalon development	PMID:20816794^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97450	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021978	telencephalon regionalization	PMID:26166575^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178753 MGI:MGI:3665330	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009953	dorsal/ventral pattern formation	PMID:12652306^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2661067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:11412024^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109448	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:9501024^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857502	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:12652306^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2661067	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:14625556^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178753	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007492	endoderm development	PMID:11412024^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:109448	P	results_in_development_of:(EMAPA:16058)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007417	central nervous system development	PMID:12652306^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2661067	P	results_in_development_of:(EMAPA:16974)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007417	central nervous system development	PMID:11731459^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857510 MGI:MGI:2150146	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32243	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	PMID:15105370^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10891582^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17168)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23056351^[22]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16910)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22992956^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16095)\|part_of:(EMAPA:16069)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19796622^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10891582^[21]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17172) part_of:(CL:0000740)\|part_of:(EMAPA:19155) part_of:(CL:0000748)\|part_of:(EMAPA:17168)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15105370^[11]	ECO:0000305	curator inference used in manual assertion	GO:0006357	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32243	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001708	cell fate specification	PMID:15888661^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2176222,MGI:MGI:2661065	P	has_participant:(EMAPA:16472) results_in_specification_of:(CL:0000117)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32243	F		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P32243	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001356 InterPro:IPR003022 InterPro:IPR003025 InterPro:IPR009057	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003022 InterPro:IPR003025 InterPro:IPR013851	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003022 InterPro:IPR003025 InterPro:IPR013851	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003022 InterPro:IPR003025 InterPro:IPR013851	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017970	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238 UniProtKB-KW:KW-0371	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Katoh, K et al. (2010) Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development. J. Neurosci. 30 6515-26 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Kinder, SJ et al. (2001) Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity. Int. J. Dev. Biol. 45 347-55 PubMed GONUTS page
↑ Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Kimura, C et al. (2001) Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast. Dev. Biol. 235 12-32 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Sakurai, Y et al. (2010) Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization. Dev. Biol. 347 392-403 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Hoch, RV et al. (2015) OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum. Cell Rep 12 482-94 PubMed GONUTS page
↑ Prakash, N et al. (2009) Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development 136 2545-55 PubMed GONUTS page
↑ Prakash, N et al. (2006) A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development 133 89-98 PubMed GONUTS page
↑ ^9.0 ^9.1 Kimura, K et al. (2005) Functional analysis of transcriptional repressor Otx3/Dmbx1. FEBS Lett. 579 2926-32 PubMed GONUTS page
↑ Inoue, T et al. (2006) Cloning and characterization of mr-s, a novel SAM domain protein, predominantly expressed in retinal photoreceptor cells. BMC Dev. Biol. 6 15 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Puelles, E et al. (2004) Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain. Development 131 2037-48 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Nishida, A et al. (2003) Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. Nat. Neurosci. 6 1255-63 PubMed GONUTS page
↑ Morsli, H et al. (1999) Otx1 and Otx2 activities are required for the normal development of the mouse inner ear. Development 126 2335-43 PubMed GONUTS page
↑ Kurokawa, D et al. (2004) Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development 131 3319-31 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Vernay, B et al. (2005) Otx2 regulates subtype specification and neurogenesis in the midbrain. J. Neurosci. 25 4856-67 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Kurokawa, D et al. (2004) Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm. Development 131 3307-17 PubMed GONUTS page
↑ Kimura, J et al. (2005) Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium. J. Neurosci. 25 5097-108 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Puelles, E et al. (2003) Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain. Nat. Neurosci. 6 453-60 PubMed GONUTS page
↑ Biben, C et al. (1998) Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. Dev. Biol. 194 135-51 PubMed GONUTS page
↑ Martinez-Barbera, JP et al. (2001) Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2. Development 128 4789-800 PubMed GONUTS page
↑ ^21.0 ^21.1 Baas, D et al. (2000) The subcellular localization of Otx2 is cell-type specific and developmentally regulated in the mouse retina. Brain Res. Mol. Brain Res. 78 26-37 PubMed GONUTS page
↑ Konno, D et al. (2012) The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex. PLoS ONE 7 e46577 PubMed GONUTS page
↑ Iwafuchi-Doi, M et al. (2012) Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development 139 3926-37 PubMed GONUTS page
↑ Nishiyama, A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell 5 420-33 PubMed GONUTS page

