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PMID:26166575

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Citation

Hoch, RV, Lindtner, S, Price, JD and Rubenstein, JL (2015) OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum. Cell Rep 12:482-94

Abstract

The Otx2 homeodomain transcription factor is essential for gastrulation and early neural development. We generated Otx2 conditional knockout (cKO) mice to investigate its roles in telencephalon development after neurulation (approximately embryonic day 9.0). We conducted transcriptional profiling and in situ hybridization to identify genes de-regulated in Otx2 cKO ventral forebrain. In parallel, we used chromatin immunoprecipitation sequencing to identify enhancer elements, the OTX2 binding motif, and de-regulated genes that are likely direct targets of OTX2 transcriptional regulation. We found that Otx2 was essential in septum specification, regulation of Fgf signaling in the rostral telencephalon, and medial ganglionic eminence (MGE) patterning, neurogenesis, and oligodendrogenesis. Within the MGE, Otx2 was required for ventral, but not dorsal, identity, thus controlling the production of specific MGE derivatives.

Links

PubMed PMC4512845 Online version:10.1016/j.celrep.2015.06.043

Keywords

Animals; Cerebral Cortex/cytology; Cerebral Cortex/embryology; Female; Gene Expression; Mice; Otx Transcription Factors/genetics; Otx Transcription Factors/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:OTX2

acts_upstream_of_or_within

GO:0021978: telencephalon regionalization

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2178753,MGI:MGI:3665330

P

Seeded From UniProt

complete

MOUSE:OTX2

acts_upstream_of_or_within

GO:0048709: oligodendrocyte differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2178753,MGI:MGI:3665330

P

  • occurs_in:(EMAPA:32665)|occurs_in:(EMAPA:16913)

Seeded From UniProt

complete

MOUSE:OTX2

acts_upstream_of_or_within

GO:0048663: neuron fate commitment

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2178753,MGI:MGI:3665330

P

  • occurs_in:(EMAPA:32665)

Seeded From UniProt

complete

MOUSE:OTX2

acts_upstream_of_or_within

GO:0048663: neuron fate commitment

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2178753
MGI:MGI:3665330

P

occurs_in:(EMAPA:32665)

Seeded From UniProt

complete

MOUSE:OTX2

acts_upstream_of_or_within

GO:0048709: oligodendrocyte differentiation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2178753
MGI:MGI:3665330

P

occurs_in:(EMAPA:32665)|occurs_in:(EMAPA:16913)

Seeded From UniProt

complete

MOUSE:OTX2

acts_upstream_of_or_within

GO:0021978: telencephalon regionalization

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2178753
MGI:MGI:3665330

P

Seeded From UniProt

complete

Notes

See also

References

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