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Lillard-Wetherell, K, Combs, KA and Groden, J (2005) BLM helicase complements disrupted type II telomere lengthening in telomerase-negative sgs1 yeast. Cancer Res. 65:5520-2


Recombination-mediated pathways for telomere lengthening may be utilized in the absence of telomerase activity. The RecQ-like helicases, BLM and Sgs1, are implicated in recombination-mediated telomere lengthening in human cells and budding yeast, respectively. Here, we show that BLM expression rescues disrupted telomere lengthening in telomerase-negative sgs1 yeast. BLM helicase activity is required for this complementation, indicating BLM and Sgs1 resolve the same telomeric structures. These data support a conserved function for BLM and Sgs1 in recombination-mediated telomere lengthening.


PubMed Online version:10.1158/0008-5472.CAN-05-0632


Adenosine Triphosphatases/genetics; Adenosine Triphosphatases/metabolism; Adenosine Triphosphatases/physiology; DNA Helicases/deficiency; DNA Helicases/genetics; DNA Helicases/metabolism; DNA Helicases/physiology; Mutagenesis, Site-Directed; RecQ Helicases; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/ultrastructure; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/metabolism; Saccharomyces cerevisiae Proteins/physiology; Telomerase/deficiency; Telomere/genetics; Telomere/metabolism; Telomere/physiology



Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status

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