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YEAST:CTK1

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Species (Taxon ID) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s) CTK1
Protein Name(s) CTD kinase subunit alpha

CTDK-I subunit alpha CTD kinase 58 kDa subunit CTD kinase subunit 1

External Links
UniProt Q03957
EMBL M69024
Z28139
BK006944
PIR S32593
RefSeq NP_012783.1
ProteinModelPortal Q03957
SMR Q03957
BioGrid 33997
DIP DIP-6631N
IntAct Q03957
MINT MINT-636105
STRING 4932.YKL139W
MaxQB Q03957
PaxDb Q03957
PeptideAtlas Q03957
EnsemblFungi [example_ID YKL139W]
GeneID 853718
KEGG sce:YKL139W
CYGD YKL139w
SGD S000001622
eggNOG COG0515
GeneTree ENSGT00770000120511
HOGENOM HOG000233024
InParanoid Q03957
KO K00916
OMA SCHEYEV
OrthoDB EOG7K3TWD
BioCyc YEAST:G3O-31916-MONOMER
BRENDA 2.7.11.22
NextBio 974737
PRO PR:Q03957
Proteomes UP000002311
Genevestigator Q03957
GO GO:0005737
GO:0005730
GO:0005654
GO:0005634
GO:0070692
GO:0005524
GO:0004693
GO:0008353
GO:0006974
GO:0031124
GO:0018105
GO:0070816
GO:0032786
GO:0045943
GO:0045903
GO:0006468
GO:0051726
GO:0006351
GO:0006412
InterPro IPR011009
IPR000719
IPR017441
IPR002290
IPR008271
Pfam PF00069
SMART SM00220
SUPFAM SSF56112
PROSITE PS00107
PS50011
PS00108

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

enables

GO:0004672

protein kinase activity

PMID:16319894[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:16319894[1]

ECO:0007005

high throughput direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006413

translational initiation

PMID:25416238[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070816

phosphorylation of RNA polymerase II C-terminal domain

PMID:19328068[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0070692

CTDK-1 complex

PMID:7565723[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0045943

positive regulation of transcription by RNA polymerase I

PMID:15520468[5]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045903

positive regulation of translational fidelity

PMID:17545469[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032786

positive regulation of DNA-templated transcription, elongation

PMID:9110987[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0031124

mRNA 3'-end processing

PMID:12504017[8]

ECO:0000316

genetic interaction evidence used in manual assertion

SGD:S000003388

P

Seeded From UniProt

complete

involved_in

GO:0031124

mRNA 3'-end processing

PMID:12504017[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:17545469[6]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:1820212[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:1820212[9]

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:P00546

P

Seeded From UniProt

complete

colocalizes_with

GO:0005844

polysome

PMID:17545469[6]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

PMID:15520468[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

PMID:15520468[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:9110987[7]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004693

cyclin-dependent protein serine/threonine kinase activity

PMID:7565723[4]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0070816

phosphorylation of RNA polymerase II C-terminal domain

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0037093
PANTHER:PTN001936021
SGD:S000001622
SGD:S000006365
UniProtKB:Q14004
UniProtKB:Q9NYV4

P

Seeded From UniProt

complete

involved_in

GO:0070816

phosphorylation of RNA polymerase II C-terminal domain

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0037093
PANTHER:PTN000623455
SGD:S000001622
SGD:S000006365
UniProtKB:Q14004
UniProtKB:Q9NYV4

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0019949
PANTHER:PTN000623455
UniProtKB:P50750

P

Seeded From UniProt

complete

enables

GO:0044212

transcription regulatory region DNA binding

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1328368
PANTHER:PTN000623455

F

Seeded From UniProt

complete

involved_in

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001936021
SGD:S000006365

P

Seeded From UniProt

complete

enables

GO:0030332

cyclin binding

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0037093
MGI:MGI:1916812
PANTHER:PTN000623455
RGD:621111
UniProtKB:Q14004
UniProtKB:Q9NYV4

