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PMID:15972105

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Citation

Jaskoll, T, Abichaker, G, Witcher, D, Sala, FG, Bellusci, S, Hajihosseini, MK and Melnick, M (2005) FGF10/FGFR2b signaling plays essential roles during in vivo embryonic submandibular salivary gland morphogenesis. BMC Dev. Biol. 5:11

Abstract

Analyses of Fgf10 and Fgfr2b mutant mice, as well as human studies, suggest that FGF10/FGFR2b signaling may play an essential, nonredundant role during embryonic SMG development. To address this question, we have analyzed the SMG phenotype in Fgf10 and Fgfr2b heterozygous and null mutant mice. In addition, although previous studies suggest that the FGF10/FGFR2b and FGF8/FGFR2c signaling pathways are functionally interrelated, little is known about the functional relationship between these two pathways during SMG development. We have designed in vivo and in vitro experiments to address this question.

Links

PubMed PMC1184065 Online version:10.1186/1471-213X-5-11

Keywords

Animals; Cell Proliferation; Embryo, Mammalian; Epithelial Cells/cytology; Fibroblast Growth Factor 10/genetics; Fibroblast Growth Factor 10/physiology; Fibroblast Growth Factor 8/physiology; Genotype; Mice; Mice, Knockout; Morphogenesis; Receptor, Fibroblast Growth Factor, Type 2/genetics; Receptor, Fibroblast Growth Factor, Type 2/physiology; Signal Transduction/physiology; Submandibular Gland/cytology; Submandibular Gland/embryology; Submandibular Gland/growth & development

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:FGF10

acts_upstream_of_or_within

GO:0050679: positive regulation of epithelial cell proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

Seeded From UniProt

complete

MOUSE:FGFR2

acts_upstream_of_or_within

GO:0008543: fibroblast growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1099809

P

  • occurs_in:(CL:0000066)
  • occurs_in:(EMAPA:17756)

Seeded From UniProt

complete

MOUSE:FGFR2

acts_upstream_of_or_within

GO:0050679: positive regulation of epithelial cell proliferation

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1099809

P

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0060667: branch elongation involved in salivary gland morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0060664: epithelial cell proliferation involved in salivary gland morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:95523

P

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0060664: epithelial cell proliferation involved in salivary gland morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0060445: branching involved in salivary gland morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:95523

P

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0050678: regulation of epithelial cell proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

Seeded From UniProt

complete

MOUSE:FGFR2

acts_upstream_of_or_within

GO:0050679: positive regulation of epithelial cell proliferation

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1098809

P

Seeded From UniProt

complete

MOUSE:FGFR2

acts_upstream_of_or_within

GO:0008543: fibroblast growth factor receptor signaling pathway

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1099809

P

  • occurs_in:(EMAPA:17756)
  • occurs_in:(CL:0000066)

Seeded From UniProt

complete

MOUSE:FGFR2

acts_upstream_of_or_within

GO:0060664: epithelial cell proliferation involved in salivary gland morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2153811

P

Seeded From UniProt

complete

MOUSE:FGFR2

acts_upstream_of_or_within

GO:0060664: epithelial cell proliferation involved in salivary gland morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1099809

P

Seeded From UniProt

complete

MOUSE:FGFR2

acts_upstream_of_or_within

GO:0060667: branch elongation involved in salivary gland morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2153811

P

Seeded From UniProt

complete

MOUSE:FGFR2

acts_upstream_of_or_within

GO:0060667: branch elongation involved in salivary gland morphogenesis

ECO:0000316: genetic interaction evidence used in manual assertion

MGI:MGI:1099809

P

Seeded From UniProt

complete


See also

References

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