CAEEL:FOXO

Species (Taxon ID)	Caenorhabditis elegans. (6239)
Gene Name(s)	daf-16 (ECO:0000312 with EMBL:AAB84392.1)
Protein Name(s)	Forkhead box protein O FOXO (ECO:0000303 with PMID:12750521^[1]) Abnormal dauer formation protein 16 (ECO:0000312 with EMBL:AAB84392.1)
External Links
UniProt	O16850
EMBL	AF020342 AF020343 AF020344 AF032112 FO081472 FO081472 FO081472 FO081472 FO081472 FO081472 FO080113 FO081472 FO080113 FO081472 FO080113
PIR	T42234 T42255
RefSeq	NP_001021593.1 NP_001021594.1 NP_001021595.1 NP_001021596.1 NP_001021597.1 NP_001021598.2 NP_001251490.1 NP_001251492.1
UniGene	Cel.18378
ProteinModelPortal	O16850
SMR	O16850
BioGrid	38392
DIP	DIP-25581N
IntAct	O16850
MINT	MINT-1069794
PaxDb	O16850
PRIDE	O16850
EnsemblMetazoa	R13H8.1h
GeneID	172981
KEGG	cel:CELE_R13H8.1
UCSC	R13H8.1c
CTD	172981
WormBase	R13H8.1a R13H8.1b R13H8.1c R13H8.1d R13H8.1e R13H8.1f R13H8.1g R13H8.1h
eggNOG	COG5025
GeneTree	ENSGT00390000000589
HOGENOM	HOG000019698
InParanoid	O16850
OMA	ANSAGPI
OrthoDB	EOG79GT6N
Reactome	REACT_183486 REACT_197684 REACT_206399 REACT_229685 REACT_237300 REACT_254189
SignaLink	O16850
NextBio	877779
Proteomes	UP000001940
GO	GO:0005737 GO:0005829 GO:0005634 GO:0033613 GO:0000977 GO:0043565 GO:0003700 GO:0031625 GO:0007568 GO:0006974 GO:0034605 GO:0040024 GO:0050829 GO:0008340 GO:0045087 GO:0008286 GO:0060537 GO:0040015 GO:0002119 GO:0002821 GO:0043065 GO:0045944 GO:0010564 GO:0043620 GO:0046890 GO:0006355 GO:0009411 GO:0006351
Gene3D	1.10.10.10
InterPro	IPR001766 IPR018122 IPR011991
Pfam	PF00250
PRINTS	PR00053
SMART	SM00339
PROSITE	PS00658 PS50039

