YEAST:CTK1

Species (Taxon ID)	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). (559292)
Gene Name(s)	CTK1
Protein Name(s)	CTD kinase subunit alpha CTDK-I subunit alpha CTD kinase 58 kDa subunit CTD kinase subunit 1
External Links
UniProt	Q03957
EMBL	M69024 Z28139 BK006944
PIR	S32593
RefSeq	NP_012783.1
ProteinModelPortal	Q03957
SMR	Q03957
BioGrid	33997
DIP	DIP-6631N
IntAct	Q03957
MINT	MINT-636105
STRING	4932.YKL139W
MaxQB	Q03957
PaxDb	Q03957
PeptideAtlas	Q03957
EnsemblFungi	[example_ID YKL139W]
GeneID	853718
KEGG	sce:YKL139W
CYGD	YKL139w
SGD	S000001622
eggNOG	COG0515
GeneTree	ENSGT00770000120511
HOGENOM	HOG000233024
InParanoid	Q03957
KO	K00916
OMA	SCHEYEV
OrthoDB	EOG7K3TWD
BioCyc	YEAST:G3O-31916-MONOMER
BRENDA	2.7.11.22
NextBio	974737
PRO	PR:Q03957
Proteomes	UP000002311
Genevestigator	Q03957
GO	GO:0005737 GO:0005730 GO:0005654 GO:0005634 GO:0070692 GO:0005524 GO:0004693 GO:0008353 GO:0006974 GO:0031124 GO:0018105 GO:0070816 GO:0032786 GO:0045943 GO:0045903 GO:0006468 GO:0051726 GO:0006351 GO:0006412
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0004672	protein kinase activity	PMID:16319894^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:16319894^[1]	ECO:0007005	high throughput direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006413	translational initiation	PMID:25416238^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	PMID:19328068^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0070692	CTDK-1 complex	PMID:7565723^[4]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0045943	positive regulation of transcription by RNA polymerase I	PMID:15520468^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0045903	positive regulation of translational fidelity	PMID:17545469^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0032786	positive regulation of DNA-templated transcription, elongation	PMID:9110987^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0031124	mRNA 3'-end processing	PMID:12504017^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	SGD:S000003388	P	Seeded From UniProt	complete
involved_in	GO:0031124	mRNA 3'-end processing	PMID:12504017^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:17545469^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:1820212^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:1820212^[9]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P00546	P	Seeded From UniProt	complete
colocalizes_with	GO:0005844	polysome	PMID:17545469^[6]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	PMID:15520468^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	PMID:15520468^[5]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9110987^[7]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:7565723^[4]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037093 PANTHER:PTN001936021 SGD:S000001622 SGD:S000006365 UniProtKB:Q14004 UniProtKB:Q9NYV4	P	Seeded From UniProt	complete
involved_in	GO:0070816	phosphorylation of RNA polymerase II C-terminal domain	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037093 PANTHER:PTN000623455 SGD:S000001622 SGD:S000006365 UniProtKB:Q14004 UniProtKB:Q9NYV4	P	Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019949 PANTHER:PTN000623455 UniProtKB:P50750	P	Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1328368 PANTHER:PTN000623455	F	Seeded From UniProt	complete
involved_in	GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001936021 SGD:S000006365	P	Seeded From UniProt	complete
enables	GO:0030332	cyclin binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0037093 MGI:MGI:1916812 PANTHER:PTN000623455 RGD:621111 UniProtKB:Q14004 UniProtKB:Q9NYV4	F	Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019949 FB:FBgn0037093 MGI:MGI:1328368 PANTHER:PTN001936021 PomBase:SPAC2F3.15 PomBase:SPBC32H8.10 SGD:S000006365 UniProtKB:P50750 UniProtKB:Q14004 UniProtKB:Q9NYV4	F	Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019949 FB:FBgn0037093 MGI:MGI:1328368 PANTHER:PTN000623455 PomBase:SPAC2F3.15 PomBase:SPBC32H8.10 SGD:S000006365 UniProtKB:P50750 UniProtKB:Q14004 UniProtKB:Q9NYV4	F	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000623455 RGD:1359638	F	Seeded From UniProt	complete
part_of	GO:0008024	cyclin/CDK positive transcription elongation factor complex	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1328368 PANTHER:PTN000623455 UniProtKB:P50750	C	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004106 FB:FBgn0005640 FB:FBgn0013435 FB:FBgn0013762 FB:FBgn0015618 FB:FBgn0263237 MGI:MGI:101765 MGI:MGI:104772 MGI:MGI:88351 MGI:MGI:88357 PANTHER:PTN000623091 RGD:621124 RGD:70514 SGD:S000001622 SGD:S000001865 SGD:S000005488 SGD:S000005952 SGD:S000005963 SGD:S000006365 TAIR:locus:2119961 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P21127 UniProtKB:P24941 UniProtKB:P50750 UniProtKB:Q00534 UniProtKB:Q00646 UniProtKB:Q9UQ88 WB:WBGene00000405 WB:WBGene00000407 WB:WBGene00019362 ZFIN:ZDB-GENE-040808-34 dictyBase:DDB_G0267442 dictyBase:DDB_G0272813 dictyBase:DDB_G0288677	P	Seeded From UniProt	complete
involved_in	GO:0006368	transcription elongation from RNA polymerase II promoter	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019949 PANTHER:PTN000623455	P	Seeded From UniProt	complete
part_of	GO:0005694	chromosome	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000623455 WB:WBGene00000410 WB:WBGene00007135	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0015618 FB:FBgn0019949 FB:FBgn0263237 MGI:MGI:101765 MGI:MGI:102956 MGI:MGI:104772 MGI:MGI:1328368 MGI:MGI:88353 MGI:MGI:88357 MGI:MGI:894318 PANTHER:PTN000623091 PomBase:SPAC2F3.15 PomBase:SPBC11B10.09 PomBase:SPBC32H8.10 RGD:1305435 RGD:1359638 RGD:2319 RGD:619874 RGD:621120 RGD:621124 RGD:70486 RGD:70514 SGD:S000000364 SGD:S000001622 SGD:S000002266 SGD:S000005952 TAIR:locus:2008595 TAIR:locus:2027819 TAIR:locus:2033349 TAIR:locus:2080290 TAIR:locus:2084086 TAIR:locus:2099478 TAIR:locus:2119961 TAIR:locus:2158554 TAIR:locus:2194045 UniProtKB:O76039 UniProtKB:O94921 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P21127 UniProtKB:P24941 UniProtKB:P49336 UniProtKB:P50613 UniProtKB:P61075 UniProtKB:P79432 UniProtKB:Q00534 UniProtKB:Q00535 UniProtKB:Q00646 UniProtKB:Q5B3E4 UniProtKB:Q8IDW1 UniProtKB:Q8IIL5 UniProtKB:Q8IJQ1 UniProtKB:Q8RWN3 UniProtKB:Q8W4P1 UniProtKB:Q92772 UniProtKB:Q96VK3 UniProtKB:Q9NYV4 UniProtKB:Q9UQ88 WB:WBGene00000405 dictyBase:DDB_G0267442 dictyBase:DDB_G0288677	C	Seeded From UniProt	complete
enables	GO:0004693	cyclin-dependent protein serine/threonine kinase activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0004106 FB:FBgn0005640 FB:FBgn0013762 FB:FBgn0019949 FB:FBgn0263237 MGI:MGI:104772 MGI:MGI:88351 MGI:MGI:88357 PANTHER:PTN000623091 PomBase:SPAC23H4.17c PomBase:SPAC2F3.15 PomBase:SPBC11B10.09 PomBase:SPBC19F8.07 PomBase:SPBC32H8.10 RGD:2319 RGD:621120 RGD:621124 RGD:70486 RGD:70514 SGD:S000000364 SGD:S000001622 SGD:S000005952 SGD:S000005963 SGD:S000006365 TAIR:locus:2011761 UniProtKB:A0A1D8PDA6 UniProtKB:C9K505 UniProtKB:O94921 UniProtKB:P06493 UniProtKB:P11802 UniProtKB:P24941 UniProtKB:P50750 UniProtKB:P61075 UniProtKB:Q00534 UniProtKB:Q00646 UniProtKB:Q8IJQ1 WB:WBGene00000405 ZFIN:ZDB-GENE-010131-2 dictyBase:DDB_G0272813 dictyBase:DDB_G0288677	F	Seeded From UniProt	complete
part_of	GO:0000790	nuclear chromatin	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001936021 PomBase:SPAC2F3.15 PomBase:SPBC32H8.10	C	Seeded From UniProt	complete
part_of	GO:0000307	cyclin-dependent protein kinase holoenzyme complex	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001936021 PomBase:SPBC32H8.10 SGD:S000006365	C	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004693	P	Seeded From UniProt	complete
involved_in	GO:0051726	regulation of cell cycle	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004693	P	Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F	Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P	Seeded From UniProt	complete
enables	GO:0008353	RNA polymerase II CTD heptapeptide repeat kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.23	F	Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
involved_in	GO:0006397	mRNA processing	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0507	P	Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F	Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F	Seeded From UniProt	complete
involved_in	GO:0006412	translation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0648	P	Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P	Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ptacek, J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438 679-84 PubMed GONUTS page
↑ Coordes, B et al. (2015) Ctk1 function is necessary for full translation initiation activity in Saccharomyces cerevisiae. Eukaryotic Cell 14 86-95 PubMed GONUTS page
↑ Qiu, H et al. (2009) Phosphorylation of the Pol II CTD by KIN28 enhances BUR1/BUR2 recruitment and Ser2 CTD phosphorylation near promoters. Mol. Cell 33 752-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Sterner, DE et al. (1995) The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. Mol. Cell. Biol. 15 5716-24 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Bouchoux, C et al. (2004) CTD kinase I is involved in RNA polymerase I transcription. Nucleic Acids Res. 32 5851-60 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Röther, S & Strässer, K (2007) The RNA polymerase II CTD kinase Ctk1 functions in translation elongation. Genes Dev. 21 1409-21 PubMed GONUTS page
↑ ^7.0 ^7.1 Lee, JM & Greenleaf, AL (1997) Modulation of RNA polymerase II elongation efficiency by C-terminal heptapeptide repeat domain kinase I. J. Biol. Chem. 272 10990-3 PubMed GONUTS page
↑ ^8.0 ^8.1 Skaar, DA & Greenleaf, AL (2002) The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p. Mol. Cell 10 1429-39 PubMed GONUTS page
↑ ^9.0 ^9.1 Lee, JM & Greenleaf, AL (1991) CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae. Gene Expr. 1 149-67 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16319894-1] 1.0 ^1.1 Ptacek, J et al. (2005) Global analysis of protein phosphorylation in yeast. Nature 438 679-84 PubMed GONUTS page

