MOUSE:NRP1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Nrp1 (synonyms: Nrp)
Protein Name(s)	Neuropilin-1 A5 protein
External Links
UniProt	P97333
EMBL	D50086 CH466525 BC060129
CCDS	CCDS22790.1
RefSeq	NP_032763.2 XP_006530829.1
UniGene	Mm.271745
PDB	4GZ9 4GZA
PDBsum	4GZ9 4GZA
ProteinModelPortal	P97333
SMR	P97333
BioGrid	201848
DIP	DIP-39360N
IntAct	P97333
MINT	MINT-99860
STRING	10090.ENSMUSP00000026917
PhosphoSite	P97333
MaxQB	P97333
PaxDb	P97333
PRIDE	P97333
Ensembl	ENSMUST00000026917
GeneID	18186
KEGG	mmu:18186
UCSC	uc009nzr.2
CTD	8829
MGI	MGI:106206
eggNOG	NOG150941
GeneTree	ENSGT00760000119073
HOGENOM	HOG000039978
HOVERGEN	HBG000502
InParanoid	P97333
KO	K06724
OMA	YCACWHN
OrthoDB	EOG7ZWD1D
TreeFam	TF316506
Reactome	REACT_307441 REACT_314392 REACT_329019 REACT_336251 REACT_340782 REACT_353319
ChiTaRS	Nrp1
NextBio	293506
PRO	PR:P97333
Proteomes	UP000000589
Bgee	P97333
CleanEx	MM_NRP1
ExpressionAtlas	P97333
Genevisible	P97333
GO	GO:0030424 GO:0005829 GO:0005769 GO:0005615 GO:0005925 GO:0016021 GO:0005883 GO:0005886 GO:0097443 GO:0019838 GO:0008201 GO:0046872 GO:0017154 GO:0038085 GO:0005021 GO:0001525 GO:0060978 GO:0048844 GO:0048846 GO:0007411 GO:0007413 GO:0060385 GO:0021785 GO:0016477 GO:0060980 GO:0002042 GO:0035729 GO:0035924 GO:0071679 GO:0060982 GO:0016358 GO:0060666 GO:0035767 GO:0021612 GO:1903375 GO:0061552 GO:0021828 GO:0007507 GO:0048012 GO:0008045 GO:0030517 GO:0048843 GO:2001237 GO:0043524 GO:0021675 GO:1901166 GO:0048666 GO:0001764 GO:0043049 GO:0001569 GO:0048008 GO:0050918 GO:0048842 GO:0070374 GO:0050731 GO:1902336 GO:1902946 GO:0048841 GO:0090259 GO:0061441 GO:0061299 GO:0031290 GO:0071526 GO:1902287 GO:1902285 GO:0097374 GO:0002040 GO:0061549 GO:0048485 GO:0097490 GO:0097491 GO:1901998 GO:0061551 GO:0021636 GO:0021637 GO:0048010 GO:0038190 GO:1902378 GO:0036486 GO:0021649
Gene3D	2.60.120.260 2.60.120.290
InterPro	IPR000421 IPR013320 IPR000859 IPR008979 IPR000998 IPR014648 IPR022579 IPR027146
PANTHER	PTHR10127:SF616
Pfam	PF00431 PF11980 PF00754 PF00629
PIRSF	PIRSF036960
PRINTS	PR00020
SMART	SM00042 SM00231 SM00137
SUPFAM	SSF49785 SSF49854 SSF49899
PROSITE	PS01180 PS01285 PS01286 PS50022 PS00740 PS50060

