HUMAN:BAG3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BAG3 (synonyms: BIS)
Protein Name(s)	BAG family molecular chaperone regulator 3 BAG-3 Bcl-2-associated athanogene 3 Bcl-2-binding protein Bis Docking protein CAIR-1
External Links
UniProt	O95817
EMBL	AF095193 AF127139 AF071218 AK291333 AL137582 BC006418 BC014656 BC107786
CCDS	CCDS7615.1
RefSeq	NP_004272.2
UniGene	Hs.523309
ProteinModelPortal	O95817
SMR	O95817
BioGrid	114907
DIP	DIP-41273N
IntAct	O95817
MINT	MINT-208995
STRING	9606.ENSP00000358081
PhosphoSite	O95817
BioMuta	BAG3
MaxQB	O95817
PaxDb	O95817
PeptideAtlas	O95817
PRIDE	O95817
DNASU	9531
Ensembl	ENST00000369085
GeneID	9531
KEGG	hsa:9531
UCSC	uc001lel.3
CTD	9531
GeneCards	GC10P119651
GeneReviews	BAG3
HGNC	HGNC:939
HPA	HPA018493 HPA020586
MIM	603883 612954 613881
neXtProt	NX_O95817
Orphanet	154 199340
PharmGKB	PA25239
eggNOG	NOG238690
GeneTree	ENSGT00530000063256
HOGENOM	HOG000050234
HOVERGEN	HBG003419
InParanoid	O95817
KO	K09557
OMA	VYPQLRP
OrthoDB	EOG75B85S
PhylomeDB	O95817
TreeFam	TF102013
Reactome	R-HSA-3371453
SignaLink	O95817
ChiTaRS	BAG3
GeneWiki	BAG3
GenomeRNAi	9531
NextBio	35732
PMAP-CutDB	O95817
PRO	PR:O95817
Proteomes	UP000005640
Bgee	O95817
CleanEx	HS_BAG3
ExpressionAtlas	O95817
Genevisible	O95817
GO	GO:0005737 GO:0005829 GO:0043005 GO:0005886 GO:0030018 GO:0007420 GO:0034605 GO:0071260 GO:0097192 GO:0008625 GO:0043066 GO:0010664 GO:0006457 GO:0050821 GO:1900034 GO:0021510
Gene3D	1.20.58.120
InterPro	IPR003103 IPR001202
Pfam	PF02179 PF00397
SMART	SM00264 SM00456
SUPFAM	SSF51045
PROSITE	PS51035 PS01159 PS50020

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005737	cytoplasm	PMID:25149536^[1]	ECO:0000314			C		Immunohistochemical analysis of BAG3 expression in Figure 1 A, E and F.	complete CACAO 11018
enables	GO:0045505	dynein intermediate chain binding	PMID:21252941^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1905337	positive regulation of aggrephagy	PMID:18006506^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0034620)	Seeded From UniProt	complete
involved_in	GO:0034620	cellular response to unfolded protein	PMID:18006506^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:18006506^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:Q9UJY1)	Seeded From UniProt	complete
part_of	GO:0101031	chaperone complex	PMID:18006506^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	PMID:18006506^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q9UJY1	F		Seeded From UniProt	complete
involved_in	GO:0046716	muscle cell cellular homeostasis	PMID:19085932^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001133)\|occurs_in:(UBERON:0018254)	Seeded From UniProt	complete
involved_in	GO:0010664	negative regulation of striated muscle cell apoptotic process	PMID:19085932^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(UBERON:0001133)\|occurs_in:(UBERON:0018254)	Seeded From UniProt	complete
enables	GO:0045296	cadherin binding	PMID:25468996^[5]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26159920^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:26159920^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:26159920^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042307	positive regulation of protein import into nucleus	PMID:26159920^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046827	positive regulation of protein export from nucleus	PMID:26159920^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097201	negative regulation of transcription from RNA polymerase II promoter in response to stress	PMID:26159920^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0000774	adenyl-nucleotide exchange factor activity	PMID:24318877^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:10597216^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006457	protein folding	PMID:9873016^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:10597216^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:10597216^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0000774	adenyl-nucleotide exchange factor activity	PMID:20060297^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0000774	P		Seeded From UniProt	complete
involved_in	GO:0050790	regulation of catalytic activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0000774	P		Seeded From UniProt	complete
involved_in	GO:1903215	negative regulation of protein targeting to mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	P		Seeded From UniProt	complete
involved_in	GO:0061684	chaperone-mediated autophagy	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	F		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	C		Seeded From UniProt	complete
involved_in	GO:0021510	spinal cord development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	P		Seeded From UniProt	complete
part_of	GO:0001725	stress fiber	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	C		Seeded From UniProt	complete
involved_in	GO:0000045	autophagosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5U2U8 ensembl:ENSRNOP00000027616	P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV1 ensembl:ENSMUSP00000033136	P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV1 ensembl:ENSMUSP00000033136	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV1 ensembl:ENSMUSP00000033136	P		Seeded From UniProt	complete
involved_in	GO:0046716	muscle cell cellular homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV1 ensembl:ENSMUSP00000033136	P		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV1 ensembl:ENSMUSP00000033136	F		Seeded From UniProt	complete
part_of	GO:0030018	Z disc	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV1 ensembl:ENSMUSP00000033136	C		Seeded From UniProt	complete
involved_in	GO:0010664	negative regulation of striated muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLV1 ensembl:ENSMUSP00000033136	P		Seeded From UniProt	complete
enables	GO:0051087	chaperone binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003103 InterPro:IPR036533 InterPro:IPR039773	F		Seeded From UniProt	complete
involved_in	GO:0072321	chaperone-mediated protein transport	PMID:21681022^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0016235	aggresome	PMID:21681022^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008565	obsolete protein transporter activity	PMID:21681022^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	transports_or_maintains_localization_of:(GO:0016235)	Seeded From UniProt	complete
involved_in	GO:0098840	protein transport along microtubule	PMID:21681022^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	transports_or_maintains_localization_of:(GO:0016235)	Seeded From UniProt	complete
involved_in	GO:0070842	aggresome assembly	PMID:21681022^[11]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900034	regulation of cellular response to heat	Reactome:R-HSA-3371453	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-5252079	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Chiappetta, G et al. (2014) The anti-apoptotic BAG3 protein is expressed in lung carcinomas and regulates small cell lung carcinoma (SCLC) tumor growth. Oncotarget 5 6846-53 PubMed GONUTS page
↑ Gamerdinger, M et al. (2011) BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins. EMBO Rep. 12 149-56 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Carra, S et al. (2008) HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy. J. Biol. Chem. 283 1437-44 PubMed GONUTS page
↑ ^4.0 ^4.1 Selcen, D et al. (2009) Mutation in BAG3 causes severe dominant childhood muscular dystrophy. Ann. Neurol. 65 83-9 PubMed GONUTS page
↑ Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Jin, YH et al. (2015) BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress. Biochem. Biophys. Res. Commun. 464 561-7 PubMed GONUTS page
↑ Rauch, JN & Gestwicki, JE (2014) Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. J. Biol. Chem. 289 1402-14 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Lee, JH et al. (1999) Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene 18 6183-90 PubMed GONUTS page
↑ Takayama, S et al. (1999) An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J. Biol. Chem. 274 781-6 PubMed GONUTS page
↑ Arndt, V et al. (2010) Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr. Biol. 20 143-8 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 ^11.3 ^11.4 Behl, C (2011) BAG3 and friends: co-chaperones in selective autophagy during aging and disease. Autophagy 7 795-8 PubMed GONUTS page

[PMID:25149536-1] Chiappetta, G et al. (2014) The anti-apoptotic BAG3 protein is expressed in lung carcinomas and regulates small cell lung carcinoma (SCLC) tumor growth. Oncotarget 5 6846-53 PubMed GONUTS page

[PMID:21252941-2] Gamerdinger, M et al. (2011) BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins. EMBO Rep. 12 149-56 PubMed GONUTS page

[PMID:18006506-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Carra, S et al. (2008) HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy. J. Biol. Chem. 283 1437-44 PubMed GONUTS page

[PMID:19085932-4] 4.0 ^4.1 Selcen, D et al. (2009) Mutation in BAG3 causes severe dominant childhood muscular dystrophy. Ann. Neurol. 65 83-9 PubMed GONUTS page

[PMID:25468996-5] Guo, Z et al. (2014) E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Sci Signal 7 rs7 PubMed GONUTS page

[PMID:26159920-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 Jin, YH et al. (2015) BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress. Biochem. Biophys. Res. Commun. 464 561-7 PubMed GONUTS page

[PMID:24318877-7] Rauch, JN & Gestwicki, JE (2014) Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. J. Biol. Chem. 289 1402-14 PubMed GONUTS page

[PMID:10597216-8] 8.0 ^8.1 ^8.2 Lee, JH et al. (1999) Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene 18 6183-90 PubMed GONUTS page

[PMID:9873016-9] Takayama, S et al. (1999) An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J. Biol. Chem. 274 781-6 PubMed GONUTS page

[PMID:20060297-10] Arndt, V et al. (2010) Chaperone-assisted selective autophagy is essential for muscle maintenance. Curr. Biol. 20 143-8 PubMed GONUTS page

[PMID:21681022-11] 11.0 ^11.1 ^11.2 ^11.3 ^11.4 Behl, C (2011) BAG3 and friends: co-chaperones in selective autophagy during aging and disease. Autophagy 7 795-8 PubMed GONUTS page

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HUMAN:BAG3

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References

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