MOUSE:MECP2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Mecp2
Protein Name(s)	Methyl-CpG-binding protein 2 MeCp-2 protein MeCp2
External Links
UniProt	Q9Z2D6
EMBL	AF072251 AJ132922 AF121351 AF158181 AK158664 AL672002 AL672002 BC027153
CCDS	CCDS41016.1 CCDS41017.1
RefSeq	NP_001075448.1 NP_034918.1 XP_006527951.1
UniGene	Mm.131408 Mm.414303
ProteinModelPortal	Q9Z2D6
SMR	Q9Z2D6
BioGrid	201380
IntAct	Q9Z2D6
MINT	MINT-225556
PhosphoSite	Q9Z2D6
MaxQB	Q9Z2D6
PaxDb	Q9Z2D6
PRIDE	Q9Z2D6
Ensembl	ENSMUST00000033770 ENSMUST00000100750 ENSMUST00000170481
GeneID	17257
KEGG	mmu:17257
UCSC	uc009tnt.2 uc009tnu.2
CTD	4204
MGI	MGI:99918
eggNOG	NOG237320
GeneTree	ENSGT00530000063687
HOGENOM	HOG000015809
HOVERGEN	HBG052445
InParanoid	Q9Z2D6
KO	K11588
OMA	KMPRAGS
OrthoDB	EOG71RXKS
PhylomeDB	Q9Z2D6
TreeFam	TF332974
NextBio	291736
PRO	PR:Q9Z2D6
Proteomes	UP000000589
Bgee	Q9Z2D6
CleanEx	MM_MECP2
ExpressionAtlas	Q9Z2D6
Genevestigator	Q9Z2D6
GO	GO:0005737 GO:0005829 GO:0005615 GO:0000792 GO:0005634 GO:0003682 GO:0003677 GO:0010385 GO:0008327 GO:0003729 GO:0003700 GO:0035197 GO:0008134 GO:0008344 GO:0001662 GO:0007420 GO:0032048 GO:0050432 GO:0006576 GO:0021549 GO:0006342 GO:0016358 GO:0008211 GO:0006541 GO:0016573 GO:0016571 GO:0006020 GO:0007612 GO:0007616 GO:0060291 GO:0007613 GO:0006122 GO:0033555 GO:0035067 GO:0031061 GO:0043524 GO:0045892 GO:0001976 GO:0050905 GO:0050884 GO:0030182 GO:0042551 GO:0031175 GO:0009405 GO:0046470 GO:0008284 GO:0051965 GO:0045893 GO:0009791 GO:0019230 GO:0008104 GO:0060079 GO:0010468 GO:0006349 GO:0040029 GO:0002087 GO:0048167 GO:0006355 GO:0007585 GO:0001666 GO:0019233 GO:0035176 GO:0001964 GO:0007416 GO:0007268 GO:0006351 GO:0021591 GO:0008542
Gene3D	3.30.890.10
InterPro	IPR017956 IPR016177 IPR017353 IPR001739
Pfam	PF01429
PIRSF	PIRSF038006
SMART	SM00384 SM00391
SUPFAM	SSF54171
PROSITE	PS50982

