MOUSE:KDM1A

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Kdm1a (synonyms: Aof2, Kiaa0601, Lsd1)
Protein Name(s)	Lysine-specific histone demethylase 1A BRAF35-HDAC complex protein BHC110 Flavin-containing amine oxidase domain-containing protein 2
External Links
UniProt	Q6ZQ88
EMBL	AK129170 AL671173 BC019417 BC059885
CCDS	CCDS51331.1
RefSeq	NP_598633.2
UniGene	Mm.28540
ProteinModelPortal	Q6ZQ88
SMR	Q6ZQ88
BioGrid	221360
DIP	DIP-38599N
IntAct	Q6ZQ88
MINT	MINT-4100561
PhosphoSite	Q6ZQ88
MaxQB	Q6ZQ88
PaxDb	Q6ZQ88
PRIDE	Q6ZQ88
Ensembl	ENSMUST00000116273
GeneID	99982
KEGG	mmu:99982
UCSC	uc008vig.2
CTD	23028
MGI	MGI:1196256
eggNOG	COG1231
GeneTree	ENSGT00530000062888
HOGENOM	HOG000246945
InParanoid	Q6ZQ88
KO	K11450
OrthoDB	EOG7X9G66
PhylomeDB	Q6ZQ88
TreeFam	TF312972
Reactome	REACT_198649 REACT_256030 REACT_257106
ChiTaRS	Kdm1a
NextBio	354201
PRO	PR:Q6ZQ88
Proteomes	UP000000589
Bgee	Q6ZQ88
CleanEx	MM_AOF2
ExpressionAtlas	Q6ZQ88
Genevestigator	Q6ZQ88
GO	GO:0000790 GO:0005634 GO:0005667 GO:0050681 GO:0003682 GO:0019899 GO:0050660 GO:0032452 GO:0034648 GO:0032453 GO:0032454 GO:0030374 GO:0043426 GO:0016491 GO:0001085 GO:0003700 GO:0008134 GO:0044212 GO:0008283 GO:0030851 GO:0034720 GO:0033169 GO:0001701 GO:0055001 GO:0043518 GO:0051572 GO:0051573 GO:1902166 GO:0032091 GO:0043433 GO:0000122 GO:0045892 GO:0021983 GO:0045648 GO:0046886 GO:0045654 GO:2000179 GO:0051091 GO:2000648 GO:0045944 GO:0010725 GO:0034401 GO:0006357 GO:0006351
Gene3D	1.10.10.10
InterPro	IPR002937 IPR017366 IPR009057 IPR007526 IPR011991
Pfam	PF01593 PF04433
PIRSF	PIRSF038051
SUPFAM	SSF46689
PROSITE	PS50934

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0033235	positive regulation of protein sumoylation	PMID:17392792^[1]	ECO:0000315			P		Fig 5d	complete CACAO 9041
	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)	PMID:29370269^[2]	ECO:0000315			F		Figure 5B shows that the inhibition of LSD1 (alpha-LSD1), had significantly higher levels of H3K4me2 (di-methylation) versus the functioning LSD1 denoted as KDM1A in UNIPROT, in mice.	complete CACAO 13062
Colocalizes with	GO:0016581	NuRD complex	PMID:29370269^[2]	ECO:0000314			C		Figure 2D shows how KDMA1 (called LSD1 in paper) is associated with the NuRD complex in mice.	complete CACAO 13078
	GO:0034649	histone demethylase activity (H3-monomethyl-K4 specific)	PMID:29370269^[2]	ECO:0000315			F		Figure 5B shows that the inhibition of LSD1 (alpha-LSD1), had significantly higher levels of H3K4me1 (mono-methylation) versus the functioning LSD1, denoted as KDM1A in UNIPROT, in mice.	complete CACAO 13065
	GO:0045665	negative regulation of neuron differentiation	PMID:29370269^[2]	ECO:0000316		UniProtKB:PAX2_MOUSE	P		Figure 6 shows that PAX2 interacting with KDM1A (called LSD1 in paper) causes negitive regulation of neuronal differentiation in mice.	complete CACAO 13141
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:27566776^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:28053041^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:28053041^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000648	positive regulation of stem cell proliferation	PMID:20123967^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000179	positive regulation of neural precursor cell proliferation	PMID:20123967^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0055001	muscle cell development	PMID:20833138^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051573	negative regulation of histone H3-K9 methylation	PMID:20123967^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051572	negative regulation of histone H3-K4 methylation	PMID:20123967^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:19497860^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
enables	GO:0043426	MRF binding	PMID:20833138^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10085	F		Seeded From UniProt	complete
involved_in	GO:0006342	chromatin silencing	PMID:20123967^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033169	histone H3-K9 demethylation	PMID:20833138^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0032452	histone demethylase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:17277772^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q8VCD7	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:20833138^[6]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q63943	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19497860^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0001085	RNA polymerase II transcription factor binding	PMID:20123967^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q64104	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:20833138^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:19497860^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
involved_in	GO:0045654	positive regulation of megakaryocyte differentiation	PMID:17707228^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045648	positive regulation of erythrocyte differentiation	PMID:17707228^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034720	histone H3-K4 demethylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
enables	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
involved_in	GO:0033169	histone H3-K9 demethylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
enables	GO:0032454	histone demethylase activity (H3-K9 specific)	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0032453	histone demethylase activity (H3-K4 specific)	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
involved_in	GO:0030851	granulocyte differentiation	PMID:17707228^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
involved_in	GO:0010725	regulation of primitive erythrocyte differentiation	PMID:17707228^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60341	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002473317 UniProtKB:O60341	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1196256 PANTHER:PTN002473317 RGD:1562975 UniProtKB:O60341	P		Seeded From UniProt	complete
enables	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1196256 PANTHER:PTN002473317 UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000743742 UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1196256 PANTHER:PTN002473317 RGD:1562975 UniProtKB:O60341	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0260397 MGI:MGI:1196256 PANTHER:PTN002473317 RGD:1562975 UniProtKB:O60341	C		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002473317 RGD:1562975 UniProtKB:O60341	F		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1196256 PANTHER:PTN002473317 RGD:1562975 UniProtKB:O60341	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1196256 PANTHER:PTN002473317 UniProtKB:O60341	P		Seeded From UniProt	complete
part_of	GO:1990391	DNA repair complex	PMID:24217620^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990138	neuron projection extension	PMID:25018020^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1924151	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990138	neuron projection extension	PMID:25018020^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903827	regulation of cellular protein localization	PMID:24217620^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071480	cellular response to gamma radiation	PMID:24217620^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
enables	GO:0061752	telomeric repeat-containing RNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050768	negative regulation of neurogenesis	PMID:25018020^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050768	negative regulation of neurogenesis	PMID:25018020^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050767	regulation of neurogenesis	PMID:25018020^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1924151	P		Seeded From UniProt	complete
enables	GO:0050681	androgen receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046886	positive regulation of hormone biosynthetic process	PMID:17392792^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3690467,MGI:MGI:3711205	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046098	guanine metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1562975	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:17392792^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3690467,MGI:MGI:3711205,MGI:MGI:3711561	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1562975	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045793	positive regulation of cell size	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1562975	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043433	negative regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
enables	GO:0043426	MRF binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0042162	telomeric DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035563	positive regulation of chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1562975	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034720	histone H3-K4 demethylation	PMID:24217620^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034720	histone H3-K4 demethylation	PMID:24843136^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034720	histone H3-K4 demethylation	PMID:24217620^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034720	histone H3-K4 demethylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034720	histone H3-K4 demethylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1562975	P		Seeded From UniProt	complete
enables	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)	PMID:24843136^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034644	cellular response to UV	PMID:24217620^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033184	positive regulation of histone ubiquitination	PMID:24217620^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033169	histone H3-K9 demethylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:24217620^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	C		Seeded From UniProt	complete
enables	GO:0032454	histone demethylase activity (H3-K9 specific)	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0032453	histone demethylase activity (H3-K4 specific)	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0032452	histone demethylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0032451	demethylase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032091	negative regulation of protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
enables	GO:0030374	nuclear receptor transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021983	pituitary gland development	PMID:17392792^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3690467,MGI:MGI:3711205	P	results_in_development_of:(EMAPA:16898)	Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010976	positive regulation of neuron projection development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1562975	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010569	regulation of double-strand break repair via homologous recombination	PMID:24217620^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	PMID:17392792^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3690467,MGI:MGI:3711205	P	occurs_in:(EMAPA:16898)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:17392792^[1]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O88712 UniProtKB:P31266 UniProtKB:Q00286 UniProtKB:Q64318 UniProtKB:Q6ZPI3 UniProtKB:Q8C796	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1562975	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006482	protein demethylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:17392792^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1562975	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:17392792^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:16898) has_regulation_target:(MGI:MGI:97762)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:98848)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:97588)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:1341800)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:88316)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:97762)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:98848)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:97588)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:1341800)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:88316)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:97762)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:98848)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:97588)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:1341800)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:88316)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:97762)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:98848)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:97588)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:1341800)\|occurs_in(EMAPA:16898) has_regulation_target:(MGI:MGI:88316)	Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:24217620^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1562975	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002052	positive regulation of neuroblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
enables	GO:0002039	p53 binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001701	in utero embryonic development	PMID:17392792^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3711561	P		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	C		Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1562975	C		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17392792^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:95707)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:17392792^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3690467,MGI:MGI:3711205	P	has_regulation_target:(MGI:MGI:1341800)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O60341	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR009057	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017366	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017366	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002937	F		Seeded From UniProt	complete
involved_in	GO:0034720	histone H3-K4 demethylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017366	P		Seeded From UniProt	complete
enables	GO:0050660	flavin adenine dinucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017366	F		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002937	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Wang, J et al. (2007) Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 446 882-7 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Patel, D et al. (2018) The histone demethylase LSD1 regulates inner ear progenitor differentiation through interactions with Pax2 and the NuRD repressor complex. PLoS ONE 13 e0191689 PubMed GONUTS page
↑ Zeng, X et al. (2016) Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation. Genes Dev. 30 1822-36 PubMed GONUTS page
↑ ^4.0 ^4.1 Muralidharan, B et al. (2017) LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11. J. Neurosci. 37 194-203 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Sun, G et al. (2010) Histone demethylase LSD1 regulates neural stem cell proliferation. Mol. Cell. Biol. 30 1997-2005 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Choi, J et al. (2010) Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors. Biochem. Biophys. Res. Commun. 401 327-32 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Hu, X et al. (2009) LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc. Natl. Acad. Sci. U.S.A. 106 10141-6 PubMed GONUTS page
↑ Wissmann, M et al. (2007) Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat. Cell Biol. 9 347-53 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Saleque, S et al. (2007) Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol. Cell 27 562-72 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 ^11.9 Mosammaparast, N et al. (2013) The histone demethylase LSD1/KDM1A promotes the DNA damage response. J. Cell Biol. 203 457-70 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Han, X et al. (2014) Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development. Mol. Cell 55 482-94 PubMed GONUTS page
↑ ^13.0 ^13.1 Upadhyay, G et al. (2014) Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation. Proc. Natl. Acad. Sci. U.S.A. 111 8071-6 PubMed GONUTS page

[PMID:17392792-1] 1.00 ^1.01 ^1.02 ^1.03 ^1.04 ^1.05 ^1.06 ^1.07 ^1.08 ^1.09 ^1.10 Wang, J et al. (2007) Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature 446 882-7 PubMed GONUTS page

[PMID:29370269-2] 2.0 ^2.1 ^2.2 ^2.3 Patel, D et al. (2018) The histone demethylase LSD1 regulates inner ear progenitor differentiation through interactions with Pax2 and the NuRD repressor complex. PLoS ONE 13 e0191689 PubMed GONUTS page

[PMID:27566776-3] Zeng, X et al. (2016) Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation. Genes Dev. 30 1822-36 PubMed GONUTS page

[PMID:28053041-4] 4.0 ^4.1 Muralidharan, B et al. (2017) LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11. J. Neurosci. 37 194-203 PubMed GONUTS page

[PMID:20123967-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Sun, G et al. (2010) Histone demethylase LSD1 regulates neural stem cell proliferation. Mol. Cell. Biol. 30 1997-2005 PubMed GONUTS page

[PMID:20833138-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Choi, J et al. (2010) Histone demethylase LSD1 is required to induce skeletal muscle differentiation by regulating myogenic factors. Biochem. Biophys. Res. Commun. 401 327-32 PubMed GONUTS page

[PMID:19497860-7] 7.0 ^7.1 ^7.2 Hu, X et al. (2009) LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc. Natl. Acad. Sci. U.S.A. 106 10141-6 PubMed GONUTS page

[PMID:17277772-8] Wissmann, M et al. (2007) Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat. Cell Biol. 9 347-53 PubMed GONUTS page

[PMID:17707228-9] 9.0 ^9.1 ^9.2 ^9.3 Saleque, S et al. (2007) Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1. Mol. Cell 27 562-72 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 ^10.7 ^10.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24217620-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 ^11.5 ^11.6 ^11.7 ^11.8 ^11.9 Mosammaparast, N et al. (2013) The histone demethylase LSD1/KDM1A promotes the DNA damage response. J. Cell Biol. 203 457-70 PubMed GONUTS page

[PMID:25018020-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Han, X et al. (2014) Destabilizing LSD1 by Jade-2 promotes neurogenesis: an antibraking system in neural development. Mol. Cell 55 482-94 PubMed GONUTS page

[PMID:24843136-13] 13.0 ^13.1 Upadhyay, G et al. (2014) Antagonistic actions of Rcor proteins regulate LSD1 activity and cellular differentiation. Proc. Natl. Acad. Sci. U.S.A. 111 8071-6 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

MOUSE:KDM1A

Contents

Annotations

Notes

References

c

d

e

f

g

h

i

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools