HUMAN:NEP

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MME (synonyms: EPN)
Protein Name(s)	Neprilysin Atriopeptidase Common acute lymphocytic leukemia antigen CALLA Enkephalinase Neutral endopeptidase 24.11 NEP Neutral endopeptidase Skin fibroblast elastase SFE
External Links
UniProt	P08473
EMBL	Y00811 J03779 M26628 M26607 M26608 M26609 M26610 M26611 M26612 M26613 M26614 M26615 M26616 M26617 M26618 M26619 M26620 M26621 M26622 M26623 M26624 M26625 M26626 M26627 AK291761 EU326307 CH471052 CH471052 CH471052 CH471052 CH471052 BC101632 BC101658 X07166
CCDS	CCDS3172.1
PIR	A41387
RefSeq	NP_000893.2 NP_009218.2 NP_009219.2 NP_009220.2 XP_006713709.1 XP_006713710.1
UniGene	Hs.307734
PDB	1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9 4CTH
PDBsum	1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9 4CTH
ProteinModelPortal	P08473
SMR	P08473
BioGrid	110455
IntAct	P08473
STRING	9606.ENSP00000353679
BindingDB	P08473
ChEMBL	CHEMBL1944
DrugBank	DB00616 DB06655
GuidetoPHARMACOLOGY	1611
MEROPS	M13.001
PhosphoSite	P08473
DMDM	128062
MaxQB	P08473
PaxDb	P08473
PeptideAtlas	P08473
PRIDE	P08473
Ensembl	ENST00000360490 ENST00000460393 ENST00000462745 ENST00000492661 ENST00000493237 ENST00000615825
GeneID	4311
KEGG	hsa:4311
UCSC	uc003fab.1
CTD	4311
GeneCards	GC03P154741
HGNC	HGNC:7154
HPA	CAB000013
MIM	120520
neXtProt	NX_P08473
PharmGKB	PA30864
eggNOG	COG3590
GeneTree	ENSGT00760000119162
HOGENOM	HOG000245574
HOVERGEN	HBG005554
InParanoid	P08473
KO	K01389
OMA	LQNLMSW
OrthoDB	EOG7PZRWQ
PhylomeDB	P08473
TreeFam	TF315192
Reactome	REACT_147707
ChiTaRS	MME
EvolutionaryTrace	P08473
GeneWiki	Neprilysin
GenomeRNAi	4311
NextBio	16959
PRO	PR:P08473
Proteomes	UP000005640
Bgee	P08473
CleanEx	HS_MME
ExpressionAtlas	P08473
Genevestigator	P08473
GO	GO:0030424 GO:0005903 GO:0005737 GO:0030425 GO:0070062 GO:0005925 GO:0016021 GO:0005887 GO:0044306 GO:0005886 GO:0045202 GO:0008021 GO:0004175 GO:0004222 GO:0042277 GO:0008270 GO:0002003 GO:0050435 GO:0044267 GO:0071345 GO:0071492 GO:0071493 GO:0046449 GO:0001822 GO:0006518 GO:0006508 GO:0090399 GO:0019233
Gene3D	3.40.390.10
InterPro	IPR024079 IPR029727 IPR000718 IPR018497 IPR008753
PANTHER	PTHR11733 PTHR11733:SF114
Pfam	PF01431 PF05649
PRINTS	PR00786
PROSITE	PS00142

