PMID:12652306

Citation	Puelles, E, Acampora, D, Lacroix, E, Signore, M, Annino, A, Tuorto, F, Filosa, S, Corte, G, Wurst, W, Ang, SL and Simeone, A (2003) Otx dose-dependent integrated control of antero-posterior and dorso-ventral patterning of midbrain. Nat. Neurosci. 6:453-60
Abstract	Organizing centers emit signaling molecules that specify different neuronal cell types at precise positions along the anterior-posterior (A-P) and dorsal-ventral (D-V) axes of neural tube during development. Here we report that reduction in Otx proteins near the alar-basal plate boundary (ABB) of murine midbrain resulted in a dorsal shift of Shh expression, and reduction in Otx proteins at the midbrain-hindbrain boundary (MHB) resulted in an anterior expansion of the Fgf8 domain. Our data thus indicate that an Otx dose-dependent repressive effect coordinates proper positioning of Shh and Fgf8 expression. Furthermore, this control is effective for conferring proper cell identity in the floor-plate region of midbrain and does not require an Otx2-specific property. We propose that this mechanism may provide both A-P and D-V positional information to neuronal precursors located within the midbrain.
Links	PubMed Online version:10.1038/nn1037
Keywords	Animals; Body Patterning/genetics; Female; Gene Expression Regulation, Developmental/physiology; Homeodomain Proteins/biosynthesis; Homeodomain Proteins/genetics; Male; Mesencephalon/embryology; Mesencephalon/metabolism; Mice; Mice, Mutant Strains; Nerve Tissue Proteins/biosynthesis; Nerve Tissue Proteins/genetics; Otx Transcription Factors; Recombinant Proteins/biosynthesis; Recombinant Proteins/genetics; Trans-Activators/biosynthesis; Trans-Activators/genetics; Transcription Factors/biosynthesis; Transcription Factors/genetics
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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