YEAST:SGS1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	SGS1 (synonyms: TPS1)
Protein Name(s)	ATP-dependent helicase SGS1 Helicase TPS1
External Links
UniProt	P35187
EMBL	U22341 L07870 Z47815 BK006946
PIR	S50918
RefSeq	NP_013915.1
PDB	1D8B
PDBsum	1D8B
ProteinModelPortal	P35187
SMR	P35187
BioGrid	35368
DIP	DIP-2911N
IntAct	P35187
MINT	MINT-442647
STRING	4932.YMR190C
MaxQB	P35187
PaxDb	P35187
PeptideAtlas	P35187
EnsemblFungi	[example_ID YMR190C]
GeneID	855228
KEGG	sce:YMR190C
CYGD	YMR190c
SGD	S000004802
eggNOG	COG0514
GeneTree	ENSGT00550000074520
HOGENOM	HOG000141897
InParanoid	P35187
KO	K10901
OMA	TIFEICD
OrthoDB	EOG7CRTZ8
BioCyc	YEAST:G3O-32877-MONOMER
EvolutionaryTrace	P35187
NextBio	978762
Proteomes	UP000002311
Genevestigator	P35187
GO	GO:0005730 GO:0031422 GO:0005524 GO:0043140 GO:0004003 GO:0003676 GO:0051276 GO:0000729 GO:0032508 GO:0006265 GO:0006268 GO:0000724 GO:0031292 GO:0031573 GO:0045132 GO:0000706 GO:0000070 GO:0010947 GO:0010520 GO:0001302 GO:0000723 GO:0000722 GO:0031860
Gene3D	1.10.10.10 1.10.150.80 3.40.50.300
InterPro	IPR011545 IPR002464 IPR004589 IPR014001 IPR001650 IPR022758 IPR010997 IPR002121 IPR027417 IPR018982 IPR011991
Pfam	PF00270 PF00271 PF11408 PF09382
SMART	SM00487 SM00490 SM00341 SM00956
SUPFAM	SSF47819 SSF52540
TIGRFAMs	TIGR00614
PROSITE	PS00690 PS51192 PS51194 PS50967

