CHICK:IF2A

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	EIF2S1 (synonyms: EIF2A)
Protein Name(s)	Eukaryotic translation initiation factor 2 subunit 1 Eukaryotic translation initiation factor 2 subunit alpha eIF-2-alpha eIF-2A eIF-2alpha
External Links
UniProt	Q5ZLX2
EMBL	BU385483 AJ719612
RefSeq	NP_001006477.1
UniGene	Gga.21991
ProteinModelPortal	Q5ZLX2
SMR	Q5ZLX2
STRING	9031.ENSGALP00000015560
PaxDb	Q5ZLX2
PRIDE	Q5ZLX2
Ensembl	ENSGALT00000015576
GeneID	423279
KEGG	gga:423279
CTD	1965
eggNOG	COG1093
GeneTree	ENSGT00390000007015
HOGENOM	HOG000199476
HOVERGEN	HBG001910
InParanoid	Q5ZLX2
KO	K03237
OMA	CTERFAK
OrthoDB	EOG7FZ012
PhylomeDB	Q5ZLX2
TreeFam	TF101502
Reactome	REACT_280530 REACT_309802 REACT_315214 REACT_323836 REACT_339756
NextBio	20825771
PRO	PR:Q5ZLX2
Proteomes	UP000000539
GO	GO:0005737 GO:0010494 GO:0033290 GO:0005850 GO:0005851 GO:0070062 GO:0016020 GO:0043614 GO:0005634 GO:0005840 GO:0044822 GO:0043022 GO:0003743 GO:0046777 GO:1903146 GO:0043558 GO:0006413
Gene3D	1.10.150.190 2.40.50.140 3.30.70.1130
InterPro	IPR012340 IPR003029 IPR022967 IPR024055 IPR024054 IPR011488
Pfam	PF07541 PF00575
SMART	SM00316
SUPFAM	SSF110993 SSF116742 SSF50249
PROSITE	PS50126

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZWX6	P	Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZWX6	P	Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZWX6	P	Seeded From UniProt	complete
involved_in	GO:0032057	negative regulation of translational initiation in response to stress	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q6ZWX6	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q98TT1	C	Seeded From UniProt	complete
part_of	GO:0043614	multi-eIF complex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000063908 SGD:S000003767	C	Seeded From UniProt	complete
enables	GO:0043022	ribosome binding	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000063907 UniProtKB:P05198	F	Seeded From UniProt	complete
part_of	GO:0033290	eukaryotic 48S preinitiation complex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000063908 SGD:S000003767	C	Seeded From UniProt	complete
part_of	GO:0005851	eukaryotic translation initiation factor 2B complex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000063908 UniProtKB:P05198	C	Seeded From UniProt	complete
part_of	GO:0005850	eukaryotic translation initiation factor 2 complex	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000063908 RGD:620963 SGD:S000003767 UniProtKB:P05198	C	Seeded From UniProt	complete
enables	GO:0003743	translation initiation factor activity	PMID:21873635^[1]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0261609 PANTHER:PTN000063907 UniProtKB:P05198	F	Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05198 ensembl:ENSP00000256383	P	Seeded From UniProt	complete
enables	GO:0043022	ribosome binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05198 ensembl:ENSP00000256383	F	Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05198 ensembl:ENSP00000256383	P	Seeded From UniProt	complete
part_of	GO:0005851	eukaryotic translation initiation factor 2B complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05198 ensembl:ENSP00000256383	C	Seeded From UniProt	complete
part_of	GO:0005850	eukaryotic translation initiation factor 2 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05198 ensembl:ENSP00000256383	C	Seeded From UniProt	complete
enables	GO:0003743	translation initiation factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05198 ensembl:ENSP00000256383	F	Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZWX6 ensembl:ENSMUSP00000071214	P	Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZWX6 ensembl:ENSMUSP00000071214	C	Seeded From UniProt	complete
involved_in	GO:0043558	regulation of translational initiation in response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZWX6 ensembl:ENSMUSP00000071214	P	Seeded From UniProt	complete
involved_in	GO:0034976	response to endoplasmic reticulum stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZWX6 ensembl:ENSMUSP00000071214	P	Seeded From UniProt	complete
involved_in	GO:0034644	cellular response to UV	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZWX6 ensembl:ENSMUSP00000071214	P	Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZWX6 ensembl:ENSMUSP00000071214	P	Seeded From UniProt	complete
involved_in	GO:0034198	cellular response to amino acid starvation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZWX6 ensembl:ENSMUSP00000071214	P	Seeded From UniProt	complete
involved_in	GO:0034063	stress granule assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZWX6 ensembl:ENSMUSP00000071214	P	Seeded From UniProt	complete
involved_in	GO:0032057	negative regulation of translational initiation in response to stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZWX6 ensembl:ENSMUSP00000071214	P	Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZWX6 ensembl:ENSMUSP00000071214	C	Seeded From UniProt	complete
involved_in	GO:0006412	translation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZWX6 ensembl:ENSMUSP00000071214	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZWX6 ensembl:ENSMUSP00000071214	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q6ZWX6 ensembl:ENSMUSP00000071214	C	Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003029	F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011488	F	Seeded From UniProt	complete
enables	GO:0003743	translation initiation factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011488	F	Seeded From UniProt	complete
involved_in	GO:0006412	translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0648	P	Seeded From UniProt	complete
enables	GO:0003743	translation initiation factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0396	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963	C	Seeded From UniProt	complete
involved_in	GO:0006413	translational initiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0396	P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
involved_in	GO:0006417	regulation of translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0810	P	Seeded From UniProt	complete
part_of	GO:0010494	cytoplasmic stress granule	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0496	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21873635-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CHICK:IF2A

Contents

Annotations

Notes

References

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