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:1900114	positive regulation of histone H3-K9 trimethylation	PMID:25722434^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(ENSEMBL:ENSMUSG00000015605)\|has_direct_input:(ENSEMBL:ENSMUSG00000020542)\|has_direct_input:(ENSEMBL:ENSMUSG00000023913)	Seeded From UniProt	complete
enables	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	PMID:25722434^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(ENSEMBL:ENSMUSG00000015605) occurs_at:(SO:0001952)\|has_direct_input(ENSEMBL:ENSMUSG00000020542) occurs_at:(SO:0001952)\|has_direct_input(ENSEMBL:ENSMUSG00000023913) occurs_at:(SO:0001952)\|has_direct_input(ENSEMBL:ENSMUSG00000030562) occurs_at:(SO:0001952)\|has_direct_input(ENSEMBL:ENSMUSG00000022475) occurs_at:(SO:0001952)	Seeded From UniProt	complete
involved_in	GO:2000820	negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation	PMID:25722434^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSMUSG00000015605)\|regulates_transcription_of:(ENSEMBL:ENSMUSG00000020542)\|regulates_transcription_of:(ENSEMBL:ENSMUSG00000023913)\|regulates_transcription_of:(ENSEMBL:ENSMUSG00000030562)\|regulates_transcription_of:(ENSEMBL:ENSMUSG00000022475)	Seeded From UniProt	complete
involved_in	GO:0051151	negative regulation of smooth muscle cell differentiation	PMID:25722434^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0010385	double-stranded methylated DNA binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99918 PANTHER:PTN001806349 RGD:3075 UniProtKB:P51608	F		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1333850 PANTHER:PTN000386636	P		Seeded From UniProt	complete
enables	GO:0008327	methyl-CpG binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99918 PANTHER:PTN001806349 RGD:3075	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99918 PANTHER:PTN001806349 RGD:3075	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1333850 MGI:MGI:99918 PANTHER:PTN001431162 RGD:3075 UniProtKB:P51608	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1333850 MGI:MGI:99918 PANTHER:PTN000386636	F		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:99918 PANTHER:PTN001806349 UniProtKB:P51608	C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1333850 PANTHER:PTN001431162	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[2]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001806349 RGD:3075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000635	negative regulation of primary miRNA processing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905643	positive regulation of DNA methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51608	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905492	positive regulation of branching morphogenesis of a nerve	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903861	positive regulation of dendrite extension	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903860	negative regulation of dendrite extension	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901956	positive regulation of retrograde dense core granule transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901953	positive regulation of anterograde dense core granule transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090063	positive regulation of microtubule nucleation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51608	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071317	cellular response to isoquinoline alkaloid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061000	negative regulation of dendritic spine development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060291	long-term synaptic potentiation	PMID:16087343^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060079	excitatory postsynaptic potential	PMID:17920015^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050905	neuromuscular process	PMID:16467389^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3800596	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050905	neuromuscular process	PMID:16199017^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158353,MGI:MGI:2176754	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050884	neuromuscular process controlling posture	PMID:11242117^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050807	regulation of synapse organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050432	catecholamine secretion	PMID:17050729^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158354	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048712	negative regulation of astrocyte differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048167	regulation of synaptic plasticity	PMID:16399702^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183727	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51608	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046470	phosphatidylcholine metabolic process	PMID:17237885^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:18511691^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16782889^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:17108082^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183727	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:17050729^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158354	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:16467389^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3800596	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:15608638^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:18511691^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:10888872^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51608	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
enables	GO:0045322	unmethylated CpG binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044030	regulation of DNA methylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043537	negative regulation of blood vessel endothelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51608	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043524	negative regulation of neuron apoptotic process	PMID:17997046^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
