PMID:12591607

Citation	Suto, F, Murakami, Y, Nakamura, F, Goshima, Y and Fujisawa, H (2003) Identification and characterization of a novel mouse plexin, plexin-A4. Mech. Dev. 120:385-96
Abstract	Plexins belonging to the plexin-A subfamily form complexes with neuropilins and propagate signals of class 3 semaphorins into neurons, even though they do not directly bind the semaphorins. In this study, we identified a new member of the plexin-A subfamily in the mice, plexin-A4, and showed that it was expressed in the developing nervous system with a pattern different to that of other members of the plexin-A subfamily (plexin-A1, plexin-A2 and plexin-A3). COS-7 cells coexpressing plexin-A4 with neuropilin-1 were induced to contract by Sema3A, a member of the class 3 semaphorin. Ectopic expression of plexin-A4 in mitral cells that are originally insensitive to Sema3A resulted in the collapse of growth cones in the presence of Sema3A. These results suggest that plexin-A4 plays a role in the propagation of Sema3A activities.
Links	PubMed
Keywords	Amino Acid Sequence; Animals; Axons/metabolism; Brain/embryology; Brain/metabolism; COS Cells; Carrier Proteins/genetics; Carrier Proteins/metabolism; Cloning, Molecular; Ganglia/embryology; Ganglia, Sensory/embryology; Gene Expression Regulation, Developmental; Growth Cones/metabolism; Mice; Mice, Inbred ICR; Molecular Sequence Data; Multigene Family; Mutation; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Nervous System/embryology; Nervous System/growth & development; Neuropilin-1/genetics; Neuropilin-1/metabolism; Olfactory Bulb/cytology; Olfactory Bulb/embryology; Organ of Corti/growth & development; Receptors, Cell Surface/genetics; Receptors, Cell Surface/metabolism; Retina/growth & development; Semaphorin-3A
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