PMID:15939091

Citation	Nagai, K, Miyake, K and Kubota, T (2005) A transcriptional repressor MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth. Brain Res. Dev. Brain Res. 157:103-6
Abstract	An epigenetic key protein MeCP2 is thought to be expressed exclusively in mature neurons. Here, we show that MeCP2 is expressed in embryonic non-neuronal cells by immunocytochemistry and Western blotting, and that knockdown of MeCP2 levels using RNA interference reduces their proliferation. These findings suggest that MeCP2 is essential to non-neuronal cell growth during brain development, which may be associated with microcephaly of Rett syndrome patients with MeCP2 mutations.
Links	PubMed Online version:10.1016/j.devbrainres.2005.03.011
Keywords	Animals; Blotting, Western/methods; Bromodeoxyuridine/metabolism; Cell Count/methods; Cell Fractionation/methods; Cell Proliferation/drug effects; Cells, Cultured; Cerebral Cortex/cytology; Chromosomal Proteins, Non-Histone/chemistry; Chromosomal Proteins, Non-Histone/deficiency; Chromosomal Proteins, Non-Histone/metabolism; DNA-Binding Proteins/chemistry; DNA-Binding Proteins/deficiency; DNA-Binding Proteins/metabolism; Embryo, Mammalian; Gene Expression Regulation, Developmental/physiology; Glial Fibrillary Acidic Protein/metabolism; Immunohistochemistry/methods; Methyl-CpG-Binding Protein 2; Mice; Mice, Knockout; Microtubule-Associated Proteins/metabolism; Neuroglia/drug effects; Neuroglia/metabolism; RNA, Small Interfering/pharmacology; Repressor Proteins/chemistry; Repressor Proteins/metabolism; Rett Syndrome/genetics; Rett Syndrome/metabolism; Time Factors
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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