MOUSE:BTK

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Btk (synonyms: Bpk)
Protein Name(s)	Tyrosine-protein kinase BTK Agammaglobulinemia tyrosine kinase ATK B-cell progenitor kinase BPK Bruton tyrosine kinase Kinase EMB
External Links
UniProt	P35991
EMBL	L08967 L10627 L29788 U58105
CCDS	CCDS30396.1
PIR	I49553
RefSeq	NP_038510.2 XP_006528546.1 XP_006528547.1 XP_006528548.1
UniGene	Mm.4475
ProteinModelPortal	P35991
SMR	P35991
BioGrid	198400
IntAct	P35991
MINT	MINT-1549372
PhosphoSite	P35991
MaxQB	P35991
PaxDb	P35991
PRIDE	P35991
Ensembl	ENSMUST00000033617
GeneID	12229
KEGG	mmu:12229
UCSC	uc009uge.2
CTD	695
MGI	MGI:88216
eggNOG	COG0515
GeneTree	ENSGT00760000119011
HOGENOM	HOG000233859
HOVERGEN	HBG008761
InParanoid	P35991
KO	K07370
OMA	KYGKWQG
OrthoDB	EOG7KM5SC
PhylomeDB	P35991
TreeFam	TF351634
BRENDA	2.7.10.2
Reactome	REACT_188185 REACT_188194 REACT_188202 REACT_230045
NextBio	280647
PRO	PR:P35991
Proteomes	UP000000589
Bgee	P35991
CleanEx	MM_BTK
ExpressionAtlas	P35991
Genevestigator	P35991
GO	GO:0005737 GO:0031410 GO:0005829 GO:0042629 GO:0045121 GO:0005634 GO:0048471 GO:0005886 GO:0005524 GO:0046872 GO:0004715 GO:0005547 GO:0004713 GO:0006915 GO:0048469 GO:0071226 GO:0034614 GO:0002553 GO:0007249 GO:0045087 GO:0018108 GO:0046777 GO:0006468 GO:0006355 GO:0006351
Gene3D	2.30.29.30 3.30.505.10
InterPro	IPR011009 IPR001849 IPR011993 IPR000719 IPR017441 IPR001245 IPR000980 IPR001452 IPR008266 IPR020635 IPR001562
Pfam	PF00779 PF00169 PF07714 PF00017 PF00018
PRINTS	PR00401 PR00452 PR00402 PR00109
SMART	SM00107 SM00233 SM00252 SM00326 SM00219
SUPFAM	SSF50044 SSF55550 SSF56112
PROSITE	PS50003 PS00107 PS50011 PS00109 PS50001 PS50002 PS51113