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0150020	basal dendrite arborization	PMID:22683681^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O08665	P	occurs_in:(CL:0002609) occurs_in:(UBERON:0005394)	Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	PMID:22683681^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0004040)\|part_of:(UBERON:0005343)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:22683681^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6ZQ29	F	occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:22683681^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UL54	F		Seeded From UniProt	complete
involved_in	GO:0150018	basal dendrite development	PMID:22683681^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0002609) occurs_in:(UBERON:0005391)\|occurs_in:(CL:0002609) occurs_in:(UBERON:0005392)	Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	PMID:24863063^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0007229) part_of:(GO:0038189) occurs_in:(CL:0000115) has_regulation_target:(UniProtKB:Q8VI36) positively_regulates:(GO:0043542)\|part_of(GO:0038189) occurs_in:(UBERON:0000966) part_of:(GO:0007229) positively_regulates:(GO:0001525) has_regulation_target:(UniProtKB:Q8VI36)	Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:24863063^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045766	positive regulation of angiogenesis	PMID:24863063^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000966)	Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	PMID:24863063^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0038189) occurs_in:(UBERON:0000966) part_of:(GO:0007229) positively_regulates:(GO:0001525)	Seeded From UniProt	complete
NOT\|involved_in	GO:0003253	cardiac neural crest cell migration involved in outflow tract morphogenesis	PMID:26053665^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	PMID:26051942^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002028)	Seeded From UniProt	complete
involved_in	GO:0038189	neuropilin signaling pathway	PMID:26051942^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032489	regulation of Cdc42 protein signal transduction	PMID:26051942^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0038189) part_of:(GO:0007229) causally_upstream_of:(GO:0090050)	Seeded From UniProt	complete
involved_in	GO:0003148	outflow tract septum morphogenesis	PMID:26053665^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0004699) part_of:(GO:0071526)	Seeded From UniProt	complete
involved_in	GO:0097475	motor neuron migration	PMID:26503042^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0036486	ventral trunk neural crest cell migration	PMID:19386662^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904835	dorsal root ganglion morphogenesis	PMID:19386662^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_morphogenesis_of:(UBERON:0000044)	Seeded From UniProt	complete
involved_in	GO:1901166	neural crest cell migration involved in autonomic nervous system development	PMID:19386662^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_movement_of:(CL:0000011)	Seeded From UniProt	complete
involved_in	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance	PMID:18804103^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0005023)\|occurs_in:(CL:0005025)	Seeded From UniProt	complete
involved_in	GO:1901166	neural crest cell migration involved in autonomic nervous system development	PMID:18356247^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_movement_of:(CL:0000008)	Seeded From UniProt	complete
involved_in	GO:0097374	sensory neuron axon guidance	PMID:18356247^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061551	trigeminal ganglion development	PMID:18356247^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903375	facioacoustic ganglion development	PMID:18356247^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905040	otic placode development	PMID:18356247^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021785	branchiomotor neuron axon guidance	PMID:18804103^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021649	vestibulocochlear nerve structural organization	PMID:18356247^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021637	trigeminal nerve structural organization	PMID:18804103^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_morphogenesis_of:(UBERON:0000375)\|results_in_morphogenesis_of:(UBERON:0000377)\|results_in_morphogenesis_of:(UBERON:0000348)	Seeded From UniProt	complete
involved_in	GO:0021612	facial nerve structural organization	PMID:18356247^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021612	facial nerve structural organization	PMID:18804103^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	results_in_morphogenesis_of:(CL:0005023)\|results_in_morphogenesis_of:(CL:0005025)	Seeded From UniProt	complete
involved_in	GO:0008045	motor neuron axon guidance	PMID:18804103^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0005025)	Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	PMID:21828096^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000165)	Seeded From UniProt	complete
involved_in	GO:1902946	protein localization to early endosome	PMID:23639442^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P35918) occurs_in:(CL:0000115)	Seeded From UniProt	complete
involved_in	GO:1902378	VEGF-activated neuropilin signaling pathway involved in axon guidance	PMID:21658587^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000740)	Seeded From UniProt	complete
involved_in	GO:1902336	positive regulation of retinal ganglion cell axon guidance	PMID:21658587^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance	PMID:22790009^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1901166	neural crest cell migration involved in autonomic nervous system development	PMID:19325129^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097491	sympathetic neuron projection guidance	PMID:22790009^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097490	sympathetic neuron projection extension	PMID:22790009^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0097443	sorting endosome	PMID:23639442^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1000413)	Seeded From UniProt	complete
involved_in	GO:0090259	regulation of retinal ganglion cell axon guidance	PMID:21658587^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071679	commissural neuron axon guidance	PMID:21658587^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000740) occurs_in:(UBERON:0000959)	Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:23639442^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1000413) part_of:(GO:0038084)\|occurs_in(UBERON:0000948) part_of:(GO:0038084)	Seeded From UniProt	complete
involved_in	GO:0061549	sympathetic ganglion development	PMID:19325129^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061549	sympathetic ganglion development	PMID:22790009^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061441	renal artery morphogenesis	PMID:23639442^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061299	retina vasculature morphogenesis in camera-type eye	PMID:24401374^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060982	coronary artery morphogenesis	PMID:23639442^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060980	cell migration involved in coronary vasculogenesis	PMID:24401374^[14]	ECO:0000305	curator inference used in manual assertion	GO:0060978	P		Seeded From UniProt	complete
involved_in	GO:0060978	angiogenesis involved in coronary vascular morphogenesis	PMID:24401374^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060385	axonogenesis involved in innervation	PMID:22790009^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000948)\|occurs_in:(UBERON:0000947)	Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	PMID:21658587^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000740)	Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	PMID:23639442^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1000413) part_of:(GO:0038084) has_regulation_target:(UniProtKB:P35918)	Seeded From UniProt	complete
involved_in	GO:0048846	axon extension involved in axon guidance	PMID:22790009^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048844	artery morphogenesis	PMID:24401374^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0048844	artery morphogenesis	PMID:23639442^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002103)	Seeded From UniProt	complete
involved_in	GO:0048842	positive regulation of axon extension involved in axon guidance	PMID:21658587^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000740) occurs_in:(UBERON:0000959)	Seeded From UniProt	complete
involved_in	GO:0048666	neuron development	PMID:21828096^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000165)	Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:23639442^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1000413) part_of:(GO:0038084)\|occurs_in(UBERON:0000948) part_of:(GO:0038084)	Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:21828096^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000165)	Seeded From UniProt	complete
involved_in	GO:0038190	VEGF-activated neuropilin signaling pathway	PMID:23639442^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:1000413) part_of:(GO:0038084)\|occurs_in(UBERON:0000948) part_of:(GO:0038084)	Seeded From UniProt	complete
enables	GO:0038085	vascular endothelial growth factor binding	PMID:24401374^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P15692-4	F		Seeded From UniProt	complete
involved_in	GO:0035924	cellular response to vascular endothelial growth factor stimulus	PMID:24401374^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031290	retinal ganglion cell axon guidance	PMID:21658587^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21828096^[9]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000165)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:21658587^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000740) part_of:(UBERON:0000959)	Seeded From UniProt	complete
involved_in	GO:0021828	gonadotrophin-releasing hormone neuronal migration to the hypothalamus	PMID:21059704^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0021675	nerve development	PMID:22790009^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:23639442^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1000413)	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:23639442^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:1000413)	Seeded From UniProt	complete
enables	GO:0005021	vascular endothelial growth factor-activated receptor activity	PMID:21658587^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0000740)	Seeded From UniProt	complete
involved_in	GO:0002042	cell migration involved in sprouting angiogenesis	PMID:23315162^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0030902) occurs_in:(CL:0000115)	Seeded From UniProt	complete
involved_in	GO:0002042	cell migration involved in sprouting angiogenesis	PMID:24401374^[14]	ECO:0000305	curator inference used in manual assertion	GO:0061299	P	occurs_in:(UBERON:0000966)	Seeded From UniProt	complete
involved_in	GO:0002040	sprouting angiogenesis	PMID:24401374^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001764	neuron migration	PMID:22790009^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	PMID:24401374^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0002028)\|occurs_in:(UBERON:0000966)	Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	PMID:21852397^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	PMID:23315162^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0030902) occurs_in:(CL:0000115)	Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:23639442^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	PMID:24401374^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000966)	Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	PMID:24863063^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0038189) occurs_in:(UBERON:0000966) causally_upstream_of:(GO:0001525)	Seeded From UniProt	complete
involved_in	GO:0038189	neuropilin signaling pathway	PMID:24863063^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000966) causally_upstream_of:(GO:0001525) part_of:(GO:0007229)	Seeded From UniProt	complete
involved_in	GO:0043542	endothelial cell migration	PMID:24863063^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0007229) part_of:(GO:0038189)\|part_of:(GO:0038189) occurs_in:(UBERON:0000966) causally_upstream_of:(GO:0001525) part_of:(GO:0007229)	Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	PMID:26051942^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0000353) occurs_in:(UBERON:0003714) occurs_in:(UBERON:0002028)	Seeded From UniProt	complete
involved_in	GO:0071526	semaphorin-plexin signaling pathway	PMID:26053665^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	PMID:16540575^[18]	ECO:0006063	over expression analysis evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
involved_in	GO:0099173	postsynapse organization	PMID:16540575^[18]	ECO:0005589	confocal microscopy evidence used in manual assertion		P	occurs_in:(GO:0098978) occurs_in:(UBERON:0000061) occurs_in:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0099055	integral component of postsynaptic membrane	PMID:16540575^[18]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(GO:0098978) part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:16540575^[18]	ECO:0006063	over expression analysis evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	PMID:16540575^[18]	ECO:0005589	confocal microscopy evidence used in manual assertion		C	part_of:(UBERON:0000061) part_of:(UBERON:0000956)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000251	positive regulation of actin cytoskeleton reorganization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901998	toxin transport	PMID:23716698^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071526	semaphorin-plexin signaling pathway	PMID:15239958^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2154244	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071526	semaphorin-plexin signaling pathway	PMID:12591607^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107558 MGI:MGI:2179061	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071526	semaphorin-plexin signaling pathway	PMID:15239958^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching	PMID:17626059^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107558	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching	PMID:17626059^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051491	positive regulation of filopodium assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048843	negative regulation of axon extension involved in axon guidance	PMID:9753685^[23]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:18631) regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048843	