HUMAN:SOX9

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	SOX9
Protein Name(s)	Transcription factor SOX-9
External Links
UniProt	P48436
EMBL	Z46629 S74506 S74504 S74505 BT006875 CH471099 BC007951 BC056420
CCDS	CCDS11689.1
PIR	A55204
RefSeq	NP_000337.1
UniGene	Hs.647409
PDB	1S9M 1SX9 4EUW
PDBsum	1S9M 1SX9 4EUW
ProteinModelPortal	P48436
SMR	P48436
BioGrid	112545
IntAct	P48436
STRING	9606.ENSP00000245479
PhosphoSite	P48436
DMDM	1351096
MaxQB	P48436
PaxDb	P48436
PRIDE	P48436
DNASU	6662
Ensembl	ENST00000245479
GeneID	6662
KEGG	hsa:6662
UCSC	uc002jiw.3
CTD	6662
GeneCards	GC17P070117
GeneReviews	SOX9
HGNC	HGNC:11204
HPA	CAB022456 HPA001758
MIM	114290 278850 608160
neXtProt	NX_P48436
Orphanet	2138 393 140 718
PharmGKB	PA36041
eggNOG	NOG295709
GeneTree	ENSGT00760000118988
HOGENOM	HOG000108876
HOVERGEN	HBG002061
InParanoid	P48436
KO	K18435
OMA	STFTYMS
OrthoDB	EOG7Q2N5K
PhylomeDB	P48436
SignaLink	P48436
ChiTaRS	SOX9
GeneWiki	SOX9
GenomeRNAi	6662
NextBio	25973
PRO	PR:P48436
Proteomes	UP000005640
Bgee	P48436
CleanEx	HS_SOX9
ExpressionAtlas	P48436
Genevestigator	P48436
GO	GO:0044798 GO:0005634 GO:0043234 GO:0003682 GO:0001046 GO:0035326 GO:0001158 GO:0097157 GO:0034236 GO:0004672 GO:0001077 GO:0003705 GO:0003700 GO:0060018 GO:0001658 GO:0019933 GO:0001502 GO:0051216 GO:0001708 GO:0071364 GO:0071504 GO:0071347 GO:0071260 GO:0071300 GO:0071560 GO:0003413 GO:0003415 GO:0006338 GO:0090103 GO:0007010 GO:0003203 GO:0031018 GO:0007173 GO:0060517 GO:0001837 GO:0060441 GO:0070371 GO:0030198 GO:0001942 GO:0003170 GO:0003188 GO:0003179 GO:0060729 GO:0035622 GO:0060174 GO:0060487 GO:0019100 GO:0008584 GO:0030879 GO:0072289 GO:0061138 GO:0043066 GO:0070168 GO:0030502 GO:0090090 GO:0032331 GO:0030857 GO:0050680 GO:0002683 GO:2001054 GO:0045662 GO:0030279 GO:0046533 GO:0045892 GO:0014032 GO:0030903 GO:0006334 GO:0048709 GO:0001503 GO:0030916 GO:0090190 GO:0061036 GO:0008284 GO:2000138 GO:0032332 GO:0030858 GO:0010634 GO:0050679 GO:1901203 GO:0090184 GO:2000020 GO:0002053 GO:2000741 GO:0014068 GO:0045732 GO:0001934 GO:0045944 GO:0045893 GO:0030850 GO:0006461 GO:0043491 GO:0042981 GO:0061046 GO:0030155 GO:0010564 GO:0042127 GO:0060784 GO:2000794 GO:0072034 GO:0060041 GO:0060221 GO:0060009 GO:0060008 GO:0007165 GO:0016337 GO:0001501 GO:0035019 GO:0007283 GO:0001894 GO:0006366 GO:0072197 GO:0072193 GO:0072190
Gene3D	1.10.30.10
InterPro	IPR009071 IPR029548 IPR022151
PANTHER	PTHR10270:SF212
Pfam	PF00505 PF12444
SMART	SM00398
SUPFAM	SSF47095
PROSITE	PS50118

