HUMAN:BCL2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BCL2
Protein Name(s)	Apoptosis regulator Bcl-2
External Links
UniProt	P10415
EMBL	M13994 M13995 M14745 X06487 AY220759 AC021803 AC022726 CH471096 BC027258 S72602
CCDS	CCDS11981.1 CCDS45882.1
PIR	B29409 C37332
RefSeq	NP_000624.2 NP_000648.2
UniGene	Hs.150749
PDB	1G5M 1GJH 1YSW 2O21 2O22 2O2F 2W3L 2XA0 4AQ3 4IEH 4LVT 4LXD 4MAN 5AGW 5AGX
PDBsum	1G5M 1GJH 1YSW 2O21 2O22 2O2F 2W3L 2XA0 4AQ3 4IEH 4LVT 4LXD 4MAN 5AGW 5AGX
DisProt	DP00297
ProteinModelPortal	P10415
SMR	P10415
BioGrid	107068
DIP	DIP-1043N
IntAct	P10415
MINT	MINT-87089
STRING	9606.ENSP00000329623
BindingDB	P10415
ChEMBL	CHEMBL4860
DrugBank	DB01248 DB01050 DB01229 DB01367
GuidetoPHARMACOLOGY	2844
iPTMnet	P10415
PhosphoSite	P10415
BioMuta	BCL2
DMDM	231632
EPD	P10415
MaxQB	P10415
PaxDb	P10415
PRIDE	P10415
DNASU	596
Ensembl	ENST00000333681 ENST00000398117 ENST00000589955
GeneID	596
KEGG	hsa:596
UCSC	uc002lit.2
CTD	596
GeneCards	BCL2
HGNC	HGNC:990
HPA	CAB000003
MalaCards	BCL2
MIM	151430
neXtProt	NX_P10415
Orphanet	545 98839
PharmGKB	PA25302
eggNOG	KOG4728 ENOG41123S0
GeneTree	ENSGT00530000062935
HOGENOM	HOG000056452
HOVERGEN	HBG004472
InParanoid	P10415
KO	K02161
OMA	IVLKYIH
OrthoDB	EOG70GMGD
PhylomeDB	P10415
TreeFam	TF315834
Reactome	R-HSA-111447 R-HSA-111453 R-HSA-844455
ChiTaRS	BCL2
EvolutionaryTrace	P10415
GeneWiki	Bcl-2
GenomeRNAi	596
NextBio	2423
PMAP-CutDB	P10415
PRO	PR:P10415
Proteomes	UP000005640
Bgee	P10415
CleanEx	HS_BCL2
ExpressionAtlas	P10415
Genevisible	P10415
GO	GO:0005737 GO:0005829 GO:0005783 GO:0005789 GO:0016020 GO:0005741 GO:0005739 GO:0043209 GO:0031965 GO:0005634 GO:0046930 GO:0051434 GO:0015267 GO:0016248 GO:0042802 GO:0002020 GO:0046982 GO:0042803 GO:0043565 GO:0031625 GO:0007015 GO:0006915 GO:0031103 GO:0007409 GO:0001782 GO:0002326 GO:0042100 GO:0050853 GO:0001662 GO:0001658 GO:0043375 GO:0007569 GO:0016049 GO:0006974 GO:0042149 GO:0071456 GO:0071310 GO:0021747 GO:0051607 GO:0048546 GO:0043583 GO:0032469 GO:0097192 GO:0008625 GO:0007565 GO:0048041 GO:0022612 GO:0032835 GO:0031069 GO:0048873 GO:0006959 GO:0045087 GO:0097193 GO:0008630 GO:0070059 GO:0008631 GO:0002320 GO:0008584 GO:0006582 GO:0030318 GO:0014031 GO:0001656 GO:2000811 GO:0043066 GO:2001234 GO:0010507 GO:0010523 GO:0030308 GO:0030336 GO:0032848 GO:2001240 GO:2000134 GO:2001243 GO:0051902 GO:0033033 GO:0043524 GO:0030279 GO:0033689 GO:2000378 GO:0046671 GO:0051402 GO:0035872 GO:0048599 GO:0035265 GO:0001503 GO:0001541 GO:0018105 GO:0018107 GO:0048753 GO:0030890 GO:0043085 GO:0030307 GO:2001244 GO:0045636 GO:0040018 GO:0014042 GO:0033138 GO:1900740 GO:0048743 GO:0014911 GO:0009791 GO:0012501 GO:0006470 GO:0000209 GO:0072593 GO:0051924 GO:0001952 GO:0010468 GO:0010559 GO:0046902 GO:0051881 GO:0006808 GO:0043497 GO:0043496 GO:0031647 GO:0022898 GO:0045069 GO:0001836 GO:0003014 GO:0034097 GO:0042493 GO:0010332 GO:0051384 GO:0042542 GO:0010039 GO:0002931 GO:0035094 GO:0009314 GO:0009636 GO:0010224 GO:0048536 GO:0033077 GO:0043029 GO:0048538 GO:0055085
InterPro	IPR013278 IPR002475 IPR004725 IPR020717 IPR020726 IPR020728 IPR003093 IPR020731 IPR026298
PANTHER	PTHR11256 PTHR11256:SF11
Pfam	PF00452 PF02180
PRINTS	PR01863 PR01862
SMART	SM00265
TIGRFAMs	TIGR00865
PROSITE	PS50062 PS01080 PS01258 PS01259 PS01260 PS50063