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:23770237^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q09444)	Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:23770237^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:17277769^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q21693	P		Seeded From UniProt	complete
involved_in	GO:1900075	positive regulation of neuromuscular synaptic transmission	PMID:23665919^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q18223,UniProtKB:Q968Y9	P		Seeded From UniProt	complete
involved_in	GO:0045887	positive regulation of synaptic growth at neuromuscular junction	PMID:23665919^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q18223,UniProtKB:Q968Y9	P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:17526726^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:O16202)\|has_input:(UniProtKB:Q09975)\|has_input:(UniProtKB:Q22291)\|has_input:(UniProtKB:Q21327)\|has_input:(UniProtKB:Q95XX2)\|has_input:(UniProtKB:Q9XUD5)\|has_input:(UniProtKB:Q9XUE0)	Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:24972867^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0005737	cytoplasm	PMID:24957743^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0005634	nucleus	PMID:24957743^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:27564576^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:17277769^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1905909	regulation of dauer entry	PMID:24671950^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9NEK7	P		Seeded From UniProt	complete
involved_in	GO:1905909	regulation of dauer entry	PMID:24671950^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q968Y9	P		Seeded From UniProt	complete
enables	GO:0017151	DEAD/H-box RNA helicase binding	PMID:26195740^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q18212	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:26154057^[11]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(WBbt:0005792)	Seeded From UniProt	complete
involved_in	GO:0061065	regulation of dauer larval development	PMID:1732156^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q8I4N4	P		Seeded From UniProt	complete
involved_in	GO:0034599	cellular response to oxidative stress	PMID:15905404^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q18825	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15905404^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_transcription_of:(WB:WBGene00004932)	Seeded From UniProt	complete
enables	GO:0008013	beta-catenin binding	PMID:15905404^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q18825	F	part_of:(GO:0034599)	Seeded From UniProt	complete
enables	GO:0071889	14-3-3 protein binding	PMID:17098225^[14]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q20655	F		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:23665919^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007614	short-term memory	PMID:26675724^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00000898	P		Seeded From UniProt	complete
involved_in	GO:0045887	positive regulation of synaptic growth at neuromuscular junction	PMID:23665919^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:G5ECN9,UniProtKB:Q18223	P		Seeded From UniProt	complete
involved_in	GO:0008582	regulation of synaptic growth at neuromuscular junction	PMID:23665919^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q17551,UniProtKB:Q20347	P		Seeded From UniProt	complete
enables	GO:1990381	ubiquitin-specific protease binding	PMID:26154057^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q7JKC3	F		Seeded From UniProt	complete
involved_in	GO:0061066	positive regulation of dauer larval development	PMID:6583682^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088538	P		Seeded From UniProt	complete
involved_in	GO:1900426	positive regulation of defense response to bacterium	PMID:22554143^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(WBls:0000041)	Seeded From UniProt	complete
involved_in	GO:0061065	regulation of dauer larval development	PMID:21124868^[18]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9N3Q8	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	PMID:23028355^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q95Q89	F		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:23352664^[20]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O44408	P	happens_during:(WBls:0000041) happens_during:(GO:0042594)	Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:23352664^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(WBls:0000041) happens_during:(GO:0042594)	Seeded From UniProt	complete
involved_in	GO:0042594	response to starvation	PMID:23352664^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(WBls:0000041)	Seeded From UniProt	complete
involved_in	GO:0040024	dauer larval development	PMID:15905404^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q18825,UniProtKB:Q968Y9	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:15905404^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:25330323^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(WB:WBGene00020719)	Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:19454349^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088538 WB:WBVar00088974 WB:WBVar00089216 WB:WBVar00275574	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19454349^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00089216	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:11124266^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:19454349^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00088538 WB:WBVar00088974 WB:WBVar00089216 WB:WBVar00275574	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:11124266^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0040024	dauer larval development	PMID:11381260^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00000898	P		Seeded From UniProt	complete
involved_in	GO:0040015	negative regulation of multicellular organism growth	PMID:12571101^[25]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:20523893^[26]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00006414	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:11381260^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00000898	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:11381260^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion	WB:WBVar00089216 WB:WBVar00089230	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:11124266^[23]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19454349^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11381260^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11124266^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23911329^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19454349^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11381260^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11124266^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23911329^[27]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:11124266^[23]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	PMID:19506556^[28]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(WB:WBGene00004027)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:21531333^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:P41977)\|has_regulation_target:(UniProtKB:Q20363)\|has_regulation_target:(UniProtKB:P17511)\|has_regulation_target:(UniProtKB:O16202)	Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:21531333^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q968Y9	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	PMID:21531333^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q968Y9	P	has_regulation_target:(UniProtKB:P41977)\|has_regulation_target:(UniProtKB:Q20363)\|has_regulation_target:(UniProtKB:P17511)\|has_regulation_target:(UniProtKB:O16202)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21531333^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21531333^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0071889	14-3-3 protein binding	PMID:21531333^[29]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q20655	F		Seeded From UniProt	complete
involved_in	GO:1905909	regulation of dauer entry	PMID:21531333^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q968Y9	P		Seeded From UniProt	complete
involved_in	GO:0010883	regulation of lipid storage	PMID:21531333^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q968Y9	P		Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	PMID:21531333^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q968Y9	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	PMID:21531333^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q968Y9	P		Seeded From UniProt	complete
involved_in	GO:0010286	heat acclimation	PMID:21531333^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q968Y9	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:21531333^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:21531333^[29]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9U2X0	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:27001890^[30]	ECO:0000316	genetic interaction evidence used in manual assertion	WB:WBGene00001609	P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:22560223^[31]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060537	muscle tissue development	PMID:18397876^[32]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046890	regulation of lipid biosynthetic process	PMID:18762027^[33]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043620	regulation of DNA-templated transcription in response to stress	PMID:12750521^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:17934462^[34]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:11381260^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034605	cellular response to heat	PMID:11747825^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	PMID:19103192^[36]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q20561	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:17276341^[37]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O45962	F		Seeded From UniProt	complete
involved_in	GO:0010564	regulation of cell cycle process	PMID:17934462^[34]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	PMID:11747825^[35]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:11381260^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:11747821^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:22922647^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008340	determination of adult lifespan	PMID:19103192^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:11747825^[35]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007568	aging	PMID:19103192^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:22922647^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:17096597^[40]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:17894411^[41]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:22922647^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11381260^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11747821^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22922647^[39]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11381260^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11747821^[38]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19252938^[42]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:22922647^[39]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002821	positive regulation of adaptive immune response	PMID:17096597^[40]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002821	positive regulation of adaptive immune response	PMID:18245330^[43]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002119	nematode larval development	PMID:11747821^[38]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:1891915 PANTHER:PTN002908599 RGD:620283 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	F		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 PANTHER:PTN000215135 UniProtKB:A4L7N3 UniProtKB:P98177 WB:WBGene00000912	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1890077 PANTHER:PTN002908599 UniProtKB:P98177	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:2676586 PANTHER:PTN002908599 RGD:1309196 RGD:1561201 RGD:620283 UniProtKB:A4L7N3 UniProtKB:F1NNE8 UniProtKB:F1RME6 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 MGI:MGI:2676586 PANTHER:PTN002908599 RGD:1309196 RGD:1561201 RGD:620283 UniProtKB:A4L7N3 UniProtKB:F1RME6 UniProtKB:O43524 UniProtKB:P98177 UniProtKB:Q12778 WB:WBGene00000912	C		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0038197 MGI:MGI:1890077 MGI:MGI:1890081 PANTHER:PTN002908599 RGD:620283 UniProtKB:O43524 UniProtKB:P98177 WB:WBGene00000912	F		Seeded From UniProt	complete
enables	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:2676586 PANTHER:PTN002908599	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:21873635^[44]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002908599 UniProtKB:O43524 WB:WBGene00000912 ZFIN:ZDB-GENE-990708-6	P		Seeded From UniProt	complete
enables	GO:0003700	DNA-binding transcription factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	P		Seeded From UniProt	complete
enables	GO:0043565	sequence-specific DNA binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001766 InterPro:IPR030456	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:23665919^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:23665919^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24671950^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:24671950^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:11747821^[38]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
involved_in	GO:0007275	multicellular organism development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0217	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0341	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Hsu, AL et al. (2003) Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300 1142-5 PubMed GONUTS page
↑ ^2.0 ^2.1 Matilainen, O et al. (2013) Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4. Cell Rep 3 1980-95 PubMed GONUTS page
↑ ^3.0 ^3.1 Syntichaki, P et al. (2007) eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature 445 922-6 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Hung, WL et al. (2013) Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development. EMBO J. 32 1745-60 PubMed GONUTS page
↑ Alper, S et al. (2007) Specificity and complexity of the Caenorhabditis elegans innate immune response. Mol. Cell. Biol. 27 5544-53 PubMed GONUTS page
↑ Kong, C et al. (2014) Orthosiphon stamineus protects Caenorhabditis elegans against Staphylococcus aureus infection through immunomodulation. Biol Open 3 644-55 PubMed GONUTS page
↑ ^7.0 ^7.1 Fischer, M et al. (2014) The zinc matrix metalloproteinase ZMP-2 increases survival of Caenorhabditis elegans through interference with lipoprotein absorption. Genes Nutr 9 414 PubMed GONUTS page
↑ Ishii, T et al. (2016) Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans. PLoS Genet. 12 e1006276 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Hung, WL et al. (2014) A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication. Development 141 1767-79 PubMed GONUTS page
↑ Seo, M et al. (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 112 E4246-55 PubMed GONUTS page
↑ ^11.0 ^11.1 Heimbucher, T et al. (2015) The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity. Cell Metab. 22 151-63 PubMed GONUTS page
↑ Vowels, JJ & Thomas, JH (1992) Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics 130 105-23 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 Essers, MA et al. (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308 1181-4 PubMed GONUTS page
↑ Li, J et al. (2007) The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans. Dev. Biol. 301 82-91 PubMed GONUTS page
↑ Kaletsky, R et al. (2016) The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators. Nature 529 92-6 PubMed GONUTS page
↑ Golden, JW & Riddle, DL (1984) A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc. Natl. Acad. Sci. U.S.A. 81 819-23 PubMed GONUTS page
↑ Twumasi-Boateng, K et al. (2012) An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan. Aging Cell 11 659-67 PubMed GONUTS page
↑ Jensen, VL et al. (2010) Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25. PLoS Genet. 6 e1001199 PubMed GONUTS page
↑ Chiang, WC et al. (2012) C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress. PLoS Genet. 8 e1002948 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Uno, M et al. (2013) A fasting-responsive signaling pathway that extends life span in C. elegans. Cell Rep 3 79-91 PubMed GONUTS page
↑ Warnhoff, K et al. (2014) The DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylation. PLoS Genet. 10 e1004703 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 ^22.3 ^22.4 Anyanful, A et al. (2009) Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity. Cell Host Microbe 5 450-62 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 Cahill, CM et al. (2001) Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. J. Biol. Chem. 276 13402-10 PubMed GONUTS page
↑ ^24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 ^24.6 ^24.7 ^24.8 Lin, K et al. (2001) Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat. Genet. 28 139-45 PubMed GONUTS page
↑ Hirose, T et al. (2003) Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C elegans. Development 130 1089-99 PubMed GONUTS page
↑ Schreiber, MA et al. (2010) Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1. PLoS Genet. 6 e1000972 PubMed GONUTS page
↑ ^27.0 ^27.1 Tepper, RG et al. (2013) PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity. Cell 154 676-90 PubMed GONUTS page
↑ Curran, SP et al. (2009) A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature 459 1079-84 PubMed GONUTS page
↑ ^29.00 ^29.01 ^29.02 ^29.03 ^29.04 ^29.05 ^29.06 ^29.07 ^29.08 ^29.09 ^29.10 ^29.11 ^29.12 Takahashi, Y et al. (2011) Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16. Cell Metab. 13 505-16 PubMed GONUTS page
↑ Nakamura, S et al. (2016) Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals. Nat Commun 7 10944 PubMed GONUTS page
↑ Robida-Stubbs, S et al. (2012) TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15 713-24 PubMed GONUTS page
↑ Catoire, H et al. (2008) Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1. Hum. Mol. Genet. 17 2108-17 PubMed GONUTS page
↑ Perez, CL & Van Gilst, MR (2008) A 13C isotope labeling strategy reveals the influence of insulin signaling on lipogenesis in C. elegans. Cell Metab. 8 266-74 PubMed GONUTS page
↑ ^34.0 ^34.1 Pinkston-Gosse, J & Kenyon, C (2007) DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Nat. Genet. 39 1403-9 PubMed GONUTS page
↑ ^35.0 ^35.1 ^35.2 Henderson, ST & Johnson, TE (2001) daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr. Biol. 11 1975-80 PubMed GONUTS page
↑ ^36.0 ^36.1 ^36.2 Liachko, N et al. (2009) Combined informatic and expression screen identifies the novel DAF-16 target HLH-13. Dev. Biol. 327 97-105 PubMed GONUTS page
↑ Li, W et al. (2007) RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination. Dev. Cell 12 235-46 PubMed GONUTS page
↑ ^38.0 ^38.1 ^38.2 ^38.3 ^38.4 Lee, RY et al. (2001) Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr. Biol. 11 1950-7 PubMed GONUTS page
↑ ^39.0 ^39.1 ^39.2 ^39.3 ^39.4 Vilchez, D et al. (2012) RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Nature 489 263-8 PubMed GONUTS page
↑ ^40.0 ^40.1 Troemel, ER et al. (2006) p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet. 2 e183 PubMed GONUTS page
↑ Wolf, M et al. (2008) The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness. J. Cell. Physiol. 214 721-9 PubMed GONUTS page
↑ Hartwig, K et al. (2009) Feeding a ROS-generator to Caenorhabditis elegans leads to increased expression of small heat shock protein HSP-16.2 and hormesis. Genes Nutr 4 59-67 PubMed GONUTS page
↑ Miyata, S et al. (2008) DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans. Genetics 178 903-18 PubMed GONUTS page
↑ ^44.0 ^44.1 ^44.2 ^44.3 ^44.4 ^44.5 ^44.6 ^44.7 ^44.8 ^44.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12750521-1] 1.0 ^1.1 Hsu, AL et al. (2003) Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300 1142-5 PubMed GONUTS page

