PMID:12196344

Citation	Forgione, MA, Cap, A, Liao, R, Moldovan, NI, Eberhardt, RT, Lim, CC, Jones, J, Goldschmidt-Clermont, PJ and Loscalzo, J (2002) Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure. Circulation 106:1154-8
Abstract	Oxidant stress has been implicated in the pathogenesis of atherothrombosis and other vascular disorders accompanied by endothelial dysfunction. Glutathione peroxidases (GPx) play an important role in the cellular defense against oxidant stress by utilizing glutathione (GSH) to reduce lipid hydroperoxides and hydrogen peroxide to their corresponding alcohols. Cellular GPx (GPx-1) is the principal intracellular isoform of GPx. We hypothesized that GPx-1 deficiency per se induces endothelial dysfunction and structural vascular abnormalities through increased oxidant stress.
Links	PubMed
Keywords	Animals; Antioxidants/pharmacology; Aorta, Thoracic/chemistry; Aorta, Thoracic/metabolism; Aorta, Thoracic/pathology; Bradykinin/pharmacology; Coronary Vessels/pathology; Cyclic GMP/analysis; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Targeting; Glutathione Peroxidase/deficiency; Glutathione Peroxidase/genetics; Heterozygote; Male; Mesentery/blood supply; Mesentery/physiopathology; Metabolism, Inborn Errors/genetics; Metabolism, Inborn Errors/pathology; Metabolism, Inborn Errors/physiopathology; Mice; Microcirculation/drug effects; Muscarinic Agonists/pharmacology; Myocardial Contraction/drug effects; Myocardial Contraction/genetics; Myocardium/metabolism; Myocardium/pathology; Nitric Oxide Donors/pharmacology; Oxidative Stress; Vasodilator Agents/pharmacology; Vasomotor System/drug effects; Vasomotor System/physiopathology
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