MOUSE:GPX1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Gpx1
Protein Name(s)	Glutathione peroxidase 1 GPx-1 GSHPx-1 Cellular glutathione peroxidase Selenium-dependent glutathione peroxidase 1
External Links
UniProt	P11352
EMBL	X03920 AK002245 AK010999 AK011019 AK028171 AK150548 AK154833 AK160388 BC086649 X15667
CCDS	CCDS23522.1
PIR	A25106 S05317
RefSeq	NP_032186.2
UniGene	Mm.1090
ProteinModelPortal	P11352
SMR	P11352
IntAct	P11352
MINT	MINT-1855025
PeroxiBase	3709
PhosphoSite	P11352
REPRODUCTION-2DPAGE	IPI00319652 P11352
SWISS-2DPAGE	P11352
MaxQB	P11352
PaxDb	P11352
PRIDE	P11352
Ensembl	ENSMUST00000082429
GeneID	14775
KEGG	mmu:14775
UCSC	uc009rpf.3
CTD	2876
MGI	MGI:104887
eggNOG	COG0386
GeneTree	ENSGT00760000119230
HOGENOM	HOG000277055
HOVERGEN	HBG004333
InParanoid	P11352
KO	K00432
OMA	CEVNGEK
OrthoDB	EOG7KQ23C
PhylomeDB	P11352
TreeFam	TF105318
Reactome	REACT_189141 REACT_196559 REACT_196569 REACT_206751 REACT_253802
ChiTaRS	Gpx1
NextBio	286877
PRO	PR:P11352
Proteomes	UP000000589
Bgee	P11352
CleanEx	MM_GPX1
Genevestigator	P11352
GO	GO:0005737 GO:0070062 GO:0005739 GO:0005634 GO:0043295 GO:0004602 GO:0047066 GO:0008430 GO:0007568 GO:0060055 GO:0006915 GO:0043534 GO:0008283 GO:0045454 GO:0001885 GO:0045444 GO:0006749 GO:0060047 GO:0042744 GO:0051702 GO:0008631 GO:0006629 GO:0051450 GO:0014902 GO:0043066 GO:0043154 GO:1902042 GO:0002862 GO:1902176 GO:0090201 GO:0051897 GO:0018158 GO:0040029 GO:0033599 GO:0043523 GO:0061136 GO:0032355 GO:0051593 GO:0010332 GO:0009749 GO:0042542 GO:0033194 GO:0006982 GO:0035094 GO:0006979 GO:0000302 GO:0010269 GO:0009609 GO:0009636 GO:0009611 GO:0009410 GO:0007605 GO:0048741 GO:0043403 GO:0001659 GO:0006641 GO:0009650 GO:0042311
Gene3D	3.40.30.10
InterPro	IPR000889 IPR029759 IPR029760 IPR012336
PANTHER	PTHR11592
Pfam	PF00255
PIRSF	PIRSF000303
PRINTS	PR01011
SUPFAM	SSF52833
PROSITE	PS00460 PS00763 PS51355

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07203	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07203	C		Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104887 PANTHER:PTN002613004 RGD:2729 UniProtKB:P00435 UniProtKB:P07203	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104887 PANTHER:PTN002613004 UniProtKB:P07203	P		Seeded From UniProt	complete
involved_in	GO:0010269	response to selenium ion	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002613004 RGD:2729 UniProtKB:P07203	P		Seeded From UniProt	complete
involved_in	GO:0006749	glutathione metabolic process	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002613004 RGD:2729 UniProtKB:P00435 UniProtKB:P07203	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002613004 RGD:2729 UniProtKB:P07203	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104887 PANTHER:PTN002613004 RGD:2729 UniProtKB:P07203	C		Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104887 MGI:MGI:105102 MGI:MGI:106609 PANTHER:PTN000904512 RGD:2729 RGD:69224 RGD:727780 UniProtKB:P00435 UniProtKB:P07203 UniProtKB:P22352	F		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10129 FB:FBgn0035438 MGI:MGI:104767 MGI:MGI:104887 MGI:MGI:105102 MGI:MGI:106609 PANTHER:PTN000173826 RGD:2729 RGD:69224 RGD:69226 RGD:727780 SGD:S000000448 SGD:S000001476 SGD:S000001509 TAIR:locus:2031331 UniProtKB:P00435 UniProtKB:P07203 UniProtKB:P22352 UniProtKB:P36969 UniProtKB:P83564 UniProtKB:Q6JAH6 UniProtKB:Q8I5T2 UniProtKB:Q8TED1 UniProtKB:Q96SL4	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006749	glutathione metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006749	glutathione metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2729	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006641	triglyceride metabolic process	PMID:12117267^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	occurs_in:(EMAPA:35690)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006629	lipid metabolic process	PMID:10754271^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3589261	P	has_participant:(EMAPA:16846)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2729	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:14651853^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846)\|part_of:(EMAPA:16894)\|part_of:(EMAPA:17373)\|part_of:(EMAPA:16105)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:10754271^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3589261	C	part_of:(EMAPA:16846)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:9126277^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2729	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2729	C		Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	PMID:9788901^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	F		Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	PMID:9386101^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	F	occurs_in:(EMAPA:16894)\|occurs_in:(EMAPA:16105)\|occurs_in:(EMAPA:17373)\|occurs_in:(EMAPA:16846)\|occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	PMID:15827346^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2388705	F		Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	PMID:15182862^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	F	occurs_in:(EMAPA:16894)\|occurs_in:(EMAPA:16105)\|occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	PMID:12751789^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	F	occurs_in:(EMAPA:18666)	Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	PMID:12117267^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	F	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	PMID:11893559^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	F	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	PMID:11545230^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	F	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	PMID:11518697^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	F	occurs_in:(EMAPA:18666)\|occurs_in:(EMAPA:32764)\|occurs_in:(EMAPA:18939)	Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	PMID:11311045^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	F	occurs_in:(EMAPA:17838)	Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	PMID:10915653^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	F	occurs_in:(EMAPA:18666)	Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	PMID:10915565^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	F	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	PMID:10490281^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	F		Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	PMID:12646716^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	PMID:12521604^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	F		Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2729	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	PMID:12751789^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104887 MGI:MGI:106609	P	regulates_o_has_participant:(EMAPA:19252)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001885	endothelial cell development	PMID:16373599^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001659	temperature homeostasis	PMID:11518697^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104887 MGI:MGI:106609	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000302	response to reactive oxygen species	PMID:17145560^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	occurs_in:(EMAPA:35578) occurs_in:(CL:0000515)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000302	response to reactive oxygen species	PMID:16962942^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	occurs_in:(CL:0000056)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000302	response to reactive oxygen species	PMID:16373599^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000302	response to reactive oxygen species	PMID:11562367^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000302	response to reactive oxygen species	PMID:10915565^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	PMID:16373599^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	regulates_o_occurs_in:(CL:0000115)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	P		Seeded From UniProt	complete
colocalizes_with	GO:0097413	Lewy body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090201	negative regulation of release of cytochrome c from mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071333	cellular response to glucose stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2729	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061136	regulation of proteasomal protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060055	angiogenesis involved in wound healing	PMID:16373599^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	results_in_formation_of:(EMAPA:17458)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060047	heart contraction	PMID:12196344^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060047	heart contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051897	positive regulation of protein kinase B signaling	PMID:15663476^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051702	interaction with symbiont	PMID:12751789^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104887 MGI:MGI:106609	P	has_participant:(EMAPA:19252)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051450	myoblast proliferation	PMID:16962942^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051450	myoblast proliferation	PMID:12368211^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048741	skeletal muscle fiber development	PMID:16962942^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	occurs_in:(EMAPA:32634)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045454	cell redox homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045444	fat cell differentiation	PMID:16962942^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	results_in_acquisition_of_features_of:(CL:0000056)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043534	blood vessel endothelial cell migration	PMID:16373599^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	results_in_movement_of:(CL:0000115)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043523	regulation of neuron apoptotic process	PMID:11579147^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2388705	P	regulates_o_occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043403	skeletal muscle tissue regeneration	PMID:16962942^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	has_participant:(EMAPA:35866)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	PMID:16934683^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	regulates_o_occurs_in:(CL:0000056)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042744	hydrogen peroxide catabolic process	PMID:9788901^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042744	hydrogen peroxide catabolic process	PMID:15827346^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2388705	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042744	hydrogen peroxide catabolic process	PMID:15182862^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042744	hydrogen peroxide catabolic process	PMID:11545230^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042744	hydrogen peroxide catabolic process	PMID:10915565^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	occurs_in:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042744	hydrogen peroxide catabolic process	PMID:10754271^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3589261	P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042744	hydrogen peroxide catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042744	hydrogen peroxide catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2729	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042542	response to hydrogen peroxide	PMID:16373599^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042542	response to hydrogen peroxide	PMID:14732290^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2388705	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042542	response to hydrogen peroxide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042311	vasodilation	PMID:12196344^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	has_participant:(EMAPA:35146)\|has_participant:(EMAPA:17312)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042311	vasodilation	PMID:11893559^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	has_participant:(EMAPA:36286)\|has_participant:(EMAPA:17312)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0040029	regulation of gene expression, epigenetic	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033599	regulation of mammary gland epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033194	response to hydroperoxide	PMID:16723478^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2388705	P	has_participant:(EMAPA:17168)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018158	protein oxidation	PMID:10428770^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014902	myotube differentiation	PMID:16962942^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014902	myotube differentiation	PMID:12368211^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010332	response to gamma radiation	PMID:15182862^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104887 MGI:MGI:98352	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010269	response to selenium ion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009650	UV protection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P07203	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009636	response to toxic substance	PMID:10627575^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009611	response to wounding	PMID:11579147^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2388705	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009609	response to symbiotic bacterium	PMID:12751789^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104887 MGI:MGI:106609	P	has_participant:(EMAPA:19252)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009410	response to xenobiotic stimulus	PMID:10915565^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	has_participant:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	PMID:15663476^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	PMID:11562367^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	PMID:14732290^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2388705	P	acts_on_population_of:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007605	sensory perception of sound	PMID:11545230^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	PMID:15182862^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104887 MGI:MGI:98352	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	PMID:16962942^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	PMID:15182862^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	PMID:12196344^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	PMID:11893559^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	PMID:10915565^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	has_participant:(EMAPA:16894)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	PMID:10627575^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	PMID:10428770^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	has_participant:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	PMID:16962942^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158814	P	occurs_in:(CL:0000056)	Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004601	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004601	P		Seeded From UniProt	complete
involved_in	GO:0098869	cellular oxidant detoxification	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004602	P		Seeded From UniProt	complete
involved_in	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	P		Seeded From UniProt	complete
part_of	GO:0097413	Lewy body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	C		Seeded From UniProt	complete
involved_in	GO:0090201	negative regulation of release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	P		Seeded From UniProt	complete
involved_in	GO:0061136	regulation of proteasomal protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	P		Seeded From UniProt	complete
involved_in	GO:0060047	heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	P		Seeded From UniProt	complete
involved_in	GO:0045454	cell redox homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	P		Seeded From UniProt	complete
involved_in	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	P		Seeded From UniProt	complete
involved_in	GO:0042744	hydrogen peroxide catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	P		Seeded From UniProt	complete
involved_in	GO:0040029	regulation of gene expression, epigenetic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	P		Seeded From UniProt	complete
involved_in	GO:0033599	regulation of mammary gland epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	P		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	F		Seeded From UniProt	complete
involved_in	GO:0010269	response to selenium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	P		Seeded From UniProt	complete
involved_in	GO:0009650	UV protection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	P		Seeded From UniProt	complete
involved_in	GO:0006749	glutathione metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	C		Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07203 ensembl:ENSP00000407375	F		Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000889	F		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000889	P		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000889	P		Seeded From UniProt	complete
enables	GO:0004602	glutathione peroxidase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:1.11.1.9	F		Seeded From UniProt	complete
enables	GO:0004601	peroxidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0575	F		Seeded From UniProt	complete
enables	GO:0016491	oxidoreductase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0055114	oxidation-reduction process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0560	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^2.0 ^2.1 South, PK et al. (2002) Effects of dietary iron overload on glutathione peroxidase knockout mice. Biol Trace Elem Res 88 79-85 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Esposito, LA et al. (2000) Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene. Free Radic. Biol. Med. 28 754-66 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
↑ Esworthy, RS et al. (1997) The Gpx1 gene encodes mitochondrial glutathione peroxidase in the mouse liver. Arch. Biochem. Biophys. 340 59-63 PubMed GONUTS page
↑ ^7.0 ^7.1 Ho, YS et al. (1998) The nature of antioxidant defense mechanisms: a lesson from transgenic studies. Environ. Health Perspect. 106 Suppl 5 1219-28 PubMed GONUTS page
↑ Yoshida, T et al. (1997) Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury. Circulation 96 II-216-20 PubMed GONUTS page
↑ ^9.0 ^9.1 de Haan, JB et al. (2005) Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathy. Am. J. Physiol. Renal Physiol. 289 F544-51 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Van Remmen, H et al. (2004) Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. Free Radic. Biol. Med. 36 1625-34 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 Esworthy, RS et al. (2003) Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression. Biol. Chem. 384 597-607 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Forgione, MA et al. (2002) Cellular glutathione peroxidase deficiency and endothelial dysfunction. Am. J. Physiol. Heart Circ. Physiol. 282 H1255-61 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Ohlemiller, KK et al. (2000) Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice. J. Assoc. Res. Otolaryngol. 1 243-54 PubMed GONUTS page
↑ ^14.0 ^14.1 Esworthy, RS et al. (2001) Mice with combined disruption of Gpx1 and Gpx2 genes have colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 281 G848-55 PubMed GONUTS page
↑ Spector, A et al. (2001) The effect of aging on glutathione peroxidase-i knockout mice-resistance of the lens to oxidative stress. Exp. Eye Res. 72 533-45 PubMed GONUTS page
↑ Esworthy, RS et al. (2000) Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from gamma-irradiation damage. Am. J. Physiol. Gastrointest. Liver Physiol. 279 G426-36 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 Jiang, D et al. (2000) Chronic brain oxidation in a glutathione peroxidase knockout mouse model results in increased resistance to induced epileptic seizures. Exp. Neurol. 164 257-68 PubMed GONUTS page
↑ Fu, Y et al. (1999) Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress. Free Radic. Biol. Med. 27 605-11 PubMed GONUTS page
↑ Khan, JY & Black, SM (2003) Developmental changes in murine brain antioxidant enzymes. Pediatr. Res. 54 77-82 PubMed GONUTS page
↑ Felix, K et al. (2003) Redox imbalance and mutagenesis in spleens of mice harboring a hypomorphic allele of Gpdx(a) encoding glucose 6-phosphate dehydrogenase. Free Radic. Biol. Med. 34 226-32 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 Galasso, G et al. (2006) Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction. Circ. Res. 98 254-61 PubMed GONUTS page
↑ Vasilaki, A et al. (2006) Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS generation in quiescent, but not contracting, skeletal muscle cells. Free Radic. Biol. Med. 41 1719-25 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 ^23.7 Lee, S et al. (2006) Glutathione-peroxidase-1 null muscle progenitor cells are globally defective. Free Radic. Biol. Med. 41 1174-84 PubMed GONUTS page
↑ ^24.0 ^24.1 Fu, Y et al. (2001) Opposite roles of selenium-dependent glutathione peroxidase-1 in superoxide generator diquat- and peroxynitrite-induced apoptosis and signaling. J. Biol. Chem. 276 43004-9 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Forgione, MA et al. (2002) Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure. Circulation 106 1154-8 PubMed GONUTS page
↑ ^26.0 ^26.1 Taylor, JM et al. (2005) Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death. J. Neurochem. 92 283-93 PubMed GONUTS page
↑ ^27.0 ^27.1 Staversky, RJ et al. (2002) Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1). Am. J. Pathol. 161 1383-93 PubMed GONUTS page
↑ ^28.0 ^28.1 Crack, PJ et al. (2001) Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury. J. Neurochem. 78 1389-99 PubMed GONUTS page
↑ Gueven, N et al. (2006) Dramatic extension of tumor latency and correction of neurobehavioral phenotype in Atm-mutant mice with a nitroxide antioxidant. Free Radic. Biol. Med. 41 992-1000 PubMed GONUTS page
↑ ^30.0 ^30.1 de Haan, JB et al. (2004) Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death. Free Radic. Biol. Med. 36 53-64 PubMed GONUTS page
↑ Gosbell, AD et al. (2006) Retinal light damage: structural and functional effects of the antioxidant glutathione peroxidase-1. Invest. Ophthalmol. Vis. Sci. 47 2613-22 PubMed GONUTS page
↑ ^32.0 ^32.1 Cheng, W et al. (1999) Selenium-dependent cellular glutathione peroxidase protects mice against a pro-oxidant-induced oxidation of NADPH, NADH, lipids, and protein. FASEB J. 13 1467-75 PubMed GONUTS page
↑ ^33.0 ^33.1 Klivenyi, P et al. (2000) Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. J. Neurosci. 20 1-7 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12117267-2] 2.0 ^2.1 South, PK et al. (2002) Effects of dietary iron overload on glutathione peroxidase knockout mice. Biol Trace Elem Res 88 79-85 PubMed GONUTS page

[PMID:10754271-3] 3.0 ^3.1 ^3.2 Esposito, LA et al. (2000) Mitochondrial oxidative stress in mice lacking the glutathione peroxidase-1 gene. Free Radic. Biol. Med. 28 754-66 PubMed GONUTS page

[PMID:18614015-4] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:14651853-5] Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page

[PMID:9126277-6] Esworthy, RS et al. (1997) The Gpx1 gene encodes mitochondrial glutathione peroxidase in the mouse liver. Arch. Biochem. Biophys. 340 59-63 PubMed GONUTS page

[PMID:9788901-7] 7.0 ^7.1 Ho, YS et al. (1998) The nature of antioxidant defense mechanisms: a lesson from transgenic studies. Environ. Health Perspect. 106 Suppl 5 1219-28 PubMed GONUTS page

[PMID:9386101-8] Yoshida, T et al. (1997) Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury. Circulation 96 II-216-20 PubMed GONUTS page

[PMID:15827346-9] 9.0 ^9.1 de Haan, JB et al. (2005) Kidney expression of glutathione peroxidase-1 is not protective against streptozotocin-induced diabetic nephropathy. Am. J. Physiol. Renal Physiol. 289 F544-51 PubMed GONUTS page

[PMID:15182862-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Van Remmen, H et al. (2004) Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress. Free Radic. Biol. Med. 36 1625-34 PubMed GONUTS page

[PMID:12751789-11] 11.0 ^11.1 ^11.2 ^11.3 Esworthy, RS et al. (2003) Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression. Biol. Chem. 384 597-607 PubMed GONUTS page

[PMID:11893559-12] 12.0 ^12.1 ^12.2 Forgione, MA et al. (2002) Cellular glutathione peroxidase deficiency and endothelial dysfunction. Am. J. Physiol. Heart Circ. Physiol. 282 H1255-61 PubMed GONUTS page

[PMID:11545230-13] 13.0 ^13.1 ^13.2 Ohlemiller, KK et al. (2000) Targeted mutation of the gene for cellular glutathione peroxidase (Gpx1) increases noise-induced hearing loss in mice. J. Assoc. Res. Otolaryngol. 1 243-54 PubMed GONUTS page

[PMID:11518697-14] 14.0 ^14.1 Esworthy, RS et al. (2001) Mice with combined disruption of Gpx1 and Gpx2 genes have colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 281 G848-55 PubMed GONUTS page

[PMID:11311045-15] Spector, A et al. (2001) The effect of aging on glutathione peroxidase-i knockout mice-resistance of the lens to oxidative stress. Exp. Eye Res. 72 533-45 PubMed GONUTS page