enables	GO:0042826	histone deacetylase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042551	neuron maturation	PMID:18295506^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183727	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042551	neuron maturation	PMID:17532643^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158354	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042551	neuron maturation	PMID:15519245^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158354	P	occurs_in:(EMAPA:35257) results_in_maturation_of:(CL:0000598)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042220	response to cocaine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040029	regulation of gene expression, epigenetic	PMID:17532643^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158354	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040029	regulation of gene expression, epigenetic	PMID:15757975^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035865	cellular response to potassium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
enables	GO:0035197	siRNA binding	PMID:15342650^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035176	social behavior	PMID:18321864^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035176	social behavior	PMID:16199017^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158353,MGI:MGI:2176754	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035176	social behavior	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033555	multicellular organismal response to stress	PMID:17108082^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183727	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032091	negative regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032048	cardiolipin metabolic process	PMID:17237885^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031915	positive regulation of synaptic plasticity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031175	neuron projection development	PMID:15345242^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158354	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030182	neuron differentiation	PMID:15345242^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158354	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021591	ventricular system development	PMID:18571096^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158354	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021549	cerebellum development	PMID:18571096^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158354	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51608	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019233	sensory perception of pain	PMID:18321864^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019230	proprioception	PMID:18321864^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019230	proprioception	PMID:16467389^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3800596	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016573	histone acetylation	PMID:15757975^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016573	histone acetylation	PMID:15608638^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016571	histone methylation	PMID:15757975^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016571	histone methylation	PMID:15608638^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016525	negative regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51608	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016358	dendrite development	PMID:17532643^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158354	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016358	dendrite development	PMID:15519245^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158354	P	occurs_in:(EMAPA:35257) occurs_in:(CL:0000598)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51608	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51608	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:18203756^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0010385	double-stranded methylated DNA binding	PMID:15757975^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0010385	double-stranded methylated DNA binding	PMID:14593184^[26]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0010385	double-stranded methylated DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	F		Seeded From UniProt	complete
enables	GO:0010385	double-stranded methylated DNA binding	PMID:17296936^[27]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P51608	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009791	post-embryonic development	PMID:16467389^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3800596	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009405	pathogenesis	PMID:17997046^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008542	visual learning	PMID:16399702^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183727	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	PMID:16467389^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3800596	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008344	adult locomotory behavior	PMID:11242117^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
enables	GO:0008327	methyl-CpG binding	PMID:17108082^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008327	methyl-CpG binding	PMID:15342650^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008327	methyl-CpG binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:15939091^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51608	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008211	glucocorticoid metabolic process	PMID:17108082^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183727	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:14593184^[26]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q60520	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008104	protein localization	PMID:17296936^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007616	long-term memory	PMID:16399702^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183727	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007613	memory	PMID:16399702^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183727	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007612	learning	PMID:18321864^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007612	learning	PMID:16467389^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3800596	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007585	respiratory gaseous exchange	PMID:11242117^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007420	brain development	PMID:18571096^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158354	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007416	synapse assembly	PMID:18295506^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183727	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007416	synapse assembly	PMID:17920015^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007268	chemical synaptic transmission	PMID:16399702^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183727	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007052	mitotic spindle organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51608	