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0004175	endopeptidase activity	PMID:18539150^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:P20366:PRO_0000033530)\|has_input:(UniProtKB:P01042:PRO_0000006688)\|has_input:(UniProtKB:P01019:PRO_0000032457)\|has_input:(UniProtKB:P01019:PRO_0000032458)\|has_input:(UniProtKB:P01210:PRO_0000008252)\|has_input:(UniProtKB:P01210:PRO_0000008254)\|has_input:(UniProtKB:P30990)	Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:16226260^[2]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0150094	amyloid-beta clearance by cellular catabolic process	PMID:15100223^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P05067:PRO_0000000093) occurs_in:(CL:0000540)\|has_input(UniProtKB:P05067:PRO_0000000092) occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0097242	amyloid-beta clearance	PMID:15100223^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P05067:PRO_0000000093) occurs_in:(GO:0005615) has_agent:(CL:0000540)\|has_input(UniProtKB:P05067:PRO_0000000092) occurs_in:(GO:0005615) has_agent:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:15100223^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:0097242	amyloid-beta clearance	PMID:14749444^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q61391	P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0150094	amyloid-beta clearance by cellular catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07861	P	occurs_in:(CL:0000129)	Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:24825898^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	part_of:(GO:0150094)	Seeded From UniProt	complete
enables	GO:1901612	cardiolipin binding	PMID:22183801^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001786	phosphatidylserine binding	PMID:22183801^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:22183801^[6]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(GO:0045121)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:22183801^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:19057576^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:19057576^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:18602473^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P05067:PRO_0000000093)	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:18539150^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:P20366:PRO_0000033530)\|has_input:(UniProtKB:P01042:PRO_0000006688)\|has_input:(UniProtKB:P01019:PRO_0000032457)\|has_input:(UniProtKB:P01019:PRO_0000032458)\|has_input:(UniProtKB:P01210:PRO_0000008252)\|has_input:(UniProtKB:P01210:PRO_0000008254)\|has_input:(UniProtKB:P30990)	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:14749444^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q61391	P	occurs_in:(UBERON:0002421) part_of:(GO:0097242)	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:24825898^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:15100223^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005802	trans-Golgi network	PMID:15100223^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:15100223^[3]	ECO:0000303	author statement without traceable support used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:15100223^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	PMID:15100223^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:15100223^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:15100223^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:14749444^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q61391	F	occurs_in:(UBERON:0002421) part_of:(GO:0097242)	Seeded From UniProt	complete
part_of	GO:0030424	axon	PMID:14749444^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q61391	C	part_of:(UBERON:0001885)	Seeded From UniProt	complete
part_of	GO:0098793	presynapse	PMID:14749444^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q61391	C	part_of:(UBERON:0001885)	Seeded From UniProt	complete
involved_in	GO:0097242	amyloid-beta clearance	PMID:12657655^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:24825898^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P		Seeded From UniProt	complete
involved_in	GO:0050769	positive regulation of neurogenesis	PMID:24825898^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	occurs_in:(UBERON:0001885)	Seeded From UniProt	complete
involved_in	GO:0061837	neuropeptide processing	PMID:24825898^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	has_input:(UniProtKB:P01303) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:24825898^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	C	part_of:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0150094	amyloid-beta clearance by cellular catabolic process	PMID:24825898^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067	P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	PMID:27588448^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:27588448^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008238	exopeptidase activity	PMID:6208535^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P30990)\|has_direct_input:(UniProtKB:P20366:PRO_0000033530)	Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	PMID:15283675^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P01019:PRO_0000032457)\|has_direct_input:(UniProtKB:P01019:PRO_0000420659)\|has_direct_input:(UniProtKB:P01019:PRO_0000032458)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:23533145^[13]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:21423176^[14]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	PMID:19056867^[15]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001088)	Seeded From UniProt	complete
involved_in	GO:0097242	amyloid-beta clearance	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07861	P	has_start_location:(CL:0002609) has_target_end_location:(GO:0005576) has_target_start_location:(GO:0005576)	Seeded From UniProt	complete
involved_in	GO:0090399	replicative senescence	PMID:20876573^[16]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071493	cellular response to UV-B	PMID:20876573^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071492	cellular response to UV-A	PMID:20876573^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071345	cellular response to cytokine stimulus	PMID:20876573^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61391	P		Seeded From UniProt	complete
involved_in	GO:0046449	creatinine metabolic process	PMID:22024547^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61391	C		Seeded From UniProt	complete
part_of	GO:0044306	neuron projection terminus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61391	C		Seeded From UniProt	complete
enables	GO:0042277	peptide binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07861	F		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61391	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61391	C		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61391	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:2968607^[18]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	PMID:8168535^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61391	C		Seeded From UniProt	complete
