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MOUSE:NRP1

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Nrp1 (synonyms: Nrp)
Protein Name(s) Neuropilin-1

A5 protein

External Links
UniProt P97333
EMBL D50086
CH466525
BC060129
CCDS CCDS22790.1
RefSeq NP_032763.2
XP_006530829.1
UniGene Mm.271745
PDB 4GZ9
4GZA
PDBsum 4GZ9
4GZA
ProteinModelPortal P97333
SMR P97333
BioGrid 201848
DIP DIP-39360N
IntAct P97333
MINT MINT-99860
STRING 10090.ENSMUSP00000026917
PhosphoSite P97333
MaxQB P97333
PaxDb P97333
PRIDE P97333
Ensembl ENSMUST00000026917
GeneID 18186
KEGG mmu:18186
UCSC uc009nzr.2
CTD 8829
MGI MGI:106206
eggNOG NOG150941
GeneTree ENSGT00760000119073
HOGENOM HOG000039978
HOVERGEN HBG000502
InParanoid P97333
KO K06724
OMA YCACWHN
OrthoDB EOG7ZWD1D
TreeFam TF316506
Reactome REACT_307441
REACT_314392
REACT_329019
REACT_336251
REACT_340782
REACT_353319
ChiTaRS Nrp1
NextBio 293506
PRO PR:P97333
Proteomes UP000000589
Bgee P97333
CleanEx MM_NRP1
ExpressionAtlas P97333
Genevisible P97333
GO GO:0030424
GO:0005829
GO:0005769
GO:0005615
GO:0005925
GO:0016021
GO:0005883
GO:0005886
GO:0097443
GO:0019838
GO:0008201
GO:0046872
GO:0017154
GO:0038085
GO:0005021
GO:0001525
GO:0060978
GO:0048844
GO:0048846
GO:0007411
GO:0007413
GO:0060385
GO:0021785
GO:0016477
GO:0060980
GO:0002042
GO:0035729
GO:0035924
GO:0071679
GO:0060982
GO:0016358
GO:0060666
GO:0035767
GO:0021612
GO:1903375
GO:0061552
GO:0021828
GO:0007507
GO:0048012
GO:0008045
GO:0030517
GO:0048843
GO:2001237
GO:0043524
GO:0021675
GO:1901166
GO:0048666
GO:0001764
GO:0043049
GO:0001569
GO:0048008
GO:0050918
GO:0048842
GO:0070374
GO:0050731
GO:1902336
GO:1902946
GO:0048841
GO:0090259
GO:0061441
GO:0061299
GO:0031290
GO:0071526
GO:1902287
GO:1902285
GO:0097374
GO:0002040
GO:0061549
GO:0048485
GO:0097490
GO:0097491
GO:1901998
GO:0061551
GO:0021636
GO:0021637
GO:0048010
GO:0038190
GO:1902378
GO:0036486
GO:0021649
Gene3D 2.60.120.260
2.60.120.290
InterPro IPR000421
IPR013320
IPR000859
IPR008979
IPR000998
IPR014648
IPR022579
IPR027146
PANTHER PTHR10127:SF616
Pfam PF00431
PF11980
PF00754
PF00629
PIRSF PIRSF036960
PRINTS PR00020
SMART SM00042
SM00231
SM00137
SUPFAM SSF49785
SSF49854
SSF49899
PROSITE PS01180
PS01285
PS01286
PS50022
PS00740
PS50060

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001525

angiogenesis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014648
InterPro:IPR027146

P

Seeded From UniProt

GO:0001525

angiogenesis

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0037

P

Seeded From UniProt

GO:0001525

angiogenesis

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:O14786

P

Seeded From UniProt

GO:0001525

angiogenesis

PMID:12852851[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2450311
MGI:MGI:3512101

P

Seeded From UniProt

GO:0001525

angiogenesis

PMID:15376331[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857853

P

Seeded From UniProt

GO:0001525

angiogenesis

PMID:23639442[3]

