PMID:12386932

Citation	Mazumdar, A and Mazumdar, M (2002) How one becomes many: blastoderm cellularization in Drosophila melanogaster. Bioessays 24:1012-22
Abstract	Embryonic development in Drosophila melanogaster begins with a rapid series of mitotic nuclear divisions, unaccompanied by cytokinesis, to produce a multi-nucleated single cell embryo, the syncytial blastoderm. The syncytium then undergoes a process of cell formation, in which the individual nuclei become enclosed in individual cells. This process of cellularization involves integrating mechanisms of cell polarity, cell-cell adhesion and a specialized form of cytokinesis. The detailed molecular mechanism, however, is highly complex and, despite extensive analysis, remains poorly understood. Nevertheless, new insights are emerging from recent studies on aspects of membrane polarization and insertion, which show that membrane components from intracellular organelles are involved. In addition, actin and actin-associated proteins have been heavily implicated while new evidence shows that microtubule cytoskeletal elements are mechanistically involved in all aspects of cellularization. This review will draw on both the traditional models and the new data to provide a current perspective on the nature of cellular blastoderm formation in Drosophila melanogaster.
Links	PubMed Online version:10.1002/bies.10184
Keywords	Animals; Blastoderm/cytology; Blastoderm/physiology; Cell Adhesion/physiology; Cell Division/physiology; Cell Membrane/metabolism; Cell Nucleus/metabolism; Cell Polarity/physiology; Cytoskeleton/metabolism; Drosophila melanogaster/embryology; Drosophila melanogaster/genetics; Genes, Insect; Models, Biological
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Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
DROME:M9PHN1	located_in	GO:0019898: extrinsic component of membrane	ECO:0000304: author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
DROME:M9PHN1	involved_in	GO:0007349: cellularization	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
DROME:SRYA	involved_in	GO:0007349: cellularization	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
DROME:NULLO	involved_in	GO:0007349: cellularization	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
DROME:CDC42	involved_in	GO:0007349: cellularization	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
DROME:BNK	involved_in	GO:0007015: actin filament organization	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
DROME:PNUT	involved_in	GO:0007349: cellularization	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
DROME:SEPT1	involved_in	GO:0007349: cellularization	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
DROME:CADF	involved_in	GO:0000915: actomyosin contractile ring assembly	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
DROME:SEPT2	involved_in	GO:0007349: cellularization	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
DROME:Q24175	located_in	GO:0019898: extrinsic component of membrane	ECO:0000304: author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
DROME:Q24175	involved_in	GO:0007349: cellularization	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
DROME:Q8T9K5	located_in	GO:0019898: extrinsic component of membrane	ECO:0000304: author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
DROME:Q8T9K5	involved_in	GO:0007349: cellularization	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
DROME:PATJ	involved_in	GO:0016332: establishment or maintenance of polarity of embryonic epithelium	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
DROME:Q9V4A1	enables	GO:0008569: minus-end-directed microtubule motor activity	ECO:0000303: author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
DROME:Q9VME5	involved_in	GO:0061024: membrane organization	ECO:0000303: author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
DROME:Q9XZ29	enables	GO:0008574: plus-end-directed microtubule motor activity	ECO:0000303: author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
DROME:Q9XZ29	involved_in	GO:0007140: male meiotic nuclear division	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
DROME:STX1A	involved_in	GO:0007349: cellularization	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
DROME:PROF	involved_in	GO:0000915: actomyosin contractile ring assembly	ECO:0000304: author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete

References

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