F

Seeded From UniProt

complete

enables

GO:0008353

RNA polymerase II CTD heptapeptide repeat kinase activity

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0019949
FB:FBgn0037093
MGI:MGI:1328368
PANTHER:PTN001936021
PomBase:SPAC2F3.15
PomBase:SPBC32H8.10
SGD:S000006365
UniProtKB:P50750
UniProtKB:Q14004
UniProtKB:Q9NYV4

F

Seeded From UniProt

complete

enables

GO:0008353

RNA polymerase II CTD heptapeptide repeat kinase activity

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0019949
FB:FBgn0037093
MGI:MGI:1328368
PANTHER:PTN000623455
PomBase:SPAC2F3.15
PomBase:SPBC32H8.10
SGD:S000006365
UniProtKB:P50750
UniProtKB:Q14004
UniProtKB:Q9NYV4

F

Seeded From UniProt

complete

enables

GO:0008134

transcription factor binding

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000623455
RGD:1359638

F

Seeded From UniProt

complete

part_of

GO:0008024

cyclin/CDK positive transcription elongation factor complex

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1328368
PANTHER:PTN000623455
UniProtKB:P50750

C

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004106
FB:FBgn0005640
FB:FBgn0013435
FB:FBgn0013762
FB:FBgn0015618
FB:FBgn0263237
MGI:MGI:101765
MGI:MGI:104772
MGI:MGI:88351
MGI:MGI:88357
PANTHER:PTN000623091
RGD:621124
RGD:70514
SGD:S000001622
SGD:S000001865
SGD:S000005488
SGD:S000005952
SGD:S000005963
SGD:S000006365
TAIR:locus:2119961
UniProtKB:P06493
UniProtKB:P11802
UniProtKB:P21127
UniProtKB:P24941
UniProtKB:P50750
UniProtKB:Q00534
UniProtKB:Q00646
UniProtKB:Q9UQ88
WB:WBGene00000405
WB:WBGene00000407
WB:WBGene00019362
ZFIN:ZDB-GENE-040808-34
dictyBase:DDB_G0267442
dictyBase:DDB_G0272813
dictyBase:DDB_G0288677

P

Seeded From UniProt

complete

involved_in

GO:0006368

transcription elongation from RNA polymerase II promoter

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0019949
PANTHER:PTN000623455

P

Seeded From UniProt

complete

part_of

GO:0005694

chromosome

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000623455
WB:WBGene00000410
WB:WBGene00007135

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0015618
FB:FBgn0019949
FB:FBgn0263237
MGI:MGI:101765
MGI:MGI:102956
MGI:MGI:104772
MGI:MGI:1328368
MGI:MGI:88353
MGI:MGI:88357
MGI:MGI:894318
PANTHER:PTN000623091
PomBase:SPAC2F3.15
PomBase:SPBC11B10.09
PomBase:SPBC32H8.10
RGD:1305435
RGD:1359638
RGD:2319
RGD:619874
RGD:621120
RGD:621124
RGD:70486
RGD:70514
SGD:S000000364
SGD:S000001622
SGD:S000002266
SGD:S000005952
TAIR:locus:2008595
TAIR:locus:2027819
TAIR:locus:2033349
TAIR:locus:2080290
TAIR:locus:2084086
TAIR:locus:2099478
TAIR:locus:2119961
TAIR:locus:2158554
TAIR:locus:2194045
UniProtKB:O76039
UniProtKB:O94921
UniProtKB:P06493
UniProtKB:P11802
UniProtKB:P21127
UniProtKB:P24941
UniProtKB:P49336
UniProtKB:P50613
UniProtKB:P61075
UniProtKB:P79432
UniProtKB:Q00534
UniProtKB:Q00535
UniProtKB:Q00646
UniProtKB:Q5B3E4
UniProtKB:Q8IDW1
UniProtKB:Q8IIL5
UniProtKB:Q8IJQ1
UniProtKB:Q8RWN3
UniProtKB:Q8W4P1
UniProtKB:Q92772
UniProtKB:Q96VK3
UniProtKB:Q9NYV4
UniProtKB:Q9UQ88
WB:WBGene00000405
dictyBase:DDB_G0267442
dictyBase:DDB_G0288677

