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PMID:15890343
| Citation |
Kimura, K, Miki, T, Shibasaki, T, Zhang, Y, Ogawa, M, Saisho, H, Okuno, M, Iwanaga, T and Seino, S (2005) Functional analysis of transcriptional repressor Otx3/Dmbx1. FEBS Lett. 579:2926-32 |
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| Abstract |
Otx3/Dmbx1 is a member of paired class homeodomain transcription factors. In this study, we found that Otx3/Dmbx1 represses the Otx2-mediated transactivation by forming heterodimer with Otx2 on the P3C (TAATCCGATTA) sequence in vitro. The 156 amino acid region (residues 1-156) of Otx3/Dmbx1 is required for its repressor activity, and interacts directly with Otx2. Co-localization of Otx3/Dmbx1 and Otx2 in brain sections was confirmed by in situ hybridization. These data suggest that Otx3/Dmbx1 represses Otx2-mediated transcription in the developing brain. We also identified the consensus binding sequence [TAATCCGATTA and TAATCC(N2-4)TAATCC] of Otx3/Dmbx1. |
| Links |
PubMed Online version:10.1016/j.febslet.2005.04.042 |
| Keywords |
Animals; Base Sequence; DNA Primers; Dimerization; Homeodomain Proteins/chemistry; Homeodomain Proteins/physiology; Mice; Nerve Tissue Proteins/chemistry; Nerve Tissue Proteins/physiology; Otx Transcription Factors; Repressor Proteins/chemistry; Repressor Proteins/physiology; Transcription, Genetic/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
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