IGI: Inferred from Genetic Interaction

UniProtKB:O14786

P

Seeded From UniProt

GO:0001525

angiogenesis

PMID:24401374[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0001569

patterning of blood vessels

PMID:17428830[5]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3512099

P

Seeded From UniProt

GO:0001569

patterning of blood vessels

PMID:21852397[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0001569

patterning of blood vessels

PMID:23315162[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0001569

patterning of blood vessels

PMID:24401374[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0001764

neuron migration

PMID:22790009[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0002040

sprouting angiogenesis

PMID:24401374[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0002042

cell migration involved in sprouting angiogenesis

PMID:23315162[7]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0002042

cell migration involved in sprouting angiogenesis

PMID:24401374[4]

IC: Inferred by Curator

GO:0061299

P

Seeded From UniProt

GO:0005021

vascular endothelial growth factor-activated receptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014648
InterPro:IPR027146

F

Seeded From UniProt

GO:0005021

vascular endothelial growth factor-activated receptor activity

PMID:21658587[9]

IMP: Inferred from Mutant Phenotype

F

Seeded From UniProt

GO:0005515

protein binding

PMID:10520994[10]

IPI: Inferred from Physical Interaction

UniProtKB:P70206

F

Seeded From UniProt

GO:0005515

protein binding

PMID:15239958[11]

IPI: Inferred from Physical Interaction

UniProtKB:O08665

F

Seeded From UniProt

GO:0005515

protein binding

PMID:15239958[11]

IPI: Inferred from Physical Interaction

UniProtKB:Q62181

F

Seeded From UniProt

GO:0005515

protein binding

PMID:15978582[12]

IPI: Inferred from Physical Interaction

UniProtKB:Q9Z0G0

F

Seeded From UniProt

GO:0005515

protein binding

PMID:18464795[13]

IPI: Inferred from Physical Interaction

UniProtKB:P34152

F

Seeded From UniProt

GO:0005515

protein binding

PMID:18550718[14]

IPI: Inferred from Physical Interaction

UniProtKB:P11627

F

Seeded From UniProt

GO:0005615

extracellular space

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000265371

C

Seeded From UniProt

GO:0005615

extracellular space

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:O14786

C

Seeded From UniProt

GO:0005769

early endosome

PMID:23639442[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005829

cytosol

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000265371

C

Seeded From UniProt

GO:0005829

cytosol

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:O14786

C

Seeded From UniProt

GO:0005883

neurofilament

PMID:15814794[15]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000265371

C

Seeded From UniProt

GO:0005886

plasma membrane

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:O14786

C

Seeded From UniProt

GO:0005886

plasma membrane

PMID:23639442[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_120968

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_19181

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_19192

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_19256

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_19300

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_19361

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_19374

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_19383

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005886

plasma membrane

Reactome:REACT_22421

TAS: Traceable Author Statement

C

Seeded From UniProt

GO:0005925

focal adhesion

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000265371

C

Seeded From UniProt

GO:0005925

focal adhesion

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:O14786

C

Seeded From UniProt

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

GO:0007399

nervous system development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0524

P

Seeded From UniProt

GO:0007411

axon guidance

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014648
InterPro:IPR027146

P

Seeded From UniProt

GO:0007411

axon guidance

PMID:12852851[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3512099

P

Seeded From UniProt

GO:0007411

axon guidance

PMID:15604101[16]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857853

P

Seeded From UniProt

GO:0007411

axon guidance

PMID:15814794[15]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0007411

axon guidance

PMID:15814794[15]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857853

P

Seeded From UniProt

GO:0007413

axonal fasciculation

PMID:17428830[5]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3512099

P

Seeded From UniProt

GO:0007507

heart development

PMID:12852851[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:1100492

P

Seeded From UniProt

GO:0008045

motor neuron axon guidance

PMID:18804103[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0008201

heparin binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0358

F

Seeded From UniProt

GO:0009887

organ morphogenesis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR027146

P

Seeded From UniProt

GO:0016020

membrane

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR000998

C

Seeded From UniProt

GO:0016020

membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0472

C

Seeded From UniProt

GO:0016020

membrane

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

GO:0016021

integral component of membrane

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0812

C

Seeded From UniProt

GO:0016358

dendrite development

PMID:12852851[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:3512099

P

Seeded From UniProt

GO:0016477

cell migration

PMID:15376331[2]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857853

P

Seeded From UniProt

GO:0017154

semaphorin receptor activity

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014648
InterPro:IPR027146

F

Seeded From UniProt

GO:0017154

semaphorin receptor activity

PMID:12591607[18]