negative regulation of axon extension involved in axon guidance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621588	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048841	regulation of axon extension involved in axon guidance	PMID:15814794^[24]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:17157)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048485	sympathetic nervous system development	PMID:15814794^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857853	P	results_in_development_of:(EMAPA:16985)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048012	hepatocyte growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048010	vascular endothelial growth factor receptor signaling pathway	PMID:12852851^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450311,MGI:MGI:3512101	P	occurs_in:(EMAPA:16104)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043542	endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621588	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042327	positive regulation of phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038190	VEGF-activated neuropilin signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0038189	neuropilin signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
enables	GO:0038085	vascular endothelial growth factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035767	endothelial cell chemotaxis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035729	cellular response to hepatocyte growth factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034446	substrate adhesion-dependent cell spreading	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032489	regulation of Cdc42 protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030517	negative regulation of axon extension	PMID:12852851^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107558	P	regulates_o_occurs_in:(EMAPA:16668) regulates_o_occurs_in:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621588	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:15677725^[26]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17797) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621588	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021636	trigeminal nerve morphogenesis	PMID:15814794^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857853	P		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	PMID:10705382^[27]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q00731	F	occurs_in:(EMAPA:35269) has_direct_input:(PR:Q00731-2)\|occurs_in(EMAPA:35689)	Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	F		Seeded From UniProt	complete
enables	GO:0017154	semaphorin receptor activity	PMID:15239958^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q6ZQ83	F		Seeded From UniProt	complete
enables	GO:0017154	semaphorin receptor activity	PMID:12591607^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2179061	F		Seeded From UniProt	complete
enables	GO:0017154	semaphorin receptor activity	PMID:15239958^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0017154	semaphorin receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621588	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	PMID:15376331^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857853	P	occurs_in:(EMAPA:16916) results_in_movement_of:(CL:0000704)\|occurs_in(EMAPA:16104) results_in_movement_of:(CL:0000704)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016358	dendrite development	PMID:12852851^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3512099	P	occurs_in:(EMAPA:17544) occurs_in:(CL:0000598)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621588	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	PMID:12852851^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1100492	P	results_in_development_of:(EMAPA:16346)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007413	axonal fasciculation	PMID:17428830^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3512099	P	occurs_in:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:15814794^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857853	P	occurs_in:(EMAPA:16668)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:15604101^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857853	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:12852851^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3512099	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007411	axon guidance	PMID:15814794^[24]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17157)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006930	substrate-dependent cell migration, cell extension	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	C		Seeded From UniProt	complete
part_of	GO:0005883	neurofilament	PMID:15814794^[24]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:32815)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	C		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001569	branching involved in blood vessel morphogenesis	PMID:17428830^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3512099	P	occurs_in:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:15376331^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857853	P	has_participant:(EMAPA:16916)\|has_participant:(EMAPA:16104)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	PMID:12852851^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2450311,MGI:MGI:3512101	P	has_participant:(EMAPA:16104)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001525	angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O14786	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:0043547	positive regulation of GTPase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005096	P		Seeded From UniProt	complete
involved_in	GO:2000251	positive regulation of actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0051894	positive regulation of focal adhesion assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0051496	positive regulation of stress fiber assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0051491	positive regulation of filopodium assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0048012	hepatocyte growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0043542	endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0042327	positive regulation of phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0038190	VEGF-activated neuropilin signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0038189	neuropilin signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
enables	GO:0038085	vascular endothelial growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	F		Seeded From UniProt	complete
involved_in	GO:0035767	endothelial cell chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0035729	cellular response to hepatocyte growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0034446	substrate adhesion-dependent cell spreading	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0032489	regulation of Cdc42 protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	F		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0007229	integrin-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0006930	substrate-dependent cell migration, cell extension	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	C		Seeded From UniProt	complete
