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PMID:14604677
| Citation |
Kumagai, A, Nagaoka, Y, Obayashi, T, Terashima, Y, Tokuda, H, Hara, Y, Mukainaka, T, Nishino, H, Kuwajima, H and Uesato, S (2003) Tumor chemopreventive activity of 3-O-acylated (--)-epigallocatechins. Bioorg. Med. Chem. 11:5143-8 |
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| Abstract |
In order to seek promising cancer chemopreventive agents, we assessed the antitumor promoting activities of 3-O-octanoyl- or 3-O-(2-methyloctanoyl)-(--)-epigallocatechins, inhibiting markedly the activation of Epstein-Barr virus early antigen, in a two-stage mouse skin carcinogenesis assay. As a result, these derivatives inhibited a papilloma formation 1.3-1.6-fold more strongly than (--)-epigallocatechin gallate well established as anti-tumor promoter. |
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| Keywords |
Acylation; Animals; Anticarcinogenic Agents/chemistry; Anticarcinogenic Agents/pharmacology; Catechin/analogs & derivatives; Catechin/chemistry; Catechin/pharmacology; Magnetic Resonance Spectroscopy; Mice; Papilloma/prevention & control; Skin Neoplasms/prevention & control; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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