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0004676	3-phosphoinositide-dependent protein kinase activity	PMID:20660724^[1]	ECO:0000315			F		In Fig 1 b and 1 c screen was conducted that showed that the overexpression of Bcl-2 leads to decrease in levels of autophagy and type III P13 kinase. Screen showed that there was an increase in cell viability and decrease in levels of PtdIns3P following knock down of the hit genes in H4 cells expressing Bcl-2 compared to WT controls	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:28280358^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS000029D9F1_9606	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	PMID:28280358^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS000029D9F1_9606	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:15733859^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:20041405^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21212266^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:9660918^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q07812	P		Seeded From UniProt	complete
part_of	GO:0046930	pore complex	PMID:9219694^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:9219694^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0022898	regulation of transmembrane transporter activity	PMID:9219694^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016248	channel inhibitor activity	PMID:9219694^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0015267	channel activity	PMID:9219694^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051881	regulation of mitochondrial membrane potential	PMID:9843949^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10417	P		Seeded From UniProt	complete
involved_in	GO:0046902	regulation of mitochondrial membrane permeability	PMID:9843949^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10417	P		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	PMID:16307838^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	PMID:9843949^[8]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P10417	P		Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	PMID:11684014^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001234	negative regulation of apoptotic signaling pathway	PMID:20097879^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000811	negative regulation of anoikis	PMID:15006356^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q08117)	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:10620603^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0051434	BH3 domain binding	PMID:9111042^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q16611	F		Seeded From UniProt	complete
enables	GO:0051434	BH3 domain binding	PMID:9111042^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q07812	F		Seeded From UniProt	complete
involved_in	GO:0050853	B cell receptor signaling pathway	PMID:17875758^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:9111042^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q07812	F		Seeded From UniProt	complete
involved_in	GO:0043497	regulation of protein heterodimerization activity	PMID:9111042^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043496	regulation of protein homodimerization activity	PMID:9111042^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:17289999^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q07812)	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:9027314^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10506221^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10620603^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:9111042^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10415	F		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:17875758^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	PMID:12421819^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032848	negative regulation of cellular pH reduction	PMID:10506221^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	PMID:8402648^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	PMID:1502141^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:20889974^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60260	F		Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	PMID:17875758^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010039	response to iron ion	PMID:11264898^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009314	response to radiation	PMID:15799693^[24]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007565	female pregnancy	PMID:11530860^[25]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:17875758^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	PMID:8402648^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:8402648^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:9027314^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:9027314^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11530860^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0002020	protease binding	PMID:10620603^[13]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	PMID:9027314^[17]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000135647 UniProtKB:P10415 UniProtKB:Q07817 ZFIN:ZDB-GENE-010730-1	P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101769 MGI:MGI:108052 MGI:MGI:1097161 MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 UniProtKB:Q07820	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 RGD:2192 RGD:2199 RGD:2200 RGD:620525 RGD:620621 RGD:620717 RGD:621635 RGD:70984 UniProtKB:P10415 UniProtKB:Q07812 UniProtKB:Q07820 UniProtKB:Q16611 UniProtKB:Q92843 ZFIN:ZDB-GENE-000511-7 ZFIN:ZDB-GENE-030825-1 ZFIN:ZDB-GENE-051012-1	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:101769 MGI:MGI:102687 MGI:MGI:88138 MGI:MGI:88139 PANTHER:PTN000135647 RGD:2199 RGD:2200 RGD:620525 UniProtKB:P10415 UniProtKB:Q07817 UniProtKB:Q07820 UniProtKB:Q92843 WB:WBGene00000423 ZFIN:ZDB-GENE-000511-7 ZFIN:ZDB-GENE-010730-1	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1330841 MGI:MGI:1858494 MGI:MGI:99702 PANTHER:PTN000135648 RGD:621635 UniProtKB:P10415 UniProtKB:Q07812 UniProtKB:Q16611	F		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0029131 MGI:MGI:101769 MGI:MGI:1097161 MGI:MGI:88138 MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648	P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:21873635^[26]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:88139 MGI:MGI:99702 PANTHER:PTN000135648 RGD:2192 RGD:2200 UniProtKB:P10415 UniProtKB:Q07817 WB:WBGene00000423	C		Seeded From UniProt	complete