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0009408	response to heat	PMID:22579450^[1]	ECO:0000314			P		Figure 3 represents assays on the amount of the protein present after heat was applied. Expression was measured using RNeasy Mini Kit. Selected primers were seen in table 1	complete CACAO 8985
part_of	GO:0005634	nucleus	PMID:22842922^[2]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:12482937^[3]	ECO:0007001	high throughput mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031422	RecQ helicase-Topo III complex	PMID:25588990^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0000086)	Seeded From UniProt	complete
involved_in	GO:0051276	chromosome organization	PMID:11138010^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045132	meiotic chromosome segregation	PMID:7736577^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	PMID:18440969^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031860	telomeric 3' overhang formation	PMID:20808892^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000002379	P		Seeded From UniProt	complete
involved_in	GO:0031860	telomeric 3' overhang formation	PMID:19595717^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000003143	P		Seeded From UniProt	complete
involved_in	GO:0031573	intra-S DNA damage checkpoint	PMID:19158388^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000002771	P		Seeded From UniProt	complete
involved_in	GO:0031573	intra-S DNA damage checkpoint	PMID:19158388^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031422	RecQ helicase-Topo III complex	PMID:15889139^[11]	ECO:0000353	physical interaction evidence used in manual assertion	SGD:S000004224 SGD:S000005945	C		Seeded From UniProt	complete
part_of	GO:0031422	RecQ helicase-Topo III complex	PMID:15899853^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0031292	gene conversion at mating-type locus, DNA double-strand break processing	PMID:18806779^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000005559	P		Seeded From UniProt	complete
involved_in	GO:0010947	negative regulation of meiotic joint molecule formation	PMID:18691964^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000002794	P		Seeded From UniProt	complete
involved_in	GO:0010520	regulation of reciprocal meiotic recombination	PMID:18691965^[15]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000302	P		Seeded From UniProt	complete
involved_in	GO:0006268	DNA unwinding involved in DNA replication	PMID:10366502^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006265	DNA topological change	PMID:22885009^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:10198430^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004003	ATP-dependent DNA helicase activity	PMID:9545297^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0001302	replicative cell aging	PMID:9271578^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001302	replicative cell aging	PMID:11248051^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000729	DNA double-strand break processing	PMID:18806779^[13]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000897 SGD:S000005559	P		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:19158388^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000998 SGD:S000001441 SGD:S000002771	P		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:19158388^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:19595717^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000005559	P		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:19595717^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000003143	P		Seeded From UniProt	complete
involved_in	GO:0000722	telomere maintenance via recombination	PMID:17550308^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000006657	P		Seeded From UniProt	complete
involved_in	GO:0000722	telomere maintenance via recombination	PMID:17550308^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000722	telomere maintenance via recombination	PMID:15994923^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000706	meiotic DNA double-strand break processing	PMID:20150422^[24]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000000981 SGD:S000005559	P		Seeded From UniProt	complete
involved_in	GO:0000070	mitotic sister chromatid segregation	PMID:7736577^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1990426	mitotic recombination-dependent replication fork processing	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 PomBase:SPAC2G11.12	P		Seeded From UniProt	complete
involved_in	GO:1903221	regulation of mitotic recombination involved in replication fork processing	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 PomBase:SPAC2G11.12	P		Seeded From UniProt	complete
involved_in	GO:0071140	resolution of mitotic recombination intermediates	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 PomBase:SPAC2G11.12	P		Seeded From UniProt	complete
involved_in	GO:0070914	UV-damage excision repair	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 PomBase:SPAC2G11.12	P		Seeded From UniProt	complete
involved_in	GO:0045132	meiotic chromosome segregation	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 SGD:S000004802	P		Seeded From UniProt	complete
enables	GO:0043140	ATP-dependent 3'-5' DNA helicase activity	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002906 FB:FBgn0040290 MGI:MGI:1328362 PANTHER:PTN000344873 PomBase:SPAC2G11.12 UniProtKB:O94761 WB:WBGene00006944	F		Seeded From UniProt	complete
part_of	GO:0035861	site of double-strand break	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 PomBase:SPAC2G11.12	C		Seeded From UniProt	complete
involved_in	GO:0032508	DNA duplex unwinding	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002906 FB:FBgn0040290 PANTHER:PTN000344873 PomBase:SPAC2G11.12 SGD:S000004802 TAIR:locus:2127998 TAIR:locus:2180255 TAIR:locus:2197555 UniProtKB:O94761 UniProtKB:P54132 UniProtKB:Q14191 UniProtKB:Q8I2W7 UniProtKB:Q9I920	P		Seeded From UniProt	complete
involved_in	GO:0031860	telomeric 3' overhang formation	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 SGD:S000004802	P		Seeded From UniProt	complete
involved_in	GO:0031573	intra-S DNA damage checkpoint	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 PomBase:SPAC2G11.12 SGD:S000004802	P		Seeded From UniProt	complete
part_of	GO:0031422	RecQ helicase-Topo III complex	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 PomBase:SPAC2G11.12 SGD:S000004802	C		Seeded From UniProt	complete
involved_in	GO:0031297	replication fork processing	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 PomBase:SPAC2G11.12	P		Seeded From UniProt	complete
involved_in	GO:0010947	negative regulation of meiotic joint molecule formation	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 SGD:S000004802	P		Seeded From UniProt	complete
involved_in	GO:0010520	regulation of reciprocal meiotic recombination	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 SGD:S000004802	P		Seeded From UniProt	complete
enables	GO:0009378	four-way junction helicase activity	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000344873 TAIR:locus:2127998 TAIR:locus:2197555 UniProtKB:P54132 UniProtKB:Q14191	F		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10833 PANTHER:PTN000344873 TAIR:locus:2127998 TAIR:locus:2197394 TAIR:locus:2206031	P		Seeded From UniProt	complete
involved_in	GO:0006301	postreplication repair	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 PomBase:SPAC2G11.12	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10833 FB:FBgn0002906 MGI:MGI:1328362 PANTHER:PTN000344873 TAIR:locus:2180255 TAIR:locus:2197394 UniProtKB:O94762	P		Seeded From UniProt	complete
involved_in	GO:0006265	DNA topological change	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 SGD:S000004802	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10833 FB:FBgn0040290 MGI:MGI:1328362 PANTHER:PTN000344873	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 PomBase:SPAC2G11.12 SGD:S000004802	C		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000344873 WB:WBGene00006944	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002906 FB:FBgn0027375 FB:FBgn0040290 MGI:MGI:109635 PANTHER:PTN000749808 UniProtKB:O94762 UniProtKB:P46063 UniProtKB:P54132 WB:WBGene00004322 WB:WBGene00006944	C		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	EcoGene:EG10833 PANTHER:PTN000344873 UniProtKB:P54132 UniProtKB:Q14191 UniProtKB:Q9I920	F		Seeded From UniProt	complete
involved_in	GO:0001302	replicative cell aging	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 SGD:S000004802	P		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 PomBase:SPAC212.11 PomBase:SPBCPT2R1.08c	C		Seeded From UniProt	complete
involved_in	GO:0000724	double-strand break repair via homologous recombination	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0002906 PANTHER:PTN000344874 PomBase:SPAC2G11.12 SGD:S000004802 TAIR:locus:2197394	P		Seeded From UniProt	complete
involved_in	GO:0000723	telomere maintenance	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 SGD:S000004802	P		Seeded From UniProt	complete
involved_in	GO:0000722	telomere maintenance via recombination	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 PomBase:SPAC212.11 PomBase:SPBCPT2R1.08c SGD:S000004802	P		Seeded From UniProt	complete
involved_in	GO:0000706	meiotic DNA double-strand break processing	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 SGD:S000004802	P		Seeded From UniProt	complete
involved_in	GO:0000070	mitotic sister chromatid segregation	PMID:21873635^[25]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001009292 SGD:S000004802	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010997	F		Seeded From UniProt	complete
enables	GO:0003676	nucleic acid binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002121 InterPro:IPR011545 InterPro:IPR022758	F		Seeded From UniProt	complete
enables	GO:0003824	catalytic activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010997	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011545	F		Seeded From UniProt	complete
involved_in	GO:0006260	DNA replication	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018982	P		Seeded From UniProt	complete
involved_in	GO:0006281	DNA repair	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018982	P		Seeded From UniProt	complete
involved_in	GO:0006310	DNA recombination	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004589	P		Seeded From UniProt	complete
enables	GO:0008026	ATP-dependent helicase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR004589	F		Seeded From UniProt	complete
enables	GO:0043140	ATP-dependent 3'-5' DNA helicase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018982 InterPro:IPR022758	F		Seeded From UniProt	complete
involved_in	GO:0044237	cellular metabolic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010997	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0004386	helicase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0347	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Auesukaree, C et al. (2012) Characterization and gene expression profiles of thermotolerant Saccharomyces cerevisiae isolates from Thai fruits. J. Biosci. Bioeng. 114 144-9 PubMed GONUTS page
↑ Tkach, JM et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat. Cell Biol. 14 966-76 PubMed GONUTS page
↑ Chang, M et al. (2002) A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc. Natl. Acad. Sci. U.S.A. 99 16934-9 PubMed GONUTS page
↑ Böhm, S et al. (2015) Disruption of SUMO-targeted ubiquitin ligases Slx5-Slx8/RNF4 alters RecQ-like helicase Sgs1/BLM localization in yeast and human cells. DNA Repair (Amst.) 26 1-14 PubMed GONUTS page
↑ Myung, K et al. (2001) SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination. Nat. Genet. 27 113-6 PubMed GONUTS page
↑ ^6.0 ^6.1 Watt, PM et al. (1995) Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation. Cell 81 253-60 PubMed GONUTS page
↑ Dhar, A & Lahue, RS (2008) Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae. Nucleic Acids Res. 36 3366-73 PubMed GONUTS page
↑ Ngo, HP & Lydall, D (2010) Survival and growth of yeast without telomere capping by Cdc13 in the absence of Sgs1, Exo1, and Rad9. PLoS Genet. 6 e1001072 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Bonetti, D et al. (2009) Multiple pathways regulate 3' overhang generation at S. cerevisiae telomeres. Mol. Cell 35 70-81 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Mankouri, HW et al. (2009) Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae. Mol. Biol. Cell 20 1683-94 PubMed GONUTS page
↑ Chang, M et al. (2005) RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex. EMBO J. 24 2024-33 PubMed GONUTS page
↑ Mullen, JR et al. (2005) Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex. Mol. Cell. Biol. 25 4476-87 PubMed GONUTS page
↑ ^13.0 ^13.1 Mimitou, EP & Symington, LS (2008) Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455 770-4 PubMed GONUTS page
↑ Jessop, L & Lichten, M (2008) Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis. Mol. Cell 31 313-23 PubMed GONUTS page
↑ Oh, SD et al. (2008) RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination. Mol. Cell 31 324-36 PubMed GONUTS page
↑ Bennett, RJ et al. (1999) Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae. J. Mol. Biol. 289 235-48 PubMed GONUTS page
↑ Cejka, P et al. (2012) Decatenation of DNA by the S. cerevisiae Sgs1-Top3-Rmi1 and RPA complex: a mechanism for disentangling chromosomes. Mol. Cell 47 886-96 PubMed GONUTS page
↑ Sun, H et al. (1999) The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs. Nucleic Acids Res. 27 1978-84 PubMed GONUTS page
↑ Bennett, RJ et al. (1998) Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae. J. Biol. Chem. 273 9644-50 PubMed GONUTS page
↑ Sinclair, DA et al. (1997) Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science 277 1313-6 PubMed GONUTS page
↑ Cohen, H & Sinclair, DA (2001) Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase. Proc. Natl. Acad. Sci. U.S.A. 98 3174-9 PubMed GONUTS page
↑ ^22.0 ^22.1 Lee, JY et al. (2007) Evidence that a RecQ helicase slows senescence by resolving recombining telomeres. PLoS Biol. 5 e160 PubMed GONUTS page
↑ Lillard-Wetherell, K et al. (2005) BLM helicase complements disrupted type II telomere lengthening in telomerase-negative sgs1 yeast. Cancer Res. 65 5520-2 PubMed GONUTS page
↑ Manfrini, N et al. (2010) Processing of meiotic DNA double strand breaks requires cyclin-dependent kinase and multiple nucleases. J. Biol. Chem. 285 11628-37 PubMed GONUTS page
↑ ^25.00 ^25.01 ^25.02 ^25.03 ^25.04 ^25.05 ^25.06 ^25.07 ^25.08 ^25.09 ^25.10 ^25.11 ^25.12 ^25.13 ^25.14 ^25.15 ^25.16 ^25.17 ^25.18 ^25.19 ^25.20 ^25.21 ^25.22 ^25.23 ^25.24 ^25.25 ^25.26 ^25.27 ^25.28 ^25.29 ^25.30 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22579450-1] Auesukaree, C et al. (2012) Characterization and gene expression profiles of thermotolerant Saccharomyces cerevisiae isolates from Thai fruits. J. Biosci. Bioeng. 114 144-9 PubMed GONUTS page

[PMID:22842922-2] Tkach, JM et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat. Cell Biol. 14 966-76 PubMed GONUTS page

[PMID:12482937-3] Chang, M et al. (2002) A genome-wide screen for methyl methanesulfonate-sensitive mutants reveals genes required for S phase progression in the presence of DNA damage. Proc. Natl. Acad. Sci. U.S.A. 99 16934-9 PubMed GONUTS page

[PMID:25588990-4] Böhm, S et al. (2015) Disruption of SUMO-targeted ubiquitin ligases Slx5-Slx8/RNF4 alters RecQ-like helicase Sgs1/BLM localization in yeast and human cells. DNA Repair (Amst.) 26 1-14 PubMed GONUTS page

[PMID:11138010-5] Myung, K et al. (2001) SGS1, the Saccharomyces cerevisiae homologue of BLM and WRN, suppresses genome instability and homeologous recombination. Nat. Genet. 27 113-6 PubMed GONUTS page

[PMID:7736577-6] 6.0 ^6.1 Watt, PM et al. (1995) Sgs1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation. Cell 81 253-60 PubMed GONUTS page

[PMID:18440969-7] Dhar, A & Lahue, RS (2008) Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae. Nucleic Acids Res. 36 3366-73 PubMed GONUTS page

[PMID:20808892-8] Ngo, HP & Lydall, D (2010) Survival and growth of yeast without telomere capping by Cdc13 in the absence of Sgs1, Exo1, and Rad9. PLoS Genet. 6 e1001072 PubMed GONUTS page

[PMID:19595717-9] 9.0 ^9.1 ^9.2 Bonetti, D et al. (2009) Multiple pathways regulate 3' overhang generation at S. cerevisiae telomeres. Mol. Cell 35 70-81 PubMed GONUTS page

[PMID:19158388-10] 10.0 ^10.1 ^10.2 ^10.3 Mankouri, HW et al. (2009) Esc2 and Sgs1 act in functionally distinct branches of the homologous recombination repair pathway in Saccharomyces cerevisiae. Mol. Biol. Cell 20 1683-94 PubMed GONUTS page

[PMID:15889139-11] Chang, M et al. (2005) RMI1/NCE4, a suppressor of genome instability, encodes a member of the RecQ helicase/Topo III complex. EMBO J. 24 2024-33 PubMed GONUTS page

[PMID:15899853-12] Mullen, JR et al. (2005) Yeast Rmi1/Nce4 controls genome stability as a subunit of the Sgs1-Top3 complex. Mol. Cell. Biol. 25 4476-87 PubMed GONUTS page

[PMID:18806779-13] 13.0 ^13.1 Mimitou, EP & Symington, LS (2008) Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455 770-4 PubMed GONUTS page

[PMID:18691964-14] Jessop, L & Lichten, M (2008) Mus81/Mms4 endonuclease and Sgs1 helicase collaborate to ensure proper recombination intermediate metabolism during meiosis. Mol. Cell 31 313-23 PubMed GONUTS page

[PMID:18691965-15] Oh, SD et al. (2008) RecQ helicase, Sgs1, and XPF family endonuclease, Mus81-Mms4, resolve aberrant joint molecules during meiotic recombination. Mol. Cell 31 324-36 PubMed GONUTS page

[PMID:10366502-16] Bennett, RJ et al. (1999) Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae. J. Mol. Biol. 289 235-48 PubMed GONUTS page

[PMID:22885009-17] Cejka, P et al. (2012) Decatenation of DNA by the S. cerevisiae Sgs1-Top3-Rmi1 and RPA complex: a mechanism for disentangling chromosomes. Mol. Cell 47 886-96 PubMed GONUTS page

[PMID:10198430-18] Sun, H et al. (1999) The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs. Nucleic Acids Res. 27 1978-84 PubMed GONUTS page

[PMID:9545297-19] Bennett, RJ et al. (1998) Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae. J. Biol. Chem. 273 9644-50 PubMed GONUTS page

[PMID:9271578-20] Sinclair, DA et al. (1997) Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science 277 1313-6 PubMed GONUTS page

[PMID:11248051-21] Cohen, H & Sinclair, DA (2001) Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase. Proc. Natl. Acad. Sci. U.S.A. 98 3174-9 PubMed GONUTS page

[PMID:17550308-22] 22.0 ^22.1 Lee, JY et al. (2007) Evidence that a RecQ helicase slows senescence by resolving recombining telomeres. PLoS Biol. 5 e160 PubMed GONUTS page

[PMID:15994923-23] Lillard-Wetherell, K et al. (2005) BLM helicase complements disrupted type II telomere lengthening in telomerase-negative sgs1 yeast. Cancer Res. 65 5520-2 PubMed GONUTS page

[PMID:20150422-24] Manfrini, N et al. (2010) Processing of meiotic DNA double strand breaks requires cyclin-dependent kinase and multiple nucleases. J. Biol. Chem. 285 11628-37 PubMed GONUTS page

[PMID:21873635-25] 25.00 ^25.01 ^25.02 ^25.03 ^25.04 ^25.05 ^25.06 ^25.07 ^25.08 ^25.09 ^25.10 ^25.11 ^25.12 ^25.13 ^25.14 ^25.15 ^25.16 ^25.17 ^25.18 ^25.19 ^25.20 ^25.21 ^25.22 ^25.23 ^25.24 ^25.25 ^25.26 ^25.27 ^25.28 ^25.29 ^25.30 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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