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HUMAN:EIF3A

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) EIF3A (ECO:0000255 with HAMAP-Rule:MF_03000) (synonyms: EIF3S10 (ECO:0000255 with HAMAP-Rule:MF_03000), KIAA0139)
Protein Name(s) Eukaryotic translation initiation factor 3 subunit A (ECO:0000255 with HAMAP-Rule:MF_03000)

eIF3a (ECO:0000255 with HAMAP-Rule:MF_03000) Eukaryotic translation initiation factor 3 subunit 10 (ECO:0000255 with HAMAP-Rule:MF_03000) eIF-3-theta (ECO:0000255 with HAMAP-Rule:MF_03000) eIF3 p167 eIF3 p180 eIF3 p185

External Links
UniProt Q14152
EMBL U58046
U58047
U78311
D50929
AK302575
AL355598
CH471066
CCDS CCDS7608.1
RefSeq NP_003741.1
UniGene Hs.523299
Hs.713331
PDB 3J8B
3J8C
PDBsum 3J8B
3J8C
ProteinModelPortal Q14152
BioGrid 114210
DIP DIP-31114N
IntAct Q14152
MINT MINT-1519859
STRING 9606.ENSP00000358140
iPTMnet Q14152
PhosphoSite Q14152
SwissPalm Q14152
BioMuta EIF3A
DMDM 6685537
UCD-2DPAGE Q14152
EPD Q14152
MaxQB Q14152
PaxDb Q14152
PeptideAtlas Q14152
PRIDE Q14152
Ensembl ENST00000369144
ENST00000541549
GeneID 8661
KEGG hsa:8661
UCSC uc001ldu.4
CTD 8661
GeneCards EIF3A
H-InvDB HIX0170434
HGNC HGNC:3271
HPA HPA038315
HPA038316
MIM 602039
neXtProt NX_Q14152
PharmGKB PA27699
eggNOG KOG2072
ENOG410XQ37
GeneTree ENSGT00730000111063
HOGENOM HOG000246822
HOVERGEN HBG006128
InParanoid Q14152
KO K03254
OMA AREDSWG
OrthoDB EOG7BGHKJ
PhylomeDB Q14152
TreeFam TF101522
Reactome R-HSA-156827
R-HSA-72649
R-HSA-72689
R-HSA-72695
R-HSA-72702
R-HSA-72706
ChiTaRS EIF3A
GeneWiki EIF3A
GenomeRNAi 8661
NextBio 32483
PRO PR:Q14152
Proteomes UP000005640
Bgee Q14152
CleanEx HS_EIF3A
Genevisible Q14152
GO GO:0005737
GO:0005829
GO:0016282
GO:0033290
GO:0005852
GO:0071541
GO:0016020
GO:0005730
GO:0005634
GO:0044822
GO:0005198
GO:0003743
GO:0044267
GO:0001732
GO:0001731
GO:0010467
GO:0006446
GO:0006412
GO:0006413
HAMAP MF_03000
InterPro IPR027512
IPR000717
Pfam PF01399
SMART SM00088

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0001731

formation of translation preinitiation complex

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_03000

P

Seeded From UniProt

GO:0001732

formation of cytoplasmic translation initiation complex

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000025955

P

Seeded From UniProt

GO:0001732

formation of cytoplasmic translation initiation complex

PMID:17581632[1]

IDA: Inferred from Direct Assay

-

P

Seeded From UniProt

GO:0003743

translation initiation factor activity

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000025955

F

Seeded From UniProt

GO:0003743

translation initiation factor activity

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_03000

F

Seeded From UniProt

GO:0003743

translation initiation factor activity

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0396

F

Seeded From UniProt

GO:0005198

structural molecule activity

PMID:9150439[2]

NAS: Non-traceable Author Statement

-

F

Seeded From UniProt

GO:0005515

protein binding

PMID:11169732[3]

IPI: Inferred from Physical Interaction

UniProtKB:P08729

F

Seeded From UniProt

GO:0005515

protein binding

PMID:11169732[3]

IPI: Inferred from Physical Interaction

UniProtKB:P08729

F

Seeded From UniProt

GO:0005515

protein binding

PMID:11169732[3]