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:29503843^[1]	ECO:0000314			P		Fig 2A and 2B, Sox9 down-regulates BMP2-induced expression of Smad7. Organism: Human	complete CACAO 13152
	GO:0030279	negative regulation of ossification	PMID:29503843^[1]	ECO:0000314			P		Fig; 4 A-c shows that mineral is significantly decreased with BMP2 and Sox9 compared to the control of just BMP2. Organism: Human	complete CACAO 13212
	GO:0061036	positive regulation of cartilage development	PMID:29503843^[1]	ECO:0000314			P		“Alcian blue staining analysis indicates that Sox9 significantly promoted BMP2-induced cartilage formation from MSCs (Figure 4C-c)” Organism: Human	complete CACAO 13281
	GO:1902732	positive regulation of chondrocyte proliferation	PMID:29503843^[1]	ECO:0000314			P		At the endpoint we analyzed the cultured explants histologically and found that BMP2 promoted a coordinated expansion of cartilage zones at the growth plat, while Sox9 overexpression enhanced BMP2-induced expansion of proliferating chondrocyte zone (Figure 5Bb)” Organism: Human	complete CACAO 13283
involved_in	GO:0010628	positive regulation of gene expression	PMID:24681825^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q149M9)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[3]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR009071	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:22110751^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000139219)	Seeded From UniProt	complete
involved_in	GO:0003180	aortic valve morphogenesis	PMID:22110751^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002137)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q04890	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26634652^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002618)	Seeded From UniProt	complete
involved_in	GO:1902894	negative regulation of pri-miRNA transcription by RNA polymerase II	PMID:26687115^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_transcription_of:(ENSEMBL:ENSG00000226380)	Seeded From UniProt	complete
involved_in	GO:0071773	cellular response to BMP stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48434	P		Seeded From UniProt	complete
involved_in	GO:0014036	neural crest cell fate specification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48434	P		Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48434	P		Seeded From UniProt	complete
involved_in	GO:0001502	cartilage condensation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48434	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O18896	C	part_of:(CL:0000115) part_of:(UBERON:0002137)	Seeded From UniProt	complete
involved_in	GO:0070168	negative regulation of biomineral tissue development	PMID:22110751^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(UBERON:0002137) part_of:(GO:0003180)	Seeded From UniProt	complete
involved_in	GO:2000741	positive regulation of mesenchymal stem cell differentiation	PMID:21401405^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000020	positive regulation of male gonad development	PMID:21412441^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0090184	positive regulation of kidney development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0090103	cochlea morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0072289	metanephric nephron tubule formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0072034	renal vesicle induction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	PMID:21401405^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071504	cellular response to heparin	PMID:21512138^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	PMID:21512138^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	PMID:20079164^[10]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	PMID:12420222^[11]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:21512138^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	PMID:21512138^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0070168	negative regulation of biomineral tissue development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0061138	morphogenesis of a branching epithelium	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0061036	positive regulation of cartilage development	PMID:21401405^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060784	regulation of cell proliferation involved in tissue homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0060729	intestinal epithelial structure maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0060517	epithelial cell proliferation involved in prostatic bud elongation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0060221	retinal rod cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0060041	retina development in camera-type eye	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0060008	Sertoli cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	PMID:20103652^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0046533	negative regulation of photoreceptor cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:8640233^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20530484^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20651055^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:10805756^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:20651055^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045662	negative regulation of myoblast differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:20530484^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21367821^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
enables	GO:0035326	enhancer binding	PMID:10805756^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
enables	GO:0034236	protein kinase A catalytic subunit binding	PMID:10805756^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P05132	F		Seeded From UniProt	complete
involved_in	GO:0032332	positive regulation of chondrocyte differentiation	PMID:20676705^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032332	positive regulation of chondrocyte differentiation	PMID:21401405^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032331	negative regulation of chondrocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0030916	otic vesicle formation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0030858	positive regulation of epithelial cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	PMID:20103652^[12]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030279	negative regulation of ossification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0019933	cAMP-mediated signaling	PMID:10805756^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019100	male germ-line sex determination	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	PMID:21512138^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010564	regulation of cell cycle process	PMID:12420222^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	PMID:8640233^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	PMID:17848411^[19]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:20651055^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	PMID:21512138^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	PMID:20530484^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006338	chromatin remodeling	PMID:20484372^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006334	nucleosome assembly	PMID:20484372^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10805756^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18512230^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12420222^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:8640233^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:20484372^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21412441^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0000165)	Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:8640233^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:10805756^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	PMID:20484372^[20]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003415	chondrocyte hypertrophy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0003413	chondrocyte differentiation involved in endochondral bone morphogenesis	PMID:20676705^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0003203	endocardial cushion morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0003179	heart valve morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0003170	heart valve development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0002683	negative regulation of immune system process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0001942	hair follicle development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0001894	tissue homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0001708	cell fate specification	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0001502	cartilage condensation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	P		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	PMID:8640233^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001158	enhancer sequence-specific DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q04887	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:20484372^[20]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:21367821^[17]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:20530484^[14]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:20530484^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0048709	oligodendrocyte differentiation	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98358 MGI:MGI:98370 MGI:MGI:98371 PANTHER:PTN001615967 UniProtKB:P57074	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98358 MGI:MGI:98370 MGI:MGI:98371 PANTHER:PTN000741645 RGD:620474 UniProtKB:O18896 UniProtKB:P48436 UniProtKB:P57073	P		Seeded From UniProt	complete
involved_in	GO:0032332	positive regulation of chondrocyte differentiation	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98371 PANTHER:PTN000030548 UniProtKB:P48436	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98371 PANTHER:PTN000030548	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98371 PANTHER:PTN001615967	P		Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98371 PANTHER:PTN000030548 UniProtKB:P48434	P		Seeded From UniProt	complete
involved_in	GO:0002009	morphogenesis of an epithelium	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000741645 UniProtKB:P48434	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:21873635^[22]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:98371 PANTHER:PTN000741645	F		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0060009	Sertoli cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LYL9 ensembl:ENSRNOP00000003511	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LYL9 ensembl:ENSRNOP00000003511	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LYL9 ensembl:ENSRNOP00000003511	P		Seeded From UniProt	complete
enables	GO:0043425	bHLH transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LYL9 ensembl:ENSRNOP00000003511	F		Seeded From UniProt	complete
enables	GO:0035326	enhancer binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LYL9 ensembl:ENSRNOP00000003511	F		Seeded From UniProt	complete
involved_in	GO:0019933	cAMP-mediated signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LYL9 ensembl:ENSRNOP00000003511	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LYL9 ensembl:ENSRNOP00000003511	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LYL9 ensembl:ENSRNOP00000003511	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LYL9 ensembl:ENSRNOP00000003511	F		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:F1LYL9 ensembl:ENSRNOP00000003511	F		Seeded From UniProt	complete
involved_in	GO:2001054	negative regulation of mesenchymal cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:2000794	regulation of epithelial cell proliferation involved in lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:1901203	positive regulation of extracellular matrix assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
enables	GO:0097157	pre-mRNA intronic binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	F		Seeded From UniProt	complete
involved_in	GO:0097065	anterior head development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0090184	positive regulation of kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0090103	cochlea morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0072289	metanephric nephron tubule formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0072197	ureter morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0072193	ureter smooth muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0072190	ureter urothelium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0072189	ureter development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0072170	metanephric tubule development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0072034	renal vesicle induction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0071599	otic vesicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0071560	cellular response to transforming growth factor beta stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0071504	cellular response to heparin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0071364	cellular response to epidermal growth factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0070384	Harderian gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0070168	negative regulation of biomineral tissue development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0061145	lung smooth muscle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0061138	morphogenesis of a branching epithelium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0061046	regulation of branching involved in lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0061036	positive regulation of cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0060784	regulation of cell proliferation involved in tissue homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0060729	intestinal epithelial structure maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0060534	trachea cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0060532	bronchus cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0060517	epithelial cell proliferation involved in prostatic bud elongation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0060512	prostate gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0060487	lung epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0060441	epithelial tube branching involved in lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0060350	endochondral bone morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0060221	retinal rod cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0060174	limb bud formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0060041	retina development in camera-type eye	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0060018	astrocyte fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0060009	Sertoli cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0060008	Sertoli cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0051216	cartilage development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0050680	negative regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0048873	homeostasis of number of cells within a tissue	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0048709	oligodendrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	F		Seeded From UniProt	complete