involved_in	GO:0006518	peptide metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P07861	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:20876573^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:8168535^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005903	brush border	PMID:22272689^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002306)	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:2521388^[21]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:22272689^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(UBERON:0004134)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:20876573^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:22272689^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0002306)\|part_of:(UBERON:0003918)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20876573^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	PMID:2521388^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:2531377^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:20876573^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P15502)	Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:15283675^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P01019)	Seeded From UniProt	complete
enables	GO:0004175	endopeptidase activity	PMID:8168535^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	PMID:22272689^[20]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	PMID:15283675^[12]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0150094	amyloid-beta clearance by cellular catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07861 ensembl:ENSRNOP00000074307	P		Seeded From UniProt	complete
involved_in	GO:0097242	amyloid-beta clearance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07861 ensembl:ENSRNOP00000074307	P		Seeded From UniProt	complete
enables	GO:0070012	oligopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07861 ensembl:ENSRNOP00000074307	F		Seeded From UniProt	complete
enables	GO:0042277	peptide binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07861 ensembl:ENSRNOP00000074307	F		Seeded From UniProt	complete
involved_in	GO:0030324	lung development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07861 ensembl:ENSRNOP00000074307	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07861 ensembl:ENSRNOP00000074307	C		Seeded From UniProt	complete
involved_in	GO:0006518	peptide metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07861 ensembl:ENSRNOP00000074307	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07861 ensembl:ENSRNOP00000074307	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07861 ensembl:ENSRNOP00000074307	C		Seeded From UniProt	complete
involved_in	GO:0001890	placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07861 ensembl:ENSRNOP00000074307	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P07861 ensembl:ENSRNOP00000074307	P		Seeded From UniProt	complete
involved_in	GO:1900273	positive regulation of long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61391 ensembl:ENSMUSP00000142205	P		Seeded From UniProt	complete
involved_in	GO:0097242	amyloid-beta clearance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61391 ensembl:ENSMUSP00000142205	P		Seeded From UniProt	complete
involved_in	GO:0050435	amyloid-beta metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61391 ensembl:ENSMUSP00000142205	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61391 ensembl:ENSMUSP00000142205	C		Seeded From UniProt	complete
part_of	GO:0044306	neuron projection terminus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61391 ensembl:ENSMUSP00000142205	C		Seeded From UniProt	complete
part_of	GO:0030425	dendrite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61391 ensembl:ENSMUSP00000142205	C		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61391 ensembl:ENSMUSP00000142205	C		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61391 ensembl:ENSMUSP00000142205	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61391 ensembl:ENSMUSP00000142205	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61391 ensembl:ENSMUSP00000142205	F		Seeded From UniProt	complete
part_of	GO:0008021	synaptic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61391 ensembl:ENSMUSP00000142205	C		Seeded From UniProt	complete
enables	GO:0004222	metalloendopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000718 InterPro:IPR018497 InterPro:IPR029727	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000718 InterPro:IPR008753 InterPro:IPR018497 InterPro:IPR029727	P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024079	F		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	Reactome:R-HSA-6798743	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-6798743 Reactome:R-HSA-2022396 Reactome:R-HSA-2022368	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002003	angiotensin maturation	Reactome:R-HSA-2022396 Reactome:R-HSA-2022368	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008237	metallopeptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0482	F		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Whyteside, AR & Turner, AJ (2008) Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences. FEBS Lett. 582 2382-6 PubMed GONUTS page
↑ Russo, R et al. (2005) Neprylisin decreases uniformly in Alzheimer's disease and in normal aging. FEBS Lett. 579 6027-30 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Hama, E et al. (2004) Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons. J. Biol. Chem. 279 30259-64 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Iwata, N et al. (2004) Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain. J. Neurosci. 24 991-8 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Spencer, B et al. (2014) A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis. J. Biol. Chem. 289 17917-31 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Sato, K et al. (2012) Localization of mature neprilysin in lipid rafts. J. Neurosci. Res. 90 870-7 PubMed GONUTS page
↑ ^7.0 ^7.1 Belyaev, ND et al. (2009) Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease. EMBO Rep. 10 94-100 PubMed GONUTS page
↑ Betts, V et al. (2008) Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin. Neurobiol. Dis. 31 442-50 PubMed GONUTS page
↑ Marr, RA et al. (2003) Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J. Neurosci. 23 1992-6 PubMed GONUTS page
↑ ^10.0 ^10.1 Auer-Grumbach, M et al. (2016) Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies. Am. J. Hum. Genet. 99 607-623 PubMed GONUTS page
↑ Skidgel, RA et al. () Hydrolysis of substance p and neurotensin by converting enzyme and neutral endopeptidase. Peptides 5 769-76 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Rice, GI et al. (2004) Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem. J. 383 45-51 PubMed GONUTS page
↑ Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page
↑ Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page
↑ Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 Morisaki, N et al. (2010) Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses. J. Biol. Chem. 285 39819-27 PubMed GONUTS page
↑ Zhang, D et al. (2011) Genetic and functional effects of membrane metalloendopeptidase on diabetic nephropathy development. Am. J. Nephrol. 34 483-90 PubMed GONUTS page
↑ Shipp, MA et al. (1988) Molecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane protein. Proc. Natl. Acad. Sci. U.S.A. 85 4819-23 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 Le Moual, H et al. (1994) Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11. Eur. J. Biochem. 221 475-80 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Faa, G et al. (2012) CD10 in the developing human kidney: immunoreactivity and possible role in renal embryogenesis. J. Matern. Fetal. Neonatal. Med. 25 904-11 PubMed GONUTS page
↑ ^21.0 ^21.1 Shipp, MA et al. (1989) Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis. Proc. Natl. Acad. Sci. U.S.A. 86 297-301 PubMed GONUTS page
↑ Yandle, TG et al. () Endopeptidase-24.11 in human plasma degrades atrial natriuretic factor (ANF) to ANF(99-105/106-126). Peptides 10 891-4 PubMed GONUTS page

