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PMID:22024547

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Citation

Zhang, D, Gu, T, Forsberg, E, Efendic, S, Brismar, K and Gu, HF (2011) Genetic and functional effects of membrane metalloendopeptidase on diabetic nephropathy development. Am. J. Nephrol. 34:483-90

Abstract

Vasopeptidase as an agent inhibits membrane metalloendopeptidase (MME, also known as neutral endopeptidase). MME is widely distributed in the body and particularly abundant in the kidney. The MME gene is located on chromosome 3q25.1 within a linkage region for diabetic nephropathy (DN). The present study aims to evaluate the genetic and functional effects of MME in the development of DN.

Links

PubMed Online version:10.1159/000333006

Keywords

Adult; Case-Control Studies; Diabetic Nephropathies/enzymology; Diabetic Nephropathies/genetics; Female; Genetic Association Studies; Humans; Male; Metalloendopeptidases/physiology; Middle Aged

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:NEP

involved_in

GO:0046449: creatinine metabolic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete


See also

References

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