MOUSE:MMP2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Mmp2
Protein Name(s)	72 kDa type IV collagenase 72 kDa gelatinase Gelatinase A Matrix metalloproteinase-2 MMP-2 PEX
External Links
UniProt	P33434
EMBL	M84324 BC070430
CCDS	CCDS22523.1
PIR	A42496
RefSeq	NP_032636.1
UniGene	Mm.29564
ProteinModelPortal	P33434
SMR	P33434
IntAct	P33434
BindingDB	P33434
ChEMBL	CHEMBL3095
MEROPS	M10.003
PhosphoSite	P33434
MaxQB	P33434
PaxDb	P33434
PRIDE	P33434
Ensembl	ENSMUST00000034187
GeneID	17390
KEGG	mmu:17390
UCSC	uc009mue.1
CTD	4313
MGI	MGI:97009
eggNOG	NOG303159
HOGENOM	HOG000217926
HOVERGEN	HBG052484
InParanoid	P33434
KO	K01398
OMA	PCKFPFR
OrthoDB	EOG70KGNX
PhylomeDB	P33434
TreeFam	TF315428
Reactome	REACT_199000 REACT_199052 REACT_199055 REACT_235886 REACT_243590
ChiTaRS	Mmp2
NextBio	292012
PRO	PR:P33434
Proteomes	UP000000589
Bgee	P33434
CleanEx	MM_MMP2
ExpressionAtlas	P33434
Genevestigator	P33434
GO	GO:0005737 GO:0005615 GO:0005739 GO:0005634 GO:0005886 GO:0005578 GO:0030017 GO:0004222 GO:0008270 GO:0001525 GO:0001955 GO:0060346 GO:0071230 GO:0030574 GO:0007566 GO:0060325 GO:0001957 GO:0045089 GO:0001666 GO:0048705
Gene3D	1.10.101.10 2.10.10.10 2.110.10.10 3.40.390.10
InterPro	IPR028708 IPR000562 IPR000585 IPR018487 IPR018486 IPR013806 IPR024079 IPR001818 IPR021190 IPR021158 IPR006026 IPR002477
PANTHER	PTHR10201:SF29
Pfam	PF00040 PF00045 PF00413 PF01471
PRINTS	PR00138
SMART	SM00059 SM00120 SM00235
SUPFAM	SSF47090 SSF50923 SSF57440
PROSITE	PS00546 PS00023 PS51092 PS00024 PS51642 PS00142

