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YEAST:IF2A
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | SUI2 (synonyms: TIF211) | |
| Protein Name(s) | Eukaryotic translation initiation factor 2 subunit alpha
eIF-2-alpha | |
| External Links | ||
| UniProt | P20459 | |
| EMBL | M25552 X87611 Z49507 AY557876 BK006943 | |
| PIR | A32108 | |
| RefSeq | NP_012540.3 | |
| PDB | 1Q46 2A19 2A1A 3J81 | |
| PDBsum | 1Q46 2A19 2A1A 3J81 | |
| ProteinModelPortal | P20459 | |
| SMR | P20459 | |
| BioGrid | 33763 | |
| DIP | DIP-2327N | |
| IntAct | P20459 | |
| MINT | MINT-519024 | |
| MaxQB | P20459 | |
| PaxDb | P20459 | |
| PeptideAtlas | P20459 | |
| PRIDE | P20459 | |
| EnsemblFungi | [example_ID YJR007W] | |
| GeneID | 853463 | |
| KEGG | sce:YJR007W | |
| CYGD | YJR007w | |
| SGD | S000003767 | |
| eggNOG | COG1093 | |
| GeneTree | ENSGT00390000007015 | |
| HOGENOM | HOG000199476 | |
| InParanoid | P20459 | |
| KO | K03237 | |
| OMA | RYPEVDE | |
| OrthoDB | EOG7BW0VK | |
| BioCyc | YEAST:G3O-31653-MONOMER | |
| Reactome | REACT_248935 REACT_252688 REACT_257608 REACT_261485 | |
| EvolutionaryTrace | P20459 | |
| NextBio | 974047 | |
| PRO | PR:P20459 | |
| Proteomes | UP000002311 | |
| Genevestigator | P20459 | |
| GO | GO:0033290 GO:0005850 GO:0043614 GO:0005840 GO:0003743 GO:0001731 GO:0006413 | |
| Gene3D | 1.10.150.190 2.40.50.140 3.30.70.1130 | |
| InterPro | IPR012340 IPR003029 IPR022967 IPR024055 IPR024054 IPR011488 | |
| Pfam | PF07541 PF00575 | |
| SMART | SM00316 | |
| SUPFAM | SSF110993 SSF116742 SSF50249 | |
| PROSITE | PS50126 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0039585 |
PKR signal transduction |
ECO:0000315 |
P |
Protein kinase R (PKR) dimerization and activation loop autophosphorylation are mutually exclusive yet interdependent process. in fig 4. |
complete | |||||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0010494 |
cytoplasmic stress granule |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043614 |
multi-eIF complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043614 |
multi-eIF complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0033290 |
eukaryotic 48S preinitiation complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005850 |
eukaryotic translation initiation factor 2 complex |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005850 |
eukaryotic translation initiation factor 2 complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
Missing: with/from | |||
|
involved_in |
GO:0001731 |
formation of translation preinitiation complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0043614 |
multi-eIF complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000063908 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0043022 |
ribosome binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000063907 |
F |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0033290 |
eukaryotic 48S preinitiation complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000063908 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005851 |
eukaryotic translation initiation factor 2B complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000063908 |
C |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0005850 |
eukaryotic translation initiation factor 2 complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000063908 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0261609 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0003676 |
nucleic acid binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006413 |
translational initiation |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005840 |
ribosome |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003723 |
RNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003743 |
translation initiation factor activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006413 |
translational initiation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006412 |
translation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Dey, M et al. (2014) Activation of protein kinase PKR requires dimerization-induced cis-phosphorylation within the activation loop. J. Biol. Chem. 289 5747-57 PubMed GONUTS page
- ↑ Kumar, A et al. (2002) Subcellular localization of the yeast proteome. Genes Dev. 16 707-19 PubMed GONUTS page
- ↑ Jain, S et al. (2016) ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell 164 487-98 PubMed GONUTS page
- ↑ Asano, K et al. (2000) A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo. Genes Dev. 14 2534-46 PubMed GONUTS page
- ↑ Hinnebusch, AG et al. (2004) Study of translational control of eukaryotic gene expression using yeast. Ann. N. Y. Acad. Sci. 1038 60-74 PubMed GONUTS page
- ↑ Fringer, JM et al. (2007) Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining. Mol. Cell. Biol. 27 2384-97 PubMed GONUTS page
- ↑ 7.0 7.1 Cigan, AM et al. (1989) Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and shares sequence identity with the human alpha subunit. Proc. Natl. Acad. Sci. U.S.A. 86 2784-8 PubMed GONUTS page
- ↑ Algire, MA et al. (2002) Development and characterization of a reconstituted yeast translation initiation system. RNA 8 382-97 PubMed GONUTS page
- ↑ 9.0 9.1 9.2 9.3 9.4 9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 10.0 10.1 10.2 McCarthy, JE (1998) Posttranscriptional control of gene expression in yeast. Microbiol. Mol. Biol. Rev. 62 1492-553 PubMed GONUTS page
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