[PMID:25416238-2] Coordes, B et al. (2015) Ctk1 function is necessary for full translation initiation activity in Saccharomyces cerevisiae. Eukaryotic Cell 14 86-95 PubMed GONUTS page

[PMID:19328068-3] Qiu, H et al. (2009) Phosphorylation of the Pol II CTD by KIN28 enhances BUR1/BUR2 recruitment and Ser2 CTD phosphorylation near promoters. Mol. Cell 33 752-62 PubMed GONUTS page

[PMID:7565723-4] 4.0 ^4.1 Sterner, DE et al. (1995) The yeast carboxyl-terminal repeat domain kinase CTDK-I is a divergent cyclin-cyclin-dependent kinase complex. Mol. Cell. Biol. 15 5716-24 PubMed GONUTS page

[PMID:15520468-5] 5.0 ^5.1 ^5.2 Bouchoux, C et al. (2004) CTD kinase I is involved in RNA polymerase I transcription. Nucleic Acids Res. 32 5851-60 PubMed GONUTS page

[PMID:17545469-6] 6.0 ^6.1 ^6.2 Röther, S & Strässer, K (2007) The RNA polymerase II CTD kinase Ctk1 functions in translation elongation. Genes Dev. 21 1409-21 PubMed GONUTS page

[PMID:9110987-7] 7.0 ^7.1 Lee, JM & Greenleaf, AL (1997) Modulation of RNA polymerase II elongation efficiency by C-terminal heptapeptide repeat domain kinase I. J. Biol. Chem. 272 10990-3 PubMed GONUTS page

[PMID:12504017-8] 8.0 ^8.1 Skaar, DA & Greenleaf, AL (2002) The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p. Mol. Cell 10 1429-39 PubMed GONUTS page

[PMID:1820212-9] 9.0 ^9.1 Lee, JM & Greenleaf, AL (1991) CTD kinase large subunit is encoded by CTK1, a gene required for normal growth of Saccharomyces cerevisiae. Gene Expr. 1 149-67 PubMed GONUTS page

[PMID:21873635-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 ^10.12 ^10.13 ^10.14 ^10.15 ^10.16 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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YEAST:CTK1

Contents

Annotations

Notes

References

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