MOUSE:FGF10

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Fgf10
Protein Name(s)	Fibroblast growth factor 10 FGF-10 Keratinocyte growth factor 2
External Links
UniProt	O35565
EMBL	D89080 U94517 AK034742 AK045267 AK085244 AK141633 BC048229
CCDS	CCDS26795.1
RefSeq	NP_032028.1
UniGene	Mm.317323
ProteinModelPortal	O35565
SMR	O35565
BioGrid	199639
PhosphoSite	O35565
PRIDE	O35565
Ensembl	ENSMUST00000022246
GeneID	14165
KEGG	mmu:14165
UCSC	uc007ryv.2
CTD	2255
MGI	MGI:1099809
eggNOG	NOG327524
GeneTree	ENSGT00760000118859
HOGENOM	HOG000236341
HOVERGEN	HBG007580
InParanoid	O35565
KO	K04358
OMA	SSIPVTC
OrthoDB	EOG7992S1
PhylomeDB	O35565
TreeFam	TF317805
Reactome	REACT_196455 REACT_196536 REACT_196588 REACT_198525 REACT_208465 REACT_220836 REACT_223937 REACT_223993 REACT_226341 REACT_230708 REACT_234357 REACT_240139 REACT_94437
NextBio	285306
PRO	PR:O35565
Proteomes	UP000000589
Bgee	O35565
CleanEx	MM_FGF10
ExpressionAtlas	O35565
Genevestigator	O35565
GO	GO:0031012 GO:0005615 GO:0005634 GO:0005886 GO:0042056 GO:0008201 GO:0031532 GO:0000187 GO:0001525 GO:0048514 GO:0001974 GO:0060667 GO:0060445 GO:0060436 GO:0060449 GO:0060447 GO:0007267 GO:0006935 GO:0007368 GO:0048565 GO:0031076 GO:0048566 GO:0048557 GO:0030538 GO:0009880 GO:0008544 GO:0048730 GO:0030855 GO:0010631 GO:0050673 GO:0060664 GO:0060441 GO:0070371 GO:0000132 GO:0048807 GO:0060595 GO:0031069 GO:0070384 GO:0050930 GO:0042472 GO:0043616 GO:0032808 GO:0060174 GO:0060173 GO:0035108 GO:0048286 GO:0030324 GO:0060425 GO:0061115 GO:0060430 GO:0048808 GO:0060615 GO:0060594 GO:0060915 GO:0060496 GO:0001823 GO:0003338 GO:0042693 GO:0071157 GO:0045596 GO:0008285 GO:2001240 GO:0042475 GO:0048645 GO:0035265 GO:0001759 GO:0009887 GO:0030916 GO:0031016 GO:0021983 GO:0050918 GO:0032781 GO:0090263 GO:0008284 GO:0031659 GO:0045739 GO:0045740 GO:0010634 GO:0050679 GO:0070374 GO:0048146 GO:0071338 GO:0051549 GO:0010838 GO:0050671 GO:0045931 GO:0045747 GO:0050731 GO:0046579 GO:0045944 GO:0050677 GO:0030949 GO:0070352 GO:0030177 GO:0060513 GO:0034394 GO:0060019 GO:0032925 GO:0060665 GO:0050678 GO:0010468 GO:0046877 GO:0008589 GO:0060541 GO:0032355 GO:0032496 GO:0007435 GO:0061033 GO:0060879 GO:0048752 GO:0051145 GO:0035019 GO:0048536 GO:0060661 GO:0070075 GO:0048538 GO:0030878 GO:0042246 GO:0060510 GO:0050674 GO:0050872
InterPro	IPR008996 IPR028252 IPR002209 IPR028142
PANTHER	PTHR11486 PTHR11486:SF21
PRINTS	PR00263 PR00262
SMART	SM00442
SUPFAM	SSF50353
PROSITE	PS00247

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:17394208^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060019	radial glial cell differentiation	PMID:19607792^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	PMID:16956603^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	regulates_o_occurs_in:(EMAPA:16247) regulates_o_occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090263	positive regulation of canonical Wnt signaling pathway	PMID:16720875^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071338	positive regulation of hair follicle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071157	negative regulation of cell cycle arrest	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
	GO:0045893	positive regulation of transcription, DNA-dependent	PMID:17394208^[1]	ECO:0000314			P		Fig 5.	complete CACAO 6700
acts_upstream_of_or_within	GO:0070384	Harderian gland development	PMID:10964474^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927833	P	results_in_development_of:(EMAPA:19153)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21764747^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1345138 MGI:MGI:1345139	P	regulates_o_occurs_in:(EMAPA:16731)\|regulates_o_occurs_in:(EMAPA:16735)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:17202188^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95523	P	regulates_o_occurs_in:(EMAPA:29771)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:15130516^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070352	positive regulation of white fat cell proliferation	PMID:15130516^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070075	tear secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
colocalizes_with	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061115	lung proximal/distal axis specification	PMID:15531758^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0061033	secretion by lung epithelial cell involved in lung growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060915	mesenchymal cell differentiation involved in lung development	PMID:16989802^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95523	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060879	semicircular canal fusion	PMID:15765517^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	has_participant:(EMAPA:17293)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060667	branch elongation involved in salivary gland morphogenesis	PMID:15972105^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	PMID:18559345^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	PMID:15972105^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95523	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060664	epithelial cell proliferation involved in salivary gland morphogenesis	PMID:15972105^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060661	submandibular salivary gland formation	PMID:11062007^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	results_in_formation_of:(EMAPA:17751)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060615	mammary gland bud formation	PMID:11782400^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	results_in_formation_of:(EMAPA:17759)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	PMID:16720875^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	PMID:16720875^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060594	mammary gland specification	PMID:16720875^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95729	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060541	respiratory system development	PMID:11287183^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060513	prostatic bud formation	PMID:12941620^[17]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88064	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060510	type II pneumocyte differentiation	PMID:15531758^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:17655) results_in_acquisition_of_features_of:(CL:0000322)\|occurs_in(EMAPA:17663) results_in_acquisition_of_features_of:(CL:0000322)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060496	mesenchymal-epithelial cell signaling involved in lung development	PMID:15531758^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060449	bud elongation involved in lung branching	PMID:21764747^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1345138 MGI:MGI:1345139	P	has_participant:(EMAPA:16731)\|has_participant:(EMAPA:16735)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060447	bud outgrowth involved in lung branching	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060445	branching involved in salivary gland morphogenesis	PMID:15972105^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95523	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060445	branching involved in salivary gland morphogenesis	PMID:18559345^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060441	epithelial tube branching involved in lung morphogenesis	PMID:9916808^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	occurs_in:(EMAPA:17656)\|occurs_in:(EMAPA:17982)\|occurs_in:(EMAPA:17987)\|occurs_in:(EMAPA:17992)\|occurs_in:(EMAPA:17998)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060441	epithelial tube branching involved in lung morphogenesis	PMID:9784490^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927833	P	occurs_in:(EMAPA:17656)\|occurs_in:(EMAPA:17982)\|occurs_in:(EMAPA:17987)\|occurs_in:(EMAPA:17992)\|occurs_in:(EMAPA:17998)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060441	epithelial tube branching involved in lung morphogenesis	PMID:17560563^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060441	epithelial tube branching involved in lung morphogenesis	PMID:15800000^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647 MGI:MGI:3629660	P	occurs_in:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060441	epithelial tube branching involved in lung morphogenesis	PMID:9428423^[22]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16731)\|occurs_in:(EMAPA:16735)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060441	epithelial tube branching involved in lung morphogenesis	PMID:16375885^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060441	epithelial tube branching involved in lung morphogenesis	PMID:16169547^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060436	bronchiole morphogenesis	PMID:15800000^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647 MGI:MGI:3629660	P	has_participant:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060430	lung saccule development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060428	lung epithelium development	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060425	lung morphogenesis	PMID:15800000^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647 MGI:MGI:3629660	P	has_participant:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060174	limb bud formation	PMID:9784490^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927833	P	results_in_formation_of:(EMAPA:16405)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060173	limb development	PMID:10804187^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051549	positive regulation of keratinocyte migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051145	smooth muscle cell differentiation	PMID:17560563^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P	occurs_in:(EMAPA:19182) results_in_acquisition_of_features_of:(CL:0000192)\|occurs_in(EMAPA:19190) results_in_acquisition_of_features_of:(CL:0000192)\|occurs_in(EMAPA:19188) results_in_acquisition_of_features_of:(CL:0000192)\|occurs_in(EMAPA:19186) results_in_acquisition_of_features_of:(CL:0000192)\|occurs_in(EMAPA:19184) results_in_acquisition_of_features_of:(CL:0000192)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050930	induction of positive chemotaxis	PMID:16308329^[26]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16717) regulates_o_results_in_movement_of:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050918	positive chemotaxis	PMID:15531758^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050918	positive chemotaxis	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050872	white fat cell differentiation	PMID:15130516^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	occurs_in:(EMAPA:16039) results_in_acquisition_of_features_of:(CL:0000448)\|occurs_in(EMAPA:35926) results_in_acquisition_of_features_of:(CL:0000448)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050872	white fat cell differentiation	PMID:11959839^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	occurs_in:(EMAPA:35926) results_in_acquisition_of_features_of:(CL:0000448)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	PMID:16956603^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050678	regulation of epithelial cell proliferation	PMID:15972105^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050677	positive regulation of urothelial cell proliferation	