GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:12615071
| Citation |
Ohuchi, H, Tao, H, Ohata, K, Itoh, N, Kato, S, Noji, S and Ono, K (2003) Fibroblast growth factor 10 is required for proper development of the mouse whiskers. Biochem. Biophys. Res. Commun. 302:562-7 |
|---|---|
| Abstract |
Fibroblast Growth Factor (FGF) signaling is known to play an important role during cutaneous development. To elucidate the role of FGF10 during whisker formation, we examined the expression of Fgf10 in normal developing whiskers and phenotypes of Fgf10-deficient whiskers. Fgf10 is first expressed in the maxillary process, lateral and medial nasal processes, then in the mesenchymal cells underneath the future whisker placodes, and in the surrounding mesenchyme of developing whiskers. Fgf10-null whiskers exhibit a significant decrease in number and their structure is disorganized as revealed by scanning electron microscopy. Hair follicle marker genes such as Sonic hedgehog, Patched, and Patched 2 are aberrantly expressed in the mutant whiskers. Thus, FGF10 is required for proper whisker development mediated by SHH signaling in the mouse. |
| Links | |
| Keywords |
Animals; Fibroblast Growth Factor 10; Fibroblast Growth Factors/genetics; Fibroblast Growth Factors/physiology; Hedgehog Proteins; Mesoderm/metabolism; Mice; Mice, Knockout; Mice, Transgenic; Microscopy, Electron, Scanning; Phenotype; Signal Transduction; Time Factors; Trans-Activators/metabolism; Vibrissae/embryology; Vibrissae/physiology |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
