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PMID:11584269
| Citation |
Baum, B and Perrimon, N (2001) Spatial control of the actin cytoskeleton in Drosophila epithelial cells. Nat. Cell Biol. 3:883-90 |
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| Abstract |
The actin cytoskeleton orders cellular space and transduces many of the forces required for morphogenesis. Here we combine genetics and cell biology to identify genes that control the polarized distribution of actin filaments within the Drosophila follicular epithelium. We find that profilin and cofilin regulate actin-filament formation throughout the cell cortex. In contrast, CAP-a Drosophila homologue of Adenylyl Cyclase Associated Proteins-functions specifically to limit actin-filament formation catalysed by Ena at apical cell junctions. The Abl tyrosine kinase also collaborates in this process. We therefore propose that CAP, Ena and Abl act in concert to modulate the subcellular distribution of actin filaments in Drosophila. |
| Links |
PubMed Online version:10.1038/ncb1001-883 |
| Keywords |
Actin Cytoskeleton/metabolism; Actin Cytoskeleton/ultrastructure; Actins/genetics; Actins/metabolism; Animals; Cell Cycle Proteins/metabolism; Cell Polarity/genetics; Cytoskeletal Proteins; DNA-Binding Proteins/metabolism; Drosophila Proteins; Drosophila melanogaster/cytology; Drosophila melanogaster/genetics; Epithelial Cells/metabolism; Female; Genes, abl; Insect Proteins/metabolism; Microfilament Proteins; Microscopy, Fluorescence; Models, Biological; Ovarian Follicle/cytology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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