HUMAN:EIF3A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	EIF3A (ECO:0000255 with HAMAP-Rule:MF_03000) (synonyms: EIF3S10 (ECO:0000255 with HAMAP-Rule:MF_03000), KIAA0139)
Protein Name(s)	Eukaryotic translation initiation factor 3 subunit A (ECO:0000255 with HAMAP-Rule:MF_03000) eIF3a (ECO:0000255 with HAMAP-Rule:MF_03000) Eukaryotic translation initiation factor 3 subunit 10 (ECO:0000255 with HAMAP-Rule:MF_03000) eIF-3-theta (ECO:0000255 with HAMAP-Rule:MF_03000) eIF3 p167 eIF3 p180 eIF3 p185
External Links
UniProt	Q14152
EMBL	U58046 U58047 U78311 D50929 AK302575 AL355598 CH471066
CCDS	CCDS7608.1
RefSeq	NP_003741.1
UniGene	Hs.523299 Hs.713331
PDB	3J8B 3J8C
PDBsum	3J8B 3J8C
ProteinModelPortal	Q14152
BioGrid	114210
DIP	DIP-31114N
IntAct	Q14152
MINT	MINT-1519859
STRING	9606.ENSP00000358140
iPTMnet	Q14152
PhosphoSite	Q14152
SwissPalm	Q14152
BioMuta	EIF3A
DMDM	6685537
UCD-2DPAGE	Q14152
EPD	Q14152
MaxQB	Q14152
PaxDb	Q14152
PeptideAtlas	Q14152
PRIDE	Q14152
Ensembl	ENST00000369144 ENST00000541549
GeneID	8661
KEGG	hsa:8661
UCSC	uc001ldu.4
CTD	8661
GeneCards	EIF3A
H-InvDB	HIX0170434
HGNC	HGNC:3271
HPA	HPA038315 HPA038316
MIM	602039
neXtProt	NX_Q14152
PharmGKB	PA27699
eggNOG	KOG2072 ENOG410XQ37
GeneTree	ENSGT00730000111063
HOGENOM	HOG000246822
HOVERGEN	HBG006128
InParanoid	Q14152
KO	K03254
OMA	AREDSWG
OrthoDB	EOG7BGHKJ
PhylomeDB	Q14152
TreeFam	TF101522
Reactome	R-HSA-156827 R-HSA-72649 R-HSA-72689 R-HSA-72695 R-HSA-72702 R-HSA-72706
ChiTaRS	EIF3A
GeneWiki	EIF3A
GenomeRNAi	8661
NextBio	32483
PRO	PR:Q14152
Proteomes	UP000005640
Bgee	Q14152
CleanEx	HS_EIF3A
Genevisible	Q14152
GO	GO:0005737 GO:0005829 GO:0016282 GO:0033290 GO:0005852 GO:0071541 GO:0016020 GO:0005730 GO:0005634 GO:0044822 GO:0005198 GO:0003743 GO:0044267 GO:0001732 GO:0001731 GO:0010467 GO:0006446 GO:0006412 GO:0006413
HAMAP	MF_03000
InterPro	IPR027512 IPR000717
Pfam	PF01399
SMART	SM00088