IPI: Inferred from Physical Interaction

UniProtKB:P55884

F

Seeded From UniProt

GO:0005515

protein binding

PMID:11169732[3]

IPI: Inferred from Physical Interaction

UniProtKB:P55884

F

Seeded From UniProt

GO:0005515

protein binding

PMID:14688252[4]

IPI: Inferred from Physical Interaction

UniProtKB:P55884

F

Seeded From UniProt

GO:0005515

protein binding

PMID:17468741[5]

IPI: Inferred from Physical Interaction

UniProtKB:P60228

F

Seeded From UniProt

GO:0005515

protein binding

PMID:18423202[6]

IPI: Inferred from Physical Interaction

UniProtKB:Q92900-2

F

Seeded From UniProt

GO:0005515

protein binding

PMID:18628297[7]

IPI: Inferred from Physical Interaction

UniProtKB:P55884

F

Seeded From UniProt

GO:0005515

protein binding

PMID:19245811[8]

IPI: Inferred from Physical Interaction

UniProtKB:P55884

F

Seeded From UniProt

GO:0005515

protein binding

PMID:22190034[9]

IPI: Inferred from Physical Interaction

UniProtKB:Q9Q2G4

F

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSRNOP00000063484

C

Seeded From UniProt

GO:0005634

nucleus

GO_REF:0000052

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005730

nucleolus

GO_REF:0000052

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_03000

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

GO:0005737

cytoplasm

GO_REF:0000052

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005737

cytoplasm

PMID:9150439[2]

NAS: Non-traceable Author Statement

-

C

Seeded From UniProt

GO:0005829

cytosol

Reactome:R-HSA-156823

TAS: Traceable Author Statement

-

C

Seeded From UniProt

GO:0005829

cytosol

Reactome:R-HSA-157849

TAS: Traceable Author Statement

-

C

Seeded From UniProt

GO:0005829

cytosol

Reactome:R-HSA-72619

TAS: Traceable Author Statement

-

C

Seeded From UniProt

GO:0005829

cytosol

Reactome:R-HSA-72621

TAS: Traceable Author Statement

-

C

Seeded From UniProt

GO:0005829

cytosol

Reactome:R-HSA-72676

TAS: Traceable Author Statement

-

C

Seeded From UniProt

GO:0005829

cytosol

Reactome:R-HSA-72691

TAS: Traceable Author Statement

-

C

Seeded From UniProt

GO:0005829

cytosol

Reactome:R-HSA-72697

TAS: Traceable Author Statement

-

C

Seeded From UniProt

GO:0005852

eukaryotic translation initiation factor 3 complex

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR027512

C

Seeded From UniProt

GO:0005852

eukaryotic translation initiation factor 3 complex

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000025955

C

Seeded From UniProt

GO:0005852

eukaryotic translation initiation factor 3 complex

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_03000

C

Seeded From UniProt

GO:0005852

eukaryotic translation initiation factor 3 complex

PMID:17322308[10]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005852

eukaryotic translation initiation factor 3 complex

PMID:17581632[1]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0005852

eukaryotic translation initiation factor 3 complex

PMID:18599441[11]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0006412

translation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0648

P

Seeded From UniProt

GO:0006413

translational initiation

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_03000

P

Seeded From UniProt

GO:0006413

translational initiation

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0396

P

Seeded From UniProt

GO:0006413

translational initiation

PMID:17322308[10]

IC: Inferred by Curator

GO:0005852

P

Seeded From UniProt

GO:0006413

translational initiation

PMID:18599441[11]

IC: Inferred by Curator

GO:0005852

P

Seeded From UniProt

GO:0006413

translational initiation

Reactome:R-HSA-72613

TAS: Traceable Author Statement

-

P

Seeded From UniProt

GO:0006446

regulation of translational initiation

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_03000

P

Seeded From UniProt

GO:0016020

membrane

PMID:19946888[12]

