HUMAN:CHK1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CHEK1 (synonyms: CHK1)
Protein Name(s)	Serine/threonine-protein kinase Chk1 CHK1 checkpoint homolog Cell cycle checkpoint kinase Checkpoint kinase-1
External Links
UniProt	O14757
EMBL	AF016582 AF032874 AB032387 JF289264 AK292549 AK293143 AK299783 AF527555 AB451222 AB451345 AP001132 CH471065 BC004202 BC017575
CCDS	CCDS58191.1 CCDS8459.1
RefSeq	NP_001107593.1 NP_001107594.1 NP_001231775.1 NP_001265.2 XP_006718822.1
UniGene	Hs.24529 Hs.595920
PDB	1IA8 1NVQ 1NVR 1NVS 1ZLT 1ZYS 2AYP 2BR1 2BRB 2BRG 2BRH 2BRM 2BRN 2BRO 2C3J 2C3K 2C3L 2CGU 2CGV 2CGW 2CGX 2E9N 2E9O 2E9P 2E9U 2E9V 2GDO 2GHG 2HOG 2HXL 2HXQ 2HY0 2QHM 2QHN 2R0U 2WMQ 2WMR 2WMS 2WMT 2WMU 2WMV 2WMW 2WMX 2X8D 2X8E 2X8I 2XEY 2XEZ 2XF0 2YDI 2YDJ 2YDK 2YER 2YEX 2YM3 2YM4 2YM5 2YM6 2YM7 2YM8 2YWP 3F9N 3JVR 3JVS 3NLB 3OT3 3OT8 3PA3 3PA4 3PA5 3TKH 3TKI 3U9N 4FSM 4FSN 4FSQ 4FSR 4FST 4FSU 4FSW 4FSY 4FSZ 4FT0 4FT3 4FT5 4FT7 4FT9 4FTA 4FTC 4FTI 4FTJ 4FTK 4FTL 4FTM 4FTN 4FTO 4FTQ 4FTR 4FTT 4FTU 4GH2 4HYH 4HYI 4JIK
PDBsum	1IA8 1NVQ 1NVR 1NVS 1ZLT 1ZYS 2AYP 2BR1 2BRB 2BRG 2BRH 2BRM 2BRN 2BRO 2C3J 2C3K 2C3L 2CGU 2CGV 2CGW 2CGX 2E9N 2E9O 2E9P 2E9U 2E9V 2GDO 2GHG 2HOG 2HXL 2HXQ 2HY0 2QHM 2QHN 2R0U 2WMQ 2WMR 2WMS 2WMT 2WMU 2WMV 2WMW 2WMX 2X8D 2X8E 2X8I 2XEY 2XEZ 2XF0 2YDI 2YDJ 2YDK 2YER 2YEX 2YM3 2YM4 2YM5 2YM6 2YM7 2YM8 2YWP 3F9N 3JVR 3JVS 3NLB 3OT3 3OT8 3PA3 3PA4 3PA5 3TKH 3TKI 3U9N 4FSM 4FSN 4FSQ 4FSR 4FST 4FSU 4FSW 4FSY 4FSZ 4FT0 4FT3 4FT5 4FT7 4FT9 4FTA 4FTC 4FTI 4FTJ 4FTK 4FTL 4FTM 4FTN 4FTO 4FTQ 4FTR 4FTT 4FTU 4GH2 4HYH 4HYI 4JIK
ProteinModelPortal	O14757
SMR	O14757
BioGrid	107536
DIP	DIP-24182N
IntAct	O14757
MINT	MINT-1179072
STRING	9606.ENSP00000278916
BindingDB	O14757
ChEMBL	CHEMBL4630
GuidetoPHARMACOLOGY	1987
PhosphoSite	O14757
MaxQB	O14757
PaxDb	O14757
PRIDE	O14757
DNASU	1111
Ensembl	ENST00000428830 ENST00000438015 ENST00000524737 ENST00000532449 ENST00000534070 ENST00000544373
GeneID	1111
KEGG	hsa:1111
UCSC	uc001qcf.4
CTD	1111
GeneCards	GC11P125495
H-InvDB	HIX0201657
HGNC	HGNC:1925
HPA	CAB002049 HPA044364
MIM	603078
neXtProt	NX_O14757
PharmGKB	PA110
eggNOG	COG0515
GeneTree	ENSGT00730000111032
HOGENOM	HOG000216658
HOVERGEN	HBG002590
InParanoid	O14757
KO	K02216
OMA	GGFSKHI
PhylomeDB	O14757
TreeFam	TF351441
BRENDA	2.7.11.1
Reactome	REACT_111040 REACT_1614 REACT_407 REACT_6769 REACT_897
SignaLink	O14757
ChiTaRS	CHEK1
EvolutionaryTrace	O14757
GeneWiki	CHEK1
GenomeRNAi	1111
NextBio	4608
PRO	PR:O14757
Proteomes	UP000005640
Bgee	O14757
CleanEx	HS_CHEK1
ExpressionAtlas	O14757
Genevestigator	O14757
GO	GO:0005813 GO:0000785 GO:0000794 GO:0005829 GO:0005615 GO:0043231 GO:0005654 GO:0005634 GO:0005657 GO:0005524 GO:0035402 GO:0004674 GO:0071313 GO:0006974 GO:0071260 GO:0048096 GO:0000077 GO:0006975 GO:0006281 GO:0006260 GO:0031572 GO:0000086 GO:2000279 GO:0010972 GO:0045839 GO:0018107 GO:0042127 GO:0010569 GO:2000615 GO:0046602 GO:0010767 GO:0090399
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0006915	apoptotic process	PMID:23028632^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:26296656^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:26296656^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26296656^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	PMID:26296656^[2]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P54725	F		Seeded From UniProt	complete
involved_in	GO:0045787	positive regulation of cell cycle	PMID:26296656^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:22024163^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:23580065^[4]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	part_of:(UBERON:0001827)	Seeded From UniProt	complete
involved_in	GO:0090399	replicative senescence	PMID:15149599^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0000781	chromosome, telomeric region	PMID:15149599^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000615	regulation of histone H3-K9 acetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35280	P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:19593445^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048096	chromatin-mediated maintenance of transcription	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35280	P		Seeded From UniProt	complete
