HUMAN:MK01

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	MAPK1 (synonyms: ERK2, PRKM1, PRKM2)
Protein Name(s)	Mitogen-activated protein kinase 1 MAP kinase 1 MAPK 1 ERT1 Extracellular signal-regulated kinase 2 ERK-2 MAP kinase isoform p42 p42-MAPK Mitogen-activated protein kinase 2 MAP kinase 2 MAPK 2
External Links
UniProt	P28482
EMBL	M84489 Z11694 Z11695 DQ399292 AP000553 AP000554 AP000555 BC017832
CCDS	CCDS13795.1
PIR	JQ1400
RefSeq	NP_002736.3 NP_620407.1
UniGene	Hs.431850
PDB	1PME 1TVO 1WZY 2OJG 2OJI 2OJJ 2Y9Q 3D42 3D44 3I5Z 3I60 3SA0 3TEI 3W55 4FMQ 4FUX 4FUY 4FV0 4FV1 4FV2 4FV3 4FV4 4FV5 4FV6 4FV7 4FV8 4FV9 4G6N 4G6O 4H3P 4H3Q 4IZ5 4IZ7 4IZA 4N0S 4NIF 4O6E 4QTA 4QTE
PDBsum	1PME 1TVO 1WZY 2OJG 2OJI 2OJJ 2Y9Q 3D42 3D44 3I5Z 3I60 3SA0 3TEI 3W55 4FMQ 4FUX 4FUY 4FV0 4FV1 4FV2 4FV3 4FV4 4FV5 4FV6 4FV7 4FV8 4FV9 4G6N 4G6O 4H3P 4H3Q 4IZ5 4IZ7 4IZA 4N0S 4NIF 4O6E 4QTA 4QTE
ProteinModelPortal	P28482
SMR	P28482
BioGrid	111580
DIP	DIP-519N
IntAct	P28482
MINT	MINT-144006
STRING	9606.ENSP00000215832
BindingDB	P28482
ChEMBL	CHEMBL4040
DrugBank	DB01169 DB01064
GuidetoPHARMACOLOGY	1495
PhosphoSite	P28482
DMDM	119554
OGP	P28482
MaxQB	P28482
PaxDb	P28482
PeptideAtlas	P28482
PRIDE	P28482
DNASU	5594
Ensembl	ENST00000215832 ENST00000398822 ENST00000544786
GeneID	5594
KEGG	hsa:5594
UCSC	uc002zvn.3
CTD	5594
GeneCards	GC22M022108
HGNC	HGNC:6871
HPA	CAB004229 HPA003995 HPA005700 HPA030069
MIM	176948
neXtProt	NX_P28482
Orphanet	261330
PharmGKB	PA30616
eggNOG	COG0515
GeneTree	ENSGT00550000074298
HOGENOM	HOG000233024
HOVERGEN	HBG014652
InParanoid	P28482
KO	K04371
OMA	VCSAYDR
OrthoDB	EOG7M3J0K
PhylomeDB	P28482
TreeFam	TF105097
BRENDA	2.7.11.24
Reactome	REACT_1100 REACT_111133 REACT_111184 REACT_1183 REACT_120966 REACT_12436 REACT_12599 REACT_15466 REACT_160086 REACT_163701 REACT_169168 REACT_169325 REACT_169436 REACT_18334 REACT_200780 REACT_20510 REACT_20568 REACT_21326 REACT_21384 REACT_22272 REACT_22365 REACT_25195 REACT_508 REACT_9470
SignaLink	P28482
ChiTaRS	MAPK1
EvolutionaryTrace	P28482
GeneWiki	MAPK1
GenomeRNAi	5594
NextBio	21708
PRO	PR:P28482
Proteomes	UP000005640
Bgee	P28482
CleanEx	HS_MAPK1
ExpressionAtlas	P28482
Genevestigator	P28482
GO	GO:0030424 GO:0005901 GO:0005737 GO:0005856 GO:0005829 GO:0032839 GO:0005769 GO:0070062 GO:0005925 GO:0005794 GO:0005770 GO:0015630 GO:0005815 GO:0005739 GO:0072686 GO:0005654 GO:0005634 GO:0043204 GO:0043234 GO:0031143 GO:0005524 GO:0003677 GO:0004707 GO:0019902 GO:0004674 GO:0008353 GO:0000187 GO:0000186 GO:0006915 GO:0007411 GO:0050853 GO:0007596 GO:0072584 GO:0007049 GO:0006974 GO:0097011 GO:0006935 GO:0019858 GO:0007173 GO:0038127 GO:0070371 GO:0038095 GO:0038096 GO:0008543 GO:0045087 GO:0008286 GO:0060397 GO:0060716 GO:0031663 GO:0033598 GO:0000165 GO:0000189 GO:0002755 GO:0002756 GO:0045596 GO:0048011 GO:0009887 GO:0018105 GO:0018107 GO:0030168 GO:0030335 GO:0008284 GO:0010800 GO:0045893 GO:0045727 GO:0007265 GO:0051493 GO:2000641 GO:0090170 GO:0031647 GO:0051090 GO:0032872 GO:0070849 GO:0043627 GO:0043330 GO:0006950 GO:0009636 GO:0019233 GO:0007165 GO:0007264 GO:0051403 GO:0007268 GO:0050852 GO:0034166 GO:0034134 GO:0034138 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0006351 GO:0035666 GO:0016032
InterPro	IPR011009 IPR003527 IPR008349 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
PRINTS	PR01770
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS01351 PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0045941	positive regulation of transcription	PMID:19229075^[1]	ECO:0000315			P		Figure 1C: an MEK/ERK pathway inhibitor (U1026) partially suppresses expression of LXRα and apoE mRNA, suggesting that MEK/ERK plays a role in the expression of LXRα and apoE Figure 7A: this shows that effect of FGF-1 expression was partially suppressed by inhibition of the MEK/ERK pathway (using inhibitor U1026), thus the MEK/ERK plays a role in the expression of FGF-1	complete
	GO:0033624	negative regulation of integrin activation	PMID:23118220^[2]	ECO:0000314			P		Figure 1 - RSK2 inhibits integrin activation	complete CACAO 7413
	GO:0007162	negative regulation of cell adhesion	PMID:23118220^[2]	ECO:0000314			P		Figure 1 - RSK2 inhibits integrin activation and impairs cell adhesion.	complete CACAO 7416
	GO:0033629	negative regulation of cell adhesion mediated by integrin	PMID:23118220^[2]	ECO:0000314			P		Figure 2 - RSK2 inhibits integrin activation and impairs cell adhesion	complete CACAO 7419
	GO:1901202	negative regulation of extracellular matrix assembly	PMID:23118220^[2]	ECO:0000314			P		Figure 2-RSK2 inhibits fibronectin matrix assembly	complete CACAO 7420