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1904645	response to amyloid-beta	PMID:28912710^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	happens_during:(GO:0007569) occurs_in:(CL:0000129)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:24006456^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	produced_by:(CL:0002548)	Seeded From UniProt	complete
involved_in	GO:0048771	tissue remodeling	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002565602 RGD:621316	P		Seeded From UniProt	complete
involved_in	GO:0030574	collagen catabolic process	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101900 MGI:MGI:1276107 MGI:MGI:1340026 MGI:MGI:97008 MGI:MGI:97009 MGI:MGI:97011 PANTHER:PTN001303987 RGD:621316 RGD:621320 UniProtKB:P45452	P		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0033438 FB:FBgn0035049 MGI:MGI:1340026 MGI:MGI:1353466 MGI:MGI:97008 MGI:MGI:97011 PANTHER:PTN001303987 UniProtKB:P45452 WB:WBGene00006987 ZFIN:ZDB-GENE-040426-2132	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97005 MGI:MGI:97009 PANTHER:PTN000810753 RGD:3100 RGD:620196 RGD:621316 RGD:621317 RGD:621320 RGD:631408 UniProtKB:B5DFD5 UniProtKB:P02790 UniProtKB:P08253 UniProtKB:P14780 UniProtKB:P22894 UniProtKB:P39900 UniProtKB:P50281 UniProtKB:Q90611	C		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0033438 MGI:MGI:101900 MGI:MGI:1340026 MGI:MGI:1341867 MGI:MGI:97009 MGI:MGI:97011 PANTHER:PTN001303987 RGD:620196 TAIR:locus:2020548 TAIR:locus:2025891 TAIR:locus:2032467 TAIR:locus:2055605 TAIR:locus:2130928 UniProtKB:O60882 UniProtKB:O75900 UniProtKB:P03956 UniProtKB:P14780 UniProtKB:P39900 UniProtKB:P45452 UniProtKB:P51512 UniProtKB:Q90611 UniProtKB:Q99542	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:97009 PANTHER:PTN002565602 RGD:621316	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08253	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071392	cellular response to estradiol stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071230	cellular response to amino acid stimulus	PMID:20548288^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060740	prostate gland epithelium morphogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060346	bone trabecula formation	PMID:17440987^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88467	P	results_in_formation_of:(EMAPA:35503)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060325	face morphogenesis	PMID:17440987^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88467	P	has_participant:(EMAPA:35238)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048771	tissue remodeling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048705	skeletal system morphogenesis	PMID:17440987^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88467	P	has_participant:(EMAPA:35456)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048661	positive regulation of smooth muscle cell proliferation	PMID:17561096^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045906	negative regulation of vasoconstriction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043627	response to estrogen	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042542	response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042493	response to drug	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034614	cellular response to reactive oxygen species	PMID:17561096^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030574	collagen catabolic process	PMID:17440987^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2386252	P	has_direct_input:(MGI:MGI:88467)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030574	collagen catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030335	positive regulation of cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
part_of	GO:0030017	sarcomere	PMID:17349656^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17337) part_of:(CL:0000746)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016477	cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014012	peripheral nervous system axon regeneration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009612	response to mechanical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08253	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007568	aging	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007566	embryo implantation	PMID:18556655^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007507	heart development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007162	negative regulation of cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006508	proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08253	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006508	proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17349656^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17337) part_of:(CL:0000746)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18492766^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08253	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08253	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	C		Seeded From UniProt	complete
enables	GO:0004252	serine-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P08253	F		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	PMID:15212943^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	PMID:12419962^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001968	fibronectin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001957	intramembranous ossification	PMID:17440987^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88467	P	has_participant:(EMAPA:35238)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001955	blood vessel maturation	PMID:11747814^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1855698	P	results_in_maturation_of:(EMAPA:16201)\|results_in_maturation_of:(EMAPA:16240)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:17382917^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:18603) occurs_in:(CL:0000192)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001541	ovarian follicle development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:621316	P		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08253 ensembl:ENSP00000219070	P		Seeded From UniProt	complete
involved_in	GO:0035987	endodermal cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08253 ensembl:ENSP00000219070	P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08253 ensembl:ENSP00000219070	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08253 ensembl:ENSP00000219070	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P08253 ensembl:ENSP00000219070	C		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR021158 InterPro:IPR021190 InterPro:IPR028708	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR006026 InterPro:IPR021158 InterPro:IPR021190 InterPro:IPR028708	P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006026 InterPro:IPR024079 InterPro:IPR033739	F		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR006026 InterPro:IPR021158 InterPro:IPR021190 InterPro:IPR033739	F		Seeded From UniProt	complete
part_of	GO:0031012	extracellular matrix	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001818 InterPro:IPR021158 InterPro:IPR021190	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:22509276^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045089	positive regulation of innate immune response	PMID:22509276^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:22509276^[14]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22509276^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0037	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0030574	collagen catabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0177	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964	C		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0482	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Caldeira, C et al. (2017) Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation. Front Aging Neurosci 9 277 PubMed GONUTS page
↑ Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Pogribny, IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab. Invest. 90 1437-46 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Egeblad, M et al. (2007) Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development. Dev. Dyn. 236 1683-93 PubMed GONUTS page
↑ ^6.0 ^6.1 Coatrieux, C et al. (2007) MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway. Free Radic. Biol. Med. 43 80-9 PubMed GONUTS page
↑ ^7.0 ^7.1 Chow, AK et al. (2007) Caveolin-1 inhibits matrix metalloproteinase-2 activity in the heart. J. Mol. Cell. Cardiol. 42 896-901 PubMed GONUTS page
↑ Hu, SJ et al. (2008) MicroRNA expression and regulation in mouse uterus during embryo implantation. J. Biol. Chem. 283 23473-84 PubMed GONUTS page
↑ Wu, Y & Smas, CM (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am. J. Physiol. Endocrinol. Metab. 295 E205-15 PubMed GONUTS page
↑ Matsumoto, K et al. (2004) Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway. Exp. Cell Res. 297 404-14 PubMed GONUTS page
↑ Minamitani, T et al. (2002) Adhesive defect in extracellular matrix tenascin-X-null fibroblasts: a possible mechanism of tumor invasion. Biol. Pharm. Bull. 25 1472-5 PubMed GONUTS page
↑ Oh, J et al. (2001) The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell 107 789-800 PubMed GONUTS page
↑ Hou, Y et al. (2007) c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells. Cardiovasc. Res. 75 186-94 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 Lovett, DH et al. (2012) A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity. PLoS ONE 7 e34177 PubMed GONUTS page

