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CAEEL:FOXO

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Species (Taxon ID) Caenorhabditis elegans. (6239)
Gene Name(s) daf-16 (ECO:0000312 with EMBL:AAB84392.1)
Protein Name(s) Forkhead box protein O

FOXO (ECO:0000303 with PMID:12750521[1]) Abnormal dauer formation protein 16 (ECO:0000312 with EMBL:AAB84392.1)

External Links
UniProt O16850
EMBL AF020342
AF020343
AF020344
AF032112
FO081472
FO081472
FO081472
FO081472
FO081472
FO081472
FO080113
FO081472
FO080113
FO081472
FO080113
PIR T42234
T42255
RefSeq NP_001021593.1
NP_001021594.1
NP_001021595.1
NP_001021596.1
NP_001021597.1
NP_001021598.2
NP_001251490.1
NP_001251492.1
UniGene Cel.18378
ProteinModelPortal O16850
SMR O16850
BioGrid 38392
DIP DIP-25581N
IntAct O16850
MINT MINT-1069794
PaxDb O16850
PRIDE O16850
EnsemblMetazoa R13H8.1h
GeneID 172981
KEGG cel:CELE_R13H8.1
UCSC R13H8.1c
CTD 172981
WormBase R13H8.1a
R13H8.1b
R13H8.1c
R13H8.1d
R13H8.1e
R13H8.1f
R13H8.1g
R13H8.1h
eggNOG COG5025
GeneTree ENSGT00390000000589
HOGENOM HOG000019698
InParanoid O16850
OMA ANSAGPI
OrthoDB EOG79GT6N
Reactome REACT_183486
REACT_197684
REACT_206399
REACT_229685
REACT_237300
REACT_254189
SignaLink O16850
NextBio 877779
Proteomes UP000001940
GO GO:0005737
GO:0005829
GO:0005634
GO:0033613
GO:0000977
GO:0043565
GO:0003700
GO:0031625
GO:0007568
GO:0006974
GO:0034605
GO:0040024
GO:0050829
GO:0008340
GO:0045087
GO:0008286
GO:0060537
GO:0040015
GO:0002119
GO:0002821
GO:0043065
GO:0045944
GO:0010564
GO:0043620
GO:0046890
GO:0006355
GO:0009411
GO:0006351
Gene3D 1.10.10.10
InterPro IPR001766
IPR018122
IPR011991
Pfam PF00250
PRINTS PR00053
SMART SM00339
PROSITE PS00658
PS50039

Annotations

Qualifier GO ID GO term name Reference Evidence Code with/from Aspect Notes Status
GO:0000122

negative regulation of transcription from RNA polymerase II promoter

PMID:25330323[2]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0000977

RNA polymerase II regulatory region sequence-specific DNA binding

PMID:19506556[3]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0000981

RNA polymerase II transcription factor activity, sequence-specific DNA binding

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001371846

F

Seeded From UniProt

complete

GO:0002119

nematode larval development

PMID:11747821[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0002376

immune system process

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

GO:0002821

positive regulation of adaptive immune response

PMID:17096597[5]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0002821

positive regulation of adaptive immune response

PMID:18245330[6]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0003677

DNA binding

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0238

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001766

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

PMID:11124266[7]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0003700

transcription factor activity, sequence-specific DNA binding

PMID:22922647[8]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:11124266[7]

IPI: Inferred from Physical Interaction

UniProtKB:P63101

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15068796[9]

IPI: Inferred from Physical Interaction

UniProtKB:Q17941

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15068796[9]

IPI: Inferred from Physical Interaction

UniProtKB:Q2PJ68

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:15068796[9]

IPI: Inferred from Physical Interaction

UniProtKB:Q9XTG7

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16777605[10]

IPI: Inferred from Physical Interaction

UniProtKB:Q21921

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:16860373[11]

IPI: Inferred from Physical Interaction

UniProtKB:Q21921

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18358814[12]

IPI: Inferred from Physical Interaction

UniProtKB:Q17941

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18358814[12]

IPI: Inferred from Physical Interaction

UniProtKB:Q2PJ68

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:18358814[12]

IPI: Inferred from Physical Interaction

UniProtKB:Q9XTG7

F

Seeded From UniProt

complete

GO:0005515

protein binding

PMID:23255046[13]