involved_in	GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	PMID:8358790^[27]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99702	P		Seeded From UniProt	complete
involved_in	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:15776018^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051924	regulation of calcium ion transport	PMID:8022822^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:12086670^[30]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	PMID:7546744^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:7772249^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:8080725^[33]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:8050499^[34]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:7772249^[32]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:7650367^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:15776018^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:1373874^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	PMID:36599^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042100	B cell proliferation	PMID:1373874^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	PMID:9184696^[38]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030307	positive regulation of cell growth	PMID:8022822^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:7896880^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	PMID:16717086^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:10597216^[41]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:8022822^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:36599^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:7896880^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:7546744^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7896880^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:7546744^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0000209	protein polyubiquitination	PMID:16717086^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:9463381^[42]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10415	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:18835031^[43]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10415	F		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0055085	transmembrane transport	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0015267	P		Seeded From UniProt	complete
involved_in	GO:2001234	negative regulation of apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:2000378	negative regulation of reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0098609	cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0072593	reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0051881	regulation of mitochondrial membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
enables	GO:0051721	protein phosphatase 2A binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	F		Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0048873	homeostasis of number of cells within a tissue	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0048753	pigment granule organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0048743	positive regulation of skeletal muscle fiber development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0048599	oocyte development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0048589	developmental growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0048546	digestive tract morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0048545	response to steroid hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0048538	thymus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0048536	spleen development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0048087	positive regulation of developmental pigmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0048070	regulation of developmental pigmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0048066	developmental pigmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0048041	focal adhesion assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	F		Seeded From UniProt	complete
involved_in	GO:0046902	regulation of mitochondrial membrane permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0046671	negative regulation of retinal cell programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0045636	positive regulation of melanocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0045069	regulation of viral genome replication	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0043583	ear development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0043473	pigmentation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0043375	CD8-positive, alpha-beta T cell lineage commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
part_of	GO:0043209	myelin sheath	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	C		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0043067	regulation of programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0043029	T cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0042149	cellular response to glucose starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0040018	positive regulation of multicellular organism growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0035265	organ growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0033689	negative regulation of osteoblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0033077	T cell differentiation in thymus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0033033	negative regulation of myeloid cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0032880	regulation of protein localization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0032835	glomerulus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	C		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0031103	axon regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0031069	hair follicle morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0030336	negative regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0030318	melanocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0030279	negative regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0030217	T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0030183	B cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0030097	hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0022612	gland morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0021747	cochlear nucleus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	F		Seeded From UniProt	complete
involved_in	GO:0018107	peptidyl-threonine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	C		Seeded From UniProt	complete
involved_in	GO:0014911	positive regulation of smooth muscle cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0014042	positive regulation of neuron maturation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0014031	mesenchymal cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0010559	regulation of glycoprotein biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0010523	negative regulation of calcium ion transport into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0010506	regulation of autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0010332	response to gamma radiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0010224	response to UV-B	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0009887	animal organ morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0009791	post-embryonic development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0008637	apoptotic mitochondrial changes	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0008584	male gonad development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	F		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0007409	axonogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0007015	actin filament organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0006874	cellular calcium ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0006808	regulation of nitrogen utilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0006582	melanin metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0006470	protein dephosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	C		Seeded From UniProt	complete
involved_in	GO:0003014	renal system process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0002520	immune system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0002360	T cell lineage commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0002326	B cell lineage commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0002320	lymphoid progenitor cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0002260	lymphocyte homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0001952	regulation of cell-matrix adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0001822	kidney development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0001782	B cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0001776	leukocyte homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0001662	behavioral fear response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0001658	branching involved in ureteric bud morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0001657	ureteric bud development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0001656	metanephros development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0001541	ovarian follicle development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0001503	ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P10417 ensembl:ENSMUSP00000108371	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004725	C		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003093 InterPro:IPR004725 InterPro:IPR020717 InterPro:IPR020726 InterPro:IPR020728 InterPro:IPR020731 InterPro:IPR026298 InterPro:IPR036834	P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR013278	P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	PMID:1502141^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	PMID:1502141^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:1286168^[44]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	PMID:16167175^[45]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051902	negative regulation of mitochondrial depolarization	PMID:9027314^[17]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:18309324^[46]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010507	negative regulation of autophagy	PMID:18309324^[46]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:Q14457)	Seeded From UniProt	complete
involved_in	GO:0006959	humoral immune response	PMID:1908951^[47]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	Reactome:R-HSA-111453	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	Reactome:R-HSA-111447	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	Reactome:R-HSA-114352	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	Reactome:R-HSA-9011941 Reactome:R-HSA-879201 Reactome:R-HSA-6790025 Reactome:R-HSA-508163 Reactome:R-HSA-139897 Reactome:R-HSA-114352	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0182	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lipinski, MM et al. (2010) Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 107 14164-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Luan, W et al. (2017) miR-204-5p acts as a tumor suppressor by targeting matrix metalloproteinases-9 and B-cell lymphoma-2 in malignant melanoma. Onco Targets Ther 10 1237-1246 PubMed GONUTS page
↑ Kang, CB et al. (2005) The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38). FEBS Lett. 579 1469-76 PubMed GONUTS page