enables	GO:0004674	protein serine/threonine kinase activity	PMID:26996940^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:0071276	cellular response to cadmium ion	PMID:26514923^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034614	cellular response to reactive oxygen species	PMID:26514923^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63086	P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63085	P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	PMID:11404397^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	PMID:11096076^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051403	stress-activated MAPK cascade	PMID:11096076^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903351	cellular response to dopamine	PMID:24136195^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:24136195^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P0DMM9) has_regulation_target:(UniProtKB:P50225)	Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63086	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63086	C		Seeded From UniProt	complete
involved_in	GO:1904355	positive regulation of telomere capping	PMID:21531765^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0032212) part_of:(GO:0051973)	Seeded From UniProt	complete
involved_in	GO:0032212	positive regulation of telomere maintenance via telomerase	PMID:21531765^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O14746)	Seeded From UniProt	complete
involved_in	GO:0051973	positive regulation of telomerase activity	PMID:21531765^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O14746)	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:23184662^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q13541)\|has_direct_input:(UniProtKB:P05412)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16791210^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16791210^[10]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:15850461^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:15850461^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q6JBY9)	Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26696	C	exists_during:(GO:0000236)\|exists_during:(GO:0000089)	Seeded From UniProt	complete
involved_in	GO:0070849	response to epidermal growth factor	PMID:18794356^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	PMID:16314496^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038127	ERBB signaling pathway	PMID:15133037^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26696	P	has_input:(UniProtKB:Q91790) happens_during:(GO:0007143)	Seeded From UniProt	complete
enables	GO:0019902	phosphatase binding	PMID:19494114^[15]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q12913	F		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63085	P		Seeded From UniProt	complete
involved_in	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	PMID:16314496^[13]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q15648)	Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P63085	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18794356^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P26696	C	exists_during:(GO:0051329)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18794356^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18794356^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001172432 RGD:70500	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:106908 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1346865 PANTHER:PTN000622075 RGD:3046 RGD:70500 RGD:71050 UniProtKB:P78362 UniProtKB:Q16539 UniProtKB:Q96SB4 UniProtKB:Q9UPZ9 WB:WBGene00004055 WB:WBGene00004056	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1346861 PANTHER:PTN000622075 UniProtKB:A9T142	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0052703 FB:FBgn0267339 MGI:MGI:1201408 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346862 MGI:MGI:1346863 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:2444559 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:621506 RGD:628847 RGD:70500 RGD:70975 RGD:71050 SGD:S000000112 SGD:S000004103 SGD:S000004829 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P28482 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q96SB4 WB:WBGene00002178 WB:WBGene00002187 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004056 WB:WBGene00004057	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0003256 FB:FBgn0015765 MGI:MGI:1201387 MGI:MGI:1201408 MGI:MGI:1336881 MGI:MGI:1346347 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346861 MGI:MGI:1346865 MGI:MGI:1354946 MGI:MGI:1934157 MGI:MGI:2444559 