HUMAN:FOXC2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	FOXC2 (synonyms: FKHL14, MFH1)
Protein Name(s)	Forkhead box protein C2 Forkhead-related protein FKHL14 Mesenchyme fork head protein 1 MFH-1 protein Transcription factor FKH-14
External Links
UniProt	Q99958
EMBL	Y08223 GQ282998 BC113437 BC113439
CCDS	CCDS10958.1
RefSeq	NP_005242.1
UniGene	Hs.436448
PDB	1D5V
PDBsum	1D5V
ProteinModelPortal	Q99958
SMR	Q99958
BioGrid	108592
IntAct	Q99958
STRING	9606.ENSP00000326371
PhosphoSite	Q99958
DMDM	3024149
MaxQB	Q99958
PaxDb	Q99958
PRIDE	Q99958
DNASU	2303
Ensembl	ENST00000320354
GeneID	2303
KEGG	hsa:2303
UCSC	uc002fjq.3
CTD	2303
GeneCards	GC16P086600
GeneReviews	FOXC2
HGNC	HGNC:3801
MIM	153200 153300 153400 602402
neXtProt	NX_Q99958
Orphanet	33001
PharmGKB	PA28218
eggNOG	COG5025
GeneTree	ENSGT00760000118904
HOGENOM	HOG000007939
HOVERGEN	HBG051640
InParanoid	Q99958
KO	K09396
OMA	LNHLPGH
OrthoDB	EOG7C8GHD
PhylomeDB	Q99958
TreeFam	TF316127
SignaLink	Q99958
EvolutionaryTrace	Q99958
GeneWiki	FOXC2
GenomeRNAi	2303
NextBio	9351
PRO	PR:Q99958
Proteomes	UP000005640
Bgee	Q99958
CleanEx	HS_FOXC2
ExpressionAtlas	Q99958
Genevestigator	Q99958
GO	GO:0005634 GO:0031490 GO:0001077 GO:0003705 GO:0043565 GO:0003700 GO:0044212 GO:0048844 GO:0001974 GO:0043010 GO:0060038 GO:0030199 GO:0035050 GO:0048703 GO:0072011 GO:0072144 GO:0072112 GO:0007507 GO:0008286 GO:0001946 GO:0007498 GO:0001656 GO:1902257 GO:0000122 GO:0014032 GO:0007219 GO:0001503 GO:0048343 GO:0001569 GO:0033630 GO:0090050 GO:0010595 GO:0045944 GO:0045893 GO:0035470 GO:0050880 GO:0046620 GO:0009725 GO:0001756 GO:0001657 GO:0048010 GO:0055010
Gene3D	1.10.10.10
InterPro	IPR001766 IPR018122 IPR011991
Pfam	PF00250
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00657 PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:20956529^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0001228) part_of:(GO:0045944) occurs_at:(SO:0001952)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:19274049^[2]	ECO:0000255	match to sequence model evidence used in manual assertion	InterPro:IPR001766	F		Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:11551504^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:20956529^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	PMID:20956529^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	part_of:(GO:0001228)	Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000113	ECO:0005556	multiple sequence alignment evidence used in manual assertion	UniProtKB:Q61660	F		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61850	F		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	PMID:21457232^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61850	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61850	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61850	F		Seeded From UniProt	complete
involved_in	GO:0035470	positive regulation of vascular wound healing	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61850	P		Seeded From UniProt	complete
involved_in	GO:0033630	positive regulation of cell adhesion mediated by integrin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61850	P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61850	P		Seeded From UniProt	complete
enables	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	PMID:20956529^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61850	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:16081467^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9169153^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:16081467^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0031490	chromatin DNA binding	PMID:16456100^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	PMID:16456100^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:16456100^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007498	mesoderm development	PMID:8674414^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16081467^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11562355^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:9169153^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001946	lymphangiogenesis	PMID:12114478^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000930906 WB:WBGene00004013	P		Seeded From UniProt	complete
involved_in	GO:0009653	anatomical structure morphogenesis	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1347476 PANTHER:PTN000930906	P		Seeded From UniProt	complete
involved_in	GO:0006357	regulation of transcription by RNA polymerase II	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 MGI:MGI:1347472 MGI:MGI:1347477 PANTHER:PTN000930906 UniProtKB:O00358 UniProtKB:Q9Y261 ZFIN:ZDB-GENE-000616-15	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 FB:FBgn0003430 FB:FBgn0004895 FB:FBgn0014143 MGI:MGI:1347466 MGI:MGI:1347472 MGI:MGI:1347476 MGI:MGI:1347477 MGI:MGI:1349428 MGI:MGI:1353569 MGI:MGI:1927549 MGI:MGI:95546 PANTHER:PTN000930906 PomBase:SPBC32H8.11 PomBase:SPBC4C3.12 RGD:2807 RGD:2808 RGD:2809 SGD:S000000661 SGD:S000001393 UniProtKB:O00358 UniProtKB:P55317 UniProtKB:P58012 UniProtKB:Q12948 UniProtKB:Q13461 UniProtKB:Q5AS72 UniProtKB:Q99958 UniProtKB:Q9Y261 WB:WBGene00001434 WB:WBGene00001441 WB:WBGene00002601 WB:WBGene00003017 WB:WBGene00004013 WB:WBGene00006853	C		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[11]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0000659 PANTHER:PTN000930906 RGD:621723 UniProtKB:O00358 WB:WBGene00004013 ZFIN:ZDB-GENE-000616-15	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:25609649^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q99958	F		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:1990841	promoter-specific chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	F		Seeded From UniProt	complete
involved_in	GO:1902257	negative regulation of apoptotic process involved in outflow tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0072144	glomerular mesangial cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0072112	glomerular visceral epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0072011	glomerular endothelium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0060038	cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0055010	ventricular cardiac muscle tissue morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0050880	regulation of blood vessel size	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0048844	artery morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0048704	embryonic skeletal system morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0048703	embryonic viscerocranium morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0048701	embryonic cranial skeleton morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0048343	paraxial mesodermal cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0048341	paraxial mesoderm formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0048010	vascular endothelial growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0046620	regulation of organ growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	F		Seeded From UniProt	complete
involved_in	GO:0043010	camera-type eye development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0035470	positive regulation of vascular wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0035050	embryonic heart tube development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0033630	positive regulation of cell adhesion mediated by integrin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0030199	collagen fibril organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0014032	neural crest cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0010595	positive regulation of endothelial cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0007219	Notch signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	F		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	F		Seeded From UniProt	complete
involved_in	GO:0003007	heart morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0001974	blood vessel remodeling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0001945	lymph vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0001756	somitogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0001656	metanephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0001569	branching involved in blood vessel morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0001568	blood vessel development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
involved_in	GO:0001501	skeletal system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61850 ensembl:ENSMUSP00000055290	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q63246 ensembl:ENSRNOP00000065254	F		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR018122 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Zhou, J et al. (2010) Transcription elongation regulator 1 is a co-integrator of the cell fate determination factor Dachshund homolog 1. J. Biol. Chem. 285 40342-50 PubMed GONUTS page
↑ Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page
↑ Cederberg, A et al. (2001) FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 106 563-73 PubMed GONUTS page
↑ Iascone, M et al. (2012) Identification of de novo mutations and rare variants in hypoplastic left heart syndrome. Clin. Genet. 81 542-54 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Berry, FB et al. (2005) The establishment of a predictive mutational model of the forkhead domain through the analyses of FOXC2 missense mutations identified in patients with hereditary lymphedema with distichiasis. Hum. Mol. Genet. 14 2619-27 PubMed GONUTS page
↑ ^6.0 ^6.1 Miura, N et al. (1997) Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures. Genomics 41 489-92 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Fujita, H et al. (2006) Foxc2 is a common mediator of insulin and transforming growth factor beta signaling to regulate plasminogen activator inhibitor type I gene expression. Circ. Res. 98 626-34 PubMed GONUTS page
↑ Kaestner, KH et al. (1996) Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development. Development 122 1751-8 PubMed GONUTS page
↑ Kume, T et al. (2001) The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev. 15 2470-82 PubMed GONUTS page
↑ Brice, G et al. (2002) Analysis of the phenotypic abnormalities in lymphoedema-distichiasis syndrome in 74 patients with FOXC2 mutations or linkage to 16q24. J. Med. Genet. 39 478-83 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Li, X et al. (2015) Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol. Syst. Biol. 11 775 PubMed GONUTS page

