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PMID:20079164

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Citation

Yu, ZG, Xu, N, Wang, WB, Pan, SH, Li, KS and Liu, JK (2009) Interleukin-1 inhibits Sox9 and collagen type II expression via nuclear factor-kappaB in the cultured human intervertebral disc cells. Chin. Med. J. 122:2483-8

Abstract

The most significant biological change in intervertebral disc degeneration is the decrease of chondrocyte specific gene and protein expression of Sox9 and collagen type II. Interleukin-1 (IL-1) is not expressed in the normal intervertebral disc tissue but increases in the degenerated intervertebral disc tissue. This suggests that IL-1 may play a role in regulation of the expression of Sox9 and collagen type II.

Links

PubMed

Keywords

Adult; Cells, Cultured; Collagen Type II/genetics; Collagen Type II/metabolism; Curcumin/pharmacology; Electrophoretic Mobility Shift Assay; Gene Expression/drug effects; Humans; Immunoblotting; Interleukin-1/pharmacology; Intervertebral Disc/cytology; Male; NF-kappa B/metabolism; Reverse Transcriptase Polymerase Chain Reaction; SOX9 Transcription Factor/genetics; SOX9 Transcription Factor/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:SOX9

involved_in

GO:0071347: cellular response to interleukin-1

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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