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Category:GO:0033290 ! eukaryotic 48S preinitiation complex
name: eukaryotic 48S preinitiation complex
namespace: cellular_component
alt_id: GO:0016283
def: "The protein-ribosome-tRNA complex that has just recognized the start codon of a capped mRNA. It is composed of the small ribosomal subunit, eukaryote initiation factors (eIF) eIF3 complex, eIF1, eIF1A, eIF2-GDP, eIF4 complex and initiatior-methionine-tRNA. Recognition of the start codon triggers downstream steps in the pathway, including eIF1 dissociation; Pi release from eIF2; and conversion to the closed, scanning-arrested conformation of the PIC." [GOC:hjd, PMID:16510876, PMID:24319994, PMID:24499181, PMID:29735639]
synonym: "eukaryotic 48S initiation complex" RELATED []
synonym: "eukaryotic 48S pre-initiation complex" EXACT []
is_a: GO:0070993 ! translation preinitiation complex
relationship: has_part: GO:0022627 ! cytosolic small ribosomal subunit
AmiGO
<GOterm>GO:0033290</GOterm>
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