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0003723	RNA binding	PMID:27462815^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:25849773^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0003743	translation initiation factor activity	PMID:25849773^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
part_of	GO:0005852	eukaryotic translation initiation factor 3 complex	PMID:25849773^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0075522	IRES-dependent viral translational initiation	PMID:9573242^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0075525	viral translational termination-reinitiation	PMID:21347434^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0075522	IRES-dependent viral translational initiation	PMID:24357634^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0075522	IRES-dependent viral translational initiation	PMID:23766293^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:19946888^[7]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22681889^[8]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	PMID:22658674^[9]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006413	translational initiation	PMID:17322308^[10]	ECO:0000305	curator inference used in manual assertion	GO:0005852	P	Seeded From UniProt	complete
involved_in	GO:0006413	translational initiation	PMID:18599441^[11]	ECO:0000305	curator inference used in manual assertion	GO:0005852	P	Seeded From UniProt	complete
part_of	GO:0005852	eukaryotic translation initiation factor 3 complex	PMID:17322308^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005852	eukaryotic translation initiation factor 3 complex	PMID:17581632^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005852	eukaryotic translation initiation factor 3 complex	PMID:18599441^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9150439^[13]	ECO:0000303	author statement without traceable support used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	PMID:9150439^[13]	ECO:0000303	author statement without traceable support used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0003743	translation initiation factor activity	PMID:17581632^[12]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
contributes_to	GO:0003743	translation initiation factor activity	PMID:17322308^[10]	ECO:0000305	curator inference used in manual assertion	GO:0005852	F	Seeded From UniProt	complete
contributes_to	GO:0003743	translation initiation factor activity	PMID:18599441^[11]	ECO:0000305	curator inference used in manual assertion	GO:0005852	F	Seeded From UniProt	complete
involved_in	GO:0001732	formation of cytoplasmic translation initiation complex	PMID:17581632^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95301 PANTHER:PTN000360893 PomBase:SPBC17D11.05	C	Seeded From UniProt	complete
part_of	GO:0071540	eukaryotic translation initiation factor 3 complex, eIF3e	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000360893 PomBase:SPBC17D11.05	C	Seeded From UniProt	complete
part_of	GO:0043614	multi-eIF complex	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000360893 SGD:S000000283	C	Seeded From UniProt	complete
contributes_to	GO:0003743	translation initiation factor activity	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95301 PANTHER:PTN000360893 SGD:S000000283 UniProtKB:Q14152	F	Seeded From UniProt	complete
enables	GO:0003729	mRNA binding	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000360893 TAIR:locus:2123076	F	Seeded From UniProt	complete
involved_in	GO:0002188	translation reinitiation	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000360893 SGD:S000000283	P	Seeded From UniProt	complete
involved_in	GO:0001732	formation of cytoplasmic translation initiation complex	PMID:21873635^[14]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:95301 PANTHER:PTN000360893 UniProtKB:Q14152	P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23116 ensembl:ENSMUSP00000025955	C	Seeded From UniProt	complete
part_of	GO:0014069	postsynaptic density	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23116 ensembl:ENSMUSP00000025955	C	Seeded From UniProt	complete
part_of	GO:0005852	eukaryotic translation initiation factor 3 complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23116 ensembl:ENSMUSP00000025955	C	Seeded From UniProt	complete
enables	GO:0003743	translation initiation factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23116 ensembl:ENSMUSP00000025955	F	Seeded From UniProt	complete
involved_in	GO:0001732	formation of cytoplasmic translation initiation complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P23116 ensembl:ENSMUSP00000025955	P	Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1JU68 ensembl:ENSRNOP00000063484	P	Seeded From UniProt	complete
enables	GO:0030971	receptor tyrosine kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1JU68 ensembl:ENSRNOP00000063484	F	Seeded From UniProt	complete
part_of	GO:0005874	microtubule	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1JU68 ensembl:ENSRNOP00000063484	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q1JU68 ensembl:ENSRNOP00000063484	C	Seeded From UniProt	complete
part_of	GO:0005852	eukaryotic translation initiation factor 3 complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027512	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106208	C	Seeded From UniProt	complete
part_of	GO:0016282	eukaryotic 43S preinitiation complex	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106208	C	Seeded From UniProt	complete
involved_in	GO:0002183	cytoplasmic translational initiation	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106208	P	Seeded From UniProt	complete
part_of	GO:0005852	eukaryotic translation initiation factor 3 complex	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106208	C	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106208	F	Seeded From UniProt	complete
part_of	GO:0033290	eukaryotic 48S preinitiation complex	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106208	C	Seeded From UniProt	complete
involved_in	GO:0001732	formation of cytoplasmic translation initiation complex	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106208	P	Seeded From UniProt	complete
enables	GO:0003743	translation initiation factor activity	GO_REF:0000104	ECO:0000256	match to sequence model evidence used in automatic assertion	UniRule:UR000106208	F	Seeded From UniProt	complete
involved_in	GO:0006413	translational initiation	Reactome:R-HSA-72613	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-72697 Reactome:R-HSA-72691 Reactome:R-HSA-72676 Reactome:R-HSA-72621 Reactome:R-HSA-72619 Reactome:R-HSA-157849 Reactome:R-HSA-156823 Reactome:R-HSA-156808	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003743	translation initiation factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0396	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0006412	translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0648	P	Seeded From UniProt	complete
enables	GO:0003723	RNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0694	F	Seeded From UniProt	complete
involved_in	GO:0006413	translational initiation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0396	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lee, AS et al. (2016) eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature 536 96-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Lee, AS et al. (2015) eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. Nature 522 111-4 PubMed GONUTS page
↑ Sizova, DV et al. (1998) Specific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs. J. Virol. 72 4775-82 PubMed GONUTS page
↑ Powell, ML et al. (2011) Further characterisation of the translational termination-reinitiation signal of the influenza B virus segment 7 RNA. PLoS ONE 6 e16822 PubMed GONUTS page
↑ Sweeney, TR et al. (2014) The mechanism of translation initiation on Type 1 picornavirus IRESs. EMBO J. 33 76-92 PubMed GONUTS page
↑ Sun, C et al. (2013) Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. Nucleic Acids Res. 41 7512-21 PubMed GONUTS page
↑ Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
↑ Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
↑ Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Damoc, E et al. (2007) Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Mol. Cell Proteomics 6 1135-46 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Zhou, M et al. (2008) Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. Proc. Natl. Acad. Sci. U.S.A. 105 18139-44 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Masutani, M et al. (2007) Reconstitution reveals the functional core of mammalian eIF3. EMBO J. 26 3373-83 PubMed GONUTS page
↑ ^13.0 ^13.1 Scholler, JK & Kanner, SB (1997) The human p167 gene encodes a unique structural protein that contains centrosomin A homology and associates with a multicomponent complex. DNA Cell Biol. 16 515-31 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:27462815-1] Lee, AS et al. (2016) eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature 536 96-9 PubMed GONUTS page