↑ Xiong, Y et al. (2010) Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. Hepatology 51 836-45 PubMed GONUTS page
↑ Dluzen, D et al. (2011) BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner. J. Biol. Chem. 286 7705-13 PubMed GONUTS page
↑ Xu, Q & Reed, JC (1998) Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. Mol. Cell 1 337-46 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Antonsson, B et al. (1997) Inhibition of Bax channel-forming activity by Bcl-2. Science 277 370-2 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Narita, M et al. (1998) Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc. Natl. Acad. Sci. U.S.A. 95 14681-6 PubMed GONUTS page
↑ Chen, J et al. (2006) T-2 toxin induces apoptosis, and selenium partly blocks, T-2 toxin induced apoptosis in chondrocytes through modulation of the Bax/Bcl-2 ratio. Food Chem. Toxicol. 44 567-73 PubMed GONUTS page
↑ Samuels-Lev, Y et al. (2001) ASPP proteins specifically stimulate the apoptotic function of p53. Mol. Cell 8 781-94 PubMed GONUTS page
↑ Mader, I et al. (2010) Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis. FASEB J. 24 1997-2009 PubMed GONUTS page
↑ Jan, Y et al. (2004) A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors. Cell 116 751-62 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 Jacotot, E et al. (2000) The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. J. Exp. Med. 191 33-46 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Diaz, JL et al. (1997) A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members. J. Biol. Chem. 272 11350-5 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Joshi, AD et al. (2007) ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. Clin. Cancer Res. 13 5295-304 PubMed GONUTS page
↑ Willis, SN et al. (2007) Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 315 856-9 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 Yang, J et al. (1997) Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275 1129-32 PubMed GONUTS page
↑ ^18.0 ^18.1 Thangaraju, M et al. (1999) Regulation of acidification and apoptosis by SHP-1 and Bcl-2. J. Biol. Chem. 274 29549-57 PubMed GONUTS page
↑ Mai, H et al. (2003) A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis. J. Biol. Chem. 278 1886-91 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Krajewski, S et al. (1993) Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res. 53 4701-14 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Alnemri, ES et al. (1992) Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells. Proc. Natl. Acad. Sci. U.S.A. 89 7295-9 PubMed GONUTS page
↑ Chen, D et al. (2010) Parkin mono-ubiquitinates Bcl-2 and regulates autophagy. J. Biol. Chem. 285 38214-23 PubMed GONUTS page
↑ Simonart, T et al. (2001) Iron induces Bcl-2 expression in human dermal microvascular endothelial cells. Free Radic. Res. 34 221-35 PubMed GONUTS page
↑ Maguire, P et al. (2005) Medium from irradiated cells induces dose-dependent mitochondrial changes and BCL2 responses in unirradiated human keratinocytes. Radiat. Res. 163 384-90 PubMed GONUTS page
↑ ^25.0 ^25.1 Axt-Fliedner, R et al. (2001) The immunolocalization of Bcl-2 in human term placenta. Clin Exp Obstet Gynecol 28 144-7 PubMed GONUTS page
↑ ^26.0 ^26.1 ^26.2 ^26.3 ^26.4 ^26.5 ^26.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Oltvai, ZN et al. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74 609-19 PubMed GONUTS page
↑ ^28.0 ^28.1 Ruiz-Vela, A et al. (2005) Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep. 6 379-85 PubMed GONUTS page
↑ ^29.0 ^29.1 ^29.2 Lam, M et al. (1994) Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes. Proc. Natl. Acad. Sci. U.S.A. 91 6569-73 PubMed GONUTS page
↑ McGill, GG et al. (2002) Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 109 707-18 PubMed GONUTS page
↑ ^31.0 ^31.1 ^31.2 Greenlund, LJ et al. (1995) Role of BCL-2 in the survival and function of developing and mature sympathetic neurons. Neuron 15 649-61 PubMed GONUTS page
↑ ^32.0 ^32.1 Takayama, S et al. (1994) Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein. DNA Cell Biol. 13 679-92 PubMed GONUTS page
↑ Kondo, S et al. (1994) bcl-2 gene enables rescue from in vitro myelosuppression (bone marrow cell death) induced by chemotherapy. Br. J. Cancer 70 421-6 PubMed GONUTS page
↑ Kondo, S et al. (1994) bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells. Exp. Cell Res. 213 428-32 PubMed GONUTS page
↑ Broome, HE et al. (1995) Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal. J. Immunol. 155 2311-7 PubMed GONUTS page
↑ ^36.0 ^36.1 Borzillo, GV et al. (1992) Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture. Oncogene 7 869-76 PubMed GONUTS page
↑ ^37.0 ^37.1 Dublanchet, A & Durieux, R (1979) [Isolation of a strain of Streptococcus pneumoniae multiresistant to antibiotics]. Nouv Presse Med 8 872 PubMed GONUTS page
↑ Li, L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell. Immunol. 178 33-41 PubMed GONUTS page
↑ ^39.0 ^39.1 ^39.2 Yang, T et al. (1995) The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2. J. Cell Biol. 128 1173-84 PubMed GONUTS page
↑ ^40.0 ^40.1 Lin, SS et al. (2006) PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J. Biol. Chem. 281 23003-12 PubMed GONUTS page
↑ Lee, JH et al. (1999) Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene 18 6183-90 PubMed GONUTS page
↑ Huang, DC et al. (1998) The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4. EMBO J. 17 1029-39 PubMed GONUTS page
↑ Kolluri, SK et al. (2008) A short Nur77-derived peptide converts Bcl-2 from a protector to a killer. Cancer Cell 14 285-98 PubMed GONUTS page
↑ Hockenbery, DM (1992) The bcl-2 oncogene and apoptosis. Semin. Immunol. 4 413-20 PubMed GONUTS page
↑ Soane, L & Fiskum, G (2005) Inhibition of mitochondrial neural cell death pathways by protein transduction of Bcl-2 family proteins. J. Bioenerg. Biomembr. 37 179-90 PubMed GONUTS page
↑ ^46.0 ^46.1 Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page
↑ Nuñez, G et al. (1991) Bcl-2 maintains B cell memory. Nature 353 71-3 PubMed GONUTS page