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006576	cellular biogenic amine metabolic process	PMID:15975715^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006541	glutamine metabolic process	PMID:17237885^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:16087343^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006349	regulation of gene expression by genetic imprinting	PMID:15608638^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006342	chromatin silencing	PMID:15608638^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c	PMID:16782889^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006020	inositol metabolic process	PMID:17237885^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:15939091^[28]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544) part_of:(CL:0000127)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51608	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17546630^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18511691^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17997046^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17546630^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16199017^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15939091^[28]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17544) part_of:(CL:0000127)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:14593184^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11809720^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51608	C		Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:15342650^[21]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:17108082^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2183727	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:15608638^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:18511691^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:16782889^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:18511691^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:16782889^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:15608638^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002087	regulation of respiratory gaseous exchange by neurological system process	PMID:18321864^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002087	regulation of respiratory gaseous exchange by neurological system process	PMID:16354910^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001976	neurological system process involved in regulation of systemic arterial blood pressure	PMID:17544925^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001964	startle response	PMID:18321864^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137555	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:17997046^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2137311	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001662	behavioral fear response	PMID:16467389^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3800596	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001662	behavioral fear response	PMID:16199017^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158353,MGI:MGI:2176754	P		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:17296936^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	PMID:14519686^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P51608	C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	C		Seeded From UniProt	complete
enables	GO:0000400	four-way junction DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3075	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0006122	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0060079	C		Seeded From UniProt	complete
involved_in	GO:1905643	positive regulation of DNA methylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51608 ensembl:ENSP00000395535	P		Seeded From UniProt	complete
involved_in	GO:0090063	positive regulation of microtubule nucleation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51608 ensembl:ENSP00000395535	P		Seeded From UniProt	complete
enables	GO:0047485	protein N-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51608 ensembl:ENSP00000395535	F		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51608 ensembl:ENSP00000395535	P		Seeded From UniProt	complete
involved_in	GO:0043537	negative regulation of blood vessel endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51608 ensembl:ENSP00000395535	P		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51608 ensembl:ENSP00000395535	F		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51608 ensembl:ENSP00000395535	P		Seeded From UniProt	complete
involved_in	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51608 ensembl:ENSP00000395535	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51608 ensembl:ENSP00000395535	P		Seeded From UniProt	complete
enables	GO:0010385	double-stranded methylated DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51608 ensembl:ENSP00000395535	F		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51608 ensembl:ENSP00000395535	P		Seeded From UniProt	complete
involved_in	GO:0007052	mitotic spindle organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51608 ensembl:ENSP00000395535	P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51608 ensembl:ENSP00000395535	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51608 ensembl:ENSP00000395535	C		Seeded From UniProt	complete
part_of	GO:0000792	heterochromatin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P51608 ensembl:ENSP00000395535	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A140VKC4 ensembl:ENSP00000395535	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017353	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001739 InterPro:IPR016177	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001739 InterPro:IPR017353	C		Seeded From UniProt	complete
enables	GO:0010385	double-stranded methylated DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017353	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18334558^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:18334558^[35]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
colocalizes_with	GO:0000792	heterochromatin	PMID:18334558^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18334558^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15034150^[36]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:18334558^[35]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