IGI: Inferred from Genetic Interaction

MGI:MGI:2179061

F

Seeded From UniProt

GO:0017154

semaphorin receptor activity

PMID:15239958[11]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

GO:0017154

semaphorin receptor activity

PMID:15239958[11]

IPI: Inferred from Physical Interaction

UniProtKB:Q6ZQ83

F

Seeded From UniProt

GO:0019838

growth factor binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR027146

F

Seeded From UniProt

GO:0019838

growth factor binding

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:O14786

F

Seeded From UniProt

GO:0019838

growth factor binding

PMID:10705382[19]

IPI: Inferred from Physical Interaction

UniProtKB:Q00731

F

Seeded From UniProt

GO:0021612

facial nerve structural organization

PMID:18356247[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0021612

facial nerve structural organization

PMID:18804103[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0021636

trigeminal nerve morphogenesis

PMID:15814794[15]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857853

P

Seeded From UniProt

GO:0021637

trigeminal nerve structural organization

PMID:18804103[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0021649

vestibulocochlear nerve structural organization

PMID:18356247[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0021675

nerve development

PMID:22790009[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0021785

branchiomotor neuron axon guidance

PMID:18804103[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0021828

gonadotrophin-releasing hormone neuronal migration to the hypothalamus

PMID:21059704[21]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0030154

cell differentiation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0221

P

Seeded From UniProt

GO:0030424

axon

PMID:15677725[22]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0030424

axon

PMID:21658587[9]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0030424

axon

PMID:21828096[23]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0030517

negative regulation of axon extension

PMID:12852851[1]

IGI: Inferred from Genetic Interaction

MGI:MGI:107558

P

Seeded From UniProt

GO:0031290

retinal ganglion cell axon guidance

PMID:21658587[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0035729

cellular response to hepatocyte growth factor stimulus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000265371

P

Seeded From UniProt

GO:0035729

cellular response to hepatocyte growth factor stimulus

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:O14786

P

Seeded From UniProt

GO:0035767

endothelial cell chemotaxis

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR027146

P

Seeded From UniProt

GO:0035767

endothelial cell chemotaxis

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000265371

P

Seeded From UniProt

GO:0035767

endothelial cell chemotaxis

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:O14786

P

Seeded From UniProt

GO:0035924

cellular response to vascular endothelial growth factor stimulus

PMID:24401374[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0036486

ventral trunk neural crest cell migration

PMID:19386662[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0038084

vascular endothelial growth factor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR014648

P

Seeded From UniProt

GO:0038085

vascular endothelial growth factor binding

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000265371

F

Seeded From UniProt

GO:0038085

vascular endothelial growth factor binding

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:O14786

F

Seeded From UniProt

GO:0038085

vascular endothelial growth factor binding

PMID:24401374[4]

IPI: Inferred from Physical Interaction

UniProtKB:P15692-4

F

Seeded From UniProt

GO:0038190

VEGF-activated neuropilin signaling pathway

PMID:23639442[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0043049

otic placode formation

PMID:18356247[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0043524

negative regulation of neuron apoptotic process

PMID:21828096[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0046872

metal ion binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0479

F

Seeded From UniProt

GO:0048008

platelet-derived growth factor receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000265371

P

Seeded From UniProt

GO:0048008

platelet-derived growth factor receptor signaling pathway

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:O14786

P

Seeded From UniProt

GO:0048010

vascular endothelial growth factor receptor signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR027146

P

Seeded From UniProt

GO:0048010

vascular endothelial growth factor receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000265371

P

Seeded From UniProt

GO:0048010

vascular endothelial growth factor receptor signaling pathway

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:O14786

P

Seeded From UniProt

GO:0048010

vascular endothelial growth factor receptor signaling pathway

PMID:12852851[1]

IMP: Inferred from Mutant Phenotype

MGI:MGI:2450311
MGI:MGI:3512101

P

Seeded From UniProt

GO:0048010

vascular endothelial growth factor receptor signaling pathway

PMID:23639442[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0048012

hepatocyte growth factor receptor signaling pathway

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000265371

P

Seeded From UniProt

GO:0048012

hepatocyte growth factor receptor signaling pathway

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:O14786

P

Seeded From UniProt

GO:0048485

sympathetic nervous system development

PMID:15814794[15]