[PMID:28912710-1] Caldeira, C et al. (2017) Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation. Front Aging Neurosci 9 277 PubMed GONUTS page

[PMID:24006456-2] Abonnenc, M et al. (2013) Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Circ. Res. 113 1138-47 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20548288-4] Pogribny, IP et al. (2010) Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab. Invest. 90 1437-46 PubMed GONUTS page

[PMID:17440987-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Egeblad, M et al. (2007) Type I collagen is a genetic modifier of matrix metalloproteinase 2 in murine skeletal development. Dev. Dyn. 236 1683-93 PubMed GONUTS page

[PMID:17561096-6] 6.0 ^6.1 Coatrieux, C et al. (2007) MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway. Free Radic. Biol. Med. 43 80-9 PubMed GONUTS page

[PMID:17349656-7] 7.0 ^7.1 Chow, AK et al. (2007) Caveolin-1 inhibits matrix metalloproteinase-2 activity in the heart. J. Mol. Cell. Cardiol. 42 896-901 PubMed GONUTS page

[PMID:18556655-8] Hu, SJ et al. (2008) MicroRNA expression and regulation in mouse uterus during embryo implantation. J. Biol. Chem. 283 23473-84 PubMed GONUTS page

[PMID:18492766-9] Wu, Y & Smas, CM (2008) Wdnm1-like, a new adipokine with a role in MMP-2 activation. Am. J. Physiol. Endocrinol. Metab. 295 E205-15 PubMed GONUTS page

[PMID:15212943-10] Matsumoto, K et al. (2004) Induction of matrix metalloproteinase-2 by tenascin-X deficiency is mediated through the c-Jun N-terminal kinase and protein tyrosine kinase phosphorylation pathway. Exp. Cell Res. 297 404-14 PubMed GONUTS page

[PMID:12419962-11] Minamitani, T et al. (2002) Adhesive defect in extracellular matrix tenascin-X-null fibroblasts: a possible mechanism of tumor invasion. Biol. Pharm. Bull. 25 1472-5 PubMed GONUTS page

[PMID:11747814-12] Oh, J et al. (2001) The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell 107 789-800 PubMed GONUTS page

[PMID:17382917-13] Hou, Y et al. (2007) c-Myc is essential for urokinase plasminogen activator expression on hypoxia-induced vascular smooth muscle cells. Cardiovasc. Res. 75 186-94 PubMed GONUTS page

[PMID:22509276-14] 14.0 ^14.1 ^14.2 ^14.3 Lovett, DH et al. (2012) A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity. PLoS ONE 7 e34177 PubMed GONUTS page

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MOUSE:MMP2

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