MGI:MGI:96913 PANTHER:PTN000622075 PomBase:SPAC24B11.06c PomBase:SPAC31G5.09c PomBase:SPBC119.08 PomBase:SPBC530.14c RGD:3046 RGD:3663 RGD:621505 RGD:621506 RGD:628675 RGD:628847 RGD:70496 RGD:70500 SGD:S000000112 SGD:S000001072 SGD:S000003272 SGD:S000003642 SGD:S000004103 TAIR:locus:2024887 TAIR:locus:2124943 UniProtKB:A9T142 UniProtKB:O77306 UniProtKB:P20794 UniProtKB:P28482 UniProtKB:P45983 UniProtKB:P78362 UniProtKB:Q10N20 UniProtKB:Q13164 UniProtKB:Q5AZN7 UniProtKB:Q8GYQ5 UniProtKB:Q96SB4 UniProtKB:Q9LV37 UniProtKB:Q9P419 WB:WBGene00002178 WB:WBGene00003048 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004057 dictyBase:DDB_G0283903 dictyBase:DDB_G0286353	C		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN001172432 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:21873635^[16]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	CGD:CAL0000183747 FB:FBgn0015765 FB:FBgn0024846 FB:FBgn0267339 MGI:MGI:1346858 MGI:MGI:1346859 MGI:MGI:1346865 MGI:MGI:1354946 PANTHER:PTN002372889 PomBase:SPAC31G5.09c PomBase:SPBC119.08 RGD:1309340 RGD:3045 RGD:3046 RGD:621505 RGD:70496 RGD:70500 RGD:70975 SGD:S000000112 SGD:S000003272 SGD:S000006258 UniProtKB:A0A1D8PFT5 UniProtKB:A0A1D8PT38 UniProtKB:O15264 UniProtKB:P27361 UniProtKB:Q15759 UniProtKB:Q16539 WB:WBGene00003401 WB:WBGene00004055 WB:WBGene00004056 dictyBase:DDB_G0286353	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:26267534^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P28482	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16627622^[18]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P28482	F		Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
involved_in	GO:0060045	positive regulation of cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
involved_in	GO:0046697	decidualization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
involved_in	GO:0045727	positive regulation of translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
involved_in	GO:0043627	response to estrogen	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	C		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	C		Seeded From UniProt	complete
part_of	GO:0032839	dendrite cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	C		Seeded From UniProt	complete
enables	GO:0031435	mitogen-activated protein kinase kinase kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	F		Seeded From UniProt	complete
part_of	GO:0030424	axon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	C		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	F		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
involved_in	GO:0015966	diadenosine tetraphosphate biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	C		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	F		Seeded From UniProt	complete
enables	GO:0003690	double-stranded DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63086 ensembl:ENSRNOP00000002533	P		Seeded From UniProt	complete
involved_in	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0061308	cardiac neural crest cell development involved in heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0060716	labyrinthine layer blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0060440	trachea formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0060425	lung morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0060324	face development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0060291	long-term synaptic potentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0060020	Bergmann glial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0045596	negative regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0043330	response to exogenous dsRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
involved_in	GO:0042473	outer ear morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0033598	mammary gland epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
part_of	GO:0031143	pseudopodium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	C		Seeded From UniProt	complete
involved_in	GO:0030878	thyroid gland development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0030641	regulation of cellular pH	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0030278	regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
enables	GO:0019902	phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
involved_in	GO:0019858	cytosine metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
involved_in	GO:0014032	neural crest cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
	GO:0000165	MAPK cascade	PMID:25658875^[19]	ECO:0000314			P		Fig. activation and inhibition of MAPK	complete