[PMID:20463215-1] Katoh, K et al. (2010) Blimp1 suppresses Chx10 expression in differentiating retinal photoreceptor precursors to ensure proper photoreceptor development. J. Neurosci. 30 6515-26 PubMed GONUTS page

[PMID:11291865-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 Kinder, SJ et al. (2001) Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity. Int. J. Dev. Biol. 45 347-55 PubMed GONUTS page

[PMID:20439489-3] Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page

[PMID:11412024-4] 4.0 ^4.1 ^4.2 Kimura, C et al. (2001) Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast. Dev. Biol. 235 12-32 PubMed GONUTS page

[PMID:20816794-5] 5.0 ^5.1 ^5.2 Sakurai, Y et al. (2010) Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization. Dev. Biol. 347 392-403 PubMed GONUTS page

[PMID:26166575-6] 6.0 ^6.1 ^6.2 Hoch, RV et al. (2015) OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum. Cell Rep 12 482-94 PubMed GONUTS page

[PMID:19592574-7] Prakash, N et al. (2009) Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain. Development 136 2545-55 PubMed GONUTS page

[PMID:16339193-8] Prakash, N et al. (2006) A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development 133 89-98 PubMed GONUTS page

[PMID:15890343-9] 9.0 ^9.1 Kimura, K et al. (2005) Functional analysis of transcriptional repressor Otx3/Dmbx1. FEBS Lett. 579 2926-32 PubMed GONUTS page

[PMID:16539743-10] Inoue, T et al. (2006) Cloning and characterization of mr-s, a novel SAM domain protein, predominantly expressed in retinal photoreceptor cells. BMC Dev. Biol. 6 15 PubMed GONUTS page

[PMID:15105370-11] 11.0 ^11.1 ^11.2 Puelles, E et al. (2004) Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain. Development 131 2037-48 PubMed GONUTS page

[PMID:14625556-12] 12.0 ^12.1 ^12.2 ^12.3 Nishida, A et al. (2003) Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. Nat. Neurosci. 6 1255-63 PubMed GONUTS page

[PMID:10225993-13] Morsli, H et al. (1999) Otx1 and Otx2 activities are required for the normal development of the mouse inner ear. Development 126 2335-43 PubMed GONUTS page

[PMID:15201224-14] Kurokawa, D et al. (2004) Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development 131 3319-31 PubMed GONUTS page

[PMID:15888661-15] 15.0 ^15.1 ^15.2 Vernay, B et al. (2005) Otx2 regulates subtype specification and neurogenesis in the midbrain. J. Neurosci. 25 4856-67 PubMed GONUTS page

[PMID:15201223-16] 16.0 ^16.1 ^16.2 Kurokawa, D et al. (2004) Regulation of Otx2 expression and its functions in mouse epiblast and anterior neuroectoderm. Development 131 3307-17 PubMed GONUTS page

[PMID:15917450-17] Kimura, J et al. (2005) Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium. J. Neurosci. 25 5097-108 PubMed GONUTS page

[PMID:12652306-18] 18.0 ^18.1 ^18.2 Puelles, E et al. (2003) Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain. Nat. Neurosci. 6 453-60 PubMed GONUTS page

[PMID:9501024-19] Biben, C et al. (1998) Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. Dev. Biol. 194 135-51 PubMed GONUTS page

[PMID:11731459-20] Martinez-Barbera, JP et al. (2001) Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2. Development 128 4789-800 PubMed GONUTS page

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MOUSE:OTX2

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