enables	GO:0005096	GTPase activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O14786 ensembl:ENSP00000265371	P		Seeded From UniProt	complete
involved_in	GO:0048843	negative regulation of axon extension involved in axon guidance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QWJ9 ensembl:ENSRNOP00000075034	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QWJ9 ensembl:ENSRNOP00000075034	C		Seeded From UniProt	complete
part_of	GO:0030426	growth cone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QWJ9 ensembl:ENSRNOP00000075034	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QWJ9 ensembl:ENSRNOP00000075034	C		Seeded From UniProt	complete
enables	GO:0017154	semaphorin receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QWJ9 ensembl:ENSRNOP00000075034	F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QWJ9 ensembl:ENSRNOP00000075034	C		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9QWJ9 ensembl:ENSRNOP00000075034	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014648 InterPro:IPR027146	P		Seeded From UniProt	complete
enables	GO:0005021	vascular endothelial growth factor-activated receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014648 InterPro:IPR027146	F		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014648 InterPro:IPR027146	P		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027146	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000998	C		Seeded From UniProt	complete
enables	GO:0017154	semaphorin receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014648 InterPro:IPR027146	F		Seeded From UniProt	complete
enables	GO:0019838	growth factor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027146	F		Seeded From UniProt	complete
involved_in	GO:0035767	endothelial cell chemotaxis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027146	P		Seeded From UniProt	complete
involved_in	GO:0038084	vascular endothelial growth factor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR014648	P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027146	P		Seeded From UniProt	complete
involved_in	GO:0071526	semaphorin-plexin signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027146	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-NUL-421139 Reactome:R-NUL-421138 Reactome:R-NUL-421136 Reactome:R-MMU-9010950 Reactome:R-MMU-445078 Reactome:R-MMU-421148 Reactome:R-MMU-421144 Reactome:R-MMU-421143 Reactome:R-MMU-421142 Reactome:R-MMU-421140	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0221	P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0358	F		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 de Anda, FC et al. (2012) Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex. Nat. Neurosci. 15 1022-31 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Raimondi, C et al. (2014) Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. J. Exp. Med. 211 1167-83 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Plein, A et al. (2015) Neural crest-derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation. J. Clin. Invest. 125 2661-76 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Fantin, A et al. (2015) NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells. Cell Rep 11 1577-90 PubMed GONUTS page
↑ He, W et al. (2015) CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. Nature 526 710-4 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Schwarz, Q et al. (2009) Neuropilin-mediated neural crest cell guidance is essential to organise sensory neurons into segmented dorsal root ganglia. Development 136 1785-9 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Schwarz, Q et al. (2008) Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development. Dev. Biol. 324 1-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Schwarz, Q et al. (2008) Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells. Development 135 1605-13 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Cariboni, A et al. (2011) VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels. Development 138 3723-33 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 Lanahan, A et al. (2013) The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis. Dev. Cell 25 156-68 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 Erskine, L et al. (2011) VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm. Neuron 70 951-65 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Maden, CH et al. (2012) NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system. Dev. Biol. 369 277-85 PubMed GONUTS page
↑ ^13.0 ^13.1 Schwarz, Q et al. (2009) Neuropilin 1 signaling guides neural crest cells to coordinate pathway choice with cell specification. Proc. Natl. Acad. Sci. U.S.A. 106 6164-9 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 ^14.9 Fantin, A et al. (2014) Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development 141 556-62 PubMed GONUTS page
↑ Cariboni, A et al. (2011) Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for the aetiology of hypogonadotropic hypogonadism. Hum. Mol. Genet. 20 336-44 PubMed GONUTS page
↑ ^16.0 ^16.1 Fantin, A et al. (2013) NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis. Blood 121 2352-62 PubMed GONUTS page
↑ Fantin, A et al. (2011) The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins. Development 138 4185-91 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 Morita, A et al. (2006) Regulation of dendritic branching and spine maturation by semaphorin3A-Fyn signaling. J. Neurosci. 26 2971-80 PubMed GONUTS page
↑ Slater, LH et al. (2013) CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proc. Natl. Acad. Sci. U.S.A. 110 9932-7 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Gitler, AD et al. (2004) PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev. Cell 7 107-16 PubMed GONUTS page
↑ ^21.0 ^21.1 Suto, F et al. (2003) Identification and characterization of a novel mouse plexin, plexin-A4. Mech. Dev. 120 385-96 PubMed GONUTS page
↑ ^22.0 ^22.1 Chung, L et al. (2007) Semaphorin signaling facilitates cleft formation in the developing salivary gland. Development 134 2935-45 PubMed GONUTS page
↑ Chédotal, A et al. (1998) Semaphorins III and IV repel hippocampal axons via two distinct receptors. Development 125 4313-23 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 Suto, F et al. (2005) Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance. J. Neurosci. 25 3628-37 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 ^25.3 ^25.4 ^25.5 Gu, C et al. (2003) Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev. Cell 5 45-57 PubMed GONUTS page
↑ Yoshihara, S et al. (2005) Arx homeobox gene is essential for development of mouse olfactory system. Development 132 751-62 PubMed GONUTS page
↑ Halder, JB et al. (2000) Differential expression of VEGF isoforms and VEGF(164)-specific receptor neuropilin-1 in the mouse uterus suggests a role for VEGF(164) in vascular permeability and angiogenesis during implantation. Genesis 26 213-24 PubMed GONUTS page
↑ ^28.0 ^28.1 Gerhardt, H et al. (2004) Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system. Dev. Dyn. 231 503-9 PubMed GONUTS page
↑ ^29.0 ^29.1 Vieira, JM et al. (2007) Selective requirements for NRP1 ligands during neurovascular patterning. Development 134 1833-43 PubMed GONUTS page
↑ Kettunen, P et al. (2005) Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfbeta1 regulate semaphorin 3a expression in the dental mesenchyme. Development 132 323-34 PubMed GONUTS page