IDA: Inferred from Direct Assay

-

C

Seeded From UniProt

GO:0016282

eukaryotic 43S preinitiation complex

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_03000

C

Seeded From UniProt

GO:0033290

eukaryotic 48S preinitiation complex

GO_REF:0000020

IEA: Inferred from Electronic Annotation

HAMAP:MF_03000

C

Seeded From UniProt

GO:0044822

poly(A) RNA binding

PMID:22658674[13]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0044822

poly(A) RNA binding

PMID:22681889[14]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0071541

eukaryotic translation initiation factor 3 complex, eIF3m

GO_REF:0000019

IEA: Inferred from Electronic Annotation

Ensembl:ENSMUSP00000025955

C

Seeded From UniProt

GO:0075522

IRES-dependent viral translational initiation

PMID:23766293[15]

IDA: Inferred from Direct Assay

-

P

Seeded From UniProt

GO:0075522

IRES-dependent viral translational initiation

PMID:24357634[16]

IDA: Inferred from Direct Assay

-

P

Seeded From UniProt

GO:0075522

IRES-dependent viral translational initiation

PMID:9573242[17]

IDA: Inferred from Direct Assay

-

P

Seeded From UniProt

GO:0075525

viral translational termination-reinitiation

PMID:21347434[18]

IDA: Inferred from Direct Assay

-

P

Seeded From UniProt

GO:0003743

translation initiation factor activity

PMID:17322308[10]

IC: Inferred by Curator

GO:0005852

F

Seeded From UniProt

GO:0003743

translation initiation factor activity

PMID:17581632[1]

IDA: Inferred from Direct Assay

-

F

Seeded From UniProt

GO:0003743

translation initiation factor activity

PMID:18599441[11]

IC: Inferred by Curator

GO:0005852

F

Seeded From UniProt


Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 Masutani, M et al. (2007) Reconstitution reveals the functional core of mammalian eIF3. EMBO J. 26 3373-83 PubMed GONUTS page
  2. 2.0 2.1 Scholler, JK & Kanner, SB (1997) The human p167 gene encodes a unique structural protein that contains centrosomin A homology and associates with a multicomponent complex. DNA Cell Biol. 16 515-31 PubMed GONUTS page
  3. 3.0 3.1 3.2 3.3 Lin, L et al. (2001) Molecular interaction between human tumor marker protein p150, the largest subunit of eIF3, and intermediate filament protein K7. J. Cell. Biochem. 80 483-90 PubMed GONUTS page
  4. Fraser, CS et al. (2004) The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. J. Biol. Chem. 279 8946-56 PubMed GONUTS page
  5. Morris, C et al. (2007) Human INT6/eIF3e is required for nonsense-mediated mRNA decay. EMBO Rep. 8 596-602 PubMed GONUTS page
  6. Isken, O et al. (2008) Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay. Cell 133 314-27 PubMed GONUTS page
  7. Lee, CS et al. (2008) Human DDX3 functions in translation and interacts with the translation initiation factor eIF3. Nucleic Acids Res. 36 4708-18 PubMed GONUTS page
  8. Shi, J et al. (2009) Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis. FEBS Lett. 583 971-7 PubMed GONUTS page
  9. Jäger, S et al. (2012) Global landscape of HIV-human protein complexes. Nature 481 365-70 PubMed GONUTS page
  10. 10.0 10.1 10.2 Damoc, E et al. (2007) Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Mol. Cell Proteomics 6 1135-46 PubMed GONUTS page
  11. 11.0 11.1 11.2 Zhou, M et al. (2008) Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. Proc. Natl. Acad. Sci. U.S.A. 105 18139-44 PubMed GONUTS page
  12. Ghosh, D et al. (2010) Defining the membrane proteome of NK cells. J Mass Spectrom 45 1-25 PubMed GONUTS page
  13. Castello, A et al. (2012) Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Cell 149 1393-406 PubMed GONUTS page
  14. Baltz, AG et al. (2012) The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Mol. Cell 46 674-90 PubMed GONUTS page
  15. Sun, C et al. (2013) Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. Nucleic Acids Res. 41 7512-21 PubMed GONUTS page
  16. Sweeney, TR et al. (2014) The mechanism of translation initiation on Type 1 picornavirus IRESs. EMBO J. 33 76-92 PubMed GONUTS page
  17. Sizova, DV et al. (1998) Specific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs. J. Virol. 72 4775-82 PubMed GONUTS page
  18. Powell, ML et al. (2011) Further characterisation of the translational termination-reinitiation signal of the influenza B virus segment 7 RNA. PLoS ONE 6 e16822 PubMed GONUTS page