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PMID:2968607

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Citation

Shipp, MA, Richardson, NE, Sayre, PH, Brown, NR, Masteller, EL, Clayton, LK, Ritz, J and Reinherz, EL (1988) Molecular cloning of the common acute lymphoblastic leukemia antigen (CALLA) identifies a type II integral membrane protein. Proc. Natl. Acad. Sci. U.S.A. 85:4819-23

Abstract

Common acute lymphoblastic leukemia antigen (CALLA) is a 100-kDa cell-surface glycoprotein expressed on most acute lymphoblastic leukemias and certain other immature lymphoid malignancies and on normal lymphoid progenitors. The latter are either uncommitted to B- or T-cell lineage or committed to only the earliest stages of B- or T-lymphocyte maturation. To elucidate to homogeneity, obtained the NH2-terminal sequence from both the intact protein and derived tryptic and V8 protease peptides and isolated CALLA cDNAs from a Nalm-6 cell line lambda gt10 library using redundant oligonucleotide probes. The CALLA cDNA sequence predicts a 750-amino acid integral membrane protein with a single 24-amino acid hydrophobic segment that could function as both a transmembrane region and a signal peptide. The COOH-terminal 700 amino acids, including six potential N-linked glycosylation sites compose the extracellular protein segment, whereas the 25 NH2-terminal amino acids remaining after cleavage of the initiation methionine form the cytoplasmic tail. CALLA+ cells contain CALLA transcripts of 2.7 to 5.7 kilobases with the major 5.7- and 3.7-kilobase mRNAs being preferentially expressed in specific cell types.

Links

PubMed PMC280527

Keywords

Amino Acid Sequence; Antigens, Differentiation/genetics; Antigens, Neoplasm/genetics; Base Sequence; DNA/genetics; Humans; Leukemia, Lymphoid/genetics; Leukemia, Lymphoid/immunology; Membrane Proteins/genetics; Molecular Sequence Data; Neoplasm Proteins/genetics; Neprilysin; RNA, Neoplasm/analysis

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:NEP

part_of

GO:0016021: integral component of membrane

ECO:0000303: author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete


See also

References

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