IPI: Inferred from Physical Interaction

WB:WBGene00017075

F

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

GO:0005634

nucleus

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:11124266[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:11381260[14]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:11381260[14]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:11747821[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:19252938[15]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:19454349[16]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:22922647[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005634

nucleus

PMID:23911329[17]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0963

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

GO_REF:0000039

IEA: Inferred from Electronic Annotation

UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:11124266[7]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:11381260[14]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:11381260[14]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:11747821[4]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:19454349[16]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005737

cytoplasm

PMID:23911329[17]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0005829

cytosol

PMID:22922647[8]

IDA: Inferred from Direct Assay

C

Seeded From UniProt

complete

GO:0006351

transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0804

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001766

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0805

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

PMID:17096597[5]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006355

regulation of transcription, DNA-templated

PMID:17894411[18]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0006974

cellular response to DNA damage stimulus

PMID:22922647[8]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0007275

multicellular organismal development

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0217

P

Seeded From UniProt

complete

GO:0007568

aging

PMID:11747825[19]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0007568

aging

PMID:19103192[20]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:11124266[7]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0008286

insulin receptor signaling pathway

PMID:11747821[4]

TAS: Traceable Author Statement

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:11381260[14]

IGI: Inferred from Genetic Interaction

WB:WBGene00000898

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:11381260[14]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:11381260[14]

IMP: Inferred from Mutant Phenotype

WB:WBVar00089216
WB:WBVar00089230

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:11747821[4]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:19103192[20]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:20523893[21]

IGI: Inferred from Genetic Interaction

WB:WBGene00006414

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:22560223[22]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0008340

determination of adult lifespan

PMID:22922647[8]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0009411

response to UV

PMID:11747825[19]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0009653

anatomical structure morphogenesis

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001371846

P

Seeded From UniProt

complete

GO:0010564

regulation of cell cycle process

PMID:17934462[23]

IEP: Inferred from Expression Pattern

P

Seeded From UniProt

complete

GO:0030154

cell differentiation

GO_REF:0000033

IBA: Inferred from Biological aspect of Ancestor

PANTHER:PTN001371846

P

Seeded From UniProt

complete

GO:0031625

ubiquitin protein ligase binding

PMID:17276341[24]

IPI: Inferred from Physical Interaction

UniProtKB:O45962

F

Seeded From UniProt

complete

GO:0033613

activating transcription factor binding

PMID:19103192[20]

IPI: Inferred from Physical Interaction

UniProtKB:Q20561

F

Seeded From UniProt

complete

GO:0034605

cellular response to heat

PMID:11381260[14]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0034605

cellular response to heat

PMID:11747825[19]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0040008

regulation of growth

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0341

P

Seeded From UniProt

complete

GO:0040015

negative regulation of multicellular organism growth

PMID:12571101[25]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0040024

dauer larval development

PMID:11381260[14]

IGI: Inferred from Genetic Interaction

WB:WBGene00000898

P

Seeded From UniProt

complete

GO:0043065

positive regulation of apoptotic process

PMID:17934462[23]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

GO_REF:0000002

IEA: Inferred from Electronic Annotation

InterPro:IPR001766

F

Seeded From UniProt

complete

GO:0043565

sequence-specific DNA binding

PMID:11124266[7]

IDA: Inferred from Direct Assay

F

Seeded From UniProt

complete

GO:0043620

regulation of DNA-templated transcription in response to stress

PMID:12750521[1]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0045087

innate immune response

GO_REF:0000037

IEA: Inferred from Electronic Annotation

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

GO:0045087

innate immune response

PMID:19454349[16]

IMP: Inferred from Mutant Phenotype

WB:WBVar00088538
WB:WBVar00088974
WB:WBVar00089216
WB:WBVar00275574

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:11124266[7]

IDA: Inferred from Direct Assay

P

Seeded From UniProt

complete

GO:0045944

positive regulation of transcription from RNA polymerase II promoter

PMID:19454349[16]

IMP: Inferred from Mutant Phenotype

WB:WBVar00089216

P

Seeded From UniProt

complete

GO:0046890

regulation of lipid biosynthetic process

PMID:18762027[26]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0050829

defense response to Gram-negative bacterium

PMID:19454349[16]

IMP: Inferred from Mutant Phenotype

WB:WBVar00088538
WB:WBVar00088974
WB:WBVar00089216
WB:WBVar00275574

P

Seeded From UniProt

complete

GO:0060537

muscle tissue development

PMID:18397876[27]

