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PMID:16226260

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Citation

Russo, R, Borghi, R, Markesbery, W, Tabaton, M and Piccini, A (2005) Neprylisin decreases uniformly in Alzheimer's disease and in normal aging. FEBS Lett. 579:6027-30

Abstract

The proteolysis of beta-amyloid (Abeta) requires neprylisin, an enzyme that has been shown as reduced in Alzheimer's disease (AD). We investigated whether a decrease in neprilysin levels contributes to the accumulation of amyloid deposits not only in AD but also in the normal aging. We analyzed neprilysin mRNA and protein levels in cerebral cortex from 10 cognitively normal elderly subjects with amyloid plaques (NA), 10 cases of AD, and 10 control cases free of amyloid plaques. We found a significant decrease in neprilysin mRNA levels in both AD and NA compared to control cases. Thereby, the defect of neprilysin appears to correlate with Abeta deposition but not with degeneration and dementia.

Links

PubMed Online version:10.1016/j.febslet.2005.09.054

Keywords

Aging/metabolism; Alzheimer Disease/metabolism; Amyloid beta-Peptides/metabolism; Cerebral Cortex/chemistry; Cerebral Cortex/metabolism; Humans; Neprilysin/genetics; Neprilysin/metabolism; Plaque, Amyloid/metabolism; RNA, Messenger/analysis; RNA, Messenger/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:NEP

involved_in

GO:0007568: aging

ECO:0000270: expression pattern evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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