GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

PMID:15239958

From GONUTS
Jump to: navigation, search
Citation

Gitler, AD, Lu, MM and Epstein, JA (2004) PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev. Cell 7:107-16

Abstract

The identification of new signaling pathways critical for cardiac morphogenesis will contribute to our understanding of congenital heart disease (CHD), which remains a leading cause of mortality in newborn children worldwide. Signals mediated by semaphorin ligands and plexin receptors contribute to the intricate patterning of axons in the central nervous system. Here, we describe a related signaling pathway involving secreted class 3 semaphorins, neuropilins, and a plexin receptor, PlexinD1, expressed by endothelial cells. Interruption of this pathway in mice results in CHD and vascular patterning defects. The type of CHD caused by inactivation of PlexinD1 has previously been attributed to abnormalities of neural crest. Here, we show that this form of CHD can be caused by cell-autonomous endothelial defects. Thus, molecular programs that mediate axon guidance in the central nervous system also function in endothelial cells to orchestrate critical aspects of cardiac morphogenesis.

Links

PubMed Online version:10.1016/j.devcel.2004.06.002

Keywords

Animals; Autonomic Pathways/cytology; Autonomic Pathways/embryology; Autonomic Pathways/metabolism; Branchial Region/cytology; Branchial Region/embryology; Branchial Region/metabolism; Cell Line; Endothelium, Vascular/abnormalities; Endothelium, Vascular/cytology; Endothelium, Vascular/metabolism; Gene Expression Regulation, Developmental/genetics; Heart/embryology; Heart Defects, Congenital/genetics; Heart Defects, Congenital/metabolism; Heart Defects, Congenital/physiopathology; Humans; Membrane Glycoproteins/deficiency; Membrane Glycoproteins/genetics; Membrane Glycoproteins/physiology; Mice; Mice, Knockout; Muscle, Smooth, Vascular/cytology; Muscle, Smooth, Vascular/embryology; Muscle, Smooth, Vascular/metabolism; Nerve Tissue Proteins/deficiency; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/physiology; Neural Crest/cytology; Neural Crest/embryology; Neural Crest/metabolism; Neuropilin-1/genetics; Neuropilin-1/metabolism; Neuropilins/genetics; Neuropilins/metabolism; Semaphorins/genetics; Semaphorins/metabolism; Signal Transduction/genetics; Somites/cytology; Somites/metabolism; Vascular Endothelial Growth Factor A/genetics; Vascular Endothelial Growth Factor A/metabolism

Significance

Annotations

Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status


See also

References

See Help:References for how to manage references in GONUTS.