involved_in	GO:0046602	regulation of mitotic centrosome separation	PMID:15311285^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045839	negative regulation of mitotic nuclear division	PMID:15311285^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035402	histone kinase activity (H3-T11 specific)	PMID:18243098^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0072425	signal transduction involved in G2 DNA damage checkpoint	PMID:20932473^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0004672	protein kinase activity	PMID:22024163^[3]	ECO:0000315			F		Figure 1	complete CACAO 6583
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:15665856^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0042127	regulation of cell proliferation	PMID:14608368^[11]	ECO:0000314			P		Figure 1. (m) This protein, which has been shown to be involved with DNA damage checkpoint processes, has also been found in higher abundance in senescent cells. A Western blot obtained from whole-cell extracts was used to compare Chk1 abundance of senescent cells to proliferating cells to telomerized proliferating cells to irradiated proliferating cells. The results showed that Chk1 expression in senescent cells was greater than all other groups, except irradiated proliferating cells which were used to represent cells with double stranded DNA breaks.	complete
involved_in	GO:0010767	regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35280	P		Seeded From UniProt	complete
	GO:0042127		PMID:14608368^[11]	ECO:0000314					Figure 1.m. shows that phosphorylation at serine 345 is upregulated in senescent cells compared to proliferating cells.	complete CACAO 9426
involved_in	GO:0010569	regulation of double-strand break repair via homologous recombination	PMID:15665856^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006975	DNA damage induced protein phosphorylation	PMID:16963448^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:20932473^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:19716789^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	PMID:15311285^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:20932473^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:15311285^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16963448^[12]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0000794	condensed nuclear chromosome	PMID:9382850^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0000785	chromatin	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O35280	C		Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	PMID:19716789^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	PMID:16963448^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:2445031 PANTHER:PTN000678822 UniProtKB:P57059 UniProtKB:Q9H0K1 UniProtKB:Q9IA88	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:1347352 MGI:MGI:1351488 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:3037705 PANTHER:PTN000678822 RGD:1359167 RGD:3387 RGD:620545 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 TAIR:locus:2094672 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q13131 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1347559 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC32C12.03c PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:3387 RGD:620893 SGD:S000000601 SGD:S000000931 SGD:S000001124 SGD:S000001651 SGD:S000002885 SGD:S000003820 SGD:S000005127 SGD:S000006062 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q57YE4 UniProtKB:Q7XQP4 UniProtKB:Q8I3C7 UniProtKB:Q8IWQ3 UniProtKB:Q8TDC3 UniProtKB:Q940H6 UniProtKB:Q9IA88 WB:WBGene00002210 WB:WBGene00003919 WB:WBGene00020142 WB:WBGene00021012	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023169 FB:FBgn0261278 MGI:MGI:104754 MGI:MGI:1202065 MGI:MGI:1336173 MGI:MGI:2145955 MGI:MGI:2445031 PANTHER:PTN000678822 PomBase:SPAC23H4.02 PomBase:SPBC19C2.05 PomBase:SPCC74.03c RGD:69407 RGD:69653 SGD:S000001124 SGD:S000002885 SGD:S000003820 SGD:S000005947 TAIR:locus:2009812 TAIR:locus:2032075 TAIR:locus:2140104 TAIR:locus:2159597 TAIR:locus:2160559 TAIR:locus:2174999 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P43291 UniProtKB:P57059 UniProtKB:Q39192 UniProtKB:Q5N942 UniProtKB:Q7XQP4 UniProtKB:Q8TDC3 UniProtKB:Q940H6 WB:WBGene00002210	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0025625 MGI:MGI:104754 MGI:MGI:106924 MGI:MGI:1336173 MGI:MGI:1347559 MGI:MGI:1923020 MGI:MGI:2445031 MGI:MGI:2685946 PANTHER:PTN000678822 PomBase:SPAC57A10.02 