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PMID:12235209

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Citation

Clayton, E, Bardi, G, Bell, SE, Chantry, D, Downes, CP, Gray, A, Humphries, LA, Rawlings, D, Reynolds, H, Vigorito, E and Turner, M (2002) A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation. J. Exp. Med. 196:753-63

Abstract

Mice lacking the p110delta catalytic subunit of phosphatidylinositol 3-kinase have reduced numbers of B1 and marginal zone B cells, reduced levels of serum immunoglobulins, respond poorly to immunization with type II thymus-independent antigen, and are defective in their primary and secondary responses to thymus-dependent antigen. p110delta(-/-) B cells proliferate poorly in response to B cell receptor (BCR) or CD40 signals in vitro, fail to activate protein kinase B, and are prone to apoptosis. p110delta function is required for BCR-mediated calcium flux, activation of phosphlipaseCgamma2, and Bruton's tyrosine kinase. Thus, p110delta plays a critical role in B cell homeostasis and function.

Links

PubMed PMC2194055

Keywords

Animals; Antibody Formation; B-Lymphocytes/physiology; Calcium/metabolism; Isoenzymes/physiology; Lymphocyte Activation; Male; Mice; Mice, Knockout; Phosphatidylinositol 3-Kinases/physiology; Phosphatidylinositol Phosphates/biosynthesis; Phospholipase C gamma; Protein Subunits; Protein-Serine-Threonine Kinases; Protein-Tyrosine Kinases/physiology; Proto-Oncogene Proteins/physiology; Proto-Oncogene Proteins c-akt; Receptors, Antigen, B-Cell/physiology; Type C Phospholipases/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:PK3CD

acts_upstream_of_or_within

GO:0001782: B cell homeostasis

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2388047

P

Seeded From UniProt

complete

MOUSE:PK3CD

acts_upstream_of_or_within

GO:0007166: cell surface receptor signaling pathway

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2388047

P

Seeded From UniProt

complete

MOUSE:PK3CD

acts_upstream_of_or_within

GO:0042113: B cell activation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:2388047

P

Seeded From UniProt

complete

MOUSE:BTK

acts_upstream_of_or_within

GO:0006468: protein phosphorylation

ECO:0000314: direct assay evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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