[PMID:22683681-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 de Anda, FC et al. (2012) Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex. Nat. Neurosci. 15 1022-31 PubMed GONUTS page

[PMID:24863063-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 Raimondi, C et al. (2014) Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells. J. Exp. Med. 211 1167-83 PubMed GONUTS page

[PMID:26053665-3] 3.0 ^3.1 ^3.2 Plein, A et al. (2015) Neural crest-derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation. J. Clin. Invest. 125 2661-76 PubMed GONUTS page

[PMID:26051942-4] 4.0 ^4.1 ^4.2 ^4.3 Fantin, A et al. (2015) NRP1 Regulates CDC42 Activation to Promote Filopodia Formation in Endothelial Tip Cells. Cell Rep 11 1577-90 PubMed GONUTS page

[PMID:26503042-5] He, W et al. (2015) CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. Nature 526 710-4 PubMed GONUTS page

[PMID:19386662-6] 6.0 ^6.1 ^6.2 Schwarz, Q et al. (2009) Neuropilin-mediated neural crest cell guidance is essential to organise sensory neurons into segmented dorsal root ganglia. Development 136 1785-9 PubMed GONUTS page

[PMID:18804103-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Schwarz, Q et al. (2008) Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development. Dev. Biol. 324 1-9 PubMed GONUTS page

[PMID:18356247-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Schwarz, Q et al. (2008) Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells. Development 135 1605-13 PubMed GONUTS page

[PMID:21828096-9] 9.0 ^9.1 ^9.2 ^9.3 Cariboni, A et al. (2011) VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels. Development 138 3723-33 PubMed GONUTS page

