HUMAN:CASP9

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CASP9 (synonyms: MCH6)
Protein Name(s)	Caspase-9 CASP-9 Apoptotic protease Mch-6 Apoptotic protease-activating factor 3 APAF-3 ICE-like apoptotic protease 6 ICE-LAP6 Caspase-9 subunit p35 Caspase-9 subunit p10
External Links
UniProt	P55211
EMBL	U56390 U60521 AB019205 AF093130 AB015653 AB020979 AF110376 AY732490 AY214168 BT006911 AK303743 AL512883 AL512883 CH471167 CH471167 BC002452 BC006463
CCDS	CCDS158.1 CCDS159.2 CCDS59995.1
PIR	G02635
RefSeq	NP_001220.2 NP_001264983.1 NP_127463.2 XP_005246071.1
UniGene	Hs.329502
PDB	1JXQ 1NW9 2AR9 3D9T 3V3K 3YGS 4RHW
PDBsum	1JXQ 1NW9 2AR9 3D9T 3V3K 3YGS 4RHW
ProteinModelPortal	P55211
SMR	P55211
BioGrid	107292
DIP	DIP-27625N
IntAct	P55211
MINT	MINT-89165
STRING	9606.ENSP00000330237
BindingDB	P55211
ChEMBL	CHEMBL2273
GuidetoPHARMACOLOGY	1625
MEROPS	C14.010
PhosphoSite	P55211
DMDM	28558771
MaxQB	P55211
PaxDb	P55211
PRIDE	P55211
DNASU	842
Ensembl	ENST00000333868 ENST00000348549 ENST00000375890
GeneID	842
KEGG	hsa:842
UCSC	uc001awn.4 uc001awo.4
CTD	842
GeneCards	GC01M015814
HGNC	HGNC:1511
HPA	CAB004348 HPA001473
MIM	602234
neXtProt	NX_P55211
PharmGKB	PA26094
eggNOG	NOG319022
GeneTree	ENSGT00760000118912
HOVERGEN	HBG059022
InParanoid	P55211
KO	K04399
PhylomeDB	P55211
TreeFam	TF102023
BRENDA	3.4.22.62
Reactome	REACT_12564 REACT_147727 REACT_22128 REACT_607 REACT_75776 REACT_89
SABIO-RK	P55211
EvolutionaryTrace	P55211
GeneWiki	Caspase-9
GenomeRNAi	842
NextBio	3524
PMAP-CutDB	P55211
PRO	PR:P55211
Proteomes	UP000005640
Bgee	P55211
CleanEx	HS_CASP9
ExpressionAtlas	P55211
Genevestigator	P55211
GO	GO:0043293 GO:0005829 GO:0005739 GO:0005634 GO:0004197 GO:0008047 GO:0008233 GO:0019901 GO:0017124 GO:0008635 GO:0007568 GO:0006915 GO:0071549 GO:0006974 GO:0034644 GO:0007173 GO:0038095 GO:0008543 GO:0034349 GO:0045087 GO:0097193 GO:0008630 GO:0048011 GO:0048015 GO:0030220 GO:0043065 GO:0043525 GO:0042981 GO:2001020 GO:0046677 GO:0032025 GO:0032355 GO:0032496 GO:0042770
Gene3D	1.10.533.10 3.40.50.1460
InterPro	IPR001315 IPR029030 IPR017350 IPR011029 IPR011600 IPR001309 IPR016129 IPR002138 IPR015917
Pfam	PF00619 PF00656
PIRSF	PIRSF038001
PRINTS	PR00376
SMART	SM00114 SM00115
SUPFAM	SSF47986
PROSITE	PS50209 PS01122 PS01121 PS50207 PS50208