[PMID:23770237-2] 2.0 ^2.1 Matilainen, O et al. (2013) Insulin/IGF-1 signaling regulates proteasome activity through the deubiquitinating enzyme UBH-4. Cell Rep 3 1980-95 PubMed GONUTS page

[PMID:17277769-3] 3.0 ^3.1 Syntichaki, P et al. (2007) eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature 445 922-6 PubMed GONUTS page

[PMID:23665919-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 Hung, WL et al. (2013) Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development. EMBO J. 32 1745-60 PubMed GONUTS page

[PMID:17526726-5] Alper, S et al. (2007) Specificity and complexity of the Caenorhabditis elegans innate immune response. Mol. Cell. Biol. 27 5544-53 PubMed GONUTS page

[PMID:24972867-6] Kong, C et al. (2014) Orthosiphon stamineus protects Caenorhabditis elegans against Staphylococcus aureus infection through immunomodulation. Biol Open 3 644-55 PubMed GONUTS page

[PMID:24957743-7] 7.0 ^7.1 Fischer, M et al. (2014) The zinc matrix metalloproteinase ZMP-2 increases survival of Caenorhabditis elegans through interference with lipoprotein absorption. Genes Nutr 9 414 PubMed GONUTS page

[PMID:27564576-8] Ishii, T et al. (2016) Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans. PLoS Genet. 12 e1006276 PubMed GONUTS page

[PMID:24671950-9] 9.0 ^9.1 ^9.2 ^9.3 Hung, WL et al. (2014) A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication. Development 141 1767-79 PubMed GONUTS page

[PMID:26195740-10] Seo, M et al. (2015) RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans. Proc. Natl. Acad. Sci. U.S.A. 112 E4246-55 PubMed GONUTS page

[PMID:26154057-11] 11.0 ^11.1 Heimbucher, T et al. (2015) The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity. Cell Metab. 22 151-63 PubMed GONUTS page

[PMID:1732156-12] Vowels, JJ & Thomas, JH (1992) Genetic analysis of chemosensory control of dauer formation in Caenorhabditis elegans. Genetics 130 105-23 PubMed GONUTS page

[PMID:15905404-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 Essers, MA et al. (2005) Functional interaction between beta-catenin and FOXO in oxidative stress signaling. Science 308 1181-4 PubMed GONUTS page

[PMID:17098225-14] Li, J et al. (2007) The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans. Dev. Biol. 301 82-91 PubMed GONUTS page

[PMID:26675724-15] Kaletsky, R et al. (2016) The C. elegans adult neuronal IIS/FOXO transcriptome reveals adult phenotype regulators. Nature 529 92-6 PubMed GONUTS page

[PMID:6583682-16] Golden, JW & Riddle, DL (1984) A pheromone-induced developmental switch in Caenorhabditis elegans: Temperature-sensitive mutants reveal a wild-type temperature-dependent process. Proc. Natl. Acad. Sci. U.S.A. 81 819-23 PubMed GONUTS page

[PMID:22554143-17] Twumasi-Boateng, K et al. (2012) An age-dependent reversal in the protective capacities of JNK signaling shortens Caenorhabditis elegans lifespan. Aging Cell 11 659-67 PubMed GONUTS page

[PMID:21124868-18] Jensen, VL et al. (2010) Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25. PLoS Genet. 6 e1001199 PubMed GONUTS page

[PMID:23028355-19] Chiang, WC et al. (2012) C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress. PLoS Genet. 8 e1002948 PubMed GONUTS page

[PMID:23352664-20] 20.0 ^20.1 ^20.2 Uno, M et al. (2013) A fasting-responsive signaling pathway that extends life span in C. elegans. Cell Rep 3 79-91 PubMed GONUTS page

[PMID:25330323-21] Warnhoff, K et al. (2014) The DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylation. PLoS Genet. 10 e1004703 PubMed GONUTS page

[PMID:19454349-22] 22.0 ^22.1 ^22.2 ^22.3 ^22.4 Anyanful, A et al. (2009) Conditioning protects C. elegans from lethal effects of enteropathogenic E. coli by activating genes that regulate lifespan and innate immunity. Cell Host Microbe 5 450-62 PubMed GONUTS page

[PMID:11124266-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 Cahill, CM et al. (2001) Phosphatidylinositol 3-kinase signaling inhibits DAF-16 DNA binding and function via 14-3-3-dependent and 14-3-3-independent pathways. J. Biol. Chem. 276 13402-10 PubMed GONUTS page

[PMID:11381260-24] 24.0 ^24.1 ^24.2 ^24.3 ^24.4 ^24.5 ^24.6 ^24.7 ^24.8 Lin, K et al. (2001) Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nat. Genet. 28 139-45 PubMed GONUTS page

[PMID:12571101-25] Hirose, T et al. (2003) Cyclic GMP-dependent protein kinase EGL-4 controls body size and lifespan in C elegans. Development 130 1089-99 PubMed GONUTS page

[PMID:20523893-26] Schreiber, MA et al. (2010) Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1. PLoS Genet. 6 e1000972 PubMed GONUTS page

[PMID:23911329-27] 27.0 ^27.1 Tepper, RG et al. (2013) PQM-1 complements DAF-16 as a key transcriptional regulator of DAF-2-mediated development and longevity. Cell 154 676-90 PubMed GONUTS page

[PMID:19506556-28] Curran, SP et al. (2009) A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature 459 1079-84 PubMed GONUTS page

[PMID:21531333-29] 29.00 ^29.01 ^29.02 ^29.03 ^29.04 ^29.05 ^29.06 ^29.07 ^29.08 ^29.09 ^29.10 ^29.11 ^29.12 Takahashi, Y et al. (2011) Asymmetric arginine dimethylation determines life span in C. elegans by regulating forkhead transcription factor DAF-16. Cell Metab. 13 505-16 PubMed GONUTS page

[PMID:27001890-30] Nakamura, S et al. (2016) Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals. Nat Commun 7 10944 PubMed GONUTS page

[PMID:22560223-31] Robida-Stubbs, S et al. (2012) TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15 713-24 PubMed GONUTS page

[PMID:18397876-32] Catoire, H et al. (2008) Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1. Hum. Mol. Genet. 17 2108-17 PubMed GONUTS page

[PMID:18762027-33] Perez, CL & Van Gilst, MR (2008) A 13C isotope labeling strategy reveals the influence of insulin signaling on lipogenesis in C. elegans. Cell Metab. 8 266-74 PubMed GONUTS page

[PMID:17934462-34] 34.0 ^34.1 Pinkston-Gosse, J & Kenyon, C (2007) DAF-16/FOXO targets genes that regulate tumor growth in Caenorhabditis elegans. Nat. Genet. 39 1403-9 PubMed GONUTS page

[PMID:11747825-35] 35.0 ^35.1 ^35.2 Henderson, ST & Johnson, TE (2001) daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans. Curr. Biol. 11 1975-80 PubMed GONUTS page

[PMID:19103192-36] 36.0 ^36.1 ^36.2 Liachko, N et al. (2009) Combined informatic and expression screen identifies the novel DAF-16 target HLH-13. Dev. Biol. 327 97-105 PubMed GONUTS page

[PMID:17276341-37] Li, W et al. (2007) RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination. Dev. Cell 12 235-46 PubMed GONUTS page

[PMID:11747821-38] 38.0 ^38.1 ^38.2 ^38.3 ^38.4 Lee, RY et al. (2001) Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway. Curr. Biol. 11 1950-7 PubMed GONUTS page

[PMID:22922647-39] 39.0 ^39.1 ^39.2 ^39.3 ^39.4 Vilchez, D et al. (2012) RPN-6 determines C. elegans longevity under proteotoxic stress conditions. Nature 489 263-8 PubMed GONUTS page

[PMID:17096597-40] 40.0 ^40.1 Troemel, ER et al. (2006) p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet. 2 e183 PubMed GONUTS page

[PMID:17894411-41] Wolf, M et al. (2008) The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness. J. Cell. Physiol. 214 721-9 PubMed GONUTS page

[PMID:19252938-42] Hartwig, K et al. (2009) Feeding a ROS-generator to Caenorhabditis elegans leads to increased expression of small heat shock protein HSP-16.2 and hormesis. Genes Nutr 4 59-67 PubMed GONUTS page

[PMID:18245330-43] Miyata, S et al. (2008) DAF-16-dependent suppression of immunity during reproduction in Caenorhabditis elegans. Genetics 178 903-18 PubMed GONUTS page

[PMID:21873635-44] 44.0 ^44.1 ^44.2 ^44.3 ^44.4 ^44.5 ^44.6 ^44.7 ^44.8 ^44.9 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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CAEEL:FOXO

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