[PMID:23639442-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 Lanahan, A et al. (2013) The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis. Dev. Cell 25 156-68 PubMed GONUTS page

[PMID:21658587-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 Erskine, L et al. (2011) VEGF signaling through neuropilin 1 guides commissural axon crossing at the optic chiasm. Neuron 70 951-65 PubMed GONUTS page

[PMID:22790009-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Maden, CH et al. (2012) NRP1 and NRP2 cooperate to regulate gangliogenesis, axon guidance and target innervation in the sympathetic nervous system. Dev. Biol. 369 277-85 PubMed GONUTS page

[PMID:19325129-13] 13.0 ^13.1 Schwarz, Q et al. (2009) Neuropilin 1 signaling guides neural crest cells to coordinate pathway choice with cell specification. Proc. Natl. Acad. Sci. U.S.A. 106 6164-9 PubMed GONUTS page

[PMID:24401374-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 ^14.8 ^14.9 Fantin, A et al. (2014) Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis. Development 141 556-62 PubMed GONUTS page

[PMID:21059704-15] Cariboni, A et al. (2011) Defective gonadotropin-releasing hormone neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for the aetiology of hypogonadotropic hypogonadism. Hum. Mol. Genet. 20 336-44 PubMed GONUTS page

[PMID:23315162-16] 16.0 ^16.1 Fantin, A et al. (2013) NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis. Blood 121 2352-62 PubMed GONUTS page

[PMID:21852397-17] Fantin, A et al. (2011) The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins. Development 138 4185-91 PubMed GONUTS page

[PMID:16540575-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 Morita, A et al. (2006) Regulation of dendritic branching and spine maturation by semaphorin3A-Fyn signaling. J. Neurosci. 26 2971-80 PubMed GONUTS page

[PMID:23716698-19] Slater, LH et al. (2013) CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proc. Natl. Acad. Sci. U.S.A. 110 9932-7 PubMed GONUTS page

[PMID:15239958-20] 20.0 ^20.1 ^20.2 ^20.3 Gitler, AD et al. (2004) PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev. Cell 7 107-16 PubMed GONUTS page

[PMID:12591607-21] 21.0 ^21.1 Suto, F et al. (2003) Identification and characterization of a novel mouse plexin, plexin-A4. Mech. Dev. 120 385-96 PubMed GONUTS page

[PMID:17626059-22] 22.0 ^22.1 Chung, L et al. (2007) Semaphorin signaling facilitates cleft formation in the developing salivary gland. Development 134 2935-45 PubMed GONUTS page

[PMID:9753685-23] Chédotal, A et al. (1998) Semaphorins III and IV repel hippocampal axons via two distinct receptors. Development 125 4313-23 PubMed GONUTS page

[PMID:15814794-24] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 Suto, F et al. (2005) Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance. J. Neurosci. 25 3628-37 PubMed GONUTS page

[PMID:12852851-25] 25.0 ^25.1 ^25.2 ^25.3 ^25.4 ^25.5 Gu, C et al. (2003) Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev. Cell 5 45-57 PubMed GONUTS page

[PMID:15677725-26] Yoshihara, S et al. (2005) Arx homeobox gene is essential for development of mouse olfactory system. Development 132 751-62 PubMed GONUTS page

[PMID:10705382-27] Halder, JB et al. (2000) Differential expression of VEGF isoforms and VEGF(164)-specific receptor neuropilin-1 in the mouse uterus suggests a role for VEGF(164) in vascular permeability and angiogenesis during implantation. Genesis 26 213-24 PubMed GONUTS page

[PMID:15376331-28] 28.0 ^28.1 Gerhardt, H et al. (2004) Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system. Dev. Dyn. 231 503-9 PubMed GONUTS page

[PMID:17428830-29] 29.0 ^29.1 Vieira, JM et al. (2007) Selective requirements for NRP1 ligands during neurovascular patterning. Development 134 1833-43 PubMed GONUTS page

[PMID:15604101-30] Kettunen, P et al. (2005) Coordination of trigeminal axon navigation and patterning with tooth organ formation: epithelial-mesenchymal interactions, and epithelial Wnt4 and Tgfbeta1 regulate semaphorin 3a expression in the dental mesenchyme. Development 132 323-34 PubMed GONUTS page

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