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YEAST:SIR3
Contents
| Species (Taxon ID) | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292) | |
| Gene Name(s) | SIR3 (synonyms: CMT1, MAR2, STE8) | |
| Protein Name(s) | Regulatory protein SIR3
Silent information regulator 3 | |
| External Links | ||
| UniProt | P06701 | |
| EMBL | X01420 U21094 AY693157 BK006945 | |
| PIR | S59410 | |
| RefSeq | NP_013547.3 | |
| PDB | 2FL7 2FVU 3OWT 3TE6 3TU4 3ZCO 4JJN 4KUD 4KUI 4KUL 4LD9 | |
| PDBsum | 2FL7 2FVU 3OWT 3TE6 3TU4 3ZCO 4JJN 4KUD 4KUI 4KUL 4LD9 | |
| DisProt | DP00533 | |
| ProteinModelPortal | P06701 | |
| SMR | P06701 | |
| BioGrid | 31701 | |
| DIP | DIP-595N | |
| IntAct | P06701 | |
| MINT | MINT-673027 | |
| STRING | 4932.YLR442C | |
| MaxQB | P06701 | |
| PaxDb | P06701 | |
| PeptideAtlas | P06701 | |
| EnsemblFungi | [example_ID YLR442C] | |
| GeneID | 851163 | |
| KEGG | sce:YLR442C | |
| SGD | S000004434 | |
| eggNOG | COG1474 | |
| GeneTree | ENSGT00770000121601 | |
| InParanoid | P06701 | |
| KO | K11122 | |
| OMA | YLIHEIR | |
| OrthoDB | EOG7ZWD9N | |
| BioCyc | YEAST:G3O-32498-MONOMER | |
| EvolutionaryTrace | P06701 | |
| NextBio | 967960 | |
| Proteomes | UP000002311 | |
| Genevestigator | P06701 | |
| GO | GO:0005677 GO:0000781 GO:0000784 GO:0005720 GO:0005724 GO:0005730 GO:0003682 GO:0003690 GO:0042802 GO:0031493 GO:0031491 GO:0042803 GO:0003697 GO:0030466 GO:0031507 GO:0001308 GO:0070481 GO:0006351 | |
| InterPro | IPR001025 | |
| Pfam | PF01426 | |
| SMART | SM00439 | |
| PROSITE | PS51038 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
| GO:0007569 |
cell aging |
ECO:0000315 |
P |
Fig.1(A)demonstrates disruption of sir3 resulted in a 20% decrease in mean life span. |
complete | |||||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0034398 |
telomere tethering at nuclear periphery |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0097695 |
establishment of protein-containing complex localization to telomere |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
has_input:(GO:0005697) |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0000784 |
nuclear chromosome, telomeric region |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
C |
adjacent_to:(GO:0034399) |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0034398 |
telomere tethering at nuclear periphery |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006303 |
double-strand break repair via nonhomologous end joining |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006348 |
chromatin silencing at telomere |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006348 |
chromatin silencing at telomere |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030466 |
chromatin silencing at silent mating-type cassette |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0070481 |
nuclear-transcribed mRNA catabolic process, non-stop decay |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0031507 |
heterochromatin assembly |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031493 |
nucleosomal histone binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0031491 |
nucleosome binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0030466 |
chromatin silencing at silent mating-type cassette |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
SGD:S000001809 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0030466 |
chromatin silencing at silent mating-type cassette |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005730 |
nucleolus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005724 |
nuclear telomeric heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005720 |
nuclear heterochromatin |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005677 |
chromatin silencing complex |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003697 |
single-stranded DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003690 |
double-stranded DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0001308 |
negative regulation of chromatin silencing involved in replicative cell aging |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000784 |
nuclear chromosome, telomeric region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000781 |
chromosome, telomeric region |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0000784 |
nuclear chromosome, telomeric region |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000080057 |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003682 |
chromatin binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0003677 |
DNA binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Kaeberlein, M et al. (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13 2570-80 PubMed GONUTS page
- ↑ Reinders, J et al. (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res. 5 1543-54 PubMed GONUTS page
- ↑ Sickmann, A et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc. Natl. Acad. Sci. U.S.A. 100 13207-12 PubMed GONUTS page
- ↑ Guidi, M et al. (2015) Spatial reorganization of telomeres in long-lived quiescent cells. Genome Biol. 16 206 PubMed GONUTS page
- ↑ Hass, EP & Zappulla, DC (2015) The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae. Elife 4 PubMed GONUTS page
- ↑ 6.0 6.1 Laporte, D et al. (2016) Quiescent Saccharomyces cerevisiae forms telomere hyperclusters at the nuclear membrane vicinity through a multifaceted mechanism involving Esc1, the Sir complex, and chromatin condensation. Mol. Biol. Cell 27 1875-84 PubMed GONUTS page
- ↑ 7.0 7.1 Boulton, SJ & Jackson, SP (1998) Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing. EMBO J. 17 1819-28 PubMed GONUTS page
- ↑ Aparicio, OM et al. (1991) Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae. Cell 66 1279-87 PubMed GONUTS page
- ↑ Rine, J & Herskowitz, I (1987) Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics 116 9-22 PubMed GONUTS page
- ↑ Wilson, MA et al. (2007) A genomic screen in yeast reveals novel aspects of nonstop mRNA metabolism. Genetics 177 773-84 PubMed GONUTS page
- ↑ Liaw, H & Lustig, AJ (2006) Sir3 C-terminal domain involvement in the initiation and spreading of heterochromatin. Mol. Cell. Biol. 26 7616-31 PubMed GONUTS page
- ↑ Altaf, M et al. (2007) Interplay of chromatin modifiers on a short basic patch of histone H4 tail defines the boundary of telomeric heterochromatin. Mol. Cell 28 1002-14 PubMed GONUTS page
- ↑ Martino, F et al. (2009) Reconstitution of yeast silent chromatin: multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro. Mol. Cell 33 323-34 PubMed GONUTS page
- ↑ 14.0 14.1 Connelly, JJ et al. (2006) Structure and function of the Saccharomyces cerevisiae Sir3 BAH domain. Mol. Cell. Biol. 26 3256-65 PubMed GONUTS page
- ↑ 15.0 15.1 Kennedy, BK et al. (1997) Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae. Cell 89 381-91 PubMed GONUTS page
- ↑ Gotta, M et al. (1997) Localization of Sir2p: the nucleolus as a compartment for silent information regulators. EMBO J. 16 3243-55 PubMed GONUTS page
- ↑ Lynch, PJ & Rusche, LN (2010) An auxiliary silencer and a boundary element maintain high levels of silencing proteins at HMR in Saccharomyces cerevisiae. Genetics 185 113-27 PubMed GONUTS page
- ↑ Moazed, D et al. (1997) Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3. Proc. Natl. Acad. Sci. U.S.A. 94 2186-91 PubMed GONUTS page
- ↑ 19.0 19.1 Adkins, NL et al. (2009) Role of nucleic acid binding in Sir3p-dependent interactions with chromatin fibers. Biochemistry 48 276-88 PubMed GONUTS page
- ↑ Valenzuela, L et al. (2008) Long-range communication between the silencers of HMR. Mol. Cell. Biol. 28 1924-35 PubMed GONUTS page
- ↑ Bourns, BD et al. (1998) Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo. Mol. Cell. Biol. 18 5600-8 PubMed GONUTS page
- ↑ Clément, M et al. (2006) The nuclear GTPase Gsp1p can affect proper telomeric function through the Sir4 protein in Saccharomyces cerevisiae. Mol. Microbiol. 62 453-68 PubMed GONUTS page
- ↑ Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Oppikofer, M et al. (2013) Dimerization of Sir3 via its C-terminal winged helix domain is essential for yeast heterochromatin formation. EMBO J. 32 437-49 PubMed GONUTS page
- ↑ Lambert, JP et al. (2010) Defining the budding yeast chromatin-associated interactome. Mol. Syst. Biol. 6 448 PubMed GONUTS page
- ↑ King, DA et al. (2006) Domain structure and protein interactions of the silent information regulator Sir3 revealed by screening a nested deletion library of protein fragments. J. Biol. Chem. 281 20107-19 PubMed GONUTS page
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