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050674	urothelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050673	epithelial cell proliferation	PMID:15958512^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050673	epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050671	positive regulation of lymphocyte proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048808	male genitalia morphogenesis	PMID:12004962^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	has_participant:(EMAPA:18988)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048807	female genitalia morphogenesis	PMID:12004962^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	has_participant:(EMAPA:19170)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048752	semicircular canal morphogenesis	PMID:17601531^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95517	P	has_participant:(EMAPA:17293)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048730	epidermis morphogenesis	PMID:14530295^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927833	P	has_participant:(EMAPA:17528)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048645	animal organ formation	PMID:11062007^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	results_in_formation_of:(EMAPA:16898)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048566	embryonic digestive tract development	PMID:16308329^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927833	P	results_in_development_of:(EMAPA:17898)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048565	digestive tract development	PMID:15234214^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	results_in_development_of:(EMAPA:16246)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048557	embryonic digestive tract morphogenesis	PMID:16618415^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927833	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048557	embryonic digestive tract morphogenesis	PMID:15017552^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	has_participant:(EMAPA:17896)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048538	thymus development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048536	spleen development	PMID:15329346^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	results_in_development_of:(EMAPA:18659)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048514	blood vessel morphogenesis	PMID:17560563^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P	has_participant:(EMAPA:17660)\|has_participant:(EMAPA:17668)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048286	lung alveolus development	PMID:16989802^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95523	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048286	lung alveolus development	PMID:17560563^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P	results_in_development_of:(EMAPA:35433)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048146	positive regulation of fibroblast proliferation	PMID:15130516^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046877	regulation of saliva secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046579	positive regulation of Ras protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:11287183^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045931	positive regulation of mitotic cell cycle	PMID:16956603^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	regulates_o_occurs_in:(EMAPA:16247) regulates_o_occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045747	positive regulation of Notch signaling pathway	PMID:16324690^[36]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103302	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045740	positive regulation of DNA replication	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045739	positive regulation of DNA repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045596	negative regulation of cell differentiation	PMID:14604677^[37]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:0000083)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043616	keratinocyte proliferation	PMID:10984614^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	occurs_in:(EMAPA:32779) acts_on_population_of:(CL:0000312)\|occurs_in(EMAPA:32779) acts_on_population_of:(CL:0000646)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042693	muscle cell fate commitment	PMID:15800000^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647 MGI:MGI:3629660	P	results_in_commitment_to:(CL:0000192)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042475	odontogenesis of dentin-containing tooth	PMID:11880361^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	has_participant:(EMAPA:18293)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042475	odontogenesis of dentin-containing tooth	PMID:11062007^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	has_participant:(EMAPA:32906)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:16691564^[40]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1347464	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042472	inner ear morphogenesis	PMID:11062007^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	has_participant:(EMAPA:16194)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042060	wound healing	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:16308329^[26]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:16717) occurs_in:(CL:0000066)	Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:16169547^[24]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:16728) occurs_in:(CL:0000082)	Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	PMID:15531758^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(EMAPA:17663)\|occurs_in:(EMAPA:17655)	Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035265	organ growth	PMID:16618415^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927833	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035108	limb morphogenesis	PMID:9916808^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035019	somatic stem cell population maintenance	PMID:11880361^[39]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	occurs_in:(EMAPA:18293)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034394	protein localization to cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032925	regulation of activin receptor signaling pathway	PMID:15958512^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032808	lacrimal gland development	PMID:15654336^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	results_in_development_of:(EMAPA:35463)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032808	lacrimal gland development	PMID:10964474^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927833	P	results_in_development_of:(EMAPA:35463)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032808	lacrimal gland development	PMID:10821755^[42]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927833	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032808	lacrimal gland development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032781	positive regulation of ATPase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031076	embryonic camera-type eye development	PMID:15958512^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031069	hair follicle morphogenesis	PMID:11062007^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	has_participant:(EMAPA:35246)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031016	pancreas development	PMID:15329346^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	results_in_development_of:(EMAPA:17067)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	PMID:17560563^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030916	otic vesicle formation	PMID:14623822^[43]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95517	P	results_in_formation_of:(EMAPA:16194)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030878	thyroid gland development	PMID:11062007^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	results_in_development_of:(EMAPA:17068)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030855	epithelial cell differentiation	PMID:16618415^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927833	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030538	embryonic genitalia morphogenesis	PMID:12004962^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	has_participant:(EMAPA:18988)\|has_participant:(EMAPA:19170)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:9916808^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:17560563^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:9428423^[22]	ECO:0000314	direct assay evidence used in manual assertion		P	results_in_development_of:(EMAPA:16728)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030324	lung development	PMID:16375885^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030177	positive regulation of Wnt signaling pathway	PMID:17560563^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P	regulates_o_occurs_in:(EMAPA:17655) regulates_o_occurs_in:(CL:0000066)\|regulates_o_occurs_in:(EMAPA:17663) regulates_o_occurs_in:(CL:0000066)\|regulates_o_occurs_in:(EMAPA:17655) regulates_o_occurs_in:(CL:0000066)\|regulates_o_occurs_in:(EMAPA:17663) regulates_o_occurs_in:(CL:0000066)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0021983	pituitary gland development	PMID:11062007^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	results_in_development_of:(EMAPA:16898)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010838	positive regulation of keratinocyte proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010634	positive regulation of epithelial cell migration	PMID:15531758^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010634	positive regulation of epithelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010631	epithelial cell migration	PMID:15958512^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010468	regulation of gene expression	PMID:15958512^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:15843416^[44]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927833	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:12615071^[45]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	has_participant:(EMAPA:17529)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:10964474^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927833	P	has_participant:(EMAPA:19153)\|has_participant:(EMAPA:35463)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009887	animal organ morphogenesis	PMID:14651921^[46]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(EMAPA:18816)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009880	embryonic pattern specification	PMID:17522155^[47]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3629660	P	occurs_in:(EMAPA:16548)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009880	embryonic pattern specification	PMID:16618415^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927833	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008589	regulation of smoothened signaling pathway	PMID:16618415^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927833	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008589	regulation of smoothened signaling pathway	PMID:15958512^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008544	epidermis development	PMID:10984614^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	results_in_development_of:(EMAPA:17528)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:16141225^[48]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:9428423^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:15199404^[49]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:14697353^[50]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	F		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007435	salivary gland morphogenesis	PMID:15654336^[41]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	has_participant:(EMAPA:18812)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007431	salivary gland development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007368	determination of left/right symmetry	PMID:15329346^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	has_participant:(EMAPA:17067)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007267	cell-cell signaling	PMID:15199404^[49]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1927833	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007267	cell-cell signaling	PMID:9428423^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006935	chemotaxis	PMID:16169547^[24]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16728) occurs_in:(CL:0000082)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:9428423^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:9393979^[51]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15199404^[49]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12837279^[52]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	C		Seeded From UniProt	complete
enables	GO:0005111	type 2 fibroblast growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	F		Seeded From UniProt	complete
enables	GO:0005104	fibroblast growth factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003338	metanephros morphogenesis	PMID:11062007^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1859647	P	has_participant:(EMAPA:17373)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001974	blood vessel remodeling	PMID:17000704^[53]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:98493 MGI:MGI:99604	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001759	organ induction	PMID:12810586^[54]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:95517	P	regulates_o_results_in_development_of:(EMAPA:16195)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001759	organ induction	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P70492	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000187	activation of MAPK activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O15520	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000132	establishment of mitotic spindle orientation	PMID:21764747^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1345138 MGI:MGI:1345139	P	occurs_in:(EMAPA:16731)\|occurs_in:(EMAPA:16735)	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:1900087	positive regulation of G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0071338	positive regulation of hair follicle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0071157	negative regulation of cell cycle arrest	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0070075	tear secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
part_of	GO:0062023	collagen-containing extracellular matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	C		Seeded From UniProt	complete
involved_in	GO:0061033	secretion by lung epithelial cell involved in lung growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0060595	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0060447	bud outgrowth involved in lung branching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0060430	lung saccule development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0060428	lung epithelium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0051549	positive regulation of keratinocyte migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0050918	positive chemotaxis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0050677	positive regulation of urothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0050674	urothelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0050673	epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0050671	positive regulation of lymphocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0048754	branching morphogenesis of an epithelial tube	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0046877	regulation of saliva secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0046579	positive regulation of Ras protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0045740	positive regulation of DNA replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0045739	positive regulation of DNA repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
enables	GO:0042056	chemoattractant activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	F		Seeded From UniProt	complete
involved_in	GO:0034394	protein localization to cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0032808	lacrimal gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0032781	positive regulation of ATPase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0031532	actin cytoskeleton reorganization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0010838	positive regulation of keratinocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	C		Seeded From UniProt	complete
enables	GO:0008201	heparin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	F		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	F		Seeded From UniProt	complete
involved_in	GO:0007431	salivary gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	C		Seeded From UniProt	complete
enables	GO:0005111	type 2 fibroblast growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	F		Seeded From UniProt	complete
enables	GO:0005104	fibroblast growth factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	F		Seeded From UniProt	complete
involved_in	GO:0001823	mesonephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0001656	metanephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O15520 ensembl:ENSP00000264664	P		Seeded From UniProt	complete
involved_in	GO:0042246	tissue regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70492 ensembl:ENSRNOP00000016485	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70492 ensembl:ENSRNOP00000016485	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70492 ensembl:ENSRNOP00000016485	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70492 ensembl:ENSRNOP00000016485	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70492 ensembl:ENSRNOP00000016485	P		Seeded From UniProt	complete
involved_in	GO:0001759	organ induction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70492 ensembl:ENSRNOP00000016485	P		Seeded From UniProt	complete
involved_in	GO:0001525	angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70492 ensembl:ENSRNOP00000016485	P		Seeded From UniProt	complete
enables	GO:0005104	fibroblast growth factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028252	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028252	C		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002209	F		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028252	P		Seeded From UniProt	complete
involved_in	GO:0030916	otic vesicle formation	PMID:22235191^[55]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Metzger, DE et al. (2007) Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung. Dev. Dyn. 236 1175-92 PubMed GONUTS page
↑ Sahara, S & O'Leary, DD (2009) Fgf10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors. Neuron 63 48-62 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Sala, FG et al. (2006) Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development. Dev. Biol. 299 373-85 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Veltmaat, JM et al. (2006) Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development 133 2325-35 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Govindarajan, V et al. (2000) Endogenous and ectopic gland induction by FGF-10. Dev. Biol. 225 188-200 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Tang, N et al. (2011) Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape. Science 333 342-5 PubMed GONUTS page
↑ Kuslak, SL et al. (2007) The mouse seminal vesicle shape mutation is allelic with Fgfr2. Development 134 557-65 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Asaki, T et al. (2004) Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo. Mol. Cell. Endocrinol. 218 119-28 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Hyatt, BA et al. (2004) FGF-10 induces SP-C and Bmp4 and regulates proximal-distal patterning in embryonic tracheal epithelium. Am. J. Physiol. Lung Cell Mol. Physiol. 287 L1116-26 PubMed GONUTS page
↑ ^10.0 ^10.1 De Langhe, SP et al. (2006) Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev. Biol. 299 52-62 PubMed GONUTS page
↑ Ohuchi, H et al. (2005) Identification of cis-element regulating expression of the mouse Fgf10 gene during inner ear development. Dev. Dyn. 233 177-87 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 Jaskoll, T et al. (2005) FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis. BMC Dev. Biol. 5 11 PubMed GONUTS page
↑ ^13.0 ^13.1 Yamamoto, S et al. (2008) Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J. Biol. Chem. 283 23139-49 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 Ohuchi, H et al. (2000) FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development. Biochem. Biophys. Res. Commun. 277 643-9 PubMed GONUTS page
↑ Mailleux, AA et al. (2002) Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Development 129 53-60 PubMed GONUTS page
↑ ^16.0 ^16.1 Mailleux, AA et al. (2001) Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis. Mech. Dev. 102 81-94 PubMed GONUTS page
↑ Donjacour, AA et al. (2003) FGF-10 plays an essential role in the growth of the fetal prostate. Dev. Biol. 261 39-54 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 Sekine, K et al. (1999) Fgf10 is essential for limb and lung formation. Nat. Genet. 21 138-41 PubMed GONUTS page
↑ ^19.0 ^19.1 Min, H et al. (1998) Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev. 12 3156-61 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 Ramasamy, SK et al. (2007) Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. Dev. Biol. 307 237-47 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 ^21.3 Mailleux, AA et al. (2005) Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development 132 2157-66 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 Bellusci, S et al. (1997) Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development 124 4867-78 PubMed GONUTS page
↑ ^23.0 ^23.1 Del Moral, PM et al. (2006) VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. Dev. Biol. 290 177-88 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 Li, C et al. (2005) Wnt5a regulates Shh and Fgf10 signaling during lung development. Dev. Biol. 287 86-97 PubMed GONUTS page
↑ Haraguchi, R et al. (2000) Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation. Development 127 2471-9 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 Zhang, X et al. (2006) Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development. Development 133 173-80 PubMed GONUTS page
↑ Sakaue, H et al. (2002) Requirement of fibroblast growth factor 10 in development of white adipose tissue. Genes Dev. 16 908-12 PubMed GONUTS page
↑ ^28.0 ^28.1 ^28.2 ^28.3 ^28.4 ^28.5 Tao, H et al. (2005) A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge cells during mouse eyelid development. Development 132 3217-30 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Suzuki, K et al. () Embryonic development of mouse external genitalia: insights into a unique mode of organogenesis. Evol. Dev. 4 133-41 PubMed GONUTS page
↑ Zelarayan, LC et al. (2007) Differential requirements for FGF3, FGF8 and FGF10 during inner ear development. Dev. Biol. 308 379-91 PubMed GONUTS page
↑ Petiot, A et al. (2003) A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning. Development 130 5493-501 PubMed GONUTS page
↑ Fairbanks, TJ et al. (2004) A genetic mechanism for cecal atresia: the role of the Fgf10 signaling pathway. J. Surg. Res. 120 201-9 PubMed GONUTS page
↑ ^33.0 ^33.1 ^33.2 ^33.3 ^33.4 Spencer-Dene, B et al. (2006) Stomach development is dependent on fibroblast growth factor 10/fibroblast growth factor receptor 2b-mediated signaling. Gastroenterology 130 1233-44 PubMed GONUTS page
↑ Fairbanks, TJ et al. (2004) Fibroblast growth factor 10 (Fgf10) invalidation results in anorectal malformation in mice. J. Pediatr. Surg. 39 360-5; discussion 360-5 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 Hecksher-Sørensen, J et al. (2004) The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2. Development 131 4665-75 PubMed GONUTS page
↑ Grishina, IB et al. (2005) BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling. Dev. Biol. 288 334-47 PubMed GONUTS page
↑ Kumagai, A et al. (2003) Tumor chemopreventive activity of 3-O-acylated (--)-epigallocatechins. Bioorg. Med. Chem. 11 5143-8 PubMed GONUTS page
↑ ^38.0 ^38.1 Suzuki, K et al. (2000) Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene. FEBS Lett. 481 53-6 PubMed GONUTS page
↑ ^39.0 ^39.1 Harada, H et al. (2002) FGF10 maintains stem cell compartment in developing mouse incisors. Development 129 1533-41 PubMed GONUTS page
↑ Pauley, S et al. (2006) Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear. Dev. Dyn. 235 2470-82 PubMed GONUTS page
↑ ^41.0 ^41.1 Entesarian, M et al. (2005) Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands. Nat. Genet. 37 125-7 PubMed GONUTS page
↑ Makarenkova, HP et al. (2000) FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development. Development 127 2563-72 PubMed GONUTS page
↑ Alvarez, Y et al. (2003) Requirements for FGF3 and FGF10 during inner ear formation. Development 130 6329-38 PubMed GONUTS page
↑ Petiot, A et al. (2005) Development of the mammalian urethra is controlled by Fgfr2-IIIb. Development 132 2441-50 PubMed GONUTS page
↑ Ohuchi, H et al. (2003) Fibroblast growth factor 10 is required for proper development of the mouse whiskers. Biochem. Biophys. Res. Commun. 302 562-7 PubMed GONUTS page
↑ Norgaard, GA et al. (2003) FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Dev. Biol. 264 323-38 PubMed GONUTS page
↑ Que, J et al. (2007) Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development 134 2521-31 PubMed GONUTS page
↑ Yu, L et al. (2005) Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate. Development 132 4397-406 PubMed GONUTS page
↑ ^49.0 ^49.1 ^49.2 Rice, R et al. (2004) Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J. Clin. Invest. 113 1692-700 PubMed GONUTS page
↑ Burns, RC et al. (2004) Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse. Dev. Biol. 265 61-74 PubMed GONUTS page
↑ Beer, HD et al. (1997) Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expression. Oncogene 15 2211-8 PubMed GONUTS page
↑ Beyer, TA et al. (2003) Fibroblast growth factor 22 and its potential role during skin development and repair. Exp. Cell Res. 287 228-36 PubMed GONUTS page
↑ Aggarwal, VS et al. (2006) Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy. Hum. Mol. Genet. 15 3219-28 PubMed GONUTS page
↑ Wright, TJ & Mansour, SL (2003) Fgf3 and Fgf10 are required for mouse otic placode induction. Development 130 3379-90 PubMed GONUTS page
↑ Huh, SH et al. (2012) Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. PLoS Biol. 10 e1001231 PubMed GONUTS page

[PMID:17394208-1] 1.0 ^1.1 Metzger, DE et al. (2007) Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung. Dev. Dyn. 236 1175-92 PubMed GONUTS page

[PMID:19607792-2] Sahara, S & O'Leary, DD (2009) Fgf10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors. Neuron 63 48-62 PubMed GONUTS page

[PMID:16956603-3] 3.0 ^3.1 ^3.2 Sala, FG et al. (2006) Fibroblast growth factor 10 is required for survival and proliferation but not differentiation of intestinal epithelial progenitor cells during murine colon development. Dev. Biol. 299 373-85 PubMed GONUTS page

[PMID:16720875-4] 4.0 ^4.1 ^4.2 ^4.3 Veltmaat, JM et al. (2006) Gli3-mediated somitic Fgf10 expression gradients are required for the induction and patterning of mammary epithelium along the embryonic axes. Development 133 2325-35 PubMed GONUTS page

[PMID:10964474-5] 5.0 ^5.1 ^5.2 Govindarajan, V et al. (2000) Endogenous and ectopic gland induction by FGF-10. Dev. Biol. 225 188-200 PubMed GONUTS page

[PMID:21764747-6] 6.0 ^6.1 ^6.2 Tang, N et al. (2011) Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape. Science 333 342-5 PubMed GONUTS page

[PMID:17202188-7] Kuslak, SL et al. (2007) The mouse seminal vesicle shape mutation is allelic with Fgfr2. Development 134 557-65 PubMed GONUTS page

[PMID:15130516-8] 8.0 ^8.1 ^8.2 ^8.3 Asaki, T et al. (2004) Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo. Mol. Cell. Endocrinol. 218 119-28 PubMed GONUTS page

[PMID:15531758-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Hyatt, BA et al. (2004) FGF-10 induces SP-C and Bmp4 and regulates proximal-distal patterning in embryonic tracheal epithelium. Am. J. Physiol. Lung Cell Mol. Physiol. 287 L1116-26 PubMed GONUTS page

[PMID:16989802-10] 10.0 ^10.1 De Langhe, SP et al. (2006) Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung. Dev. Biol. 299 52-62 PubMed GONUTS page

[PMID:15765517-11] Ohuchi, H et al. (2005) Identification of cis-element regulating expression of the mouse Fgf10 gene during inner ear development. Dev. Dyn. 233 177-87 PubMed GONUTS page

[PMID:15972105-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 Jaskoll, T et al. (2005) FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis. BMC Dev. Biol. 5 11 PubMed GONUTS page

[PMID:18559345-13] 13.0 ^13.1 Yamamoto, S et al. (2008) Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression. J. Biol. Chem. 283 23139-49 PubMed GONUTS page

[PMID:11062007-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 Ohuchi, H et al. (2000) FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development. Biochem. Biophys. Res. Commun. 277 643-9 PubMed GONUTS page

[PMID:11782400-15] Mailleux, AA et al. (2002) Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo. Development 129 53-60 PubMed GONUTS page

[PMID:11287183-16] 16.0 ^16.1 Mailleux, AA et al. (2001) Evidence that SPROUTY2 functions as an inhibitor of mouse embryonic lung growth and morphogenesis. Mech. Dev. 102 81-94 PubMed GONUTS page

[PMID:12941620-17] Donjacour, AA et al. (2003) FGF-10 plays an essential role in the growth of the fetal prostate. Dev. Biol. 261 39-54 PubMed GONUTS page

[PMID:9916808-18] 18.0 ^18.1 ^18.2 Sekine, K et al. (1999) Fgf10 is essential for limb and lung formation. Nat. Genet. 21 138-41 PubMed GONUTS page

[PMID:9784490-19] 19.0 ^19.1 Min, H et al. (1998) Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless. Genes Dev. 12 3156-61 PubMed GONUTS page

[PMID:17560563-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 ^20.5 ^20.6 Ramasamy, SK et al. (2007) Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development. Dev. Biol. 307 237-47 PubMed GONUTS page

[PMID:15800000-21] 21.0 ^21.1 ^21.2 ^21.3 Mailleux, AA et al. (2005) Fgf10 expression identifies parabronchial smooth muscle cell progenitors and is required for their entry into the smooth muscle cell lineage. Development 132 2157-66 PubMed GONUTS page

[PMID:9428423-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 Bellusci, S et al. (1997) Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. Development 124 4867-78 PubMed GONUTS page

[PMID:16375885-23] 23.0 ^23.1 Del Moral, PM et al. (2006) VEGF-A signaling through Flk-1 is a critical facilitator of early embryonic lung epithelial to endothelial crosstalk and branching morphogenesis. Dev. Biol. 290 177-88 PubMed GONUTS page

[PMID:16169547-24] 24.0 ^24.1 ^24.2 Li, C et al. (2005) Wnt5a regulates Shh and Fgf10 signaling during lung development. Dev. Biol. 287 86-97 PubMed GONUTS page

[PMID:10804187-25] Haraguchi, R et al. (2000) Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation. Development 127 2471-9 PubMed GONUTS page

[PMID:16308329-26] 26.0 ^26.1 ^26.2 Zhang, X et al. (2006) Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development. Development 133 173-80 PubMed GONUTS page

[PMID:11959839-27] Sakaue, H et al. (2002) Requirement of fibroblast growth factor 10 in development of white adipose tissue. Genes Dev. 16 908-12 PubMed GONUTS page

[PMID:15958512-28] 28.0 ^28.1 ^28.2 ^28.3 ^28.4 ^28.5 Tao, H et al. (2005) A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge cells during mouse eyelid development. Development 132 3217-30 PubMed GONUTS page

[PMID:12004962-29] 29.0 ^29.1 ^29.2 Suzuki, K et al. () Embryonic development of mouse external genitalia: insights into a unique mode of organogenesis. Evol. Dev. 4 133-41 PubMed GONUTS page

[PMID:17601531-30] Zelarayan, LC et al. (2007) Differential requirements for FGF3, FGF8 and FGF10 during inner ear development. Dev. Biol. 308 379-91 PubMed GONUTS page

[PMID:14530295-31] Petiot, A et al. (2003) A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning. Development 130 5493-501 PubMed GONUTS page

[PMID:15234214-32] Fairbanks, TJ et al. (2004) A genetic mechanism for cecal atresia: the role of the Fgf10 signaling pathway. J. Surg. Res. 120 201-9 PubMed GONUTS page

[PMID:16618415-33] 33.0 ^33.1 ^33.2 ^33.3 ^33.4 Spencer-Dene, B et al. (2006) Stomach development is dependent on fibroblast growth factor 10/fibroblast growth factor receptor 2b-mediated signaling. Gastroenterology 130 1233-44 PubMed GONUTS page

[PMID:15017552-34] Fairbanks, TJ et al. (2004) Fibroblast growth factor 10 (Fgf10) invalidation results in anorectal malformation in mice. J. Pediatr. Surg. 39 360-5; discussion 360-5 PubMed GONUTS page

[PMID:15329346-35] 35.0 ^35.1 ^35.2 Hecksher-Sørensen, J et al. (2004) The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2. Development 131 4665-75 PubMed GONUTS page

[PMID:16324690-36] Grishina, IB et al. (2005) BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling. Dev. Biol. 288 334-47 PubMed GONUTS page

[PMID:14604677-37] Kumagai, A et al. (2003) Tumor chemopreventive activity of 3-O-acylated (--)-epigallocatechins. Bioorg. Med. Chem. 11 5143-8 PubMed GONUTS page

[PMID:10984614-38] 38.0 ^38.1 Suzuki, K et al. (2000) Defective terminal differentiation and hypoplasia of the epidermis in mice lacking the Fgf10 gene. FEBS Lett. 481 53-6 PubMed GONUTS page

[PMID:11880361-39] 39.0 ^39.1 Harada, H et al. (2002) FGF10 maintains stem cell compartment in developing mouse incisors. Development 129 1533-41 PubMed GONUTS page

[PMID:16691564-40] Pauley, S et al. (2006) Foxg1 is required for morphogenesis and histogenesis of the mammalian inner ear. Dev. Dyn. 235 2470-82 PubMed GONUTS page

[PMID:15654336-41] 41.0 ^41.1 Entesarian, M et al. (2005) Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands. Nat. Genet. 37 125-7 PubMed GONUTS page

[PMID:10821755-42] Makarenkova, HP et al. (2000) FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development. Development 127 2563-72 PubMed GONUTS page

[PMID:14623822-43] Alvarez, Y et al. (2003) Requirements for FGF3 and FGF10 during inner ear formation. Development 130 6329-38 PubMed GONUTS page

[PMID:15843416-44] Petiot, A et al. (2005) Development of the mammalian urethra is controlled by Fgfr2-IIIb. Development 132 2441-50 PubMed GONUTS page

[PMID:12615071-45] Ohuchi, H et al. (2003) Fibroblast growth factor 10 is required for proper development of the mouse whiskers. Biochem. Biophys. Res. Commun. 302 562-7 PubMed GONUTS page

[PMID:14651921-46] Norgaard, GA et al. (2003) FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Dev. Biol. 264 323-38 PubMed GONUTS page

[PMID:17522155-47] Que, J et al. (2007) Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development 134 2521-31 PubMed GONUTS page

[PMID:16141225-48] Yu, L et al. (2005) Shox2-deficient mice exhibit a rare type of incomplete clefting of the secondary palate. Development 132 4397-406 PubMed GONUTS page

[PMID:15199404-49] 49.0 ^49.1 ^49.2 Rice, R et al. (2004) Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J. Clin. Invest. 113 1692-700 PubMed GONUTS page

[PMID:14697353-50] Burns, RC et al. (2004) Requirement for fibroblast growth factor 10 or fibroblast growth factor receptor 2-IIIb signaling for cecal development in mouse. Dev. Biol. 265 61-74 PubMed GONUTS page

[PMID:9393979-51] Beer, HD et al. (1997) Mouse fibroblast growth factor 10: cDNA cloning, protein characterization, and regulation of mRNA expression. Oncogene 15 2211-8 PubMed GONUTS page

[PMID:12837279-52] Beyer, TA et al. (2003) Fibroblast growth factor 22 and its potential role during skin development and repair. Exp. Cell Res. 287 228-36 PubMed GONUTS page

[PMID:17000704-53] Aggarwal, VS et al. (2006) Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy. Hum. Mol. Genet. 15 3219-28 PubMed GONUTS page

[PMID:12810586-54] Wright, TJ & Mansour, SL (2003) Fgf3 and Fgf10 are required for mouse otic placode induction. Development 130 3379-90 PubMed GONUTS page

[PMID:22235191-55] Huh, SH et al. (2012) Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal. PLoS Biol. 10 e1001231 PubMed GONUTS page

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MOUSE:FGF10

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