	GO:0000165	MAPK cascade	PMID:25658875^[19]	ECO:0000314			P		Fig. activation and inhibition of MAPK	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	C		Seeded From UniProt	complete
enables	GO:0004708	MAP kinase kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
enables	GO:0001784	phosphotyrosine residue binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P63085 ensembl:ENSMUSP00000065983	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003527 InterPro:IPR008349	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008349 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR003527 InterPro:IPR008271 InterPro:IPR008349	P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.24	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:11404397^[5]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_input:(UniProtKB:P51812)	Seeded From UniProt	complete
involved_in	GO:0007268	chemical synaptic transmission	PMID:10051431^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:1540184^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006935	chemotaxis	PMID:10706854^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10958679^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004707	MAP kinase activity	PMID:10706854^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:2000641	regulation of early endosome to late endosome transport	PMID:19565474^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090170	regulation of Golgi inheritance	PMID:19565474^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072584	caveolin-mediated endocytosis	PMID:19565474^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051493	regulation of cytoskeleton organization	PMID:19565474^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032872	regulation of stress-activated MAPK cascade	PMID:19565474^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	PMID:19565474^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	PMID:19565474^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	PMID:19565474^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:19565474^[24] Reactome:R-NUL-9619973 Reactome:R-HSA-9627089 Reactome:R-HSA-9626832 Reactome:R-HSA-6811472 Reactome:R-HSA-6811454 Reactome:R-HSA-6803234 Reactome:R-HSA-6803233 Reactome:R-HSA-6803230 Reactome:R-HSA-6803227 Reactome:R-HSA-6802943 Reactome:R-HSA-6802942 Reactome:R-HSA-6802935 Reactome:R-HSA-6802934 Reactome:R-HSA-6802933 Reactome:R-HSA-6802932 Reactome:R-HSA-6802926 Reactome:R-HSA-6802925 Reactome:R-HSA-6802922 Reactome:R-HSA-6802921 Reactome:R-HSA-6802919 Reactome:R-HSA-6802918 Reactome:R-HSA-6802914 Reactome:R-HSA-6802912 Reactome:R-HSA-6802911 Reactome:R-HSA-6802910 Reactome:R-HSA-5675376 Reactome:R-HSA-5675206 Reactome:R-HSA-5675198 Reactome:R-HSA-5675194 Reactome:R-HSA-5674496 Reactome:R-HSA-5674387 Reactome:R-HSA-5674385 Reactome:R-HSA-5674373 Reactome:R-HSA-5674366 Reactome:R-HSA-5674132 Reactome:R-HSA-5674130 Reactome:R-HSA-5672980 Reactome:R-HSA-5672978 Reactome:R-HSA-5672973 Reactome:R-HSA-5672972 Reactome:R-HSA-5654566 Reactome:R-HSA-5654565 Reactome:R-HSA-5654562 Reactome:R-HSA-5654560 Reactome:R-HSA-445079 Reactome:R-HSA-418200 Reactome:R-HSA-418176 Reactome:R-HSA-418170 Reactome:R-HSA-418163 Reactome:R-HSA-418158 Reactome:R-HSA-3371531 Reactome:R-HSA-2029469 Reactome:R-HSA-1168459 Reactome:R-HSA-111898 Reactome:R-HSA-109864 Reactome:R-HSA-109862 Reactome:R-HSA-109858	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:19565474^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005770	late endosome	PMID:19565474^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	PMID:19565474^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:19565474^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19565474^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:1904813	ficolin-1-rich granule lumen	Reactome:R-HSA-6800434	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1900034	regulation of cellular response to heat	Reactome:R-HSA-3371453	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070371	ERK1 and ERK2 cascade	Reactome:R-HSA-112411	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051090	regulation of DNA-binding transcription factor activity	Reactome:R-HSA-450341	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	Reactome:R-HSA-2029480	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035578	azurophil granule lumen	Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0030168	platelet activation	Reactome:R-HSA-76002	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	Reactome:R-HSA-445079 