[PMID:20660724-1] Lipinski, MM et al. (2010) Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 107 14164-9 PubMed GONUTS page

[PMID:28280358-2] 2.0 ^2.1 Luan, W et al. (2017) miR-204-5p acts as a tumor suppressor by targeting matrix metalloproteinases-9 and B-cell lymphoma-2 in malignant melanoma. Onco Targets Ther 10 1237-1246 PubMed GONUTS page

[PMID:15733859-3] Kang, CB et al. (2005) The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38). FEBS Lett. 579 1469-76 PubMed GONUTS page

[PMID:20041405-4] Xiong, Y et al. (2010) Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma. Hepatology 51 836-45 PubMed GONUTS page

[PMID:21212266-5] Dluzen, D et al. (2011) BCL-2 is a downstream target of ATF5 that mediates the prosurvival function of ATF5 in a cell type-dependent manner. J. Biol. Chem. 286 7705-13 PubMed GONUTS page

[PMID:9660918-6] Xu, Q & Reed, JC (1998) Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. Mol. Cell 1 337-46 PubMed GONUTS page

[PMID:9219694-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Antonsson, B et al. (1997) Inhibition of Bax channel-forming activity by Bcl-2. Science 277 370-2 PubMed GONUTS page

[PMID:9843949-8] 8.0 ^8.1 ^8.2 Narita, M et al. (1998) Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc. Natl. Acad. Sci. U.S.A. 95 14681-6 PubMed GONUTS page

[PMID:16307838-9] Chen, J et al. (2006) T-2 toxin induces apoptosis, and selenium partly blocks, T-2 toxin induced apoptosis in chondrocytes through modulation of the Bax/Bcl-2 ratio. Food Chem. Toxicol. 44 567-73 PubMed GONUTS page

[PMID:11684014-10] Samuels-Lev, Y et al. (2001) ASPP proteins specifically stimulate the apoptotic function of p53. Mol. Cell 8 781-94 PubMed GONUTS page

[PMID:20097879-11] Mader, I et al. (2010) Identification of a novel proapoptotic function of resveratrol in fat cells: SIRT1-independent sensitization to TRAIL-induced apoptosis. FASEB J. 24 1997-2009 PubMed GONUTS page

[PMID:15006356-12] Jan, Y et al. (2004) A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors. Cell 116 751-62 PubMed GONUTS page

[PMID:10620603-13] 13.0 ^13.1 ^13.2 Jacotot, E et al. (2000) The HIV-1 viral protein R induces apoptosis via a direct effect on the mitochondrial permeability transition pore. J. Exp. Med. 191 33-46 PubMed GONUTS page

[PMID:9111042-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Diaz, JL et al. (1997) A common binding site mediates heterodimerization and homodimerization of Bcl-2 family members. J. Biol. Chem. 272 11350-5 PubMed GONUTS page

[PMID:17875758-15] 15.0 ^15.1 ^15.2 ^15.3 Joshi, AD et al. (2007) ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia. Clin. Cancer Res. 13 5295-304 PubMed GONUTS page

[PMID:17289999-16] Willis, SN et al. (2007) Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 315 856-9 PubMed GONUTS page

[PMID:9027314-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 Yang, J et al. (1997) Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275 1129-32 PubMed GONUTS page

[PMID:10506221-18] 18.0 ^18.1 Thangaraju, M et al. (1999) Regulation of acidification and apoptosis by SHP-1 and Bcl-2. J. Biol. Chem. 274 29549-57 PubMed GONUTS page

[PMID:12421819-19] Mai, H et al. (2003) A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosis. J. Biol. Chem. 278 1886-91 PubMed GONUTS page

[PMID:8402648-20] 20.0 ^20.1 ^20.2 Krajewski, S et al. (1993) Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res. 53 4701-14 PubMed GONUTS page

[PMID:1502141-21] 21.0 ^21.1 ^21.2 Alnemri, ES et al. (1992) Overexpressed full-length human BCL2 extends the survival of baculovirus-infected Sf9 insect cells. Proc. Natl. Acad. Sci. U.S.A. 89 7295-9 PubMed GONUTS page

[PMID:20889974-22] Chen, D et al. (2010) Parkin mono-ubiquitinates Bcl-2 and regulates autophagy. J. Biol. Chem. 285 38214-23 PubMed GONUTS page

[PMID:11264898-23] Simonart, T et al. (2001) Iron induces Bcl-2 expression in human dermal microvascular endothelial cells. Free Radic. Res. 34 221-35 PubMed GONUTS page

[PMID:15799693-24] Maguire, P et al. (2005) Medium from irradiated cells induces dose-dependent mitochondrial changes and BCL2 responses in unirradiated human keratinocytes. Radiat. Res. 163 384-90 PubMed GONUTS page

[PMID:11530860-25] 25.0 ^25.1 Axt-Fliedner, R et al. (2001) The immunolocalization of Bcl-2 in human term placenta. Clin Exp Obstet Gynecol 28 144-7 PubMed GONUTS page

[PMID:21873635-26] 26.0 ^26.1 ^26.2 ^26.3 ^26.4 ^26.5 ^26.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:8358790-27] Oltvai, ZN et al. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74 609-19 PubMed GONUTS page

[PMID:15776018-28] 28.0 ^28.1 Ruiz-Vela, A et al. (2005) Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep. 6 379-85 PubMed GONUTS page

[PMID:8022822-29] 29.0 ^29.1 ^29.2 Lam, M et al. (1994) Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes. Proc. Natl. Acad. Sci. U.S.A. 91 6569-73 PubMed GONUTS page

[PMID:12086670-30] McGill, GG et al. (2002) Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 109 707-18 PubMed GONUTS page

[PMID:7546744-31] 31.0 ^31.1 ^31.2 Greenlund, LJ et al. (1995) Role of BCL-2 in the survival and function of developing and mature sympathetic neurons. Neuron 15 649-61 PubMed GONUTS page

[PMID:7772249-32] 32.0 ^32.1 Takayama, S et al. (1994) Evolutionary conservation of function among mammalian, avian, and viral homologs of the Bcl-2 oncoprotein. DNA Cell Biol. 13 679-92 PubMed GONUTS page

[PMID:8080725-33] Kondo, S et al. (1994) bcl-2 gene enables rescue from in vitro myelosuppression (bone marrow cell death) induced by chemotherapy. Br. J. Cancer 70 421-6 PubMed GONUTS page

[PMID:8050499-34] Kondo, S et al. (1994) bcl-2 gene prevents apoptosis of basic fibroblast growth factor-deprived murine aortic endothelial cells. Exp. Cell Res. 213 428-32 PubMed GONUTS page

[PMID:7650367-35] Broome, HE et al. (1995) Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal. J. Immunol. 155 2311-7 PubMed GONUTS page

[PMID:1373874-36] 36.0 ^36.1 Borzillo, GV et al. (1992) Bcl-2 confers growth and survival advantage to interleukin 7-dependent early pre-B cells which become factor independent by a multistep process in culture. Oncogene 7 869-76 PubMed GONUTS page

[PMID:36599-37] 37.0 ^37.1 Dublanchet, A & Durieux, R (1979) [Isolation of a strain of Streptococcus pneumoniae multiresistant to antibiotics]. Nouv Presse Med 8 872 PubMed GONUTS page

[PMID:9184696-38] Li, L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell. Immunol. 178 33-41 PubMed GONUTS page

[PMID:7896880-39] 39.0 ^39.1 ^39.2 Yang, T et al. (1995) The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2. J. Cell Biol. 128 1173-84 PubMed GONUTS page

[PMID:16717086-40] 40.0 ^40.1 Lin, SS et al. (2006) PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J. Biol. Chem. 281 23003-12 PubMed GONUTS page

[PMID:10597216-41] Lee, JH et al. (1999) Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene 18 6183-90 PubMed GONUTS page

[PMID:9463381-42] Huang, DC et al. (1998) The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4. EMBO J. 17 1029-39 PubMed GONUTS page

[PMID:18835031-43] Kolluri, SK et al. (2008) A short Nur77-derived peptide converts Bcl-2 from a protector to a killer. Cancer Cell 14 285-98 PubMed GONUTS page

[PMID:1286168-44] Hockenbery, DM (1992) The bcl-2 oncogene and apoptosis. Semin. Immunol. 4 413-20 PubMed GONUTS page

[PMID:16167175-45] Soane, L & Fiskum, G (2005) Inhibition of mitochondrial neural cell death pathways by protein transduction of Bcl-2 family proteins. J. Bioenerg. Biomembr. 37 179-90 PubMed GONUTS page

[PMID:18309324-46] 46.0 ^46.1 Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page

[PMID:1908951-47] Nuñez, G et al. (1991) Bcl-2 maintains B cell memory. Nature 353 71-3 PubMed GONUTS page

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