colocalizes_with	GO:0000792	heterochromatin	PMID:18334558^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-9615812 Reactome:R-MMU-9615549 Reactome:R-MMU-9023599 Reactome:R-MMU-9023529 Reactome:R-MMU-9023371 Reactome:R-MMU-9023364 Reactome:R-MMU-9023138 Reactome:R-MMU-9022931 Reactome:R-MMU-9022928 Reactome:R-MMU-9022867 Reactome:R-MMU-9022767 Reactome:R-MMU-9022722 Reactome:R-MMU-9022604 Reactome:R-MMU-9022302 Reactome:R-MMU-9022187 Reactome:R-MMU-9021974 Reactome:R-MMU-9021973 Reactome:R-MMU-9021971 Reactome:R-MMU-9021969 Reactome:R-MMU-9021968 Reactome:R-MMU-9021925 Reactome:R-MMU-9021887 Reactome:R-MMU-9021849 Reactome:R-MMU-9017986 Reactome:R-MMU-9017958 Reactome:R-MMU-9017445 Reactome:R-MMU-9007015 Reactome:R-MMU-9006501 Reactome:R-MMU-9006494 Reactome:R-MMU-9006133 Reactome:R-MMU-9006014 Reactome:R-MMU-9005872 Reactome:R-MMU-9005848	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	PMID:11809720^[31]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Zhao, H et al. (2015) MicroRNA-22 regulates smooth muscle cell differentiation from stem cells by targeting methyl CpG-binding protein 2. Arterioscler. Thromb. Vasc. Biol. 35 918-29 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^3.0 ^3.1 Asaka, Y et al. (2006) Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome. Neurobiol. Dis. 21 217-27 PubMed GONUTS page
↑ ^4.0 ^4.1 Chao, HT et al. (2007) MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number. Neuron 56 58-65 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Pelka, GJ et al. (2006) Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Brain 129 887-98 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Gemelli, T et al. (2006) Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice. Biol. Psychiatry 59 468-76 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Guy, J et al. (2001) A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat. Genet. 27 322-6 PubMed GONUTS page
↑ ^8.0 ^8.1 Wang, H et al. (2006) Dysregulation of brain-derived neurotrophic factor expression and neurosecretory function in Mecp2 null mice. J. Neurosci. 26 10911-5 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 Moretti, P et al. (2006) Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome. J. Neurosci. 26 319-27 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Viola, A et al. (2007) Metabolic fingerprints of altered brain growth, osmoregulation and neurotransmission in a Rett syndrome model. PLoS ONE 2 e157 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Chahrour, M et al. (2008) MeCP2, a key contributor to neurological disease, activates and represses transcription. Science 320 1224-9 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Kriaucionis, S et al. (2006) Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome. Mol. Cell. Biol. 26 5033-42 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 McGill, BE et al. (2006) Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome. Proc. Natl. Acad. Sci. U.S.A. 103 18267-72 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Horike, S et al. (2005) Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Nat. Genet. 37 31-40 PubMed GONUTS page
↑ Rountree, MR et al. (2000) DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat. Genet. 25 269-77 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Russell, JC et al. (2007) Enhanced cell death in MeCP2 null cerebellar granule neurons exposed to excitotoxicity and hypoxia. Neuroscience 150 563-74 PubMed GONUTS page
↑ ^17.0 ^17.1 Palmer, A et al. (2008) MeCP2 mutation causes distinguishable phases of acute and chronic defects in synaptogenesis and maintenance, respectively. Mol. Cell. Neurosci. 37 794-807 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Smrt, RD et al. (2007) Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. Neurobiol. Dis. 27 77-89 PubMed GONUTS page
↑ ^19.0 ^19.1 Kishi, N & Macklis, JD (2004) MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions. Mol. Cell. Neurosci. 27 306-21 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Makedonski, K et al. (2005) MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS/AS imprinting center that affects UBE3A expression. Hum. Mol. Genet. 14 1049-58 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Jeffery, L & Nakielny, S (2004) Components of the DNA methylation system of chromatin control are RNA-binding proteins. J. Biol. Chem. 279 49479-87 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 Samaco, RC et al. (2008) A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome. Hum. Mol. Genet. 17 1718-27 PubMed GONUTS page
↑ ^23.0 ^23.1 Matarazzo, V et al. (2004) The transcriptional repressor Mecp2 regulates terminal neuronal differentiation. Mol. Cell. Neurosci. 27 44-58 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Ward, BC et al. (2008) Longitudinal brain MRI study in a mouse model of Rett Syndrome and the effects of choline. Neurobiol. Dis. 31 110-9 PubMed GONUTS page
↑ Nomura, T et al. (2008) MeCP2-dependent repression of an imprinted miR-184 released by depolarization. Hum. Mol. Genet. 17 1192-9 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Martinowich, K et al. (2003) DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302 890-3 PubMed GONUTS page
↑ ^27.0 ^27.1 ^27.2 Nan, X et al. (2007) Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. Proc. Natl. Acad. Sci. U.S.A. 104 2709-14 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 Nagai, K et al. (2005) A transcriptional repressor MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth. Brain Res. Dev. Brain Res. 157 103-6 PubMed GONUTS page
↑ Ide, S et al. (2005) Defect in normal developmental increase of the brain biogenic amine concentrations in the mecp2-null mouse. Neurosci. Lett. 386 14-7 PubMed GONUTS page
↑ ^30.0 ^30.1 Ruddock-D'Cruz, NT et al. (2008) Dynamic changes in the localization of five members of the methyl binding domain (MBD) gene family during murine and bovine preimplantation embryo development. Mol. Reprod. Dev. 75 48-59 PubMed GONUTS page
↑ ^31.0 ^31.1 Shahbazian, MD et al. (2002) Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation. Hum. Mol. Genet. 11 115-24 PubMed GONUTS page
↑ Viemari, JC et al. (2005) Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice. J. Neurosci. 25 11521-30 PubMed GONUTS page
↑ Bissonnette, JM et al. (2007) Autonomic cardiovascular control in methyl-CpG-binding protein 2 (Mecp2) deficient mice. Auton Neurosci 136 82-9 PubMed GONUTS page
↑ Craig, JM et al. (2003) Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns. Hum. Mol. Genet. 12 3109-21 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 ^35.3 ^35.4 ^35.5 Kumar, A et al. (2008) Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo. J. Cell. Sci. 121 1128-37 PubMed GONUTS page
↑ Kriaucionis, S & Bird, A (2004) The major form of MeCP2 has a novel N-terminus generated by alternative splicing. Nucleic Acids Res. 32 1818-23 PubMed GONUTS page