Reactome:R-HSA-111898	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0014066	regulation of phosphatidylinositol 3-kinase signaling	Reactome:R-HSA-6811558	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008543	fibroblast growth factor receptor signaling pathway	Reactome:R-HSA-5654743 Reactome:R-HSA-5654741 Reactome:R-HSA-5654738 Reactome:R-HSA-5654736	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007411	axon guidance	Reactome:R-HSA-422475	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-NUL-9009236 Reactome:R-HSA-9032751 Reactome:R-HSA-5675373 Reactome:R-HSA-5674387 Reactome:R-HSA-450325 Reactome:R-HSA-3857329 Reactome:R-HSA-3132737 Reactome:R-HSA-203797 Reactome:R-HSA-199959 Reactome:R-HSA-198756 Reactome:R-HSA-198746	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	Reactome:R-HSA-6800434 Reactome:R-HSA-6798751	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	Reactome:R-HSA-112409	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	Reactome:R-HSA-169893	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005819	spindle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0251	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0035	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lu, R et al. (2009) FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J. Lipid Res. 50 1156-64 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Gawecka, JE et al. (2012) RSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migration. J. Biol. Chem. 287 43424-37 PubMed GONUTS page
↑ Kutter, S et al. (2016) Regulation of Microtubule Assembly by Tau and not by Pin1. J. Mol. Biol. 428 1742-59 PubMed GONUTS page
↑ ^4.0 ^4.1 Lian, S et al. (2015) Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. Toxicology 338 104-16 PubMed GONUTS page
↑ ^5.0 ^5.1 Dineley, KT et al. (2001) Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J. Neurosci. 21 4125-33 PubMed GONUTS page
↑ ^6.0 ^6.1 Ko, YG et al. (2001) Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. J. Biol. Chem. 276 6030-6 PubMed GONUTS page
↑ ^7.0 ^7.1 Sidharthan, NP et al. (2013) Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling. J. Biol. Chem. 288 34364-74 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Cerone, MA et al. (2011) High-throughput RNAi screening reveals novel regulators of telomerase. Cancer Res. 71 3328-40 PubMed GONUTS page
↑ Hizli, AA et al. (2013) Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase. Mol. Cell. Biol. 33 596-604 PubMed GONUTS page
↑ ^10.0 ^10.1 Sigal, A et al. (2006) Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat. Methods 3 525-31 PubMed GONUTS page
↑ ^11.0 ^11.1 Eyers, CE et al. (2005) The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. Biochem. J. 389 127-35 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 Vomastek, T et al. (2008) Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. Mol. Cell. Biol. 28 6954-66 PubMed GONUTS page
↑ ^13.0 ^13.1 Pandey, PK et al. (2005) Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation. Mol. Cell. Biol. 25 10695-710 PubMed GONUTS page
↑ Kolli, S et al. (2004) The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. J. Biol. Chem. 279 29374-85 PubMed GONUTS page
↑ Sacco, F et al. (2009) Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases. J. Biol. Chem. 284 22048-58 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Herrero, A et al. (2015) Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes. Cancer Cell 28 170-82 PubMed GONUTS page
↑ Kauppinen, TM et al. (2006) Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. Proc. Natl. Acad. Sci. U.S.A. 103 7136-41 PubMed GONUTS page
↑ ^19.0 ^19.1 Kodigepalli, KM & Nanjundan, M (2015) Induction of PLSCR1 in a STING/IRF3-dependent manner upon vector transfection in ovarian epithelial cells. PLoS ONE 10 e0117464 PubMed GONUTS page
↑ Wylie, PG et al. (1999) Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors. Biochem. J. 338 ( Pt 3) 619-28 PubMed GONUTS page
↑ Owaki, H et al. (1992) Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs. Biochem. Biophys. Res. Commun. 182 1416-22 PubMed GONUTS page
↑ ^22.0 ^22.1 Kampen, GT et al. (2000) Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. Blood 95 1911-7 PubMed GONUTS page
↑ Gabai, VL et al. (2000) Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death. Mol. Cell. Biol. 20 6826-36 PubMed GONUTS page
↑ ^24.00 ^24.01 ^24.02 ^24.03 ^24.04 ^24.05 ^24.06 ^24.07 ^24.08 ^24.09 ^24.10 ^24.11 ^24.12 ^24.13 Yao, Z & Seger, R () The ERK signaling cascade--views from different subcellular compartments. Biofactors 35 407-16 PubMed GONUTS page