involved_in	GO:0046533	negative regulation of photoreceptor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0045662	negative regulation of myoblast differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0045595	regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
part_of	GO:0044798	nuclear transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	C		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	F		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	F		Seeded From UniProt	complete
involved_in	GO:0043491	protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0035622	intrahepatic bile duct development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
enables	GO:0035326	enhancer binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	F		Seeded From UniProt	complete
involved_in	GO:0035019	somatic stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0034504	protein localization to nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0032808	lacrimal gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0032332	positive regulation of chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0032331	negative regulation of chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0031018	endocrine pancreas development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0030916	otic vesicle formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0030903	notochord development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0030879	mammary gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0030858	positive regulation of epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0030857	negative regulation of epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0030850	prostate gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0030502	negative regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0030279	negative regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0030238	male sex determination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0030198	extracellular matrix organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0030155	regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0019100	male germ-line sex determination	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0014032	neural crest cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0010634	positive regulation of epithelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0010629	negative regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0007173	epidermal growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0007010	cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	F		Seeded From UniProt	complete
involved_in	GO:0003415	chondrocyte hypertrophy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0003203	endocardial cushion morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0003188	heart valve formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0003179	heart valve morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0003170	heart valve development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0002683	negative regulation of immune system process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0002063	chondrocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0002062	chondrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0002053	positive regulation of mesenchymal cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0001942	hair follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0001894	tissue homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0001837	epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0001708	cell fate specification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
involved_in	GO:0001502	cartilage condensation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	F		Seeded From UniProt	complete
enables	GO:0001158	enhancer sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	F		Seeded From UniProt	complete
enables	GO:0000976	transcription regulatory region sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q04887 ensembl:ENSMUSP00000000579	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029548	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029548	C		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR029548	P		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	Reactome:R-HSA-212436	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8985343 Reactome:R-HSA-5626938	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Zhao, C et al. (2017) Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells (MSCs). Genes Dis 4 229-239 PubMed GONUTS page
↑ Correa, RG et al. (2014) The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling. Oncotarget 5 1666-82 PubMed GONUTS page
↑ ^3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 Acharya, A et al. (2011) Inhibitory role of Notch1 in calcific aortic valve disease. PLoS ONE 6 e27743 PubMed GONUTS page
↑ Huk, DJ et al. (2016) Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification. Arterioscler. Thromb. Vasc. Biol. 36 328-38 PubMed GONUTS page
↑ Le, LT et al. (2016) The microRNA-29 family in cartilage homeostasis and osteoarthritis. J. Mol. Med. 94 583-96 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Kim, HJ & Im, GI (2011) Electroporation-mediated transfer of SOX trio genes (SOX-5, SOX-6, and SOX-9) to enhance the chondrogenesis of mesenchymal stem cells. Stem Cells Dev. 20 2103-14 PubMed GONUTS page
↑ ^8.0 ^8.1 Knower, KC et al. (2011) Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations. PLoS ONE 6 e17751 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Ling, S et al. (2011) An EGFR-ERK-SOX9 signaling cascade links urothelial development and regeneration to cancer. Cancer Res. 71 3812-21 PubMed GONUTS page
↑ Yu, ZG et al. (2009) Interleukin-1 inhibits Sox9 and collagen type II expression via nuclear factor-kappaB in the cultured human intervertebral disc cells. Chin. Med. J. 122 2483-8 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Afonja, O et al. (2002) RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition. Oncogene 21 7850-60 PubMed GONUTS page
↑ ^12.0 ^12.1 Thomsen, MK et al. (2010) SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation. Cancer Res. 70 979-87 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Südbeck, P et al. (1996) Sex reversal by loss of the C-terminal transactivation domain of human SOX9. Nat. Genet. 13 230-2 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 Masuda, T & Esumi, N (2010) SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium. J. Biol. Chem. 285 26933-44 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 Jiang, SS et al. (2010) Upregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicity. Clin. Cancer Res. 16 4363-73 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Huang, W et al. (2000) Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol. Cell. Biol. 20 4149-58 PubMed GONUTS page
↑ ^17.0 ^17.1 Ikegami, D et al. (2011) Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development 138 1507-19 PubMed GONUTS page
↑ ^18.0 ^18.1 Kim, Y et al. (2011) Generation of transgenic mice for conditional overexpression of Sox9. J. Bone Miner. Metab. 29 123-9 PubMed GONUTS page
↑ O'Shaughnessy, PJ et al. (2007) Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester. J. Clin. Endocrinol. Metab. 92 4792-801 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 Coustry, F et al. (2010) The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template. Nucleic Acids Res. 38 6018-28 PubMed GONUTS page
↑ Hoff, S et al. (2008) Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody. J. Comp. Neurol. 509 356-71 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 ^22.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:29503843-1] 1.0 ^1.1 ^1.2 ^1.3 Zhao, C et al. (2017) Sox9 augments BMP2-induced chondrogenic differentiation by downregulating Smad7 in mesenchymal stem cells (MSCs). Genes Dis 4 229-239 PubMed GONUTS page

[PMID:24681825-2] Correa, RG et al. (2014) The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling. Oncotarget 5 1666-82 PubMed GONUTS page

[PMID:19274049-3] 3.0 ^3.1 Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:22110751-4] 4.0 ^4.1 ^4.2 Acharya, A et al. (2011) Inhibitory role of Notch1 in calcific aortic valve disease. PLoS ONE 6 e27743 PubMed GONUTS page

[PMID:26634652-5] Huk, DJ et al. (2016) Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification. Arterioscler. Thromb. Vasc. Biol. 36 328-38 PubMed GONUTS page

[PMID:26687115-6] Le, LT et al. (2016) The microRNA-29 family in cartilage homeostasis and osteoarthritis. J. Mol. Med. 94 583-96 PubMed GONUTS page

[PMID:21401405-7] 7.0 ^7.1 ^7.2 ^7.3 Kim, HJ & Im, GI (2011) Electroporation-mediated transfer of SOX trio genes (SOX-5, SOX-6, and SOX-9) to enhance the chondrogenesis of mesenchymal stem cells. Stem Cells Dev. 20 2103-14 PubMed GONUTS page

[PMID:21412441-8] 8.0 ^8.1 Knower, KC et al. (2011) Failure of SOX9 regulation in 46XY disorders of sex development with SRY, SOX9 and SF1 mutations. PLoS ONE 6 e17751 PubMed GONUTS page

[PMID:21512138-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Ling, S et al. (2011) An EGFR-ERK-SOX9 signaling cascade links urothelial development and regeneration to cancer. Cancer Res. 71 3812-21 PubMed GONUTS page

[PMID:20079164-10] Yu, ZG et al. (2009) Interleukin-1 inhibits Sox9 and collagen type II expression via nuclear factor-kappaB in the cultured human intervertebral disc cells. Chin. Med. J. 122 2483-8 PubMed GONUTS page

[PMID:12420222-11] 11.0 ^11.1 ^11.2 Afonja, O et al. (2002) RAR agonists stimulate SOX9 gene expression in breast cancer cell lines: evidence for a role in retinoid-mediated growth inhibition. Oncogene 21 7850-60 PubMed GONUTS page

[PMID:20103652-12] 12.0 ^12.1 Thomsen, MK et al. (2010) SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation. Cancer Res. 70 979-87 PubMed GONUTS page

[PMID:8640233-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 Südbeck, P et al. (1996) Sex reversal by loss of the C-terminal transactivation domain of human SOX9. Nat. Genet. 13 230-2 PubMed GONUTS page

[PMID:20530484-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 Masuda, T & Esumi, N (2010) SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium. J. Biol. Chem. 285 26933-44 PubMed GONUTS page

[PMID:20651055-15] 15.0 ^15.1 ^15.2 Jiang, SS et al. (2010) Upregulation of SOX9 in lung adenocarcinoma and its involvement in the regulation of cell growth and tumorigenicity. Clin. Cancer Res. 16 4363-73 PubMed GONUTS page

[PMID:10805756-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 Huang, W et al. (2000) Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer. Mol. Cell. Biol. 20 4149-58 PubMed GONUTS page

[PMID:21367821-17] 17.0 ^17.1 Ikegami, D et al. (2011) Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways. Development 138 1507-19 PubMed GONUTS page

[PMID:20676705-18] 18.0 ^18.1 Kim, Y et al. (2011) Generation of transgenic mice for conditional overexpression of Sox9. J. Bone Miner. Metab. 29 123-9 PubMed GONUTS page

[PMID:17848411-19] O'Shaughnessy, PJ et al. (2007) Developmental changes in human fetal testicular cell numbers and messenger ribonucleic acid levels during the second trimester. J. Clin. Endocrinol. Metab. 92 4792-801 PubMed GONUTS page

[PMID:20484372-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 Coustry, F et al. (2010) The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template. Nucleic Acids Res. 38 6018-28 PubMed GONUTS page

[PMID:18512230-21] Hoff, S et al. (2008) Quantitative assessment of glial cells in the human and guinea pig enteric nervous system with an anti-Sox8/9/10 antibody. J. Comp. Neurol. 509 356-71 PubMed GONUTS page

[PMID:21873635-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 ^22.5 ^22.6 ^22.7 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:SOX9

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