[PMID:25722434-1] 1.0 ^1.1 ^1.2 ^1.3 Zhao, H et al. (2015) MicroRNA-22 regulates smooth muscle cell differentiation from stem cells by targeting methyl CpG-binding protein 2. Arterioscler. Thromb. Vasc. Biol. 35 918-29 PubMed GONUTS page

[PMID:21873635-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 ^2.5 ^2.6 ^2.7 ^2.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16087343-3] 3.0 ^3.1 Asaka, Y et al. (2006) Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome. Neurobiol. Dis. 21 217-27 PubMed GONUTS page

[PMID:17920015-4] 4.0 ^4.1 Chao, HT et al. (2007) MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number. Neuron 56 58-65 PubMed GONUTS page

[PMID:16467389-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Pelka, GJ et al. (2006) Mecp2 deficiency is associated with learning and cognitive deficits and altered gene activity in the hippocampal region of mice. Brain 129 887-98 PubMed GONUTS page

[PMID:16199017-6] 6.0 ^6.1 ^6.2 ^6.3 Gemelli, T et al. (2006) Postnatal loss of methyl-CpG binding protein 2 in the forebrain is sufficient to mediate behavioral aspects of Rett syndrome in mice. Biol. Psychiatry 59 468-76 PubMed GONUTS page

[PMID:11242117-7] 7.0 ^7.1 ^7.2 Guy, J et al. (2001) A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat. Genet. 27 322-6 PubMed GONUTS page

[PMID:17050729-8] 8.0 ^8.1 Wang, H et al. (2006) Dysregulation of brain-derived neurotrophic factor expression and neurosecretory function in Mecp2 null mice. J. Neurosci. 26 10911-5 PubMed GONUTS page

[PMID:16399702-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 Moretti, P et al. (2006) Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome. J. Neurosci. 26 319-27 PubMed GONUTS page

[PMID:17237885-10] 10.0 ^10.1 ^10.2 ^10.3 Viola, A et al. (2007) Metabolic fingerprints of altered brain growth, osmoregulation and neurotransmission in a Rett syndrome model. PLoS ONE 2 e157 PubMed GONUTS page

[PMID:18511691-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Chahrour, M et al. (2008) MeCP2, a key contributor to neurological disease, activates and represses transcription. Science 320 1224-9 PubMed GONUTS page

[PMID:16782889-12] 12.0 ^12.1 ^12.2 ^12.3 Kriaucionis, S et al. (2006) Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome. Mol. Cell. Biol. 26 5033-42 PubMed GONUTS page

[PMID:17108082-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 McGill, BE et al. (2006) Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome. Proc. Natl. Acad. Sci. U.S.A. 103 18267-72 PubMed GONUTS page

[PMID:15608638-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Horike, S et al. (2005) Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Nat. Genet. 37 31-40 PubMed GONUTS page

[PMID:10888872-15] Rountree, MR et al. (2000) DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat. Genet. 25 269-77 PubMed GONUTS page

[PMID:17997046-16] 16.0 ^16.1 ^16.2 ^16.3 Russell, JC et al. (2007) Enhanced cell death in MeCP2 null cerebellar granule neurons exposed to excitotoxicity and hypoxia. Neuroscience 150 563-74 PubMed GONUTS page

[PMID:18295506-17] 17.0 ^17.1 Palmer, A et al. (2008) MeCP2 mutation causes distinguishable phases of acute and chronic defects in synaptogenesis and maintenance, respectively. Mol. Cell. Neurosci. 37 794-807 PubMed GONUTS page

[PMID:17532643-18] 18.0 ^18.1 ^18.2 Smrt, RD et al. (2007) Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons. Neurobiol. Dis. 27 77-89 PubMed GONUTS page