[PMID:19229075-1] Lu, R et al. (2009) FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J. Lipid Res. 50 1156-64 PubMed GONUTS page

[PMID:23118220-2] 2.0 ^2.1 ^2.2 ^2.3 Gawecka, JE et al. (2012) RSK2 protein suppresses integrin activation and fibronectin matrix assembly and promotes cell migration. J. Biol. Chem. 287 43424-37 PubMed GONUTS page

[PMID:26996940-3] Kutter, S et al. (2016) Regulation of Microtubule Assembly by Tau and not by Pin1. J. Mol. Biol. 428 1742-59 PubMed GONUTS page

[PMID:26514923-4] 4.0 ^4.1 Lian, S et al. (2015) Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-кB, and AP-1 pathways in human endothelial cells. Toxicology 338 104-16 PubMed GONUTS page

[PMID:11404397-5] 5.0 ^5.1 Dineley, KT et al. (2001) Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J. Neurosci. 21 4125-33 PubMed GONUTS page

[PMID:11096076-6] 6.0 ^6.1 Ko, YG et al. (2001) Glutamine-dependent antiapoptotic interaction of human glutaminyl-tRNA synthetase with apoptosis signal-regulating kinase 1. J. Biol. Chem. 276 6030-6 PubMed GONUTS page

[PMID:24136195-7] 7.0 ^7.1 Sidharthan, NP et al. (2013) Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling. J. Biol. Chem. 288 34364-74 PubMed GONUTS page

[PMID:21531765-8] 8.0 ^8.1 ^8.2 Cerone, MA et al. (2011) High-throughput RNAi screening reveals novel regulators of telomerase. Cancer Res. 71 3328-40 PubMed GONUTS page

[PMID:23184662-9] Hizli, AA et al. (2013) Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase. Mol. Cell. Biol. 33 596-604 PubMed GONUTS page

[PMID:16791210-10] 10.0 ^10.1 Sigal, A et al. (2006) Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat. Methods 3 525-31 PubMed GONUTS page

[PMID:15850461-11] 11.0 ^11.1 Eyers, CE et al. (2005) The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ. Biochem. J. 389 127-35 PubMed GONUTS page

[PMID:18794356-12] 12.0 ^12.1 ^12.2 ^12.3 Vomastek, T et al. (2008) Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. Mol. Cell. Biol. 28 6954-66 PubMed GONUTS page

[PMID:16314496-13] 13.0 ^13.1 Pandey, PK et al. (2005) Activation of TRAP/mediator subunit TRAP220/Med1 is regulated by mitogen-activated protein kinase-dependent phosphorylation. Mol. Cell. Biol. 25 10695-710 PubMed GONUTS page

[PMID:15133037-14] Kolli, S et al. (2004) The major vault protein is a novel substrate for the tyrosine phosphatase SHP-2 and scaffold protein in epidermal growth factor signaling. J. Biol. Chem. 279 29374-85 PubMed GONUTS page

[PMID:19494114-15] Sacco, F et al. (2009) Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases. J. Biol. Chem. 284 22048-58 PubMed GONUTS page

[PMID:21873635-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:26267534-17] Herrero, A et al. (2015) Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes. Cancer Cell 28 170-82 PubMed GONUTS page

[PMID:16627622-18] Kauppinen, TM et al. (2006) Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2. Proc. Natl. Acad. Sci. U.S.A. 103 7136-41 PubMed GONUTS page

[PMID:25658875-19] 19.0 ^19.1 Kodigepalli, KM & Nanjundan, M (2015) Induction of PLSCR1 in a STING/IRF3-dependent manner upon vector transfection in ovarian epithelial cells. PLoS ONE 10 e0117464 PubMed GONUTS page

[PMID:10051431-20] Wylie, PG et al. (1999) Regulation of extracellular-signal regulated kinase and c-Jun N-terminal kinase by G-protein-linked muscarinic acetylcholine receptors. Biochem. J. 338 ( Pt 3) 619-28 PubMed GONUTS page

[PMID:1540184-21] Owaki, H et al. (1992) Extracellular signal-regulated kinases in T cells: characterization of human ERK1 and ERK2 cDNAs. Biochem. Biophys. Res. Commun. 182 1416-22 PubMed GONUTS page

[PMID:10706854-22] 22.0 ^22.1 Kampen, GT et al. (2000) Eotaxin induces degranulation and chemotaxis of eosinophils through the activation of ERK2 and p38 mitogen-activated protein kinases. Blood 95 1911-7 PubMed GONUTS page

[PMID:10958679-23] Gabai, VL et al. (2000) Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death. Mol. Cell. Biol. 20 6826-36 PubMed GONUTS page

[PMID:19565474-24] 24.00 ^24.01 ^24.02 ^24.03 ^24.04 ^24.05 ^24.06 ^24.07 ^24.08 ^24.09 ^24.10 ^24.11 ^24.12 ^24.13 Yao, Z & Seger, R () The ERK signaling cascade--views from different subcellular compartments. Biofactors 35 407-16 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

HUMAN:MK01

Contents

Annotations

Notes

References

a

b

c

d

e

f

g

h

i

k

l

m

n

o

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools