GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

DROME:PROF

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Drosophila melanogaster (Fruit fly). (7227)
Gene Name(s) chic (synonyms: chi)
Protein Name(s) Profilin

Protein chickadee

External Links
UniProt P25843
EMBL M84528
M84529
DQ062770
AE014134
AE014134
AE014134
AE014134
AY069444
AY128443
PIR A38154
RefSeq NP_001245905.1
NP_001245906.1
NP_477016.1
NP_599131.1
NP_723136.1
NP_995635.1
UniGene Dm.4775
ProteinModelPortal P25843
SMR P25843
BioGrid 59999
DIP DIP-22165N
IntAct P25843
MINT MINT-873227
PaxDb P25843
PRIDE P25843
EnsemblMetazoa FBtr0079233
FBtr0079234
FBtr0079235
FBtr0079236
FBtr0309212
FBtr0309213
GeneID 33834
KEGG dme:Dmel_CG9553
UCSC CG9553-RA
CTD 33834
FlyBase FBgn0000308
eggNOG NOG277929
GeneTree ENSGT00730000112841
InParanoid P25843
KO K05759
OMA IYEEPVQ
OrthoDB EOG7KDFCT
PhylomeDB P25843
ChiTaRS chic
GenomeRNAi 33834
NextBio 785497
PRO PR:P25843
Proteomes UP000000803
Bgee P25843
GO GO:0005737
GO:0005856
GO:0048471
GO:0003779
GO:0007015
GO:0030041
GO:0000915
GO:0007411
GO:0007420
GO:0000902
GO:0007391
GO:0007488
GO:0030717
GO:0035193
GO:0007436
GO:0032507
GO:0000281
GO:0007300
GO:0045451
GO:0051491
GO:0007283
GO:0042060
InterPro IPR005455
IPR027310
PANTHER PTHR11604
Pfam PF00235
PRINTS PR00392
PR01640
SMART SM00392
SUPFAM SSF55770
PROSITE PS00414

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0048842

positive regulation of axon extension involved in axon guidance

PMID:10069335[1]

ECO:0000315

P

Figure 1 shows the mutant and wild-type chic gene

complete
CACAO 5079

involved_in

GO:0048842

positive regulation of axon extension involved in axon guidance

PMID:10069335[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042989

sequestering of actin monomers

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000176159
SGD:S000005648
UniProtKB:O22655
UniProtKB:P35081
UniProtKB:Q9FR39

P

Seeded From UniProt

complete

part_of

GO:0005938

cell cortex

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000176159
dictyBase:DDB_G0271142

C

Seeded From UniProt

complete

enables

GO:0003785

actin monomer binding

PMID:21873635[2]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000176159
PomBase:SPAC4A8.15c
SGD:S000005648
UniProtKB:O22655
UniProtKB:P35081
UniProtKB:P35082
UniProtKB:P35083
UniProtKB:Q9FR39

F

Seeded From UniProt

complete

involved_in

GO:0048680

positive regulation of axon regeneration

PMID:24656828[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043005

neuron projection

PMID:24656828[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0036098

male germ-line stem cell population maintenance

PMID:24346697[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035019

somatic stem cell population maintenance

PMID:24346697[4]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042060

wound healing

PMID:22976306[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:22976306[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

PMID:22976306[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0051491

positive regulation of filopodium assembly

PMID:21464901[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000902

cell morphogenesis

PMID:21041442[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007411

axon guidance

PMID:18516287[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007436

larval salivary gland morphogenesis

PMID:19064711[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007488

histoblast morphogenesis

PMID:17166923[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000281

mitotic cytokinesis

PMID:16174742[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032507

maintenance of protein location in cell

PMID:16174742[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030717

oocyte karyosome formation

PMID:15979065[12]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

PMID:15964283[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000281

mitotic cytokinesis

PMID:15380073[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0000902

cell morphogenesis

PMID:12975351[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007015

actin filament organization

PMID:11584269[16]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0003779

actin binding

PMID:10908588[17]

ECO:0000250

sequence similarity evidence used in manual assertion

F

Seeded From UniProt

Missing: with/from

involved_in

GO:0035193

larval central nervous system remodeling

PMID:11030623[18]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0026084

P

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

PMID:11030623[18]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0026084

P

Seeded From UniProt

complete

involved_in

GO:0007300

ovarian nurse cell to oocyte transport

PMID:1783295[19]

ECO:0007001

high throughput mutant phenotypic evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016322

neuron remodeling

PMID:24656828[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016322

neuron remodeling

PMID:24656828[3]

ECO:0000316

genetic interaction evidence used in manual assertion

FB:FBgn0285926

P

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027310

F

Seeded From UniProt

complete

involved_in

GO:0007391

dorsal closure

PMID:12231351[20]
PMID:12147138[21]