PomBase:SPAC644.06c PomBase:SPBC19C2.05 PomBase:SPBC4F6.06 PomBase:SPCC1020.10 PomBase:SPCC297.03 PomBase:SPCC74.03c RGD:1359167 RGD:1563268 RGD:1566256 RGD:3387 RGD:620893 RGD:69407 RGD:69653 SGD:S000000931 SGD:S000001531 SGD:S000001584 SGD:S000002529 SGD:S000002885 SGD:S000004086 SGD:S000005127 SGD:S000005759 TAIR:locus:2009812 TAIR:locus:2094672 TAIR:locus:2102132 UniProtKB:O14757 UniProtKB:O60285 UniProtKB:P57059 UniProtKB:Q14680 UniProtKB:Q6SA08 UniProtKB:Q8IWQ3 UniProtKB:Q8IY84 UniProtKB:Q8TDC3 UniProtKB:Q96PF2 UniProtKB:Q9BXA6 UniProtKB:Q9BXA7 UniProtKB:Q9H093 UniProtKB:Q9H0K1 UniProtKB:Q9IA88 UniProtKB:Q9NRH2 UniProtKB:Q9STV4 WB:WBGene00003919	F		Seeded From UniProt	complete
part_of	GO:0043231	intracellular membrane-bounded organelle	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0035407	histone H3-T11 phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0035402	P		Seeded From UniProt	complete
involved_in	GO:0000077	DNA damage checkpoint	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034670	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034670	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271 InterPro:IPR034670	P		Seeded From UniProt	complete
involved_in	GO:1901796	regulation of signal transduction by p53 class mediator	Reactome:R-HSA-5633007	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070317	negative regulation of G0 to G1 transition	Reactome:R-HSA-8953750	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	Reactome:R-HSA-69604	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	Reactome:R-HSA-5684887 Reactome:R-HSA-176187	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-205328	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-9007539 Reactome:R-HSA-75010 Reactome:R-HSA-69604 Reactome:R-HSA-6799246 Reactome:R-HSA-5685242 Reactome:R-HSA-5685230 Reactome:R-HSA-5684887 Reactome:R-HSA-5684882 Reactome:R-HSA-176116	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-HSA-9007539 Reactome:R-HSA-75010 Reactome:R-HSA-6799246 Reactome:R-HSA-5685242 Reactome:R-HSA-5685230	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0234	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0007049	cell cycle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0131	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0206	C		Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0048	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Fujikane, R et al. (2012) The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine. PLoS ONE 7 e44817 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 ^2.4 Tan, X et al. (2015) hHR23A is required to control the basal turnover of Chk1. Cell. Signal. 27 2304-13 PubMed GONUTS page
↑ ^3.0 ^3.1 Petsalaki, E et al. (2011) Phosphorylation at serine 331 is required for Aurora B activation. J. Cell Biol. 195 449-66 PubMed GONUTS page
↑ Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page
↑ ^5.0 ^5.1 Herbig, U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14 501-13 PubMed GONUTS page
↑ Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Krämer, A et al. (2004) Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nat. Cell Biol. 6 884-91 PubMed GONUTS page
↑ Shimada, M et al. (2008) Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. Cell 132 221-32 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Reinhardt, HC et al. (2010) DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Mol. Cell 40 34-49 PubMed GONUTS page
↑ ^10.0 ^10.1 Sørensen, CS et al. (2005) The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat. Cell Biol. 7 195-201 PubMed GONUTS page
↑ ^11.0 ^11.1 d'Adda di Fagagna, F et al. (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature 426 194-8 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Chini, CC & Chen, J (2006) Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. J. Biol. Chem. 281 33276-82 PubMed GONUTS page
↑ ^13.0 ^13.1 Zhang, YW et al. (2009) The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. Mol. Cell 35 442-53 PubMed GONUTS page
↑ Flaggs, G et al. (1997) Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes. Curr. Biol. 7 977-86 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23028632-1] Fujikane, R et al. (2012) The identification of a novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O⁶-methylguanine. PLoS ONE 7 e44817 PubMed GONUTS page

