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PMID:12386932

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Citation

Mazumdar, A and Mazumdar, M (2002) How one becomes many: blastoderm cellularization in Drosophila melanogaster. Bioessays 24:1012-22

Abstract

Embryonic development in Drosophila melanogaster begins with a rapid series of mitotic nuclear divisions, unaccompanied by cytokinesis, to produce a multi-nucleated single cell embryo, the syncytial blastoderm. The syncytium then undergoes a process of cell formation, in which the individual nuclei become enclosed in individual cells. This process of cellularization involves integrating mechanisms of cell polarity, cell-cell adhesion and a specialized form of cytokinesis. The detailed molecular mechanism, however, is highly complex and, despite extensive analysis, remains poorly understood. Nevertheless, new insights are emerging from recent studies on aspects of membrane polarization and insertion, which show that membrane components from intracellular organelles are involved. In addition, actin and actin-associated proteins have been heavily implicated while new evidence shows that microtubule cytoskeletal elements are mechanistically involved in all aspects of cellularization. This review will draw on both the traditional models and the new data to provide a current perspective on the nature of cellular blastoderm formation in Drosophila melanogaster.

Links

PubMed Online version:10.1002/bies.10184

Keywords

Animals; Blastoderm/cytology; Blastoderm/physiology; Cell Adhesion/physiology; Cell Division/physiology; Cell Membrane/metabolism; Cell Nucleus/metabolism; Cell Polarity/physiology; Cytoskeleton/metabolism; Drosophila melanogaster/embryology; Drosophila melanogaster/genetics; Genes, Insect; Models, Biological

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:M9PHN1

located_in

GO:0019898: extrinsic component of membrane

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

DROME:M9PHN1

involved_in

GO:0007349: cellularization

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:SRYA

involved_in

GO:0007349: cellularization

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:NULLO

involved_in

GO:0007349: cellularization

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:CDC42

involved_in

GO:0007349: cellularization

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:BNK

involved_in

GO:0007015: actin filament organization

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:PNUT

involved_in

GO:0007349: cellularization

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:SEPT1

involved_in

GO:0007349: cellularization

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:CADF

involved_in

GO:0000915: actomyosin contractile ring assembly

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:SEPT2

involved_in

GO:0007349: cellularization

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q24175

located_in

GO:0019898: extrinsic component of membrane

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

DROME:Q24175

involved_in

GO:0007349: cellularization

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q8T9K5

located_in

GO:0019898: extrinsic component of membrane

ECO:0000304: author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

DROME:Q8T9K5

involved_in

GO:0007349: cellularization

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:PATJ

involved_in

GO:0016332: establishment or maintenance of polarity of embryonic epithelium

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9V4A1

enables

GO:0008569: minus-end-directed microtubule motor activity

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

DROME:Q9VME5

involved_in

GO:0061024: membrane organization

ECO:0000303: author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

DROME:Q9XZ29

enables

GO:0008574: plus-end-directed microtubule motor activity

ECO:0000303: author statement without traceable support used in manual assertion

F

Seeded From UniProt

complete

DROME:Q9XZ29

involved_in

GO:0007140: male meiotic nuclear division

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:STX1A

involved_in

GO:0007349: cellularization

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

DROME:PROF

involved_in

GO:0000915: actomyosin contractile ring assembly

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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