IMP: Inferred from Mutant Phenotype

MGI:MGI:1857853

P

Seeded From UniProt

GO:0048666

neuron development

PMID:21828096[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0048841

regulation of axon extension involved in axon guidance

PMID:15814794[15]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0048842

positive regulation of axon extension involved in axon guidance

PMID:21658587[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0048843

negative regulation of axon extension involved in axon guidance

PMID:9753685[25]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0048844

artery morphogenesis

PMID:23639442[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0048844

artery morphogenesis

PMID:24401374[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0048846

axon extension involved in axon guidance

PMID:22790009[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSP00000265371

P

Seeded From UniProt

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

GO_REF:0000096

ISO: Inferred from Sequence Orthology

UniProtKB:O14786

P

Seeded From UniProt

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

PMID:23639442[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0050918

positive chemotaxis

PMID:21658587[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0060385

axonogenesis involved in innervation

PMID:22790009[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0060666

dichotomous subdivision of terminal units involved in salivary gland branching

PMID:17626059[26]

IGI: Inferred from Genetic Interaction

MGI:MGI:107558

P

Seeded From UniProt

GO:0060666

dichotomous subdivision of terminal units involved in salivary gland branching

PMID:17626059[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0060978

angiogenesis involved in coronary vascular morphogenesis

PMID:24401374[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0060980

cell migration involved in coronary vasculogenesis

PMID:24401374[4]

IC: Inferred by Curator

GO:0060978

P

Seeded From UniProt

GO:0060982

coronary artery morphogenesis

PMID:23639442[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0061299

retina vasculature morphogenesis in camera-type eye

PMID:24401374[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0061441

renal artery morphogenesis

PMID:23639442[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0061549

sympathetic ganglion development

PMID:19325129[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0061549

sympathetic ganglion development

PMID:22790009[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0061551

trigeminal ganglion development

PMID:18356247[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0061552

ganglion morphogenesis

PMID:19386662[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0070374

positive regulation of ERK1 and ERK2 cascade

PMID:23639442[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0071526

semaphorin-plexin signaling pathway

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR027146

P

Seeded From UniProt

GO:0071526

semaphorin-plexin signaling pathway

PMID:12591607[18]

IGI: Inferred from Genetic Interaction

MGI:MGI:107558
MGI:MGI:2179061

P

Seeded From UniProt

GO:0071526

semaphorin-plexin signaling pathway

PMID:15239958[11]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

GO:0071526

semaphorin-plexin signaling pathway

PMID:15239958[11]