[PMID:26296656-2] 2.0 ^2.1 ^2.2 ^2.3 ^2.4 Tan, X et al. (2015) hHR23A is required to control the basal turnover of Chk1. Cell. Signal. 27 2304-13 PubMed GONUTS page

[PMID:22024163-3] 3.0 ^3.1 Petsalaki, E et al. (2011) Phosphorylation at serine 331 is required for Aurora B activation. J. Cell Biol. 195 449-66 PubMed GONUTS page

[PMID:23580065-4] Pieragostino, D et al. (2013) Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Mol Biosyst 9 1108-16 PubMed GONUTS page

[PMID:15149599-5] 5.0 ^5.1 Herbig, U et al. (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 14 501-13 PubMed GONUTS page

[PMID:19593445-6] Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page

[PMID:15311285-7] 7.0 ^7.1 ^7.2 ^7.3 Krämer, A et al. (2004) Centrosome-associated Chk1 prevents premature activation of cyclin-B-Cdk1 kinase. Nat. Cell Biol. 6 884-91 PubMed GONUTS page

[PMID:18243098-8] Shimada, M et al. (2008) Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression. Cell 132 221-32 PubMed GONUTS page

[PMID:20932473-9] 9.0 ^9.1 ^9.2 Reinhardt, HC et al. (2010) DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. Mol. Cell 40 34-49 PubMed GONUTS page

[PMID:15665856-10] 10.0 ^10.1 Sørensen, CS et al. (2005) The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair. Nat. Cell Biol. 7 195-201 PubMed GONUTS page

[PMID:14608368-11] 11.0 ^11.1 d'Adda di Fagagna, F et al. (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature 426 194-8 PubMed GONUTS page

[PMID:16963448-12] 12.0 ^12.1 ^12.2 Chini, CC & Chen, J (2006) Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. J. Biol. Chem. 281 33276-82 PubMed GONUTS page

[PMID:19716789-13] 13.0 ^13.1 Zhang, YW et al. (2009) The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress. Mol. Cell 35 442-53 PubMed GONUTS page

[PMID:9382850-14] Flaggs, G et al. (1997) Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes. Curr. Biol. 7 977-86 PubMed GONUTS page

[PMID:21873635-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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