[PMID:15519245-19] 19.0 ^19.1 Kishi, N & Macklis, JD (2004) MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions. Mol. Cell. Neurosci. 27 306-21 PubMed GONUTS page

[PMID:15757975-20] 20.0 ^20.1 ^20.2 ^20.3 Makedonski, K et al. (2005) MeCP2 deficiency in Rett syndrome causes epigenetic aberrations at the PWS/AS imprinting center that affects UBE3A expression. Hum. Mol. Genet. 14 1049-58 PubMed GONUTS page

[PMID:15342650-21] 21.0 ^21.1 ^21.2 Jeffery, L & Nakielny, S (2004) Components of the DNA methylation system of chromatin control are RNA-binding proteins. J. Biol. Chem. 279 49479-87 PubMed GONUTS page

[PMID:18321864-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 Samaco, RC et al. (2008) A partial loss of function allele of methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome. Hum. Mol. Genet. 17 1718-27 PubMed GONUTS page

[PMID:15345242-23] 23.0 ^23.1 Matarazzo, V et al. (2004) The transcriptional repressor Mecp2 regulates terminal neuronal differentiation. Mol. Cell. Neurosci. 27 44-58 PubMed GONUTS page

[PMID:18571096-24] 24.0 ^24.1 ^24.2 Ward, BC et al. (2008) Longitudinal brain MRI study in a mouse model of Rett Syndrome and the effects of choline. Neurobiol. Dis. 31 110-9 PubMed GONUTS page

[PMID:18203756-25] Nomura, T et al. (2008) MeCP2-dependent repression of an imprinted miR-184 released by depolarization. Hum. Mol. Genet. 17 1192-9 PubMed GONUTS page

[PMID:14593184-26] 26.0 ^26.1 ^26.2 Martinowich, K et al. (2003) DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science 302 890-3 PubMed GONUTS page

[PMID:17296936-27] 27.0 ^27.1 ^27.2 Nan, X et al. (2007) Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation. Proc. Natl. Acad. Sci. U.S.A. 104 2709-14 PubMed GONUTS page

[PMID:15939091-28] 28.0 ^28.1 ^28.2 Nagai, K et al. (2005) A transcriptional repressor MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth. Brain Res. Dev. Brain Res. 157 103-6 PubMed GONUTS page

[PMID:15975715-29] Ide, S et al. (2005) Defect in normal developmental increase of the brain biogenic amine concentrations in the mecp2-null mouse. Neurosci. Lett. 386 14-7 PubMed GONUTS page

[PMID:17546630-30] 30.0 ^30.1 Ruddock-D'Cruz, NT et al. (2008) Dynamic changes in the localization of five members of the methyl binding domain (MBD) gene family during murine and bovine preimplantation embryo development. Mol. Reprod. Dev. 75 48-59 PubMed GONUTS page

[PMID:11809720-31] 31.0 ^31.1 Shahbazian, MD et al. (2002) Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation. Hum. Mol. Genet. 11 115-24 PubMed GONUTS page

[PMID:16354910-32] Viemari, JC et al. (2005) Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice. J. Neurosci. 25 11521-30 PubMed GONUTS page

[PMID:17544925-33] Bissonnette, JM et al. (2007) Autonomic cardiovascular control in methyl-CpG-binding protein 2 (Mecp2) deficient mice. Auton Neurosci 136 82-9 PubMed GONUTS page

[PMID:14519686-34] Craig, JM et al. (2003) Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns. Hum. Mol. Genet. 12 3109-21 PubMed GONUTS page

[PMID:18334558-35] 35.0 ^35.1 ^35.2 ^35.3 ^35.4 ^35.5 Kumar, A et al. (2008) Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo. J. Cell. Sci. 121 1128-37 PubMed GONUTS page

[PMID:15034150-36] Kriaucionis, S & Bird, A (2004) The major form of MeCP2 has a novel N-terminus generated by alternative splicing. Nucleic Acids Res. 32 1818-23 PubMed GONUTS page

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