ECO:0000304

author statement supported by traceable reference used in manual assertion


P

Seeded From UniProt

complete

involved_in

GO:0000915

actomyosin contractile ring assembly

PMID:12386932[22]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030041

actin filament polymerization

PMID:12147138[21]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045451

pole plasm oskar mRNA localization

PMID:11700288[23]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007015

actin filament organization

PMID:11139280[24]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206
UniProtKB-SubCell:SL-0090

C

Seeded From UniProt

complete

enables

GO:0003779

actin binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0009

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Wills, Z et al. (1999) Profilin and the Abl tyrosine kinase are required for motor axon outgrowth in the Drosophila embryo. Neuron 22 291-9 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Medioni, C et al. (2014) Imp promotes axonal remodeling by regulating profilin mRNA during brain development. Curr. Biol. 24 793-800 PubMed GONUTS page
  4. ↑ 4.0 4.1 Shields, AR et al. (2014) The actin-binding protein profilin is required for germline stem cell maintenance and germ cell enclosure by somatic cyst cells. Development 141 73-82 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Brock, AR et al. (2012) Transcriptional regulation of Profilin during wound closure in Drosophila larvae. J. Cell. Sci. 125 5667-76 PubMed GONUTS page
  6. ↑ Gonçalves-Pimentel, C et al. (2011) Dissecting regulatory networks of filopodia formation in a Drosophila growth cone model. PLoS ONE 6 e18340 PubMed GONUTS page
  7. ↑ D'Ambrosio, MV & Vale, RD (2010) A whole genome RNAi screen of Drosophila S2 cell spreading performed using automated computational image analysis. J. Cell Biol. 191 471-8 PubMed GONUTS page
  8. ↑ Berger, J et al. (2008) Systematic identification of genes that regulate neuronal wiring in the Drosophila visual system. PLoS Genet. 4 e1000085 PubMed GONUTS page
  9. ↑ Maybeck, V & Röper, K (2009) A targeted gain-of-function screen identifies genes affecting salivary gland morphogenesis/tubulogenesis in Drosophila. Genetics 181 543-65 PubMed GONUTS page
  10. ↑ Ninov, N et al. (2007) Extrinsic and intrinsic mechanisms directing epithelial cell sheet replacement during Drosophila metamorphosis. Development 134 367-79 PubMed GONUTS page
  11. ↑ 11.0 11.1 Dean, SO et al. (2005) Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis. Proc. Natl. Acad. Sci. U.S.A. 102 13473-8 PubMed GONUTS page
  12. ↑ Djagaeva, I et al. (2005) Src64 is involved in fusome development and karyosome formation during Drosophila oogenesis. Dev. Biol. 284 143-56 PubMed GONUTS page
  13. ↑ Reeve, SP et al. (2005) The Drosophila fragile X mental retardation protein controls actin dynamics by directly regulating profilin in the brain. Curr. Biol. 15 1156-63 PubMed GONUTS page
  14. ↑ Echard, A et al. (2004) Terminal cytokinesis events uncovered after an RNAi screen. Curr. Biol. 14 1685-93 PubMed GONUTS page
  15. ↑ Rogers, SL et al. (2003) Molecular requirements for actin-based lamella formation in Drosophila S2 cells. J. Cell Biol. 162 1079-88 PubMed GONUTS page
  16. ↑ Baum, B & Perrimon, N (2001) Spatial control of the actin cytoskeleton in Drosophila epithelial cells. Nat. Cell Biol. 3 883-90 PubMed GONUTS page
  17. ↑ Goldstein, LS & Gunawardena, S (2000) Flying through the drosophila cytoskeletal genome. J. Cell Biol. 150 F63-8 PubMed GONUTS page
  18. ↑ 18.0 18.1 Boquet, I et al. (2000) Ciboulot regulates actin assembly during Drosophila brain metamorphosis. Cell 102 797-808 PubMed GONUTS page
  19. ↑ Schüpbach, T & Wieschaus, E (1991) Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology. Genetics 129 1119-36 PubMed GONUTS page
  20. ↑ Martin, P & Wood, W (2002) Epithelial fusions in the embryo. Curr. Opin. Cell Biol. 14 569-74 PubMed GONUTS page
  21. ↑ 21.0 21.1 Harden, N (2002) Signaling pathways directing the movement and fusion of epithelial sheets: lessons from dorsal closure in Drosophila. Differentiation 70 181-203 PubMed GONUTS page
  22. ↑ Mazumdar, A & Mazumdar, M (2002) How one becomes many: blastoderm cellularization in Drosophila melanogaster. Bioessays 24 1012-22 PubMed GONUTS page
  23. ↑ Johnstone, O & Lasko, P (2001) Translational regulation and RNA localization in Drosophila oocytes and embryos. Annu. Rev. Genet. 35 365-406 PubMed GONUTS page
  24. ↑ Buszczak, M & Cooley, L (2000) Eggs to die for: cell death during Drosophila oogenesis. Cell Death Differ. 7 1071-4 PubMed GONUTS page
Retrieved from "https://gowiki.tamu.edu/wiki/index.php?title=DROME:PROF&oldid=5954112"