PMID:18571096

Citation	Ward, BC, Agarwal, S, Wang, K, Berger-Sweeney, J and Kolodny, NH (2008) Longitudinal brain MRI study in a mouse model of Rett Syndrome and the effects of choline. Neurobiol. Dis. 31:110-9
Abstract	Rett Syndrome (RTT), the second most common cause of mental retardation in girls, is associated with mutations of an X-linked gene encoding the transcriptional repressor protein MeCP2. Mecp2(1lox) mutant mice express no functional MeCP2 protein and exhibit behavioral abnormalities similar to those seen in RTT patients. Here we monitor the development of both whole brain and regional volumes between 21 and 42 days of age in this model of RTT using MRI. We see decreases in whole brain volumes in both male and female mutant mice. Cerebellar and ventricular volumes are also decreased in RTT males. Previous work has suggested that perinatal choline supplementation alleviates some of the behavioral deficits in both male and female Mecp2(1lox) mutant mice. Here we show that perinatal choline supplementation also positively affects whole brain volume in heterozygous females, and cerebellar volume in male RTT mice.
Links	PubMed Online version:10.1016/j.nbd.2008.03.009
Keywords	Administration, Oral; Animals; Behavior, Animal/drug effects; Body Weight/drug effects; Brain/drug effects; Brain/pathology; Choline/administration & dosage; Disease Models, Animal; Female; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Methyl-CpG-Binding Protein 2/deficiency; Methyl-CpG-Binding Protein 2/genetics; Mice; Mice, Mutant Strains; Nootropic Agents/administration & dosage; Rett Syndrome/drug therapy; Rett Syndrome/pathology
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Gene product	Qualifier	GO ID	GO term name	Evidence Code	with/from	Aspect	Notes	Status
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