[PMID:25849773-2] 2.0 ^2.1 ^2.2 Lee, AS et al. (2015) eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. Nature 522 111-4 PubMed GONUTS page

[PMID:9573242-3] Sizova, DV et al. (1998) Specific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs. J. Virol. 72 4775-82 PubMed GONUTS page

[PMID:21347434-4] Powell, ML et al. (2011) Further characterisation of the translational termination-reinitiation signal of the influenza B virus segment 7 RNA. PLoS ONE 6 e16822 PubMed GONUTS page

[PMID:24357634-5] Sweeney, TR et al. (2014) The mechanism of translation initiation on Type 1 picornavirus IRESs. EMBO J. 33 76-92 PubMed GONUTS page

[PMID:23766293-6] Sun, C et al. (2013) Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. Nucleic Acids Res. 41 7512-21 PubMed GONUTS page

[PMID:19946888-7] Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page

[PMID:22681889-8] Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page

[PMID:22658674-9] Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page

[PMID:17322308-10] 10.0 ^10.1 ^10.2 Damoc, E et al. (2007) Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Mol. Cell Proteomics 6 1135-46 PubMed GONUTS page

[PMID:18599441-11] 11.0 ^11.1 ^11.2 Zhou, M et al. (2008) Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. Proc. Natl. Acad. Sci. U.S.A. 105 18139-44 PubMed GONUTS page

[PMID:17581632-12] 12.0 ^12.1 ^12.2 Masutani, M et al. (2007) Reconstitution reveals the functional core of mammalian eIF3. EMBO J. 26 3373-83 PubMed GONUTS page

[PMID:9150439-13] 13.0 ^13.1 Scholler, JK & Kanner, SB (1997) The human p167 gene encodes a unique structural protein that contains centrosomin A homology and associates with a multicomponent complex. DNA Cell Biol. 16 515-31 PubMed GONUTS page

[PMID:21873635-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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HUMAN:EIF3A

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Annotations

Notes

References

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