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PMID:22509276
| Citation |
Lovett, DH, Mahimkar, R, Raffai, RL, Cape, L, Maklashina, E, Cecchini, G and Karliner, JS (2012) A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity. PLoS ONE 7:e34177 |
|---|---|
| Abstract |
Experimental and clinical evidence has pinpointed a critical role for matrix metalloproteinase-2 (MMP-2) in ischemic ventricular remodeling and systolic heart failure. Prior studies have demonstrated that transgenic expression of the full-length, 68 kDa, secreted form of MMP-2 induces severe systolic failure. These mice also had unexpected and severe mitochondrial structural abnormalities and dysfunction. We hypothesized that an additional intracellular isoform of MMP-2, which affects mitochondrial function is induced under conditions of systolic failure-associated oxidative stress. |
| Links |
PubMed PMC3317925 Online version:10.1371/journal.pone.0034177 |
| Keywords |
Active Transport, Cell Nucleus/drug effects; Amino Acid Sequence; Animals; Cell Hypoxia/immunology; Cell Line; Cell Nucleus/drug effects; Cell Nucleus/metabolism; Enzyme Activation/drug effects; Enzyme Activation/immunology; Heart Injuries/enzymology; Heart Injuries/immunology; Heart Injuries/metabolism; Heart Injuries/pathology; Humans; I-kappa B Kinase/antagonists & inhibitors; Immunity, Innate/drug effects; Interferon Regulatory Factor-7/metabolism; Intracellular Space/enzymology; Isoenzymes/chemistry; Isoenzymes/genetics; Isoenzymes/metabolism; Matrix Metalloproteinase 2/chemistry; Matrix Metalloproteinase 2/genetics; Matrix Metalloproteinase 2/metabolism; Mice; Mitochondria/drug effects; Mitochondria/enzymology; Mitochondria/immunology; Mitochondria/pathology; Models, Molecular; Molecular Sequence Data; Molecular Weight; Oxidative Stress/drug effects; Oxidative Stress/immunology; Promoter Regions, Genetic/drug effects; Protein Kinase Inhibitors/pharmacology; Protein Structure, Tertiary; Proteolysis; RNA, Messenger/genetics; RNA, Messenger/metabolism; Sequence Deletion; Signal Transduction; Time Factors; Transcriptome/drug effects |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
part_of |
GO:0005739: mitochondrion |
ECO:0000314: direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:16105) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005737: cytoplasm |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005615: extracellular space |
ECO:0000314: direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
acts_upstream_of_or_within |
GO:0045089: positive regulation of innate immune response |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
Notes
See also
References
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