IGI: Inferred from Genetic Interaction

MGI:MGI:2154244

P

Seeded From UniProt

GO:0071679

commissural neuron axon guidance

PMID:21658587[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0090259

regulation of retinal ganglion cell axon guidance

PMID:21658587[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0097374

sensory neuron axon guidance

PMID:18356247[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0097443

sorting endosome

PMID:23639442[3]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

GO:0097490

sympathetic neuron projection extension

PMID:22790009[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:0097491

sympathetic neuron projection guidance

PMID:22790009[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:1901166

neural crest cell migration involved in autonomic nervous system development

PMID:18356247[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:1901166

neural crest cell migration involved in autonomic nervous system development

PMID:19325129[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:1901166

neural crest cell migration involved in autonomic nervous system development

PMID:19386662[24]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:1901998

toxin transport

PMID:23716698[28]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:1902285

semaphorin-plexin signaling pathway involved in neuron projection guidance

PMID:22790009[8]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:1902287

semaphorin-plexin signaling pathway involved in axon guidance

PMID:18804103[17]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:1902336

positive regulation of retinal ganglion cell axon guidance

PMID:21658587[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:1902378

VEGF-activated neuropilin signaling pathway involved in axon guidance

PMID:21658587[9]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:1902946

protein localization to early endosome

PMID:23639442[3]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:1903375

facioacoustic ganglion development

PMID:18356247[20]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

PMID:21828096[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt


Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 1.4 1.5 Gu, C et al. (2003) Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev. Cell 5 45-57 PubMed GONUTS page
  2. 2.0 2.1 Gerhardt, H et al. (2004) Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system. Dev. Dyn. 231 503-9 PubMed GONUTS page
  3. 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 Lanahan, A et al. (2013) The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis. Dev. Cell 25 156-68 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 4.8 4.9 Fantin, A et al. (2014) Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development 141 556-62 PubMed GONUTS page
  5. 5.0 5.1 Vieira, JM et al. (2007) Selective requirements for NRP1 ligands during neurovascular patterning. Development 134 1833-43 PubMed GONUTS page
  6. Fantin, A et al. (2011) The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins. Development 138 4185-91 PubMed GONUTS page
  7. 7.0 7.1 Fantin, A et al. (2013) NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis. Blood 121 2352-62 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 Maden, CH et al. (2012) NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system. Dev. Biol. 369 277-85 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 9.5 9.6 9.7 9.8 Erskine, L et al. (2011) VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm. Neuron 70 951-65 PubMed GONUTS page
  10. Takahashi, T et al. (1999) Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell 99 59-69 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 11.4 11.5 Gitler, AD et al. (2004) PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev. Cell 7 107-16 PubMed GONUTS page
  12. Burkhardt, C et al. (2005) Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif. FEBS Lett. 579 3821-8 PubMed GONUTS page
  13. Bechara, A et al. (2008) FAK-MAPK-dependent adhesion disassembly downstream of L1 contributes to semaphorin3A-induced collapse. EMBO J. 27 1549-62 PubMed GONUTS page
  14. Law, CO et al. (2008) The neural adhesion molecule TAG-1 modulates responses of sensory axons to diffusible guidance signals. Development 135 2361-71 PubMed GONUTS page
  15. 15.0 15.1 15.2 15.3 15.4 15.5 Suto, F et al. (2005) Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance. J. Neurosci. 25 3628-37 PubMed GONUTS page
  16. Kettunen, P et al. (2005) Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfbeta1 regulate semaphorin 3a expression in the dental mesenchyme. Development 132 323-34 PubMed GONUTS page
  17. 17.0 17.1 17.2 17.3 17.4 Schwarz, Q et al. (2008) Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development. Dev. Biol. 324 1-9 PubMed GONUTS page
  18. 18.0 18.1 Suto, F et al. (2003) Identification and characterization of a novel mouse plexin, plexin-A4. Mech. Dev. 120 385-96 PubMed GONUTS page
  19. Halder, JB et al. (2000) Differential expression of VEGF isoforms and VEGF(164)-specific receptor neuropilin-1 in the mouse uterus suggests a role for VEGF(164) in vascular permeability and angiogenesis during implantation. Genesis 26 213-24 PubMed GONUTS page
  20. 20.0 20.1 20.2 20.3 20.4 20.5 20.6 Schwarz, Q et al. (2008) Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells. Development 135 1605-13 PubMed GONUTS page
  21. Cariboni, A et al. (2011) Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for the aetiology of hypogonadotropic hypogonadism. Hum. Mol. Genet. 20 336-44 PubMed GONUTS page
  22. Yoshihara, S et al. (2005) Arx homeobox gene is essential for development of mouse olfactory system. Development 132 751-62 PubMed GONUTS page
  23. 23.0 23.1 23.2 23.3 Cariboni, A et al. (2011) VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels. Development 138 3723-33 PubMed GONUTS page
  24. 24.0 24.1 24.2 Schwarz, Q et al. (2009) Neuropilin-mediated neural crest cell guidance is essential to organise sensory neurons into segmented dorsal root ganglia. Development 136 1785-9 PubMed GONUTS page
  25. Chédotal, A et al. (1998) Semaphorins III and IV repel hippocampal axons via two distinct receptors. Development 125 4313-23 PubMed GONUTS page
  26. 26.0 26.1 Chung, L et al. (2007) Semaphorin signaling facilitates cleft formation in the developing salivary gland. Development 134 2935-45 PubMed GONUTS page
  27. 27.0 27.1 Schwarz, Q et al. (2009) Neuropilin 1 signaling guides neural crest cells to coordinate pathway choice with cell specification. Proc. Natl. Acad. Sci. U.S.A. 106 6164-9 PubMed GONUTS page
  28. Slater, LH et al. (2013) CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proc. Natl. Acad. Sci. U.S.A. 110 9932-7 PubMed GONUTS page