IMP: Inferred from Mutant Phenotype

P

Seeded From UniProt

complete

GO:0061066

positive regulation of dauer larval development

PMID:6583682[28]

IMP: Inferred from Mutant Phenotype

WB:WBVar00088538

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Hsu, AL et al. (2003) Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300 1142-5 PubMed GONUTS page
  2. Warnhoff, K et al. (2014) The DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylation. PLoS Genet. 10 e1004703 PubMed GONUTS page
  3. Curran, SP et al. (2009) A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature 459 1079-84 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Lee, RY et al. (2001) Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr. Biol. 11 1950-7 PubMed GONUTS page
  5. 5.0 5.1 Troemel, ER et al. (2006) p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet. 2 e183 PubMed GONUTS page
  6. Miyata, S et al. (2008) DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans. Genetics 178 903-18 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 7.5 7.6 Cahill, CM et al. (2001) Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. J. Biol. Chem. 276 13402-10 PubMed GONUTS page
  8. 8.0 8.1 8.2 8.3 8.4 Vilchez, D et al. (2012) RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Nature 489 263-8 PubMed GONUTS page
  9. 9.0 9.1 9.2 Hertweck, M et al. (2004) C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span. Dev. Cell 6 577-88 PubMed GONUTS page
  10. Berdichevsky, A et al. (2006) C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span. Cell 125 1165-77 PubMed GONUTS page
  11. Wang, Y et al. (2006) C. elegans 14-3-3 proteins regulate life span and interact with SIR-2.1 and DAF-16/FOXO. Mech. Ageing Dev. 127 741-7 PubMed GONUTS page
  12. 12.0 12.1 12.2 Tullet, JM et al. (2008) Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans. Cell 132 1025-38 PubMed GONUTS page
  13. Cheong, MC et al. (2013) NSBP-1 mediates the effects of cholesterol on insulin/IGF-1 signaling in Caenorhabditis elegans. Cell. Mol. Life Sci. 70 1623-36 PubMed GONUTS page
  14. 14.0 14.1 14.2 14.3 14.4 14.5 14.6 14.7 14.8 Lin, K et al. (2001) Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat. Genet. 28 139-45 PubMed GONUTS page
  15. Hartwig, K et al. (2009) Feeding a ROS-generator to Caenorhabditis elegans leads to increased expression of small heat shock protein HSP-16.2 and hormesis. Genes Nutr 4 59-67 PubMed GONUTS page
  16. 16.0 16.1 16.2 16.3 16.4 Anyanful, A et al. (2009) Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity. Cell Host Microbe 5 450-62 PubMed GONUTS page
  17. 17.0 17.1 Tepper, RG et al. (2013) PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity. Cell 154 676-90 PubMed GONUTS page
  18. Wolf, M et al. (2008) The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness. J. Cell. Physiol. 214 721-9 PubMed GONUTS page
  19. 19.0 19.1 19.2 Henderson, ST & Johnson, TE (2001) daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr. Biol. 11 1975-80 PubMed GONUTS page
  20. 20.0 20.1 20.2 Liachko, N et al. (2009) Combined informatic and expression screen identifies the novel DAF-16 target HLH-13. Dev. Biol. 327 97-105 PubMed GONUTS page
  21. Schreiber, MA et al. (2010) Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1. PLoS Genet. 6 e1000972 PubMed GONUTS page
  22. Robida-Stubbs, S et al. (2012) TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15 713-24 PubMed GONUTS page
  23. 23.0 23.1 Pinkston-Gosse, J & Kenyon, C (2007) DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Nat. Genet. 39 1403-9 PubMed GONUTS page
  24. Li, W et al. (2007) RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination. Dev. Cell 12 235-46 PubMed GONUTS page
  25. Hirose, T et al. (2003) Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C elegans. Development 130 1089-99 PubMed GONUTS page
  26. Perez, CL & Van Gilst, MR (2008) A 13C isotope labeling strategy reveals the influence of insulin signaling on lipogenesis in C. elegans. Cell Metab. 8 266-74 PubMed GONUTS page
  27. Catoire, H et al. (2008) Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1. Hum. Mol. Genet. 17 2108-17 PubMed GONUTS page
  28. Golden, JW & Riddle, DL (1984) A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc. Natl. Acad. Sci. U.S.A. 81 819-23 PubMed GONUTS page