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HUMAN:EIF3I

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) EIF3I (ECO:0000255 with HAMAP-Rule:MF_03008) (synonyms: EIF3S2 (ECO:0000255 with HAMAP-Rule:MF_03008), TRIP1)
Protein Name(s) Eukaryotic translation initiation factor 3 subunit I (ECO:0000255 with HAMAP-Rule:MF_03008)

eIF3i (ECO:0000255 with HAMAP-Rule:MF_03008) Eukaryotic translation initiation factor 3 subunit 2 (ECO:0000255 with HAMAP-Rule:MF_03008) TGF-beta receptor-interacting protein 1 TRIP-1 eIF-3-beta (ECO:0000255 with HAMAP-Rule:MF_03008) eIF3 p36 (ECO:0000255 with HAMAP-Rule:MF_03008)

External Links
UniProt Q13347
EMBL U39067
U36764
BC000413
BC003140
CCDS CCDS357.1
PIR S60335
RefSeq NP_003748.1
UniGene Hs.530096
ProteinModelPortal Q13347
SMR Q13347
BioGrid 114217
DIP DIP-31116N
IntAct Q13347
MINT MINT-5004513
STRING 9606.ENSP00000362688
PhosphoSite Q13347
DMDM 2494895
DOSAC-COBS-2DPAGE Q13347
OGP Q13347
MaxQB Q13347
PaxDb Q13347
PeptideAtlas Q13347
PRIDE Q13347
DNASU 8668
Ensembl ENST00000373586
GeneID 8668
KEGG hsa:8668
UCSC uc001bur.4
CTD 8668
GeneCards GC01P032687
HGNC HGNC:3272
HPA HPA029939
HPA029940
MIM 603911
neXtProt NX_Q13347
PharmGKB PA162384875
eggNOG COG2319
HOGENOM HOG000231322
HOVERGEN HBG000900
InParanoid Q13347
KO K03246
OMA KATVCAF
PhylomeDB Q13347
TreeFam TF101515
Reactome REACT_1079
REACT_1797
REACT_1979
REACT_2085
REACT_79
REACT_931
SignaLink Q13347
ChiTaRS EIF3I
GeneWiki EIF3I
GenomeRNAi 8668
NextBio 32515
PRO PR:Q13347
Proteomes UP000005640
Bgee Q13347
CleanEx HS_EIF3I
ExpressionAtlas Q13347
Genevestigator Q13347
GO GO:0005829
GO:0016282
GO:0033290
GO:0005852
GO:0071541
GO:0070062
GO:0003743
GO:0044267
GO:0001731
GO:0010467
GO:0006446
GO:0006412
GO:0006413
Gene3D 2.130.10.10
HAMAP MF_03008
InterPro IPR027525
IPR015943
IPR001680
IPR019775
IPR017986
Pfam PF00400
SMART SM00320
SUPFAM SSF50978
PROSITE PS00678
PS50082
PS50294

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

contributes_to

GO:0003743

translation initiation factor activity

PMID:25849773[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0005852

eukaryotic translation initiation factor 3 complex

PMID:25849773[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0070062

extracellular exosome

PMID:20458337[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(CL:0000639)

Seeded From UniProt

complete

involved_in

GO:0006413

translational initiation

PMID:17581632[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006413

translational initiation

PMID:17322308[4]

ECO:0000305

curator inference used in manual assertion

GO:0005852

P

Seeded From UniProt

complete

involved_in

GO:0006413

translational initiation

PMID:18599441[5]

ECO:0000305

curator inference used in manual assertion

GO:0005852

P

Seeded From UniProt

complete

part_of

GO:0005852

eukaryotic translation initiation factor 3 complex

PMID:17322308[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005852

eukaryotic translation initiation factor 3 complex

PMID:17581632[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005852

eukaryotic translation initiation factor 3 complex

PMID:18599441[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003743

translation initiation factor activity

PMID:17581632[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

contributes_to

GO:0003743

translation initiation factor activity

PMID:17322308[4]

ECO:0000305

curator inference used in manual assertion

GO:0005852

F

Seeded From UniProt

complete

contributes_to

GO:0003743

translation initiation factor activity

PMID:18599441[5]

ECO:0000305

curator inference used in manual assertion

GO:0005852

F

Seeded From UniProt

complete

part_of

GO:0071541

eukaryotic translation initiation factor 3 complex, eIF3m

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9QZD9
ensembl:ENSMUSP00000099653

C

Seeded From UniProt

complete

involved_in

GO:0006413

translational initiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9QZD9
ensembl:ENSMUSP00000099653

P

Seeded From UniProt

complete

part_of

GO:0005852

eukaryotic translation initiation factor 3 complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9QZD9
ensembl:ENSMUSP00000099653

C

Seeded From UniProt

complete

enables

GO:0003743

translation initiation factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9QZD9
ensembl:ENSMUSP00000099653

F

Seeded From UniProt

complete

enables

GO:0003743

translation initiation factor activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027525

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027525

C

Seeded From UniProt

complete

part_of

GO:0005852

eukaryotic translation initiation factor 3 complex

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027525

C

Seeded From UniProt

complete

part_of

GO:0005852

eukaryotic translation initiation factor 3 complex

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000107081

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000107081

C

Seeded From UniProt

complete

part_of

GO:0016282

eukaryotic 43S preinitiation complex

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000107081

C

Seeded From UniProt

complete

involved_in

GO:0001732

formation of cytoplasmic translation initiation complex

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000107081

P

Seeded From UniProt

complete

involved_in

GO:0002183

cytoplasmic translational initiation

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000107081

P

Seeded From UniProt

complete

enables

GO:0003743

translation initiation factor activity

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000107081

F

Seeded From UniProt

complete

part_of

GO:0033290

eukaryotic 48S preinitiation complex

GO_REF:0000104

ECO:0000256

match to sequence model evidence used in automatic assertion

UniRule:UR000107081

C

Seeded From UniProt

complete

involved_in

GO:0006413

translational initiation

Reactome:R-HSA-72613

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-72697
Reactome:R-HSA-72691
Reactome:R-HSA-72676
Reactome:R-HSA-72621
Reactome:R-HSA-72619
Reactome:R-HSA-157849
Reactome:R-HSA-156823
Reactome:R-HSA-156808

ECO:0000304

author statement supported by traceable reference used in manual assertion








C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0003743

translation initiation factor activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0396

F

Seeded From UniProt

complete

involved_in

GO:0006413

translational initiation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0396

P

Seeded From UniProt

complete

involved_in

GO:0006412

translation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0648

P

Seeded From UniProt

complete

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Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Lee, AS et al. (2015) eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. Nature 522 111-4 PubMed GONUTS page
  2. ↑ Buschow, SI et al. () MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Immunol. Cell Biol. 88 851-6 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 Masutani, M et al. (2007) Reconstitution reveals the functional core of mammalian eIF3. EMBO J. 26 3373-83 PubMed GONUTS page
  4. ↑ 4.0 4.1 4.2 Damoc, E et al. (2007) Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Mol. Cell Proteomics 6 1135-46 PubMed GONUTS page
  5. ↑ 5.0 5.1 5.2 Zhou, M et al. (2008) Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. Proc. Natl. Acad. Sci. U.S.A. 105 18139-44 PubMed GONUTS page
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