[PMID:18539150-1] 1.0 ^1.1 Whyteside, AR & Turner, AJ (2008) Human neprilysin-2 (NEP2) and NEP display distinct subcellular localisations and substrate preferences. FEBS Lett. 582 2382-6 PubMed GONUTS page

[PMID:16226260-2] Russo, R et al. (2005) Neprylisin decreases uniformly in Alzheimer's disease and in normal aging. FEBS Lett. 579 6027-30 PubMed GONUTS page

[PMID:15100223-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 ^3.7 ^3.8 ^3.9 Hama, E et al. (2004) Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid beta peptide clearance in primary neurons. J. Biol. Chem. 279 30259-64 PubMed GONUTS page

[PMID:14749444-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Iwata, N et al. (2004) Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain. J. Neurosci. 24 991-8 PubMed GONUTS page

[PMID:24825898-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 Spencer, B et al. (2014) A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis. J. Biol. Chem. 289 17917-31 PubMed GONUTS page

[PMID:22183801-6] 6.0 ^6.1 ^6.2 ^6.3 Sato, K et al. (2012) Localization of mature neprilysin in lipid rafts. J. Neurosci. Res. 90 870-7 PubMed GONUTS page

[PMID:19057576-7] 7.0 ^7.1 Belyaev, ND et al. (2009) Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease. EMBO Rep. 10 94-100 PubMed GONUTS page

[PMID:18602473-8] Betts, V et al. (2008) Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin. Neurobiol. Dis. 31 442-50 PubMed GONUTS page

[PMID:12657655-9] Marr, RA et al. (2003) Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J. Neurosci. 23 1992-6 PubMed GONUTS page

[PMID:27588448-10] 10.0 ^10.1 Auer-Grumbach, M et al. (2016) Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies. Am. J. Hum. Genet. 99 607-623 PubMed GONUTS page

[PMID:6208535-11] Skidgel, RA et al. () Hydrolysis of substance p and neurotensin by converting enzyme and neutral endopeptidase. Peptides 5 769-76 PubMed GONUTS page

[PMID:15283675-12] 12.0 ^12.1 ^12.2 Rice, GI et al. (2004) Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem. J. 383 45-51 PubMed GONUTS page

[PMID:23533145-13] Principe, S et al. (2013) In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Proteomics 13 1667-71 PubMed GONUTS page

[PMID:21423176-14] Kuo, JC et al. (2011) Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Nat. Cell Biol. 13 383-93 PubMed GONUTS page

[PMID:19056867-15] Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page

[PMID:20876573-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 Morisaki, N et al. (2010) Neprilysin is identical to skin fibroblast elastase: its role in skin aging and UV responses. J. Biol. Chem. 285 39819-27 PubMed GONUTS page

[PMID:22024547-17] Zhang, D et al. (2011) Genetic and functional effects of membrane metalloendopeptidase on diabetic nephropathy development. Am. J. Nephrol. 34 483-90 PubMed GONUTS page

[PMID:2968607-18] Shipp, MA et al. (1988) Molecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane protein. Proc. Natl. Acad. Sci. U.S.A. 85 4819-23 PubMed GONUTS page

[PMID:8168535-19] 19.0 ^19.1 ^19.2 Le Moual, H et al. (1994) Asp650 is crucial for catalytic activity of neutral endopeptidase 24-11. Eur. J. Biochem. 221 475-80 PubMed GONUTS page

[PMID:22272689-20] 20.0 ^20.1 ^20.2 ^20.3 Faa, G et al. (2012) CD10 in the developing human kidney: immunoreactivity and possible role in renal embryogenesis. J. Matern. Fetal. Neonatal. Med. 25 904-11 PubMed GONUTS page

[PMID:2521388-21] 21.0 ^21.1 Shipp, MA et al. (1989) Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis. Proc. Natl. Acad. Sci. U.S.A. 86 297-301 PubMed GONUTS page

[PMID:2531377-22] Yandle, TG et al. () Endopeptidase-24.11 in human plasma degrades atrial natriuretic factor (ANF) to ANF(99-105/106-126). Peptides 10 891-4 PubMed GONUTS page

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