[PMID:20956529-1] 1.0 ^1.1 ^1.2 ^1.3 Zhou, J et al. (2010) Transcription elongation regulator 1 is a co-integrator of the cell fate determination factor Dachshund homolog 1. J. Biol. Chem. 285 40342-50 PubMed GONUTS page

[PMID:19274049-2] Vaquerizas, JM et al. (2009) A census of human transcription factors: function, expression and evolution. Nat. Rev. Genet. 10 252-63 PubMed GONUTS page

[PMID:11551504-3] Cederberg, A et al. (2001) FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 106 563-73 PubMed GONUTS page

[PMID:21457232-4] Iascone, M et al. (2012) Identification of de novo mutations and rare variants in hypoplastic left heart syndrome. Clin. Genet. 81 542-54 PubMed GONUTS page

[PMID:16081467-5] 5.0 ^5.1 ^5.2 Berry, FB et al. (2005) The establishment of a predictive mutational model of the forkhead domain through the analyses of FOXC2 missense mutations identified in patients with hereditary lymphedema with distichiasis. Hum. Mol. Genet. 14 2619-27 PubMed GONUTS page

[PMID:9169153-6] 6.0 ^6.1 Miura, N et al. (1997) Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures. Genomics 41 489-92 PubMed GONUTS page

[PMID:16456100-7] 7.0 ^7.1 ^7.2 Fujita, H et al. (2006) Foxc2 is a common mediator of insulin and transforming growth factor beta signaling to regulate plasminogen activator inhibitor type I gene expression. Circ. Res. 98 626-34 PubMed GONUTS page

[PMID:8674414-8] Kaestner, KH et al. (1996) Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development. Development 122 1751-8 PubMed GONUTS page

[PMID:11562355-9] Kume, T et al. (2001) The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. Genes Dev. 15 2470-82 PubMed GONUTS page

[PMID:12114478-10] Brice, G et al. (2002) Analysis of the phenotypic abnormalities in lymphoedema-distichiasis syndrome in 74 patients with FOXC2 mutations or linkage to 16q24. J. Med. Genet. 39 478-83 PubMed GONUTS page

[PMID:21873635-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:25609649-12] Li, X et al. (2015) Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol. Syst. Biol. 11 775 PubMed GONUTS page

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HUMAN:FOXC2

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