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001818	negative regulation of cytokine production	PMID:23544144^[1]	ECO:0000315			P		Figure 2 - Btk regulates cytokine production thus activating an immune response.	complete CACAO 7399
	GO:0033625	positive regulation of integrin activation	PMID:20167705^[2]	ECO:0000314			P		Figure 1 - The Tec family kinase Btk is required for E-selectin–mediated slow rolling (integrin activation)	complete CACAO 7519
involved_in	GO:0001818	negative regulation of cytokine production	PMID:23544144^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000700360 UniProtKB:P42680	P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102960 MGI:MGI:96621 PANTHER:PTN000700360	P		Seeded From UniProt	complete
involved_in	GO:0038083	peptidyl-tyrosine autophosphorylation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231474 UniProtKB:P42680	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231474 UniProtKB:P42680 UniProtKB:P51813 UniProtKB:Q08881	F		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:102960 MGI:MGI:96621 PANTHER:PTN000700360	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:8630736^[4]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:7565679^[5]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098761	cellular response to interleukin-7	PMID:7680896^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856317	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071226	cellular response to molecule of fungal origin	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359683	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359683	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048469	cell maturation	PMID:14734712^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2449487	P	occurs_in:(EMAPA:32760) results_in_maturation_of:(CL:0000816)\|occurs_in(EMAPA:18767) results_in_maturation_of:(CL:0000816)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359683	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06187	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06187	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034614	cellular response to reactive oxygen species	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359683	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:14657254^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030889	negative regulation of B cell proliferation	PMID:7680896^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856317	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	PMID:10872802^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06187	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010033	response to organic substance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359683	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007249	I-kappaB kinase/NF-kappaB signaling	PMID:14597404^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:12235209^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06187	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06187	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11007757^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11007757^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06187	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:11007757^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:10872802^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q06187	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359683	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002553	histamine secretion by mast cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359683	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002344	B cell affinity maturation	PMID:7680896^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856317	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001812	positive regulation of type I hypersensitivity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359683	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001805	positive regulation of type III hypersensitivity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1359683	P		Seeded From UniProt	complete
part_of	GO:0042629	mast cell granule	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0002553	C		Seeded From UniProt	complete
part_of	GO:0042629	mast cell granule	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0002553	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06187 ensembl:ENSP00000483570	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06187 ensembl:ENSP00000483570	F		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06187 ensembl:ENSP00000483570	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06187 ensembl:ENSP00000483570	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06187 ensembl:ENSP00000483570	C		Seeded From UniProt	complete
enables	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q06187 ensembl:ENSP00000483570	F		Seeded From UniProt	complete
involved_in	GO:0071226	cellular response to molecule of fungal origin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	C		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	P		Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	F		Seeded From UniProt	complete
involved_in	GO:0002553	histamine secretion by mast cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	P		Seeded From UniProt	complete
involved_in	GO:0001812	positive regulation of type I hypersensitivity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	P		Seeded From UniProt	complete
involved_in	GO:0001805	positive regulation of type III hypersensitivity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A0G2K134 ensembl:ENSRNOP00000071684	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR020635	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001562	P		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-9607033 Reactome:R-MMU-9607032 Reactome:R-MMU-2730850	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0446	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Köprülü, AD et al. (2013) The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection. PLoS ONE 8 e60476 PubMed GONUTS page
↑ Mueller, H et al. (2010) Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways. Blood 115 3118-27 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Park, H et al. (1996) Regulation of Btk function by a major autophosphorylation site within the SH3 domain. Immunity 4 515-25 PubMed GONUTS page
↑ Mahajan, S et al. (1995) Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase. Mol. Cell. Biol. 15 5304-11 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Narendran, A et al. (1993) B cell developmental defects in X-linked immunodeficiency. Int. Immunol. 5 139-44 PubMed GONUTS page
↑ Middendorp, S & Hendriks, RW (2004) Cellular maturation defects in Bruton's tyrosine kinase-deficient immature B cells are amplified by premature B cell receptor expression and reduced by receptor editing. J. Immunol. 172 1371-9 PubMed GONUTS page
↑ Kraemer, FB et al. (2004) Hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesis. Mol. Endocrinol. 18 549-57 PubMed GONUTS page
↑ ^9.0 ^9.1 Iseki, M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem. Biophys. Res. Commun. 272 45-54 PubMed GONUTS page
↑ Antony, P et al. (2003) B cell receptor directs the activation of NFAT and NF-kappaB via distinct molecular mechanisms. Exp. Cell Res. 291 11-24 PubMed GONUTS page
↑ Clayton, E et al. (2002) A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J. Exp. Med. 196 753-63 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Kikuchi, Y et al. (2000) Identification and characterization of a molecule, BAM11, that associates with the pleckstrin homology domain of mouse Btk. Int. Immunol. 12 1397-408 PubMed GONUTS page

[PMID:23544144-1] 1.0 ^1.1 Köprülü, AD et al. (2013) The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection. PLoS ONE 8 e60476 PubMed GONUTS page

[PMID:20167705-2] Mueller, H et al. (2010) Tyrosine kinase Btk regulates E-selectin-mediated integrin activation and neutrophil recruitment by controlling phospholipase C (PLC) gamma2 and PI3Kgamma pathways. Blood 115 3118-27 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8630736-4] Park, H et al. (1996) Regulation of Btk function by a major autophosphorylation site within the SH3 domain. Immunity 4 515-25 PubMed GONUTS page

[PMID:7565679-5] Mahajan, S et al. (1995) Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase. Mol. Cell. Biol. 15 5304-11 PubMed GONUTS page

[PMID:7680896-6] 6.0 ^6.1 ^6.2 Narendran, A et al. (1993) B cell developmental defects in X-linked immunodeficiency. Int. Immunol. 5 139-44 PubMed GONUTS page

[PMID:14734712-7] Middendorp, S & Hendriks, RW (2004) Cellular maturation defects in Bruton's tyrosine kinase-deficient immature B cells are amplified by premature B cell receptor expression and reduced by receptor editing. J. Immunol. 172 1371-9 PubMed GONUTS page

[PMID:14657254-8] Kraemer, FB et al. (2004) Hormone-sensitive lipase is required for high-density lipoprotein cholesteryl ester-supported adrenal steroidogenesis. Mol. Endocrinol. 18 549-57 PubMed GONUTS page

[PMID:10872802-9] 9.0 ^9.1 Iseki, M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem. Biophys. Res. Commun. 272 45-54 PubMed GONUTS page

[PMID:14597404-10] Antony, P et al. (2003) B cell receptor directs the activation of NFAT and NF-kappaB via distinct molecular mechanisms. Exp. Cell Res. 291 11-24 PubMed GONUTS page

[PMID:12235209-11] Clayton, E et al. (2002) A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J. Exp. Med. 196 753-63 PubMed GONUTS page

[PMID:11007757-12] 12.0 ^12.1 ^12.2 Kikuchi, Y et al. (2000) Identification and characterization of a molecule, BAM11, that associates with the pleckstrin homology domain of mouse Btk. Int. Immunol. 12 1397-408 PubMed GONUTS page

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MOUSE:BTK

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