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YEAST:IF2A

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) SUI2 (synonyms: TIF211)
Protein Name(s) Eukaryotic translation initiation factor 2 subunit alpha

eIF-2-alpha

External Links
UniProt P20459
EMBL M25552
X87611
Z49507
AY557876
BK006943
PIR A32108
RefSeq NP_012540.3
PDB 1Q46
2A19
2A1A
3J81
PDBsum 1Q46
2A19
2A1A
3J81
ProteinModelPortal P20459
SMR P20459
BioGrid 33763
DIP DIP-2327N
IntAct P20459
MINT MINT-519024
MaxQB P20459
PaxDb P20459
PeptideAtlas P20459
PRIDE P20459
EnsemblFungi [example_ID YJR007W]
GeneID 853463
KEGG sce:YJR007W
CYGD YJR007w
SGD S000003767
eggNOG COG1093
GeneTree ENSGT00390000007015
HOGENOM HOG000199476
InParanoid P20459
KO K03237
OMA RYPEVDE
OrthoDB EOG7BW0VK
BioCyc YEAST:G3O-31653-MONOMER
Reactome REACT_248935
REACT_252688
REACT_257608
REACT_261485
EvolutionaryTrace P20459
NextBio 974047
PRO PR:P20459
Proteomes UP000002311
Genevestigator P20459
GO GO:0033290
GO:0005850
GO:0043614
GO:0005840
GO:0003743
GO:0001731
GO:0006413
Gene3D 1.10.150.190
2.40.50.140
3.30.70.1130
InterPro IPR012340
IPR003029
IPR022967
IPR024055
IPR024054
IPR011488
Pfam PF07541
PF00575
SMART SM00316
SUPFAM SSF110993
SSF116742
SSF50249
PROSITE PS50126

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0039585

PKR signal transduction

PMID:24338483[1]

ECO:0000315

P

Protein kinase R (PKR) dimerization and activation loop autophosphorylation are mutually exclusive yet interdependent process. in fig 4.

complete
CACAO 9565

part_of

GO:0005737

cytoplasm

PMID:11914276[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0010494

cytoplasmic stress granule

PMID:26777405[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043614

multi-eIF complex

PMID:11018020[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0043614

multi-eIF complex

PMID:15838098[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0033290

eukaryotic 48S preinitiation complex

PMID:17242201[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005850

eukaryotic translation initiation factor 2 complex

PMID:2649894[7]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005850

eukaryotic translation initiation factor 2 complex

PMID:2649894[7]

ECO:0000250

sequence similarity evidence used in manual assertion

C

Seeded From UniProt

Missing: with/from

involved_in

GO:0001731

formation of translation preinitiation complex

PMID:12008673[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0043614

multi-eIF complex

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000063908
SGD:S000003767

C

Seeded From UniProt

complete

enables

GO:0043022

ribosome binding

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000063907
UniProtKB:P05198

F

Seeded From UniProt

complete

part_of

GO:0033290

eukaryotic 48S preinitiation complex

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000063908
SGD:S000003767

C

Seeded From UniProt

complete

part_of

GO:0005851

eukaryotic translation initiation factor 2B complex

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000063908
UniProtKB:P05198

C

Seeded From UniProt

complete

part_of

GO:0005850

eukaryotic translation initiation factor 2 complex

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000063908
RGD:620963
SGD:S000003767
UniProtKB:P05198

C

Seeded From UniProt

complete

enables

GO:0003743

translation initiation factor activity

PMID:21873635[9]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0261609
PANTHER:PTN000063907
UniProtKB:P05198

F

Seeded From UniProt

complete

enables

GO:0003676

nucleic acid binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR003029

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011488

F

Seeded From UniProt

complete

enables

GO:0003743

translation initiation factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR011488

F

Seeded From UniProt

complete

involved_in

GO:0006413

translational initiation

PMID:9841679[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005840

ribosome

PMID:9841679[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003743

translation initiation factor activity

PMID:9841679[10]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0003723

RNA binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0694

F

Seeded From UniProt

complete

enables

GO:0003743

translation initiation factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0396

F

Seeded From UniProt

complete

involved_in

GO:0006413

translational initiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0396

P

Seeded From UniProt

complete

involved_in

GO:0006412

translation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0648

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Dey, M et al. (2014) Activation of protein kinase PKR requires dimerization-induced cis-phosphorylation within the activation loop. J. Biol. Chem. 289 5747-57 PubMed GONUTS page
  2. Kumar, A et al. (2002) Subcellular localization of the yeast proteome. Genes Dev. 16 707-19 PubMed GONUTS page
  3. Jain, S et al. (2016) ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure. Cell 164 487-98 PubMed GONUTS page
  4. Asano, K et al. (2000) A multifactor complex of eukaryotic initiation factors, eIF1, eIF2, eIF3, eIF5, and initiator tRNA(Met) is an important translation initiation intermediate in vivo. Genes Dev. 14 2534-46 PubMed GONUTS page
  5. Hinnebusch, AG et al. (2004) Study of translational control of eukaryotic gene expression using yeast. Ann. N. Y. Acad. Sci. 1038 60-74 PubMed GONUTS page
  6. Fringer, JM et al. (2007) Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining. Mol. Cell. Biol. 27 2384-97 PubMed GONUTS page
  7. 7.0 7.1 Cigan, AM et al. (1989) Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and shares sequence identity with the human alpha subunit. Proc. Natl. Acad. Sci. U.S.A. 86 2784-8 PubMed GONUTS page
  8. Algire, MA et al. (2002) Development and characterization of a reconstituted yeast translation initiation system. RNA 8 382-97 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  10. 10.0 10.1 10.2 McCarthy, JE (1998) Posttranscriptional control of gene expression in yeast. Microbiol. Mol. Biol. Rev. 62 1492-553 PubMed GONUTS page