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PMID:15979065
| Citation |
Djagaeva, I, Doronkin, S and Beckendorf, SK (2005) Src64 is involved in fusome development and karyosome formation during Drosophila oogenesis. Dev. Biol. 284:143-56 |
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| Abstract |
Src family tyrosine kinases respond to a variety of signals by regulating the organization of the actin cytoskeleton. Here, we show that during early oogenesis Src64 mutations lead to uneven accumulation of cortical actin, defects in fusome formation, mislocalization of septins, defective transport of Orb protein into the oocyte, and possible defects in cell division. Similar mutant phenotypes suggest that Src64, the Tec29 tyrosine kinase, and the actin crosslinking protein Kelch act together to regulate actin crosslinking, much as they do later during ring canal growth. Condensation of the oocyte chromatin into a compact karyosome is also defective in Src64, Tec29, and kelch mutants and in mutants for spire and chickadee (profilin), genes that regulate actin polymerization. These data, along with changes in G-actin accumulation in the oocyte nucleus, suggest that Src64 is involved in a nuclear actin function during karyosome condensation. Our results indicate that Src64 regulates actin dynamics at multiple stages of oogenesis. |
| Links |
PubMed Online version:10.1016/j.ydbio.2005.05.012 |
| Keywords |
Actins/metabolism; Animals; Blotting, Western; Cell Nucleus/physiology; Chromatin Assembly and Disassembly/physiology; Crosses, Genetic; Cytoskeleton/metabolism; Cytoskeleton/physiology; Drosophila; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila Proteins/physiology; Female; Immunohistochemistry; Microfilament Proteins/genetics; Microfilament Proteins/metabolism; Mutation/genetics; Oogenesis/physiology; Protein Transport/physiology; Protein-Tyrosine Kinases/genetics; Protein-Tyrosine Kinases/metabolism; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/metabolism; RNA-Binding Proteins/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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