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	PMID:21980415^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0010003)	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:15069058^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:11821383^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:16920334^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:19740745^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:Q15185)	Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:11821383^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2001020	regulation of response to DNA damage stimulus	PMID:15657060^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0043293	apoptosome	PMID:21827945^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042770	signal transduction in response to DNA damage	PMID:15657060^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	PMID:15657060^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:15657060^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0017124	SH3 domain binding	PMID:15657060^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:15657060^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:15657060^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:17167422^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019972 MGI:MGI:107739 MGI:MGI:109383 MGI:MGI:1261423 MGI:MGI:97295 PANTHER:PTN000047947 UniProtKB:P42574 UniProtKB:Q14790	F		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000048016 UniProtKB:P55211	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010501 FB:FBgn0020381 FB:FBgn0026404 FB:FBgn0028381 FB:FBgn0033659 MGI:MGI:107739 MGI:MGI:109383 MGI:MGI:1261423 MGI:MGI:1277950 MGI:MGI:1312922 PANTHER:PTN000047947 RGD:2274 RGD:2275 RGD:61867 RGD:620945 RGD:69274 UniProtKB:O15519 UniProtKB:P42574 UniProtKB:P55210 UniProtKB:P55211 UniProtKB:Q14790 WB:WBGene00000417	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019972 FB:FBgn0020381 FB:FBgn0026404 FB:FBgn0028381 FB:FBgn0033051 MGI:MGI:107739 MGI:MGI:1261423 MGI:MGI:1336166 MGI:MGI:97295 PANTHER:PTN000047947 RGD:2274 RGD:2275 RGD:61867 RGD:620945 RGD:70967 UniProtKB:O15519 UniProtKB:P31944 UniProtKB:Q95ND5 UniProtKB:Q9ULZ3 WB:WBGene00000417	C		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:20663920^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071549	cellular response to dexamethasone stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C3Q9 ensembl:ENSMUSP00000030747	P		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C3Q9 ensembl:ENSMUSP00000030747	P		Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C3Q9 ensembl:ENSMUSP00000030747	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C3Q9 ensembl:ENSMUSP00000030747	F		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C3Q9 ensembl:ENSMUSP00000030747	P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C3Q9 ensembl:ENSMUSP00000030747	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C3Q9 ensembl:ENSMUSP00000030747	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C3Q9 ensembl:ENSMUSP00000030747	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C3Q9 ensembl:ENSMUSP00000030747	C		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q8C3Q9 ensembl:ENSMUSP00000030747	F		Seeded From UniProt	complete
involved_in	GO:0071887	leukocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	P		Seeded From UniProt	complete
involved_in	GO:0046677	response to antibiotic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	P		Seeded From UniProt	complete
involved_in	GO:0034349	glial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	P		Seeded From UniProt	complete
involved_in	GO:0032025	response to cobalt ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	F		Seeded From UniProt	complete
involved_in	GO:0007568	aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	C		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JHK1 ensembl:ENSRNOP00000017972	P		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001309 InterPro:IPR002138 InterPro:IPR002398 InterPro:IPR033171	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001309 InterPro:IPR002138 InterPro:IPR002398 InterPro:IPR033171	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033171	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015917	F		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001315	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:15941357^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P55211-1	F		Seeded From UniProt	complete
involved_in	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	PMID:9390557^[12] Reactome:R-HSA-111459	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008047	enzyme activator activity	PMID:9390557^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:9390557^[12] Reactome:R-HSA-114259	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030220	platelet formation	PMID:18309324^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:8663294^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Reactome:R-HSA-418889	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-9627089 Reactome:R-HSA-9627078 Reactome:R-HSA-9627056 Reactome:R-HSA-6805426 Reactome:R-HSA-6804596 Reactome:R-HSA-418845 Reactome:R-HSA-373700 Reactome:R-HSA-2399985 Reactome:R-HSA-198621 Reactome:R-HSA-114261 Reactome:R-HSA-114259 Reactome:R-HSA-114256 Reactome:R-HSA-114252	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Zhang, Y et al. (2011) Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway. PLoS ONE 6 e25284 PubMed GONUTS page
↑ Broustas, CG et al. (2004) BRCC2, a novel BH3-like domain-containing protein, induces apoptosis in a caspase-dependent manner. J. Biol. Chem. 279 26780-8 PubMed GONUTS page
↑ ^3.0 ^3.1 Razmara, M et al. (2002) CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. J. Biol. Chem. 277 13952-8 PubMed GONUTS page
↑ Wang, X et al. (2006) Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death. Biochim. Biophys. Acta 1762 742-54 PubMed GONUTS page
↑ Woo, SH et al. (2009) A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function. J. Biol. Chem. 284 30871-80 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Raina, D et al. (2005) c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. J. Biol. Chem. 280 11147-51 PubMed GONUTS page
↑ Yuan, S et al. (2011) The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3. Structure 19 1084-96 PubMed GONUTS page
↑ Ribeil, JA et al. (2007) Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1. Nature 445 102-5 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Hofmann, ER et al. (2010) Identification and characterization of GRIM-1, a cell-death-associated gene product. J. Cell. Sci. 123 2781-91 PubMed GONUTS page
↑ Chao, Y et al. (2005) Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation. PLoS Biol. 3 e183 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Li, P et al. (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91 479-89 PubMed GONUTS page
↑ Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page
↑ Duan, H et al. (1996) ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J. Biol. Chem. 271 16720-4 PubMed GONUTS page

[PMID:21980415-1] Zhang, Y et al. (2011) Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway. PLoS ONE 6 e25284 PubMed GONUTS page

[PMID:15069058-2] Broustas, CG et al. (2004) BRCC2, a novel BH3-like domain-containing protein, induces apoptosis in a caspase-dependent manner. J. Biol. Chem. 279 26780-8 PubMed GONUTS page

[PMID:11821383-3] 3.0 ^3.1 Razmara, M et al. (2002) CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. J. Biol. Chem. 277 13952-8 PubMed GONUTS page

[PMID:16920334-4] Wang, X et al. (2006) Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death. Biochim. Biophys. Acta 1762 742-54 PubMed GONUTS page

[PMID:19740745-5] Woo, SH et al. (2009) A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function. J. Biol. Chem. 284 30871-80 PubMed GONUTS page

[PMID:15657060-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Raina, D et al. (2005) c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage. J. Biol. Chem. 280 11147-51 PubMed GONUTS page

[PMID:21827945-7] Yuan, S et al. (2011) The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3. Structure 19 1084-96 PubMed GONUTS page

[PMID:17167422-8] Ribeil, JA et al. (2007) Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1. Nature 445 102-5 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20663920-10] Hofmann, ER et al. (2010) Identification and characterization of GRIM-1, a cell-death-associated gene product. J. Cell. Sci. 123 2781-91 PubMed GONUTS page

[PMID:15941357-11] Chao, Y et al. (2005) Engineering a dimeric caspase-9: a re-evaluation of the induced proximity model for caspase activation. PLoS Biol. 3 e183 PubMed GONUTS page

[PMID:9390557-12] 12.0 ^12.1 ^12.2 Li, P et al. (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91 479-89 PubMed GONUTS page

[PMID:18309324-13] Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page

[PMID:8663294-14] Duan, H et al. (1996) ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J. Biol. Chem. 271 16720-4 PubMed GONUTS page

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HUMAN:CASP9

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