[PMID:10915653-16] Esworthy, RS et al. (2000) Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from gamma-irradiation damage. Am. J. Physiol. Gastrointest. Liver Physiol. 279 G426-36 PubMed GONUTS page

[PMID:10915565-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 Jiang, D et al. (2000) Chronic brain oxidation in a glutathione peroxidase knockout mouse model results in increased resistance to induced epileptic seizures. Exp. Neurol. 164 257-68 PubMed GONUTS page

[PMID:10490281-18] Fu, Y et al. (1999) Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress. Free Radic. Biol. Med. 27 605-11 PubMed GONUTS page

[PMID:12646716-19] Khan, JY & Black, SM (2003) Developmental changes in murine brain antioxidant enzymes. Pediatr. Res. 54 77-82 PubMed GONUTS page

[PMID:12521604-20] Felix, K et al. (2003) Redox imbalance and mutagenesis in spleens of mice harboring a hypomorphic allele of Gpdx(a) encoding glucose 6-phosphate dehydrogenase. Free Radic. Biol. Med. 34 226-32 PubMed GONUTS page

[PMID:16373599-21] 21.0 ^21.1 ^21.2 ^21.3 ^21.4 ^21.5 Galasso, G et al. (2006) Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction. Circ. Res. 98 254-61 PubMed GONUTS page

[PMID:17145560-22] Vasilaki, A et al. (2006) Genetic modification of the manganese superoxide dismutase/glutathione peroxidase 1 pathway influences intracellular ROS generation in quiescent, but not contracting, skeletal muscle cells. Free Radic. Biol. Med. 41 1719-25 PubMed GONUTS page

[PMID:16962942-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 ^23.7 Lee, S et al. (2006) Glutathione-peroxidase-1 null muscle progenitor cells are globally defective. Free Radic. Biol. Med. 41 1174-84 PubMed GONUTS page

[PMID:11562367-24] 24.0 ^24.1 Fu, Y et al. (2001) Opposite roles of selenium-dependent glutathione peroxidase-1 in superoxide generator diquat- and peroxynitrite-induced apoptosis and signaling. J. Biol. Chem. 276 43004-9 PubMed GONUTS page

[PMID:12196344-25] 25.0 ^25.1 ^25.2 Forgione, MA et al. (2002) Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure. Circulation 106 1154-8 PubMed GONUTS page

[PMID:15663476-26] 26.0 ^26.1 Taylor, JM et al. (2005) Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death. J. Neurochem. 92 283-93 PubMed GONUTS page

[PMID:12368211-27] 27.0 ^27.1 Staversky, RJ et al. (2002) Normal remodeling of the oxygen-injured lung requires the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1). Am. J. Pathol. 161 1383-93 PubMed GONUTS page

[PMID:11579147-28] 28.0 ^28.1 Crack, PJ et al. (2001) Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury. J. Neurochem. 78 1389-99 PubMed GONUTS page

[PMID:16934683-29] Gueven, N et al. (2006) Dramatic extension of tumor latency and correction of neurobehavioral phenotype in Atm-mutant mice with a nitroxide antioxidant. Free Radic. Biol. Med. 41 992-1000 PubMed GONUTS page

[PMID:14732290-30] 30.0 ^30.1 de Haan, JB et al. (2004) Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death. Free Radic. Biol. Med. 36 53-64 PubMed GONUTS page

[PMID:16723478-31] Gosbell, AD et al. (2006) Retinal light damage: structural and functional effects of the antioxidant glutathione peroxidase-1. Invest. Ophthalmol. Vis. Sci. 47 2613-22 PubMed GONUTS page

[PMID:10428770-32] 32.0 ^32.1 Cheng, W et al. (1999) Selenium-dependent cellular glutathione peroxidase protects mice against a pro-oxidant-induced oxidation of NADPH, NADH, lipids, and protein. FASEB J. 13 1467-75 PubMed GONUTS page

[PMID:10627575-33] 33.0 ^33.1 Klivenyi, P et al. (2000) Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine. J. Neurosci. 20 1-7 PubMed GONUTS page

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MOUSE:GPX1

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