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PMID:23544144
| Citation |
Köprülü, AD, Kastner, R, Wienerroither, S, Lassnig, C, Putz, EM, Majer, O, Reutterer, B, Sexl, V, Kuchler, K, Müller, M, Decker, T and Ellmeier, W (2013) The Tyrosine Kinase Btk Regulates the Macrophage Response to Listeria monocytogenes Infection. PLoS ONE 8:e60476 |
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| Abstract |
In this study we investigated the role of Bruton's tyrosine kinase (Btk) in the immune response to the Gram-positive intracellular bacterium Listeria monocytogenes (Lm). In response to Lm infection, Btk was activated in bone marrow-derived macrophages (BMMs) and Btk (-/-) BMMs showed enhanced TNF-α, IL-6 and IL-12p40 secretion, while type I interferons were produced at levels similar to wild-type (wt) BMMs. Although Btk-deficient BMMs displayed reduced phagocytosis of E. coli fragments, there was no difference between wt and Btk (-/-) BMMs in the uptake of Lm upon infection. Moreover, there was no difference in the response to heat-killed Lm between wt and Btk (-/-) BMMs, suggesting a role for Btk in signaling pathways that are induced by intracellular Lm. Finally, Btk (-/-) mice displayed enhanced resistance and an increased mean survival time upon Lm infection in comparison to wt mice. This correlated with elevated IFN-γ and IL-12p70 serum levels in Btk (-/-) mice at day 1 after infection. Taken together, our data suggest an important regulatory role for Btk in macrophages during Lm infection. |
| Links |
PubMed PMC3609758 Online version:10.1371/journal.pone.0060476 |
| Keywords |
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| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| GO:0001818: negative regulation of cytokine production |
ECO:0000315: |
P |
Figure 2 - Btk regulates cytokine production thus activating an immune response. |
complete | ||||
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involved_in |
GO:0001818: negative regulation of cytokine production |
ECO:0000315: mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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