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PMID:11062007

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Citation

Ohuchi, H, Hori, Y, Yamasaki, M, Harada, H, Sekine, K, Kato, S and Itoh, N (2000) FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development. Biochem. Biophys. Res. Commun. 277:643-9

Abstract

FGF receptor 2 isoform IIIb (FGFR2b), originally discovered as a receptor for FGF7, is known to be an important receptor in vertebrate morphogenesis, because FGFR2b null mice exhibit agenesis or dysgenesis of various organs, which undergo budding and branching morphogenesis. Since FGF7 null mice do not exhibit marked defects in organogenesis, it has been considered that other FGF(s) than FGF7 might function as a major ligand for FGFR2b during organogenesis. One of the candidate ligands is FGF10, because FGF10 binds to FGFR2b with high affinity and the formation of the limb and lung is arrested in FGF10 null mice as found in FGFR2b-deficient mice. Previous analyses of FGF10 null mice revealed that FGF10 is required for limb and lung development. To elucidate the role of FGF10 in wide-range organogenesis, we further analyzed the phenotypes of the FGF10 knockout mice. We found diverse phenotypes closely related to those for FGFR2b-deficient mice, which includes the absence of thyroid, pituitary, and salivary glands, while minor defects were observed in the formation of teeth, kidneys, hair follicles, and digestive organs. These results suggest that FGF10 acts as a major ligand for FGFR2b in mouse multi-organ development.

Links

PubMed Online version:10.1006/bbrc.2000.3721

Keywords

Animals; Apoptosis; Dental Enamel Hypoplasia/physiopathology; Embryonic and Fetal Development/physiology; Fibroblast Growth Factor 10; Fibroblast Growth Factors/metabolism; Gonadal Dysgenesis/physiopathology; Mice; Mice, Knockout; Phenotype; Pituitary Gland/cytology; Pituitary Gland/growth & development; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor/metabolism; Signal Transduction; Skin/cytology; Skin/growth & development

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:FGF10

acts_upstream_of_or_within

GO:0021983: pituitary gland development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

  • results_in_development_of:(EMAPA:16898)

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0031069: hair follicle morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0030878: thyroid gland development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

  • results_in_development_of:(EMAPA:17068)

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0003338: metanephros morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0060661: submandibular salivary gland formation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

  • results_in_formation_of:(EMAPA:17751)

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0048645: animal organ formation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

  • results_in_formation_of:(EMAPA:16898)

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0042475: odontogenesis of dentin-containing tooth

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0042472: inner ear morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0031069: hair follicle morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

has_participant:(EMAPA:35246)

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0042472: inner ear morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

has_participant:(EMAPA:16194)

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0042475: odontogenesis of dentin-containing tooth

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

has_participant:(EMAPA:32906)

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0060661: submandibular salivary gland formation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

results_in_formation_of:(EMAPA:17751)

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0030878: thyroid gland development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

results_in_development_of:(EMAPA:17068)

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0021983: pituitary gland development

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

results_in_development_of:(EMAPA:16898)

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0003338: metanephros morphogenesis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

has_participant:(EMAPA:17373)

Seeded From UniProt

complete

MOUSE:FGF10

acts_upstream_of_or_within

GO:0048645: animal organ formation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:1859647

P

results_in_formation_of:(EMAPA:16898)

Seeded From UniProt

complete


See also

References

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