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Sinclair, DA, Mills, K and Guarente, L (1997) Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants. Science 277:1313-6


The SGS1 gene of yeast encodes a DNA helicase with homology to the human WRN gene. Mutations in WRN result in Werner's syndrome, a disease with symptoms resembling premature aging. Mutation of SGS1 is shown to cause premature aging in yeast mother cells on the basis of a shortened life-span and the aging-induced phenotypes of sterility and redistribution of the Sir3 silencing protein from telomeres to the nucleolus. Further, in old sgs1 cells the nucleolus is enlarged and fragmented-changes that also occur in old wild-type cells. These findings suggest a conserved mechanism of cellular aging that may be related to nucleolar structure.




Cell Aging; Cell Division; Cell Nucleolus/chemistry; Cell Nucleolus/metabolism; Cell Nucleolus/ultrastructure; DNA Helicases/genetics; DNA Helicases/physiology; Exodeoxyribonucleases; Fluorescent Antibody Technique, Indirect; Fungal Proteins/analysis; Genes, Fungal; Humans; Mutation; Phenotype; RecQ Helicases; Saccharomyces cerevisiae/cytology; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/physiology; Saccharomyces cerevisiae/ultrastructure; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Trans-Activators/analysis; Werner Syndrome/genetics



Gene product Qualifier GO ID GO term name Evidence Code with/from Aspect Notes Status

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