C

Seeded From UniProt

complete

enables

GO:0004693

cyclin-dependent protein serine/threonine kinase activity

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0004106
FB:FBgn0005640
FB:FBgn0013762
FB:FBgn0019949
FB:FBgn0263237
MGI:MGI:104772
MGI:MGI:88351
MGI:MGI:88357
PANTHER:PTN000623091
PomBase:SPAC23H4.17c
PomBase:SPAC2F3.15
PomBase:SPBC11B10.09
PomBase:SPBC19F8.07
PomBase:SPBC32H8.10
RGD:2319
RGD:621120
RGD:621124
RGD:70486
RGD:70514
SGD:S000000364
SGD:S000001622
SGD:S000005952
SGD:S000005963
SGD:S000006365
TAIR:locus:2011761
UniProtKB:A0A1D8PDA6
UniProtKB:C9K505
UniProtKB:O94921
UniProtKB:P06493
UniProtKB:P11802
UniProtKB:P24941
UniProtKB:P50750
UniProtKB:P61075
UniProtKB:Q00534
UniProtKB:Q00646
UniProtKB:Q8IJQ1
WB:WBGene00000405
ZFIN:ZDB-GENE-010131-2
dictyBase:DDB_G0272813
dictyBase:DDB_G0288677

F

Seeded From UniProt

complete

part_of

GO:0000790

nuclear chromatin

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001936021
PomBase:SPAC2F3.15
PomBase:SPBC32H8.10

C

Seeded From UniProt

complete

part_of

GO:0000307

cyclin-dependent protein kinase holoenzyme complex

PMID:21873635[10]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001936021
PomBase:SPBC32H8.10
SGD:S000006365

C

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004693

P

Seeded From UniProt

complete

involved_in

GO:0051726

regulation of cell cycle

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0004693

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR017441

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

P

Seeded From UniProt

complete

enables

GO:0008353

RNA polymerase II CTD heptapeptide repeat kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.11.23

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539

C

Seeded From UniProt

complete

involved_in

GO:0006397

mRNA processing

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0507

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

involved_in

GO:0006412

translation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0648

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0227

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0188

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 Ptacek, J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438 679-84 PubMed GONUTS page
  2. Coordes, B et al. (2015) Ctk1 function is necessary for full translation initiation activity in Saccharomyces cerevisiae. Eukaryotic Cell 14 86-95 PubMed GONUTS page
  3. Qiu, H et al. (2009) Phosphorylation of the Pol II CTD by KIN28 enhances BUR1/BUR2 recruitment and Ser2 CTD phosphorylation near promoters. Mol. Cell 33 752-62 PubMed GONUTS page
  4. 4.0 4.1 Sterner, DE et al. (1995) The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. Mol. Cell. Biol. 15 5716-24 PubMed GONUTS page
  5. 5.0 5.1 5.2 Bouchoux, C et al. (2004) CTD kinase I is involved in RNA polymerase I transcription. Nucleic Acids Res. 32 5851-60 PubMed GONUTS page
  6. 6.0 6.1 6.2 Röther, S & Strässer, K (2007) The RNA polymerase II CTD kinase Ctk1 functions in translation elongation. Genes Dev. 21 1409-21 PubMed GONUTS page
  7. 7.0 7.1 Lee, JM & Greenleaf, AL (1997) Modulation of RNA polymerase II elongation efficiency by C-terminal heptapeptide repeat domain kinase I. J. Biol. Chem. 272 10990-3 PubMed GONUTS page
  8. 8.0 8.1 Skaar, DA & Greenleaf, AL (2002) The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p. Mol. Cell 10 1429-39 PubMed GONUTS page
  9. 9.0 9.1 Lee, JM & Greenleaf, AL (1991) CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae. Gene Expr. 1 149-67 PubMed GONUTS page
  10. 10.00 10.01 10.02 10.03 10.04 10.05 10.06 10.07 10.08 10.09 10.10 10.11 10.12 10.13 10.14 10.15 10.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page